|
US5906936A
(en)
|
1988-05-04 |
1999-05-25 |
Yeda Research And Development Co. Ltd. |
Endowing lymphocytes with antibody specificity
|
|
GB9125768D0
(en)
|
1991-12-04 |
1992-02-05 |
Hale Geoffrey |
Therapeutic method
|
|
US8211422B2
(en)
|
1992-03-18 |
2012-07-03 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Chimeric receptor genes and cells transformed therewith
|
|
IL104570A0
(en)
|
1992-03-18 |
1993-05-13 |
Yeda Res & Dev |
Chimeric genes and cells transformed therewith
|
|
PT1621554E
(pt)
|
1992-08-21 |
2009-07-13 |
Univ Bruxelles |
Imunoglobtainas desprovidas de cadeias leves
|
|
US5830755A
(en)
|
1995-03-27 |
1998-11-03 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
T-cell receptors and their use in therapeutic and diagnostic methods
|
|
US5840839A
(en)
|
1996-02-09 |
1998-11-24 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein
|
|
WO1998006746A2
(en)
|
1996-08-16 |
1998-02-19 |
The Johns Hopkins University School Of Medicine |
Melanoma cell lines expressing shared immunodominant melanoma antigens and methods of using same
|
|
DE69718029T2
(de)
|
1996-10-11 |
2003-10-16 |
The Regents Of The University Of California, Oakland |
Krebs immuntherapie unter verwendung von tumorzellen kombiniert mit lymphozytmischungen
|
|
US6323317B1
(en)
*
|
1996-11-01 |
2001-11-27 |
The Walter And Eliza Hall Institute Of Medical Research |
Therapeutic and diagnostics proteins comprising a SOCS box
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
JP2002535995A
(ja)
|
1999-02-03 |
2002-10-29 |
ザ チルドレンズ メディカル センター コーポレイション |
染色体標的部位での二本鎖dna切断の誘導を含む遺伝子修復
|
|
JP2000256212A
(ja)
*
|
1999-03-05 |
2000-09-19 |
Tadayasu Takada |
良性間葉系腫瘍の治療剤
|
|
EP2311951A1
(en)
|
2000-01-28 |
2011-04-20 |
The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services |
Novel MHC class II restricted T cell epitopes from the cancer antigen, NY ESO-1
|
|
EP1330156A4
(en)
|
2000-10-09 |
2006-09-13 |
Amrad Operations Pty Ltd |
MODULATION OF CYTOKINE OR HORMONE SIGNALING IN AN ANIMAL, INTEGRATING PROGRESSIVE REGULATION OF SOCS SEQUENCE EXPRESSION IN ANIMALS
|
|
US8716022B2
(en)
|
2000-11-17 |
2014-05-06 |
Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food |
Modulation of meiotic recombination
|
|
US7723111B2
(en)
|
2001-03-09 |
2010-05-25 |
The United States Of America As Represented By The Department Of Health And Human Services |
Activated dual specificity lymphocytes and their methods of use
|
|
US7070995B2
(en)
|
2001-04-11 |
2006-07-04 |
City Of Hope |
CE7-specific redirected immune cells
|
|
MXPA04001974A
(es)
|
2001-08-31 |
2004-07-16 |
Avidex Ltd |
Receptor de celula t soluble.
