JP2017503522A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017503522A5 JP2017503522A5 JP2016548235A JP2016548235A JP2017503522A5 JP 2017503522 A5 JP2017503522 A5 JP 2017503522A5 JP 2016548235 A JP2016548235 A JP 2016548235A JP 2016548235 A JP2016548235 A JP 2016548235A JP 2017503522 A5 JP2017503522 A5 JP 2017503522A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- monolith
- nucleotides
- separation device
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 34
- 108020004707 nucleic acids Proteins 0.000 claims 28
- 150000007523 nucleic acids Chemical class 0.000 claims 28
- 102000039446 nucleic acids Human genes 0.000 claims 28
- 239000002773 nucleotide Substances 0.000 claims 18
- 125000003729 nucleotide group Chemical group 0.000 claims 18
- 238000000926 separation method Methods 0.000 claims 14
- 108091034117 Oligonucleotide Proteins 0.000 claims 13
- 229920000642 polymer Polymers 0.000 claims 10
- 230000000295 complement effect Effects 0.000 claims 7
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229910052782 aluminium Inorganic materials 0.000 claims 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 3
- 230000027455 binding Effects 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 229920000620 organic polymer Polymers 0.000 claims 3
- 239000004696 Poly ether ether ketone Substances 0.000 claims 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims 2
- 239000003957 anion exchange resin Substances 0.000 claims 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 229920002530 polyetherether ketone Polymers 0.000 claims 2
- 229910000077 silane Inorganic materials 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229910000838 Al alloy Inorganic materials 0.000 claims 1
- 229920000089 Cyclic olefin copolymer Polymers 0.000 claims 1
- 239000004713 Cyclic olefin copolymer Substances 0.000 claims 1
- 108010043958 Peptoids Proteins 0.000 claims 1
- 239000004697 Polyetherimide Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical group [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 239000005350 fused silica glass Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 230000009149 molecular binding Effects 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 229920001601 polyetherimide Polymers 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- -1 polypropylene Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 238000011176 pooling Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000010453 quartz Substances 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 239000010935 stainless steel Substances 0.000 claims 1
- 229910001220 stainless steel Inorganic materials 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461932747P | 2014-01-28 | 2014-01-28 | |
| US61/932,747 | 2014-01-28 | ||
| US201462006845P | 2014-06-02 | 2014-06-02 | |
| US62/006,845 | 2014-06-02 | ||
| PCT/US2015/013382 WO2015116739A1 (en) | 2014-01-28 | 2015-01-28 | Monoliths with attached recognition compounds, arrays thereof and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017503522A JP2017503522A (ja) | 2017-02-02 |
| JP2017503522A5 true JP2017503522A5 (enExample) | 2018-03-15 |
| JP6602772B2 JP6602772B2 (ja) | 2019-11-06 |
Family
ID=53678148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016548235A Expired - Fee Related JP6602772B2 (ja) | 2014-01-28 | 2015-01-28 | 認識化合物付着モノリス、そのアレイ、およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10358641B2 (enExample) |
| EP (1) | EP3099799B1 (enExample) |
| JP (1) | JP6602772B2 (enExample) |
| KR (1) | KR20160122174A (enExample) |
| CN (1) | CN106459978B (enExample) |
| AU (1) | AU2015211020A1 (enExample) |
| BR (1) | BR112016017152A2 (enExample) |
| CA (1) | CA2940526A1 (enExample) |
| DK (1) | DK3099799T3 (enExample) |
| ES (1) | ES2732054T3 (enExample) |
| IL (1) | IL246784A0 (enExample) |
| MX (1) | MX369674B (enExample) |
| RU (1) | RU2016132972A (enExample) |
| SG (2) | SG11201606921PA (enExample) |
| WO (1) | WO2015116739A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
| WO2017119503A1 (ja) * | 2016-01-08 | 2017-07-13 | 株式会社ジーンデザイン | ゾル－ゲル法で作製される無機多孔質体を用いた核酸合成用担体 |
