CA2940526A1 - Monoliths with attached recognition compounds, arrays thereof and uses thereof - Google Patents

Monoliths with attached recognition compounds, arrays thereof and uses thereof Download PDF

Info

Publication number
CA2940526A1
CA2940526A1 CA2940526A CA2940526A CA2940526A1 CA 2940526 A1 CA2940526 A1 CA 2940526A1 CA 2940526 A CA2940526 A CA 2940526A CA 2940526 A CA2940526 A CA 2940526A CA 2940526 A1 CA2940526 A1 CA 2940526A1
Authority
CA
Canada
Prior art keywords
nucleic acid
monolith
array
compounds
attached
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2940526A
Other languages
English (en)
French (fr)
Inventor
Pehr HARBURY
Madan Paidhungat
Robin Prince
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dice Molecules SV Inc
Original Assignee
Dice Molecules SV Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dice Molecules SV Inc filed Critical Dice Molecules SV Inc
Publication of CA2940526A1 publication Critical patent/CA2940526A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00504—Pins
    • B01J2219/00509—Microcolumns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Structural Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA2940526A 2014-01-28 2015-01-28 Monoliths with attached recognition compounds, arrays thereof and uses thereof Abandoned CA2940526A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461932747P 2014-01-28 2014-01-28
US61/932,747 2014-01-28
US201462006845P 2014-06-02 2014-06-02
US62/006,845 2014-06-02
PCT/US2015/013382 WO2015116739A1 (en) 2014-01-28 2015-01-28 Monoliths with attached recognition compounds, arrays thereof and uses thereof

Publications (1)

Publication Number Publication Date
CA2940526A1 true CA2940526A1 (en) 2015-08-06

Family

ID=53678148

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2940526A Abandoned CA2940526A1 (en) 2014-01-28 2015-01-28 Monoliths with attached recognition compounds, arrays thereof and uses thereof

Country Status (15)

Country Link
US (3) US10358641B2 (enExample)
EP (1) EP3099799B1 (enExample)
JP (1) JP6602772B2 (enExample)
KR (1) KR20160122174A (enExample)
CN (1) CN106459978B (enExample)
AU (1) AU2015211020A1 (enExample)
BR (1) BR112016017152A2 (enExample)
CA (1) CA2940526A1 (enExample)
DK (1) DK3099799T3 (enExample)
ES (1) ES2732054T3 (enExample)
IL (1) IL246784A0 (enExample)
MX (1) MX369674B (enExample)
RU (1) RU2016132972A (enExample)
SG (2) SG11201606921PA (enExample)
WO (1) WO2015116739A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3079668A1 (en) 2013-12-09 2016-10-19 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
WO2017119503A1 (ja) * 2016-01-08 2017-07-13 株式会社ジーンデザイン ゾル－ゲル法で作製される無機多孔質体を用いた核酸合成用担体
US20170348666A1 (en) * 2016-06-05 2017-12-07 Dice Molecules Sv, Llc Methods of routing, compositions and uses thereof
WO2020037194A1 (en) * 2018-08-17 2020-02-20 Sierra Biosystems, Inc. Row-independent oligonucleotide synthesis
CN110724623A (zh) * 2019-09-10 2020-01-24 深圳市百迈生命科学有限公司 1536孔固相合成与萃取板