|
|
EP2034009B1
(en)
|
2002-02-08 |
2014-01-15 |
Life Technologies Corporation |
Compositions and methods for restoring immune responsiveness in patients with immunological defects basing on cd3/cd28 costimulation
|
|
US7446190B2
(en)
|
2002-05-28 |
2008-11-04 |
Sloan-Kettering Institute For Cancer Research |
Nucleic acids encoding chimeric T cell receptors
|
|
EP1517992B1
(en)
|
2002-06-05 |
2013-08-21 |
Her Majesty the Queen in Right of Canada, as represented by the Minister of Agriculture and Agri-Food |
Retrons for gene targeting
|
|
US8034334B2
(en)
*
|
2002-09-06 |
2011-10-11 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy
|
|
HUE054805T2
(hu)
|
2003-09-30 |
2021-09-28 |
Univ Pennsylvania |
Adeno-asszociált vírus (AAV) kládok, szekvenciák, az azokat tartalmazó vektorok és alkalmazásaik
|
|
US7435596B2
(en)
|
2004-11-04 |
2008-10-14 |
St. Jude Children's Research Hospital, Inc. |
Modified cell line and method for expansion of NK cell
|
|
EP1756278B1
(en)
|
2004-05-19 |
2008-09-17 |
MediGene Ltd. |
Method of improving t cell receptors
|
|
JP4773434B2
(ja)
|
2004-05-19 |
2011-09-14 |
イムノコア リミテッド |
高親和性ny−esot細胞受容体
|
|
WO2006112869A2
(en)
|
2004-07-19 |
2006-10-26 |
Baylor College Of Medicine |
Modulation of cytokine signaling regulators and applications for immunotherapy
|
|
US8889365B2
(en)
|
2005-03-16 |
2014-11-18 |
Rutgers, The State University Of New Jersey |
Methods and kit for detecting breast cancer
|
|
EP3085389A1
(en)
|
2005-04-07 |
2016-10-26 |
The Trustees Of The University Of Pennsylvania |
Method of increasing the function of an aav vector
|
|
US8389708B2
(en)
|
2005-06-15 |
2013-03-05 |
Weiping Min |
Method of cancer treatment using siRNA silencing
|
|
DK1910521T3
(da)
|
2005-08-05 |
2011-02-07 |
Helmholtz Zentrum Muenchen |
Generering af allo-begrænsede, antigenspecifikke T-celler
|
|
NZ597299A
(en)
|
2005-08-26 |
2013-03-28 |
Dupont Nutrition Biosci Aps |
Use of a cas gene in combination with CRISPR repeats for modulating resistance in a cell
|
|
US20090220488A1
(en)
*
|
2005-08-31 |
2009-09-03 |
Humphrey Gardner |
Evaluating and treating scleroderma
|
|
ES2543629T3
(es)
|
2006-05-17 |
2015-08-20 |
Hoffmann-La Roche Ag |
Células productoras de polipéptidos
|
|
US9399801B2
(en)
|
2006-05-19 |
2016-07-26 |
Dupont Nutrition Biosciences Aps |
Tagged microorganisms and methods of tagging
|
|
EP1878744A1
(en)
|
2006-07-13 |
2008-01-16 |
Max-Delbrück-Centrum für Molekulare Medizin (MDC) |
Epitope-tag for surface-expressed T-cell receptor proteins, uses thereof and method of selecting host cells expressing them
|
|
US7750449B2
(en)
|
2007-03-13 |
2010-07-06 |
Micron Technology, Inc. |
Packaged semiconductor components having substantially rigid support members and methods of packaging semiconductor components
|
|
PL2856876T3
(pl)
|
2007-03-30 |
2018-06-29 |
Memorial Sloan-Kettering Cancer Center |
Konstytutywna ekspresja ligandów kostymulujących na limfocytach T poddanych transferowi adoptywnemu
|
|
US8563314B2
(en)
|
2007-09-27 |
2013-10-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating PD1
|
|
WO2010011961A2
(en)
|
2008-07-25 |
2010-01-28 |
University Of Georgia Research Foundation, Inc. |