| JP2019523646A (ja) * | 2016-06-05 | 2019-08-29 | ダイス モレキュルズ エスヴィー， エルエルシーＤｉｃｅ Ｍｏｌｅｃｕｌｅｓ Ｓｖ， Ｌｌｃ | 経路決定の方法、組成物、およびその使用 |
| EP3837344A4 (en) * | 2018-08-17 | 2022-01-26 | Sierra Biosystems, Inc. | ROW-INDEPENDENT OLIGONUCLEOTIDE SYNTHESIS |
| CN110724623A (zh) * | 2019-09-10 | 2020-01-24 | 深圳市百迈生命科学有限公司 | 1536孔固相合成与萃取板 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1123878A (en) | 1966-08-23 | 1968-08-14 | Ici Ltd | Synthesis of norbornene derivatives |
| US4889632A (en) | 1987-12-10 | 1989-12-26 | Ceskoslovenska Akademie Ved | Macroporous polymeric membranes for the separation of polymers and a method of their application |
| IL99862A (en) | 1990-10-26 | 1995-06-29 | Genta Inc | Non-aromatic polymeric reactants for solid phase synthesis of oligomers |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5281368A (en) | 1992-03-31 | 1994-01-25 | Exxon Chemical Patents Inc. | Norbornene polymerization initiators and process for preparing same |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| HUP0003261A2 (hu) | 1997-07-22 | 2001-01-29 | Qiagen Genomics, Inc. | Több funkció- vagy mátrixelemen belül, továbbá ezek alkalmazásai |
| JP4883837B2 (ja) | 1998-06-12 | 2012-02-22 | ウォーターズ・テクノロジーズ・コーポレーション | 固相抽出及びクロマトグラフィー用の新規なイオン交換多孔質樹脂 |
| US6238565B1 (en) | 1998-09-16 | 2001-05-29 | Varian, Inc. | Monolithic matrix for separating bio-organic molecules |
| AU1318400A (en) | 1998-10-19 | 2000-05-08 | Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
| US6919181B2 (en) | 2002-03-25 | 2005-07-19 | Agilent Technologies, Inc. | Methods for generating ligand arrays |
| US7473367B2 (en) | 2002-06-26 | 2009-01-06 | Dionex Corporation | Monolithic column |
| WO2004064974A2 (en) * | 2003-01-17 | 2004-08-05 | Northeastern University | Narrow i.d. monolithic capillary columns for high efficiency separation and high sensitivity analysis of biomolecules |
| US20050095602A1 (en) * | 2003-11-04 | 2005-05-05 | West Jason A. | Microfluidic integrated microarrays for biological detection |
| US8586350B2 (en) | 2004-02-12 | 2013-11-19 | Gl Sciences Incorporated | Mechanism of separating and purifying DNA and the like |
| US7897378B2 (en) | 2004-03-18 | 2011-03-01 | Roche Molecular Systems, Inc. | Method and device for purifying nucleic acids |
| JP2006015333A (ja) | 2004-05-31 | 2006-01-19 | Showa Denko Kk | 有機ポリマーモノリス、その製造方法、およびその用途 |
| US20060078983A1 (en) * | 2004-08-27 | 2006-04-13 | Applera Corporation | Polymer monolith substrate |
| WO2006047791A2 (en) * | 2004-10-27 | 2006-05-04 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library device and method for use |
| US8394492B1 (en) | 2004-10-28 | 2013-03-12 | The United States Of America As Represented By The United States National Aeronautics And Space Administration | Surface modified aerogel monoliths |
| CN101400993A (zh) * | 2005-11-10 | 2009-04-01 | 阿普尔拉股份有限公司 | 包括多孔聚合物电极的微流体系统 |
| DE102005059315A1 (de) | 2005-12-09 | 2007-06-14 | Qiagen Gmbh | Verfahren zur Anreicherung von kurzkettigen Nukleinsäuren |
| US7608399B2 (en) | 2006-06-26 | 2009-10-27 | Blood Cell Storage, Inc. | Device and method for extraction and analysis of nucleic acids from biological samples |
| GB0614727D0 (en) | 2006-07-25 | 2006-09-06 | Chromatide Ltd | Solid support |
| CA2629589C (en) | 2007-04-20 | 2016-03-29 | F.Hoffmann-La Roche Ag | Isolation and purification of nucleic acid molecules with a solid phase |
| JP2010507831A (ja) | 2007-04-23 | 2010-03-11 | エルジー・ケム・リミテッド | 位相差フィルム、その製造方法及び位相差フィルムを含む偏光板 |
| JP4840514B2 (ja) | 2007-10-17 | 2011-12-21 | 株式会社島津製作所 | クロマトグラフィー用モノリス分離媒体及びその製造方法 |
| EP2174916B9 (fr) | 2008-10-09 | 2017-11-22 | Université Des Sciences Et Technologies De Lille | Monolithes de silice de haute pureté et son procédé de synthèse |
| WO2010053443A1 (en) * | 2008-11-06 | 2010-05-14 | Agency For Science, Technology And Research | Apparatus for biopolymer synthesis |
| EP2335820A1 (en) | 2009-12-18 | 2011-06-22 | Leopold-Franzens-Universität Innsbruck | Method for covalently attaching polymeric monoliths to polyether ether ketone (PEEK) surfaces |
