JP2022513797A - アネロソーム及び使用の方法 - Google Patents
アネロソーム及び使用の方法 Download PDFInfo
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- JP2022513797A JP2022513797A JP2021533528A JP2021533528A JP2022513797A JP 2022513797 A JP2022513797 A JP 2022513797A JP 2021533528 A JP2021533528 A JP 2021533528A JP 2021533528 A JP2021533528 A JP 2021533528A JP 2022513797 A JP2022513797 A JP 2022513797A
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- Prior art keywords
- anerosome
- nucleic acid
- orf1
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- sequence
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5184—Virus capsids or envelopes enclosing drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00023—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00041—Use of virus, viral particle or viral elements as a vector
- C12N2750/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00051—Methods of production or purification of viral material
- C12N2750/00052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00071—Demonstrated in vivo effect
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nanotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024075373A JP2024099834A (ja) | 2018-12-12 | 2024-05-07 | アネロソーム及び使用の方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862778841P | 2018-12-12 | 2018-12-12 | |
| US201862778866P | 2018-12-12 | 2018-12-12 | |
| US62/778,841 | 2018-12-12 | ||
| US62/778,866 | 2018-12-12 | ||
| PCT/US2019/065995 WO2020123816A2 (en) | 2018-12-12 | 2019-12-12 | Anellosomes and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024075373A Division JP2024099834A (ja) | 2018-12-12 | 2024-05-07 | アネロソーム及び使用の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022513797A true JP2022513797A (ja) | 2022-02-09 |
| JPWO2020123816A5 JPWO2020123816A5 (enExample) | 2022-12-20 |
Family
ID=69165586
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021533528A Withdrawn JP2022513797A (ja) | 2018-12-12 | 2019-12-12 | アネロソーム及び使用の方法 |
| JP2024075373A Pending JP2024099834A (ja) | 2018-12-12 | 2024-05-07 | アネロソーム及び使用の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024075373A Pending JP2024099834A (ja) | 2018-12-12 | 2024-05-07 | アネロソーム及び使用の方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220042042A1 (enExample) |
| EP (1) | EP3894570A2 (enExample) |
| JP (2) | JP2022513797A (enExample) |
| KR (1) | KR20210131310A (enExample) |
| CN (1) | CN113631716A (enExample) |
| AU (1) | AU2019397058A1 (enExample) |
| BR (1) | BR112021011124A2 (enExample) |
| CA (1) | CA3121528A1 (enExample) |
| IL (1) | IL283782A (enExample) |
| MX (1) | MX2021006977A (enExample) |
| WO (1) | WO2020123816A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018201160A1 (en) | 2017-04-28 | 2018-11-01 | Agrospheres, Inc. | Compositions and methods for enzyme immobilization |
| CA3056801A1 (en) | 2017-04-28 | 2018-11-01 | Agrospheres, Inc. | Compositions and methods for the encapsulation and scalable delivery of agrochemicals |
| MX2020003074A (es) | 2017-09-25 | 2020-09-14 | Agrospheres Inc | Composiciones y metodos para la produccion y la administracion expansible de productos biologicos. |
| WO2020123795A2 (en) * | 2018-12-12 | 2020-06-18 | Flagship Pioneering Innovations V, Inc. | Anellosomes for delivering protein replacement therapeutic modalities |
| WO2021252955A1 (en) * | 2020-06-12 | 2021-12-16 | Flagship Pioneering Innovations V, Inc. | Tandem anellovirus constructs |