Prokaryotic rnai-like system and methods of use
|
|
US8822647B2
(en)
|
2008-08-26 |
2014-09-02 |
City Of Hope |
Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells
|
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
|
US9404098B2
(en)
|
2008-11-06 |
2016-08-02 |
University Of Georgia Research Foundation, Inc. |
Method for cleaving a target RNA using a Cas6 polypeptide
|
|
US8889641B2
(en)
|
2009-02-11 |
2014-11-18 |
The University Of North Carolina At Chapel Hill |
Modified virus vectors and methods of making and using the same
|
|
EP2258719A1
(en)
|
2009-05-19 |
2010-12-08 |
Max-Delbrück-Centrum für Molekulare Medizin (MDC) |
Multiple target T cell receptor
|
|
US20120192298A1
(en)
|
2009-07-24 |
2012-07-26 |
Sigma Aldrich Co. Llc |
Method for genome editing
|
|
US8383099B2
(en)
*
|
2009-08-28 |
2013-02-26 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Adoptive cell therapy with young T cells
|
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
|
WO2011117258A2
(en)
|
2010-03-22 |
2011-09-29 |
Association Institut De Myologie |
Methods of increasing efficiency of vector penetration of target tissue
|
|
KR102095670B1
(ko)
*
|
2010-05-14 |
2020-03-31 |
더 제너럴 하스피톨 코포레이션 |
종양 특이적 신생항원을 확인하는 조성물 및 방법
|
|
JP5261448B2
(ja)
*
|
2010-08-09 |
2013-08-14 |
古河電気工業株式会社 |
空孔アシスト光ファイバ
|
|
WO2012033885A1
(en)
|
2010-09-08 |
2012-03-15 |
Baylor College Of Medicine |
Immunotherapy of cancer using genetically engineered gd2-specific t cells
|
|
WO2012078540A1
(en)
|
2010-12-08 |
2012-06-14 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Modulating immune cell activity using cytokine-induced src homology 2 and/or high temperature requirement a-1
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
WO2012112079A1
(en)
|
2011-02-14 |
2012-08-23 |
Vitaspero, Inc. |
IMPROVING CELLULAR IMMUNOTHERAPEUTIC VACCINES EFFICACY WITH GENE SUPPRESSION IN DENDRITIC CELLS AND T-LYMPHOCYTES USING SiRNA
|
|
US9528124B2
(en)
|
2013-08-27 |
2016-12-27 |
Recombinetics, Inc. |
Efficient non-meiotic allele introgression
|
|
US9987308B2
(en)
|
2011-03-23 |
2018-06-05 |
Fred Hutchinson Cancer Research Center |
Method and compositions for cellular immunotherapy
|
|
EP3219313B1
(en)
|
2011-04-18 |
2020-10-28 |
National Center of Neurology and Psychiatry |
Drug delivery particle and method for producing the same
|
|
WO2012164565A1
(en)
|
2011-06-01 |
2012-12-06 |
Yeda Research And Development Co. Ltd. |
Compositions and methods for downregulating prokaryotic genes
|
|
US9096642B2
(en)
|
2011-06-08 |
2015-08-04 |
Aurigene Discovery Technologies Limited |
Therapeutic compounds for immunomodulation
|
|
KR101307196B1
(ko)
|
2011-07-15 |
2013-09-12 |
국립대학법인 울산과학기술대학교 산학협력단 |
미세 세포 배양 장치
|
|
US10421960B2
(en)
|
2011-09-16 |
2019-09-24 |
The Trustees Of The University Of Pennsylvania |
RNA engineered T cells for the treatment of cancer
|
|
WO2013049330A1
(en)
|
2011-09-28 |
2013-04-04 |
The Regents Of The University Of California |
Synthetic transcriptional control elements and methods of generating and using such elements
|
|
US9279159B2
(en)
|
2011-10-21 |
2016-03-08 |
Adaptive Biotechnologies Corporation |