| CN102711978B (zh) | 2010-01-08 | 2015-11-25 | 塔斯马尼亚大学 | 多孔聚合物整料、其制备方法及其用途 |
| US20110240541A1 (en) | 2010-04-06 | 2011-10-06 | Binghe Gu | Monolithic column technology for liquid chromatography |
| NZ603616A (en) | 2010-05-18 | 2015-02-27 | Abbvie Inc | Apparatus and process of purification of proteins |
| US8603833B2 (en) | 2010-06-03 | 2013-12-10 | University Of South Florida | Germania-silica-based sol-gel monolith and uses thereof |
| ES2510766T3 (es) | 2010-06-08 | 2014-10-21 | Firmenich Sa | Biciclo-cetonas como ingredientes perfumantes |
| EP2405000A1 (en) | 2010-07-06 | 2012-01-11 | Alacris Theranostics GmbH | Synthesis of chemical libraries |
| US20150315569A1 (en) | 2014-05-02 | 2015-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Method for screening a nucleic acid-programmed small molecule library |
-
2015
- 2015-01-28 RU RU2016132972A patent/RU2016132972A/ru not_active Application Discontinuation
- 2015-01-28 ES ES15743623T patent/ES2732054T3/es active Active
- 2015-01-28 MX MX2016009798A patent/MX369674B/es active IP Right Grant
- 2015-01-28 US US14/608,114 patent/US10358641B2/en active Active
- 2015-01-28 CN CN201580017011.3A patent/CN106459978B/zh active Active
- 2015-01-28 CA CA2940526A patent/CA2940526A1/en not_active Abandoned
- 2015-01-28 WO PCT/US2015/013382 patent/WO2015116739A1/en not_active Ceased
- 2015-01-28 AU AU2015211020A patent/AU2015211020A1/en not_active Abandoned
- 2015-01-28 KR KR1020167023649A patent/KR20160122174A/ko not_active Withdrawn
- 2015-01-28 SG SG11201606921PA patent/SG11201606921PA/en unknown
- 2015-01-28 SG SG10201803094QA patent/SG10201803094QA/en unknown
- 2015-01-28 DK DK15743623.9T patent/DK3099799T3/da active
- 2015-01-28 BR BR112016017152A patent/BR112016017152A2/pt not_active Application Discontinuation
- 2015-01-28 JP JP2016548235A patent/JP6602772B2/ja not_active Expired - Fee Related
- 2015-01-28 EP EP15743623.9A patent/EP3099799B1/en active Active
-
2016
- 2016-07-14 IL IL246784A patent/IL246784A0/en unknown
-
2017
- 2017-03-08 US US15/452,730 patent/US20180179517A9/en not_active Abandoned
-
2019
- 2019-04-09 US US16/379,679 patent/US20190270985A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7203893B2 (ja) | 固形支持体でのサンプル調製 | |
| JP2017503522A5 (enExample) | ||
| JP7010875B2 (ja) | Ｄｎａコード化ライブラリを作製およびスクリーニングする方法 | |
| AU2020227672A1 (en) | Compositions and methods for next generation sequencing | |
| AU2012271487B2 (en) | Methods for preparative in vitro cloning | |
| JP2020508661A5 (enExample) | ||
| WO2015047186A1 (en) | Methods to profile molecular complexes by using proximity bar-coding | |
| JP2016527313A5 (enExample) | ||
| US20220154179A1 (en) | Oligonucleotide directed and recorded combinitorial synthesis of encoded probe molecules | |
| WO2006026614A3 (en) | Method of error reduction in nucleic acid populations | |
| JP2009519041A5 (enExample) | ||
| JP2012198225A5 (enExample) | ||
| WO2014102396A1 (en) | Molecular coding for analysis of composition of macromolecules and molecular complexes | |
| US20220298552A1 (en) | Method for identifying high-affinity complexes made of two ligands and one receptor, device for implementing the method and self-assembling chemical library for use in the method | |
| AU2015230180B2 (en) | Purification of DNA-conjugate products | |
| RU2016132972A (ru) | Монолиты с присоединенными распознающими соединениями, их система и их применение | |
| EP3752631A1 (en) | Charge-tagged nucleotides and methods of use thereof | |
| CN103882532B (zh) | 一种先导化合物的合成及筛选方法与试剂盒 | |
| JP2017529062A5 (enExample) | ||
| WO2014094621A1 (zh) | 一种先导化合物的合成及筛选方法与试剂盒 | |
| FI4077713T3 (fi) | Menetelmä ja kitti kokogenomiamplifikaatioon ja biologisessa näytteessä olevien kohdemolekyylien analysointiin | |
| WO2012156718A1 (en) | Method of immobilising rna onto a surface | |
| WO2013096777A3 (en) | Integrated compound discovery systems and methods | |
| RU2017126986A (ru) | Иммобилизация модифицированного олигонуклеотида на полимерном субстрате посредством физической адсорбции | |
| WO2023056379A2 (en) | Sorting of oligonucleotide-directed combinatorial libraries |