CA2915088A1 - Sc-.beta. cells and compositions and methods for generating the same - Google Patents

Sc-.beta. cells and compositions and methods for generating the same Download PDF

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Publication number
CA2915088A1
CA2915088A1 CA2915088A CA2915088A CA2915088A1 CA 2915088 A1 CA2915088 A1 CA 2915088A1 CA 2915088 A CA2915088 A CA 2915088A CA 2915088 A CA2915088 A CA 2915088A CA 2915088 A1 CA2915088 A1 CA 2915088A1
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CA
Canada
Prior art keywords
cells
positive
cell
nkx6
population
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Pending
Application number
CA2915088A
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English (en)
French (fr)
Inventor
Quinn P. Peterson
Felicia J. Pagliuca
Douglas A. Melton
Jeffrey R. Millman
Michael Saris Segel
Mads GURTLER
Benjamin Fryer
Alireza Rezania
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Harvard University
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Janssen Biotech Inc
Harvard University
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Publication of CA2915088A1 publication Critical patent/CA2915088A1/en
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N2501/10—Growth factors
    • C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/395—Thyroid hormones
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
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  • Gastroenterology & Hepatology (AREA)
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CA2915088A 2013-06-11 2014-06-11 Sc-.beta. cells and compositions and methods for generating the same Pending CA2915088A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361833898P 2013-06-11 2013-06-11
US61/833,898 2013-06-11
US201461972212P 2014-03-28 2014-03-28
US61/972,212 2014-03-28
PCT/US2014/041988 WO2015002724A2 (en) 2013-06-11 2014-06-11 SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME

Publications (1)

Publication Number Publication Date
CA2915088A1 true CA2915088A1 (en) 2015-01-08

Family

ID=52022750

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2915088A Pending CA2915088A1 (en) 2013-06-11 2014-06-11 Sc-.beta. cells and compositions and methods for generating the same
CA2915091A Pending CA2915091A1 (en) 2013-06-11 2014-06-11 Sc-.beta. cells and compositions and methods for generating the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2915091A Pending CA2915091A1 (en) 2013-06-11 2014-06-11 Sc-.beta. cells and compositions and methods for generating the same

Country Status (17)

Country Link
US (16) US20170029778A1 (enExample)
EP (4) EP4461806A3 (enExample)
JP (8) JP6677634B2 (enExample)
KR (12) KR102580225B1 (enExample)
CN (6) CN105579577A (enExample)
AU (7) AU2014284677B2 (enExample)
BR (2) BR112015030946A8 (enExample)
CA (2) CA2915088A1 (enExample)
DE (2) DE202014011287U1 (enExample)
DK (1) DK3008168T3 (enExample)
GB (3) GB2531952C (enExample)
HK (1) HK1257187B (enExample)
MX (2) MX2015017103A (enExample)
PH (1) PH12015502767A1 (enExample)
RU (2) RU2016100219A (enExample)
SG (3) SG11201510176VA (enExample)
WO (2) WO2015002724A2 (enExample)

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RU2684215C2 (ru) 2012-12-31 2019-04-04 Янссен Байотек, Инк. Способ получения панкреатических эндокринных клеток (варианты) и способ увеличения выхода бета-клеток
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EP3286563B1 (en) * 2015-04-23 2022-11-02 The Regents of The University of California Controlled induction of human pancreatic progenitors produces functional beta-like cells
PT3286300T (pt) * 2015-04-24 2020-12-28 Univ Copenhagen Isolamento de células progenitoras pancreáticas genuínas
PL3285572T3 (pl) * 2015-04-24 2021-06-28 University Of Copenhagen Sposób wytwarzania komórek produkujących insulinę
EP3328404A4 (en) * 2015-07-27 2018-12-26 The Regents of The University of California Methods and compositions for producing pancreatic beta cells
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