Quantification of adaptive immune cell genomes in a complex mixture of cells
|
|
US9688740B2
(en)
|
2011-10-26 |
2017-06-27 |
National Cancer Center |
Mutant CTLA4 gene transfected T cell and composition including same for anticancer immunotherapy
|
|
WO2013074916A1
(en)
|
2011-11-18 |
2013-05-23 |
Board Of Regents, The University Of Texas System |
Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
|
|
EP2790708B1
(en)
|
2011-12-16 |
2024-10-23 |
Targetgene Biotechnologies Ltd. |
Compositions and methods for modifying a predetermined target nucleic acid sequence
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
CN104507963B
(zh)
|
2012-05-22 |
2017-12-15 |
美国卫生和人力服务部 |
鼠抗‑ny‑eso‑1 t细胞受体
|
|
EP4541818A3
(en)
|
2012-05-25 |
2025-07-23 |
Cellectis |
Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
|
|
LT3401400T
(lt)
|
2012-05-25 |
2019-06-10 |
The Regents Of The University Of California |
Būdai ir kompozicijos, skirtos rnr molekulės nukreipiamai tikslinės dnr modifikacijai ir rnr molekulės nukreipiamam transkripcijos moduliavimui
|
|
US20150017136A1
(en)
|
2013-07-15 |
2015-01-15 |
Cellectis |
Methods for engineering allogeneic and highly active t cell for immunotherapy
|
|
US9969696B2
(en)
|
2012-07-04 |
2018-05-15 |
Indian Institute Of Science |
Compounds as inhibitor of DNA double-strand break repair, methods and applications thereof
|
|
JP2015527889A
(ja)
|
2012-07-25 |
2015-09-24 |
ザ ブロード インスティテュート, インコーポレイテッド |
誘導可能なdna結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用
|
|
WO2014022702A2
(en)
|
2012-08-03 |
2014-02-06 |
The Regents Of The University Of California |
Methods and compositions for controlling gene expression by rna processing
|
|
PL3824905T3
(pl)
|
2012-08-20 |
2025-05-05 |
Fred Hutchinson Cancer Center |
Sposób i kompozycje do immunoterapii komórkowej
|
|
EP3763810A3
(en)
*
|
2012-10-10 |
2021-07-14 |
Sangamo Therapeutics, Inc. |
T cell modifying compounds and uses thereof
|
|
US20140113375A1
(en)
|
2012-10-21 |
2014-04-24 |
Lixin Liu |
Transient Expression And Reverse Transcription Aided Genome Alteration System
|
|
PL4397760T3
(pl)
|
2012-10-23 |
2026-03-30 |
Toolgen Incorporated |
Kompozycja do rozszczepiania docelowego dna zawierająca prowadzące rna specyficzne dla docelowego dna i kwas nukleinowy kodujący białko cas lub białko cas oraz jej zastosowanie
|
|
GB2508414A
(en)
|
2012-11-30 |
2014-06-04 |
Max Delbrueck Centrum |
Tumour specific T cell receptors (TCRs)
|
|
EP3135765A1
(en)
|
2012-12-06 |
2017-03-01 |
Sigma-Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
EP2896697B1
(en)
|
2012-12-12 |
2015-09-02 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
|
JP2016504026A
(ja)
|
2012-12-12 |
2016-02-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための系、方法および最適化ガイド組成物のエンジニアリング
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
CN114634950A
(zh)
|
2012-12-12 |
2022-06-17 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
IL239317B
(en)
|
2012-12-12 |
2022-07-01 |
Broad Inst Inc |
Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
SG10201912991WA
(en)
|
2012-12-17 |
2020-03-30 |
Harvard College |
Rna-guided human genome engineering
|
|
WO2014127287A1
(en)
|
2013-02-14 |
2014-08-21 |
