JP6602772B2 - 認識化合物付着モノリス、そのアレイ、およびその使用 - Google Patents

認識化合物付着モノリス、そのアレイ、およびその使用 Download PDF

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JP6602772B2
JP6602772B2 JP2016548235A JP2016548235A JP6602772B2 JP 6602772 B2 JP6602772 B2 JP 6602772B2 JP 2016548235 A JP2016548235 A JP 2016548235A JP 2016548235 A JP2016548235 A JP 2016548235A JP 6602772 B2 JP6602772 B2 JP 6602772B2
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nucleic acid
monolith
bond
well
compound
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JP2017503522A5 (enExample
JP2017503522A (ja
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ペール ハーブリー，
マダン パイドゥンガット，
ロビン プリンス，
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Dice Molecules SV Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00504—Pins
    • B01J2219/00509—Microcolumns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

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  • Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Computational Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Structural Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
JP2016548235A 2014-01-28 2015-01-28 認識化合物付着モノリス、そのアレイ、およびその使用 Expired - Fee Related JP6602772B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461932747P 2014-01-28 2014-01-28
US61/932,747 2014-01-28
US201462006845P 2014-06-02 2014-06-02
US62/006,845 2014-06-02
PCT/US2015/013382 WO2015116739A1 (en) 2014-01-28 2015-01-28 Monoliths with attached recognition compounds, arrays thereof and uses thereof

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JP2017503522A JP2017503522A (ja) 2017-02-02
JP2017503522A5 JP2017503522A5 (enExample) 2018-03-15
JP6602772B2 true JP6602772B2 (ja) 2019-11-06

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US (3) US10358641B2 (enExample)
EP (1) EP3099799B1 (enExample)
JP (1) JP6602772B2 (enExample)
KR (1) KR20160122174A (enExample)
CN (1) CN106459978B (enExample)
AU (1) AU2015211020A1 (enExample)
BR (1) BR112016017152A2 (enExample)
CA (1) CA2940526A1 (enExample)
DK (1) DK3099799T3 (enExample)
ES (1) ES2732054T3 (enExample)
IL (1) IL246784A0 (enExample)
MX (1) MX369674B (enExample)
RU (1) RU2016132972A (enExample)
SG (2) SG10201803094QA (enExample)
WO (1) WO2015116739A1 (enExample)

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Publication number Priority date Publication date Assignee Title
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
WO2017119503A1 (ja) * 2016-01-08 2017-07-13 株式会社ジーンデザイン ゾル－ゲル法で作製される無機多孔質体を用いた核酸合成用担体
EP3464590A4 (en) * 2016-06-05 2020-04-01 Dice Molecules SV, LLC ROUTING METHODS, COMPOSITIONS AND USES THEREOF
EP3837344A4 (en) * 2018-08-17 2022-01-26 Sierra Biosystems, Inc. ROW-INDEPENDENT OLIGONUCLEOTIDE SYNTHESIS
CN110724623A (zh) * 2019-09-10 2020-01-24 深圳市百迈生命科学有限公司 1536孔固相合成与萃取板