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1123878A (en) 1966-08-23 1968-08-14 Ici Ltd Synthesis of norbornene derivatives
US4889632A (en) 1987-12-10 1989-12-26 Ceskoslovenska Akademie Ved Macroporous polymeric membranes for the separation of polymers and a method of their application
WO1992007882A1 (en) 1990-10-26 1992-05-14 Genta Incorporated Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5281368A (en) 1992-03-31 1994-01-25 Exxon Chemical Patents Inc. Norbornene polymerization initiators and process for preparing same
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
NZ501775A (en) 1997-07-22 2001-08-31 Qiagen Genomics Inc Hybridization analysis using low density nucleic acid arrays
DE69936920T2 (de) 1998-06-12 2008-05-15 Waters Investments Ltd., New Castle Neue poröse ionenaustauschharze für die festphasenextraktion und chromatographie
US6238565B1 (en) 1998-09-16 2001-05-29 Varian, Inc. Monolithic matrix for separating bio-organic molecules
CA2346989A1 (en) * 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
US6919181B2 (en) * 2002-03-25 2005-07-19 Agilent Technologies, Inc. Methods for generating ligand arrays
US7473367B2 (en) 2002-06-26 2009-01-06 Dionex Corporation Monolithic column
US20040200776A1 (en) * 2003-01-17 2004-10-14 Ivanov Alexander R. Narrow I.D. monolithic capillary columns for high efficiency separation and high sensitivity analysis of biomolecules
US20050095602A1 (en) * 2003-11-04 2005-05-05 West Jason A. Microfluidic integrated microarrays for biological detection
WO2005078088A1 (ja) 2004-02-12 2005-08-25 Gl Sciences Incorporated Ｄｎａなどの分離精製機構
US7897378B2 (en) 2004-03-18 2011-03-01 Roche Molecular Systems, Inc. Method and device for purifying nucleic acids
JP2006015333A (ja) 2004-05-31 2006-01-19 Showa Denko Kk 有機ポリマーモノリス、その製造方法、およびその用途
EP1786552A1 (en) * 2004-08-27 2007-05-23 Applera Corporation Method of making polymer monolith composite substrate and resulting substrate as well as beads and bead array
US20060099626A1 (en) * 2004-10-27 2006-05-11 Harbury Pehr B DNA-templated combinatorial library device and method for use
US8394492B1 (en) 2004-10-28 2013-03-12 The United States Of America As Represented By The United States National Aeronautics And Space Administration Surface modified aerogel monoliths
CN101400993A (zh) 2005-11-10 2009-04-01 阿普尔拉股份有限公司 包括多孔聚合物电极的微流体系统
DE102005059315A1 (de) 2005-12-09 2007-06-14 Qiagen Gmbh Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren
EP2041318A2 (en) 2006-06-26 2009-04-01 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
GB0614727D0 (en) * 2006-07-25 2006-09-06 Chromatide Ltd Solid support
CA2629589C (en) 2007-04-20 2016-03-29 F.Hoffmann-La Roche Ag Isolation and purification of nucleic acid molecules with a solid phase
CN101558131B (zh) 2007-04-23 2013-03-13 Lg化学株式会社 光学延迟膜、制备该光学延迟膜的方法以及包括该光学延迟膜的偏光片
US8217094B2 (en) 2007-10-17 2012-07-10 Shimadzu Corporation Monolith separation medium for chromatographic use and method of producing the same
EP2174916B9 (fr) 2008-10-09 2017-11-22 Université Des Sciences Et Technologies De Lille Monolithes de silice de haute pureté et son procédé de synthèse
WO2010053443A1 (en) * 2008-11-06 2010-05-14 Agency For Science, Technology And Research Apparatus for biopolymer synthesis
EP2335820A1 (en) 2009-12-18 2011-06-22 Leopold-Franzens-Universität Innsbruck Method for covalently attaching polymeric monoliths to polyether ether ketone (PEEK) surfaces
US9475914B2 (en) 2010-01-08 2016-10-25 University Of Tasmania Porous polymer monoliths, processes for preparation and use thereof
US20110240541A1 (en) 2010-04-06 2011-10-06 Binghe Gu Monolithic column technology for liquid chromatography
BR112012030530A2 (pt) 2010-05-18 2022-12-20 Abbvie Inc Aparelho e processo para purificação de proteínas
US8603833B2 (en) 2010-06-03 2013-12-10 University Of South Florida Germania-silica-based sol-gel monolith and uses thereof
WO2011154859A1 (en) 2010-06-08 2011-12-15 Firmenich Sa Bicyclo-ketones as perfuming ingredients
EP2405000A1 (en) 2010-07-06 2012-01-11 Alacris Theranostics GmbH Synthesis of chemical libraries
US20150315569A1 (en) 2014-05-02 2015-11-05 The Board Of Trustees Of The Leland Stanford Junior University Method for screening a nucleic acid-programmed small molecule library