Massachusetts Institute Of Technology |
Method for in vivo tergated mutagenesis
|
|
EP2958996B1
(en)
|
2013-02-25 |
2019-10-16 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing nuclease-mediated gene disruption
|
|
BR112015020516A2
(pt)
|
2013-02-26 |
2017-10-10 |
Memorial Sloan Kettering Cancer Center |
composições e métodos para imunoterapia
|
|
US9393257B2
(en)
|
2013-03-01 |
2016-07-19 |
Regents Of The University Of Minnesota |
TALEN-based gene correction
|
|
WO2014153118A1
(en)
|
2013-03-14 |
2014-09-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Treatment of diseases and conditions associated with dysregulation of mammalian target of rapamycin complex 1 (mtorc1)
|
|
SG11201507378UA
(en)
|
2013-03-14 |
2015-10-29 |
Caribou Biosciences Inc |
Compositions and methods of nucleic acid-targeting nucleic acids
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
US10378027B2
(en)
|
2013-03-15 |
2019-08-13 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
JP2016522679A
(ja)
|
2013-04-04 |
2016-08-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
CRISPR/Cas系を用いたゲノム編集の治療的使用
|
|
US11311575B2
(en)
|
2013-05-13 |
2022-04-26 |
Cellectis |
Methods for engineering highly active T cell for immunotherapy
|
|
RU2725542C2
(ru)
|
2013-05-13 |
2020-07-02 |
Селлектис |
Способы конструирования высокоактивных т-клеток для иммунотерапии
|
|
EP3730615A3
(en)
|
2013-05-15 |
2020-12-09 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treatment of a genetic condition
|
|
ES2670531T3
(es)
|
2013-05-29 |
2018-05-30 |
Cellectis S.A. |
Un método para producir una escisión de ADN precisa utilizando la actividad nickasa de Cas9
|
|
DK3309248T3
(da)
|
2013-05-29 |
2021-08-02 |
Cellectis |
Fremgangsmåde til manipulering af T-celler til immunterapi under anvendelse af et RNA-guidet CAS-nuklease-system
|
|
ES2883131T3
(es)
|
2013-05-29 |
2021-12-07 |
Cellectis |
Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
|
|
JP6195474B2
(ja)
|
2013-05-31 |
2017-09-13 |
ギガフォトン株式会社 |
極端紫外光生成装置及び極端紫外光生成システムにおけるレーザシステムの制御方法
|
|
JP6665088B2
(ja)
|
2013-06-17 |
2020-03-13 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための最適化されたCRISPR−Cas二重ニッカーゼ系、方法および組成物
|
|
MX2015017312A
(es)
|
2013-06-17 |
2017-04-10 |
Broad Inst Inc |
Suministro y uso de composiciones, vectores y sistemas crispr-cas para la modificación dirigida y terapia hepáticas.
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
WO2014204723A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions
|
|
CN105793425B
(zh)
|
2013-06-17 |
2021-10-26 |
布罗德研究所有限公司 |
使用病毒组分靶向障碍和疾病的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
JP6738729B2
(ja)
|
2013-06-17 |
2020-08-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
分裂終了細胞の疾患および障害をターゲティングおよびモデリングするための系、方法および組成物の送達、エンジニアリングおよび最適化
|
|
WO2015002293A1
(ja)
*
|
2013-07-05 |
2015-01-08 |
学校法人岩手医科大学 |
Wntシグナル阻害剤
|
|
JP2016528890A
(ja)
|
2013-07-09 |
2016-09-23 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
CRISPR/Cas系を用いるゲノム編集の治療用の使用
|
|
BR112016000571B1
(pt)
|
2013-07-10 |
2023-12-26 |
President And Fellows Of Harvard College |