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1123878A (en) 1966-08-23 1968-08-14 Ici Ltd Synthesis of norbornene derivatives
US4889632A (en) 1987-12-10 1989-12-26 Ceskoslovenska Akademie Ved Macroporous polymeric membranes for the separation of polymers and a method of their application
EP0554407A1 (en) 1990-10-26 1993-08-11 Genta Incorporated Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5281368A (en) 1992-03-31 1994-01-25 Exxon Chemical Patents Inc. Norbornene polymerization initiators and process for preparing same
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
WO1999005320A1 (en) * 1997-07-22 1999-02-04 Rapigene, Inc. Multiple functionalities within an array element and uses thereof
AU4437399A (en) 1998-06-12 1999-12-30 Waters Investments Limited Novel ion exchange porous resins for solid phase extraction and chromatography
US6238565B1 (en) 1998-09-16 2001-05-29 Varian, Inc. Monolithic matrix for separating bio-organic molecules
WO2000023458A1 (en) 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
US6919181B2 (en) 2002-03-25 2005-07-19 Agilent Technologies, Inc. Methods for generating ligand arrays
US7473367B2 (en) 2002-06-26 2009-01-06 Dionex Corporation Monolithic column
US20040200776A1 (en) * 2003-01-17 2004-10-14 Ivanov Alexander R. Narrow I.D. monolithic capillary columns for high efficiency separation and high sensitivity analysis of biomolecules
US20050095602A1 (en) 2003-11-04 2005-05-05 West Jason A. Microfluidic integrated microarrays for biological detection
WO2005078088A1 (ja) 2004-02-12 2005-08-25 Gl Sciences Incorporated Ｄｎａなどの分離精製機構
US7897378B2 (en) 2004-03-18 2011-03-01 Roche Molecular Systems, Inc. Method and device for purifying nucleic acids
JP2006015333A (ja) * 2004-05-31 2006-01-19 Showa Denko Kk 有機ポリマーモノリス、その製造方法、およびその用途
EP1786552A1 (en) * 2004-08-27 2007-05-23 Applera Corporation Method of making polymer monolith composite substrate and resulting substrate as well as beads and bead array
WO2006047791A2 (en) * 2004-10-27 2006-05-04 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library device and method for use
US8394492B1 (en) 2004-10-28 2013-03-12 The United States Of America As Represented By The United States National Aeronautics And Space Administration Surface modified aerogel monoliths
CN101400993A (zh) 2005-11-10 2009-04-01 阿普尔拉股份有限公司 包括多孔聚合物电极的微流体系统
DE102005059315A1 (de) 2005-12-09 2007-06-14 Qiagen Gmbh Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren
US7608399B2 (en) 2006-06-26 2009-10-27 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
GB0614727D0 (en) * 2006-07-25 2006-09-06 Chromatide Ltd Solid support
CA2629589C (en) 2007-04-20 2016-03-29 F.Hoffmann-La Roche Ag Isolation and purification of nucleic acid molecules with a solid phase
JP2010507831A (ja) 2007-04-23 2010-03-11 エルジー・ケム・リミテッド 位相差フィルム、その製造方法及び位相差フィルムを含む偏光板
CN101861518B (zh) 2007-10-17 2012-05-30 株式会社岛津制作所 色谱分析用整体柱分离介质及其制造方法
EP2174916B9 (fr) 2008-10-09 2017-11-22 Université Des Sciences Et Technologies De Lille Monolithes de silice de haute pureté et son procédé de synthèse
WO2010053443A1 (en) 2008-11-06 2010-05-14 Agency For Science, Technology And Research Apparatus for biopolymer synthesis
EP2335820A1 (en) 2009-12-18 2011-06-22 Leopold-Franzens-Universität Innsbruck Method for covalently attaching polymeric monoliths to polyether ether ketone (PEEK) surfaces
BR112012016882B1 (pt) 2010-01-08 2021-02-23 University Of Tasmania método de armazenamento de um fluido corpóreo para análise futura
US20110240541A1 (en) 2010-04-06 2011-10-06 Binghe Gu Monolithic column technology for liquid chromatography
MX354845B (es) * 2010-05-18 2018-03-22 Abbvie Inc Star Aparato y proceso de purificación de proteínas.
US8603833B2 (en) 2010-06-03 2013-12-10 University Of South Florida Germania-silica-based sol-gel monolith and uses thereof
JP5826256B2 (ja) 2010-06-08 2015-12-02 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ 付香成分としてのビシクロケトン
EP2405000A1 (en) 2010-07-06 2012-01-11 Alacris Theranostics GmbH Synthesis of chemical libraries
US20150315569A1 (en) 2014-05-02 2015-11-05 The Board Of Trustees Of The Leland Stanford Junior University Method for screening a nucleic acid-programmed small molecule library

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MX2016009798A (es) 2017-02-28
EP3099799A4 (en) 2017-09-20
US10358641B2 (en) 2019-07-23
KR20160122174A (ko) 2016-10-21
US20170191056A1 (en) 2017-07-06
CN106459978A (zh) 2017-02-22
EP3099799A1 (en) 2016-12-07
US20190270985A1 (en) 2019-09-05
DK3099799T3 (da) 2019-07-01
EP3099799B1 (en) 2019-05-15
SG11201606921PA (en) 2016-10-28
JP2017503522A (ja) 2017-02-02
AU2015211020A2 (en) 2016-08-25
HK1231511A1 (en) 2017-12-22
CN106459978B (zh) 2020-05-19
AU2015211020A1 (en) 2016-08-11
BR112016017152A2 (pt) 2017-08-08
WO2015116739A1 (en) 2015-08-06
IL246784A0 (en) 2016-08-31
MX369674B (es) 2019-11-15
RU2016132972A (ru) 2018-03-05
US20180179517A9 (en) 2018-06-28
US20150209753A1 (en) 2015-07-30
SG10201803094QA (en) 2018-06-28
ES2732054T3 (es) 2019-11-20
CA2940526A1 (en) 2015-08-06

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