CA2912943A1 - Benzofuranone-indole/azaindole coupled derivatives, their preparation and use thereof - Google Patents
Benzofuranone-indole/azaindole coupled derivatives, their preparation and use thereof Download PDFInfo
- Publication number
- CA2912943A1 CA2912943A1 CA2912943A CA2912943A CA2912943A1 CA 2912943 A1 CA2912943 A1 CA 2912943A1 CA 2912943 A CA2912943 A CA 2912943A CA 2912943 A CA2912943 A CA 2912943A CA 2912943 A1 CA2912943 A1 CA 2912943A1
- Authority
- CA
- Canada
- Prior art keywords
- acid
- oxo
- derivatives
- azaindole
- combinations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000002360 preparation method Methods 0.000 title claims description 24
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title claims description 18
- PURZPTHFQRDYLF-UHFFFAOYSA-N C1=CC=C2NC=CC2=C1.C1=CC=C2OC(=O)CC2=C1 Chemical compound C1=CC=C2NC=CC2=C1.C1=CC=C2OC(=O)CC2=C1 PURZPTHFQRDYLF-UHFFFAOYSA-N 0.000 title claims description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 37
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 34
- 201000010099 disease Diseases 0.000 claims abstract description 30
- 239000003814 drug Substances 0.000 claims abstract description 29
- -1 oxo indirubin Chemical compound 0.000 claims abstract description 27
- 229940079593 drug Drugs 0.000 claims abstract description 22
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 18
- 230000002757 inflammatory effect Effects 0.000 claims abstract description 12
- 208000023275 Autoimmune disease Diseases 0.000 claims abstract description 11
- 208000027866 inflammatory disease Diseases 0.000 claims abstract description 9
- 230000004770 neurodegeneration Effects 0.000 claims abstract description 5
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310202029.3 | 2013-05-28 | ||
| CN201310202029.3A CN103333161B (zh) | 2013-05-28 | 2013-05-28 | 1’-氧代靛玉红的制备和用途 |
| PCT/CN2014/000525 WO2014190758A1 (zh) | 2013-05-28 | 2014-05-26 | 苯并呋喃酮与吲哚或氮杂吲哚偶合物及其制备与应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2912943A1 true CA2912943A1 (en) | 2014-12-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2912943A Abandoned CA2912943A1 (en) | 2013-05-28 | 2014-05-26 | Benzofuranone-indole/azaindole coupled derivatives, their preparation and use thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9868734B2 (enExample) |
| EP (1) | EP3006442A4 (enExample) |
| JP (1) | JP2016519167A (enExample) |
| KR (1) | KR20160012984A (enExample) |
| CN (2) | CN103333161B (enExample) |
| AU (1) | AU2014273751A1 (enExample) |
| CA (1) | CA2912943A1 (enExample) |
| MX (1) | MX2015016217A (enExample) |
| RU (1) | RU2015140611A (enExample) |
| WO (1) | WO2014190758A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103333161B (zh) * | 2013-05-28 | 2015-09-30 | 滁州市洛达生物科技有限公司 | 1’-氧代靛玉红的制备和用途 |
| CN108721279B (zh) * | 2017-04-19 | 2021-06-29 | 安尼根有限公司 | 包含5′-羟基-5-硝基-靛玉红-3′-肟作为活性成分的乳腺癌治疗剂 |
| CN106946760A (zh) * | 2017-04-28 | 2017-07-14 | 遵义医学院 | 靛玉红衍生物或药学上能接受的盐用于抗肿瘤药物及制备方法 |
| CN111233741B (zh) * | 2020-03-04 | 2021-04-16 | 大连理工大学 | 一种有机催化靛红自缩合制备异靛蓝类化合物的方法 |
| WO2021188855A1 (en) * | 2020-03-19 | 2021-09-23 | Board Of Regents Of The University Of Nebraska | Symbiotic prodrugs for the treatment of cancer and other diseases |
| WO2022171265A1 (en) * | 2021-02-09 | 2022-08-18 | Boehringer Ingelheim International Gmbh | Modulators of complex i |
| CN113072540B (zh) * | 2021-03-29 | 2023-07-14 | 贵州医科大学 | 一种靛玉红衍生的降解剂及其制备与应用 |
| WO2023090935A1 (ko) * | 2021-11-18 | 2023-05-25 | 애니젠 주식회사 | 뉴클레오린에 특이적으로 결합하는 agm 펩타이드를 제조하는 방법 |
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| US6503937B1 (en) * | 1998-10-22 | 2003-01-07 | Ciba Specialty Chemicals Corporation | Oxobenzofuranylide-dihydroindolone |