Métodos in vitro para modular a expressão e para alterar um ou mais ácidos nucleicos alvo em uma célula simultaneamente com a regulação da expressão de um ou mais ácidos nucleicos alvo em uma célula, bem como célula de levedura ou bactéria compreendendo ácidos nucleicos
|
|
US20150020233A1
(en)
|
2013-07-12 |
2015-01-15 |
Oms Investments, Inc. |
Plants comprising events pp009-401, pp009-415, and pp009-469, compositions, sequences, and methods for detection thereof
|
|
US10563225B2
(en)
|
2013-07-26 |
2020-02-18 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US20150044772A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
Crispr/cas system-based novel fusion protein and its applications in genome editing
|
|
CA3221516A1
(en)
|
2013-08-22 |
2015-02-26 |
E. I. Du Pont De Nemours And Company |
Plant genome modification using guide rna/cas endonuclease systems and methods of use
|
|
CN104427476B
(zh)
|
2013-09-10 |
2019-05-07 |
中兴通讯股份有限公司 |
位置信息上报方法、集群服务处理方法及系统
|
|
WO2015048577A2
(en)
|
2013-09-27 |
2015-04-02 |
Editas Medicine, Inc. |
Crispr-related methods and compositions
|
|
WO2015048690A1
(en)
|
2013-09-27 |
2015-04-02 |
The Regents Of The University Of California |
Optimized small guide rnas and methods of use
|
|
US20150098954A1
(en)
|
2013-10-08 |
2015-04-09 |
Elwha Llc |
Compositions and Methods Related to CRISPR Targeting
|
|
DE102013111099B4
(de)
|
2013-10-08 |
2023-11-30 |
Eberhard Karls Universität Tübingen Medizinische Fakultät |
Permanente Genkorrektur mittels nukleotidmodifizierter messenger RNA
|
|
CN106459995B
(zh)
|
2013-11-07 |
2020-02-21 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
CA2930877A1
(en)
|
2013-11-18 |
2015-05-21 |
Crispr Therapeutics Ag |
Crispr-cas system materials and methods
|
|
US10787684B2
(en)
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
JP2016538001A
(ja)
|
2013-11-28 |
2016-12-08 |
ホライズン・ジェノミクス・ゲーエムベーハー |
体細胞半数体ヒト細胞株
|
|
CN106061488B
(zh)
|
2013-12-02 |
2021-04-09 |
菲奥医药公司 |
癌症的免疫治疗
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
BR112016013213A2
(pt)
|
2013-12-12 |
2017-12-05 |
Massachusetts Inst Technology |
administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para visar distúrbios e doenças usando componentes de administração de partículas
|
|
CN103820454B
(zh)
|
2014-03-04 |
2016-03-30 |
上海金卫生物技术有限公司 |
CRISPR-Cas9特异性敲除人PD1基因的方法以及用于特异性靶向PD1基因的sgRNA
|
|
MX373460B
(es)
|
2014-03-11 |
2020-04-07 |
Cellectis |
Metodo para generar celulas t compatibles para el trasplante alogenico.
|
|
EP3593812A3
(en)
|
2014-03-15 |
2020-05-27 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor
|
|
MX374472B
(es)
*
|
2014-03-20 |
2025-03-06 |
H Lee Moffitt Cancer Ct & Res |
Composiciones y métodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva.
|
|
EP3129490A4
(en)
|
2014-04-08 |
2017-10-04 |
North Carolina State University |
Methods and compositions for rna-directed repression of transcription using crispr-associated genes
|
|
WO2015157534A1
(en)
|
2014-04-10 |
2015-10-15 |
The Regents Of The University Of California |
Methods and compositions for using argonaute to modify a single stranded target nucleic acid
|
|
KR102595473B1
(ko)
|
2014-04-18 |
2023-10-30 |
에디타스 메디신, 인코포레이티드 |
암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분
|
|
IL313845A
(en)
|
