CA3110552A1 - Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases - Google Patents

Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Info

Publication number
CA3110552A1
CA3110552A1 CA3110552A CA3110552A CA3110552A1 CA 3110552 A1 CA3110552 A1 CA 3110552A1 CA 3110552 A CA3110552 A CA 3110552A CA 3110552 A CA3110552 A CA 3110552A CA 3110552 A1 CA3110552 A1 CA 3110552A1
Authority
CA
Canada
Prior art keywords
cancer
yloxy
methyl
pyridin
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3110552A
Other languages
English (en)
French (fr)
Inventor
Zhi-Fu Tao
Xilu Wang
Michael D. Wendt
Andrew J. Souers
Andrew S. Judd
Aaron Kunzer
Gerard Sullivan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
Original Assignee
AbbVie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51529947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA3110552(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AbbVie Inc filed Critical AbbVie Inc
Publication of CA3110552A1 publication Critical patent/CA3110552A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3110552A 2013-03-14 2014-02-21 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases Pending CA3110552A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361781070P 2013-03-14 2013-03-14
US61/781,070 2013-03-14
US14/176,506 2014-02-10
US14/176,506 US20140275082A1 (en) 2013-03-14 2014-02-10 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2899041A CA2899041A1 (en) 2013-03-14 2014-02-21 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2899041A Division CA2899041A1 (en) 2013-03-14 2014-02-21 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Publications (1)

Publication Number Publication Date
CA3110552A1 true CA3110552A1 (en) 2014-10-02

Family

ID=51529947

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3110552A Pending CA3110552A1 (en) 2013-03-14 2014-02-21 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2899041A Abandoned CA2899041A1 (en) 2013-03-14 2014-02-21 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2899041A Abandoned CA2899041A1 (en) 2013-03-14 2014-02-21 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Country Status (35)

Country Link
US (6) US20140275082A1 (enExample)
EP (2) EP2970257B1 (enExample)
JP (4) JP6449222B2 (enExample)
KR (2) KR20210021613A (enExample)
CN (2) CN105026394B (enExample)
AR (2) AR095263A1 (enExample)
AU (2) AU2014242104B2 (enExample)
BR (1) BR112015021115B1 (enExample)
CA (2) CA3110552A1 (enExample)
CL (2) CL2015002640A1 (enExample)
CR (1) CR20150510A (enExample)
CY (1) CY1120862T1 (enExample)
DK (1) DK2970257T3 (enExample)
DO (1) DOP2018000026A (enExample)
ES (1) ES2689679T3 (enExample)
GT (1) GT201500248A (enExample)
HR (1) HRP20181403T8 (enExample)
HU (1) HUE038983T2 (enExample)
IL (3) IL240010B (enExample)
LT (1) LT2970257T (enExample)
MX (2) MX360541B (enExample)
MY (1) MY178821A (enExample)
NZ (1) NZ631701A (enExample)
PE (2) PE20151555A1 (enExample)
PL (1) PL2970257T4 (enExample)
PT (1) PT2970257T (enExample)
RS (1) RS57750B1 (enExample)
RU (2) RU2018127315A (enExample)
SG (2) SG10201908388UA (enExample)
SI (1) SI2970257T1 (enExample)
TW (2) TWI717662B (enExample)
UA (1) UA120035C2 (enExample)
UY (1) UY35406A (enExample)
WO (1) WO2014158528A1 (enExample)
ZA (1) ZA201505203B (enExample)

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JP7558977B2 (ja) * 2019-05-24 2024-10-01 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド メチル基及びトリフルオロメチル基を含む二置換スルファミド系選択的ｂｃｌ－２阻害剤
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