| JP2002541244A (ja) * | 1999-04-12 | 2002-12-03 | ゲルハルト アイゼンブランド | インジゴイドビスインドール誘導体 |
| WO2000061124A2 (en) * | 1999-04-12 | 2000-10-19 | Gerhard Eisenbrand | Use off cell membrane penetrating indigoid bisindole derivatives |
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| DE10125763A1 (de) * | 2001-05-17 | 2002-11-28 | Schering Ag | Verwendung selektiver Indirubinderivate als VEGF-R Inhibitoren |
| DE10129028A1 (de) * | 2001-06-11 | 2003-01-02 | Schering Ag | Lösliche Cdk-inhibitorische Indirubinderivate |
| US20050154046A1 (en) * | 2004-01-12 | 2005-07-14 | Longgui Wang | Methods of treating an inflammatory-related disease |
| US20100098702A1 (en) * | 2008-09-16 | 2010-04-22 | Longgui Wang | Method of treating androgen independent prostate cancer |
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| KR100588803B1 (ko) * | 2004-01-27 | 2006-06-12 | 학교법인조선대학교 | 암세포주에 항암활성을 지닌 인디루빈 유도체 |
| US8552053B2 (en) * | 2005-12-23 | 2013-10-08 | Centre National De La Recherche Scientifique | 7-substituted indirubin-3′oximes and their applications |
| CN101023944A (zh) * | 2006-02-23 | 2007-08-29 | 黎明涛 | 靛玉红衍生物在制备治疗神经退行性变疾病药物中的应用 |
| CN101314584A (zh) * | 2007-05-28 | 2008-12-03 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | HGF/c-Met信号通道抑制剂及其制备方法和用途 |
| CN101074229B (zh) | 2007-06-08 | 2010-09-01 | 无锡杰西医药科技有限公司 | 7-氮杂靛玉红和7-氮杂异靛蓝衍生物制备及其药学用途 |
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| EP2379549B1 (en) * | 2008-12-22 | 2016-09-21 | Eisenbrand, Gerhard | 7-azaindirubins, 7'-azaindirubins, 7-7'-diazaindirubin and the corresponding 3'-oxime ether derivates: production thereof, their production and use as a medicament |
| CN101492465A (zh) * | 2009-03-05 | 2009-07-29 | 上海交通大学 | 用于抗肿瘤药物的7，7＇-二氮杂靛玉红类化合物 |
| CN101492448B (zh) * | 2009-03-05 | 2012-09-19 | 上海交通大学 | 用于抗肿瘤药物的7＇-氮杂靛玉红类化合物 |
| CN101492410B (zh) * | 2009-03-05 | 2011-06-22 | 上海交通大学 | 用于抗肿瘤药物的靛玉红类化合物 |
| CN101704813B (zh) * | 2009-11-25 | 2011-11-16 | 上海交通大学 | 1′-硫代靛玉红类化合物、用途及其制备方法 |
| CN101747339B (zh) * | 2009-11-25 | 2012-04-25 | 上海交通大学 | 1′-硫代氮杂靛玉红类化合物、用途及其制备方法 |
| KR101180030B1 (ko) * | 2010-02-05 | 2012-09-05 | 광주과학기술원 | 사이클린-의존적 키나제 저해제로서 항암 활성을 지닌 인디루빈-3'-옥심 유도체 |
| US9051306B2 (en) * | 2011-07-15 | 2015-06-09 | Nihon University | Indirubin derivative having highly selective cytotoxicity for malignant tumors |
| CN103333161B (zh) * | 2013-05-28 | 2015-09-30 | 滁州市洛达生物科技有限公司 | 1’-氧代靛玉红的制备和用途 |
| CN103627748B (zh) * | 2013-11-21 | 2016-03-30 | 华侨大学 | 一种靛玉红衍生物的制备方法 |
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- 2014-05-26 US US14/779,719 patent/US9868734B2/en not_active Expired - Fee Related
- 2014-05-26 AU AU2014273751A patent/AU2014273751A1/en not_active Abandoned
- 2014-05-26 MX MX2015016217A patent/MX2015016217A/es unknown
- 2014-05-26 KR KR1020157026851A patent/KR20160012984A/ko not_active Withdrawn
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- 2014-05-26 CA CA2912943A patent/CA2912943A1/en not_active Abandoned
- 2014-05-26 RU RU2015140611A patent/RU2015140611A/ru unknown
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| EP3006442A1 (en) | 2016-04-13 |
| EP3006442A4 (en) | 2017-03-08 |
| MX2015016217A (es) | 2016-03-01 |
| CN103333161A (zh) | 2013-10-02 |
| KR20160012984A (ko) | 2016-02-03 |
| US9868734B2 (en) | 2018-01-16 |
| CN103333161B (zh) | 2015-09-30 |
| CN105189486A (zh) | 2015-12-23 |
| CN105189486B (zh) | 2018-07-31 |
| RU2015140611A (ru) | 2017-07-04 |
| JP2016519167A (ja) | 2016-06-30 |
| US20160185771A1 (en) | 2016-06-30 |
| AU2014273751A1 (en) | 2015-10-29 |
| WO2014190758A1 (zh) | 2014-12-04 |
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