2014-04-23 |
2024-08-01 |
Juno Therapeutics Inc |
Methods for enriching or producing immune cell populations for adoptive therapy
|
|
EP3151846A4
(en)
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
US20170224731A1
(en)
|
2014-06-10 |
2017-08-10 |
Monash University |
Method of producing leukocytes using ptpn2 inhibition for adoptive cell transfer
|
|
WO2015191693A2
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
TWI530276B
(zh)
|
2014-07-08 |
2016-04-21 |
原相科技股份有限公司 |
具去噪功能之生理偵測模組及其生理偵測方法
|
|
AU2015289644A1
(en)
|
2014-07-15 |
2017-02-02 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
|
JP2017522884A
(ja)
*
|
2014-07-29 |
2017-08-17 |
ファイザー・インク |
がん免疫療法のためのEGFRvIII特異的キメラ抗原受容体
|
|
IL287561B2
(en)
|
2014-10-01 |
2024-03-01 |
Massachusetts Gen Hospital |
Methods for increasing efficiency of nuclease-induced homology-directed repair
|
|
CN107074932A
(zh)
|
2014-10-02 |
2017-08-18 |
美国卫生和人力服务部 |
分离对癌症特异性突变具有抗原特异性的t细胞受体的方法
|
|
AU2015330699B2
(en)
|
2014-10-10 |
2021-12-02 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
KR20170075013A
(ko)
|
2014-10-31 |
2017-06-30 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
Cart 세포에서 유전자 발현의 변경 및 그의 용도
|
|
WO2016089433A1
(en)
|
2014-12-03 |
2016-06-09 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
|
CA2972454C
(en)
|
2014-12-31 |
2024-09-10 |
Phykion Inc. |
Compositions and methods for high efficiency in in vivo genome editing
|
|
US10280451B2
(en)
|
2015-01-09 |
2019-05-07 |
Bio-Rad Laboratories, Inc. |
Detection of genome editing
|
|
CN107429263A
(zh)
|
2015-01-15 |
2017-12-01 |
斯坦福大学托管董事会 |
调控基因组编辑的方法
|
|
KR102422108B1
(ko)
|
2015-01-20 |
2022-07-19 |
삼성디스플레이 주식회사 |
유기 발광 표시 장치
|
|
AU2016243583B2
(en)
*
|
2015-03-27 |
2022-03-10 |
President And Fellows Of Harvard College |
Modified T cells and methods of making and using the same
|
|
EP3294343A4
(en)
|
2015-05-13 |
2018-09-26 |
Seattle Children's Hospital, dba Seattle Children's Research Institute |
Enhancing endonuclease based gene editing in primary cells
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
CN108024544B
(zh)
|
2015-07-13 |
2022-04-29 |
桑格摩生物治疗股份有限公司 |
用于核酸酶介导的基因组工程化的递送方法及组合物
|
|
GB2557123B
(en)
|
2015-07-31 |
2021-11-03 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
JP2019505498A
(ja)
|
2015-12-16 |
2019-02-28 |
ザ・ウォルター・アンド・エリザ・ホール・インスティテュート・オブ・メディカル・リサーチ |
Nk細胞におけるサイトカイン誘導性sh2タンパク質の阻害
|
|
US9570114B1
(en)
|
2016-01-15 |
2017-02-14 |
HGST Netherlands B.V. |
Laminated film-packed hard disk drive for hermetic sealing
|
|
US11746349B2
(en)
|
2016-02-09 |
2023-09-05 |
President And Fellows Of Harvard College |
DNA-guided gene editing and regulation
|
|
MX2019000149A
(es)
*
|
2016-07-07 |
2019-09-23 |
Iovance Biotherapeutics Inc |
Proteinas de union a ligando 1 de muerte programada 1 (pd-l1) y metodos de uso de las mismas.
|
|
GB2573406B
(en)
*
|
2016-10-18 |
2021-11-10 |
Univ Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
CN111344396A
(zh)
|
2016-10-27 |
2020-06-26 |
因提玛生物科学公司 |
制备遗传修饰细胞的病毒方法
|
|
JP2020530307A
(ja)
|
2017-06-30 |
2020-10-22 |
インティマ・バイオサイエンス,インコーポレーテッド |
遺伝子治療のためのアデノ随伴ウイルスベクター
|
|
CN111836891A
(zh)
|
2017-09-07 |
2020-10-27 |
莱兰斯坦福初级大学评议会 |
用于基因工程的核酸酶系统
|