| CA3206361A1 (en) * | 2020-12-23 | 2022-06-30 | Flagship Pioneering Innovations V, Inc. | In vitro assembly of anellovirus capsids enclosing rna |
| EP4337235A4 (en) * | 2021-05-12 | 2025-07-02 | Flagship Pioneering Innovations V Inc | ANELLOVECTORS AND METHODS OF USE |
| TW202430215A (zh) | 2022-12-14 | 2024-08-01 | 美商旗艦先鋒創新有限責任(Vii)公司 | 用於將治療劑遞送至骨之組成物和方法 |
| WO2025080985A1 (en) | 2023-10-13 | 2025-04-17 | Flagship Pioneering Innovations V, Inc. | Tissue specific anellovector delivery |
| WO2025160409A1 (en) | 2024-01-26 | 2025-07-31 | Flagship Pioneering Innovations V, Inc. | Viral vectors for modulating vegf function |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003525583A (ja) * | 1999-02-05 | 2003-09-02 | アボット・ラボラトリーズ | Ttウイルスの使用法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2932479A1 (en) * | 2013-12-12 | 2015-06-18 | The Rockefeller University | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders |
| KR20200038236A (ko) * | 2017-06-13 | 2020-04-10 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 큐론을 포함하는 조성물 및 그의 용도 |
| CA3119339A1 (en) * | 2018-12-12 | 2020-06-18 | Flagship Pioneering Innovations V, Inc. | Anellosomes for delivering intracellular therapeutic modalities |
| WO2020123795A2 (en) * | 2018-12-12 | 2020-06-18 | Flagship Pioneering Innovations V, Inc. | Anellosomes for delivering protein replacement therapeutic modalities |
| BR112021009379A2 (pt) * | 2018-12-12 | 2021-08-17 | Flagship Pioneering Innovations V, Inc | anelossomos para entrega de modalidades terapêuticas secretadas |
-
2019
- 2019-12-12 MX MX2021006977A patent/MX2021006977A/es unknown
- 2019-12-12 US US17/413,392 patent/US20220042042A1/en active Pending
- 2019-12-12 BR BR112021011124A patent/BR112021011124A2/pt unknown
- 2019-12-12 EP EP19836738.5A patent/EP3894570A2/en active Pending
- 2019-12-12 JP JP2021533528A patent/JP2022513797A/ja not_active Withdrawn
- 2019-12-12 CA CA3121528A patent/CA3121528A1/en active Pending
- 2019-12-12 WO PCT/US2019/065995 patent/WO2020123816A2/en not_active Ceased
- 2019-12-12 KR KR1020217021777A patent/KR20210131310A/ko not_active Ceased
- 2019-12-12 AU AU2019397058A patent/AU2019397058A1/en active Pending
- 2019-12-12 CN CN201980091082.6A patent/CN113631716A/zh active Pending
-
2021
- 2021-06-07 IL IL283782A patent/IL283782A/en unknown
-
2024
- 2024-05-07 JP JP2024075373A patent/JP2024099834A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003525583A (ja) * | 1999-02-05 | 2003-09-02 | アボット・ラボラトリーズ | Ttウイルスの使用法 |
Non-Patent Citations (4)
| Title |
|---|
| EUR RESPIR J, vol. 42, JPN6024024628, 2013, pages 470 - 479, ISSN: 0005353606 * |
| J VIROLOGY, vol. 78, JPN6023043858, 2004, pages 10820 - 10824, ISSN: 0005353604 * |
| JOURNAL OF VIROLOGY, vol. 85, no. 14, JPN6024024629, 2011, pages 7284 - 7295, ISSN: 0005353605 * |
| VIROLOGY, vol. 321, JPN6023043859, 2004, pages 341 - 348, ISSN: 0005353603 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021011124A2 (pt) | 2022-03-15 |
| US20220042042A1 (en) | 2022-02-10 |
| CN113631716A (zh) | 2021-11-09 |
| JP2024099834A (ja) | 2024-07-25 |
| WO2020123816A2 (en) | 2020-06-18 |
| IL283782A (en) | 2021-07-29 |
| MX2021006977A (es) | 2021-10-13 |
| WO2020123816A3 (en) | 2020-08-06 |
| KR20210131310A (ko) | 2021-11-02 |
| CA3121528A1 (en) | 2020-06-18 |
| AU2019397058A1 (en) | 2021-06-10 |
| EP3894570A2 (en) | 2021-10-20 |
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