Also Published As

Publication number Publication date
EP3099799B1 (en) 2019-05-15
MX369674B (es) 2019-11-15
JP6602772B2 (ja) 2019-11-06
CN106459978B (zh) 2020-05-19
WO2015116739A1 (en) 2015-08-06
US20180179517A9 (en) 2018-06-28
EP3099799A4 (en) 2017-09-20
SG10201803094QA (en) 2018-06-28
BR112016017152A2 (pt) 2017-08-08
US20190270985A1 (en) 2019-09-05
CN106459978A (zh) 2017-02-22
KR20160122174A (ko) 2016-10-21
DK3099799T3 (da) 2019-07-01
RU2016132972A (ru) 2018-03-05
EP3099799A1 (en) 2016-12-07
ES2732054T3 (es) 2019-11-20
IL246784A0 (en) 2016-08-31
US20170191056A1 (en) 2017-07-06
US20150209753A1 (en) 2015-07-30
AU2015211020A2 (en) 2016-08-25
AU2015211020A1 (en) 2016-08-11
SG11201606921PA (en) 2016-10-28
US10358641B2 (en) 2019-07-23
HK1231511A1 (en) 2017-12-22
JP2017503522A (ja) 2017-02-02
MX2016009798A (es) 2017-02-28

Similar Documents

Publication Publication Date Title
US20190270985A1 (en) Monoliths with attached recognition compounds, arrays thereof and uses thereof
AU2022231730A1 (en) Variant libraries of the immunological synapse and synthesis thereof
CN102365262B (zh) 疏水单体、疏水衍生载体及其制备和使用方法
JP2002510554A (ja) 触媒の発見および最適化のための並行コンビナトリアル方法およびその使用
JP2010500919A (ja) 固体支持体
KR102549800B1 (ko) 크로마토그래피용 담체, 리간드 고정 담체, 크로마토그래피 칼럼, 표적 물질의 정제 방법 및 크로마토그래피용 담체의 제조 방법
Yano et al. Stereoselective recognition of dipeptide derivatives in molecularly imprinted polymers which incorporate an L-valine derivative as a novel functional monomer
CA2469301A1 (en) Functionalized materials and libraries thereof
Schmiegel et al. Direct Asymmetric Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts
Ketterer et al. Dual-gated microparticles for switchable antibody release
HK1231511B (en) Arrays of monoliths with attached recognition compounds
Kuciński et al. Silica surface modification and its application in permanent link with nucleic acids
Nicholls et al. Some recent developments in the preparation of novel recognition systems: A recognition site for the selective catalysis of an aldol condensation using molecular imprinting and specific affinity motifs for α‐chymotrypsin using a phage display peptide library
CN108129660B (zh) 一种有机整体材料及其制备和应用
US20030152961A1 (en) Polyfunctional support material for complex nucleic acid analysis
CN109959791A (zh) 一种用于特异性识别肿瘤细胞的多重作用印迹材料及其制备和应用
Elsner et al. Miniaturized biocatalysis on polyacrylate‐based capillary monoliths
JP4300183B2 (ja) 官能基が導入されたポリアミド固相
Fraczyk et al. Cellulose functionalysed with grafted oligopeptides
JP4113950B2 (ja) 微粒子の片側のみをビオチン化した異方性ビチオン化ラテックス微粒子
Miriyala Fluorous methods for the synthesis of peptides and oligonucleotides
US20170348666A1 (en) Methods of routing, compositions and uses thereof
Kebe et al. Surface Engineering of Porous Monoliths via Click Chemistry: Towards Functional Materials for Flow Chemistry Applications
HK1213002A1 (zh) 陰離子交換-疏水性混合模式

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20210831

FZDE Discontinued

Effective date: 20210831