CA2904332A1 - Insulin-incretin conjugates - Google Patents
Insulin-incretin conjugates Download PDFInfo
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- CA2904332A1 CA2904332A1 CA2904332A CA2904332A CA2904332A1 CA 2904332 A1 CA2904332 A1 CA 2904332A1 CA 2904332 A CA2904332 A CA 2904332A CA 2904332 A CA2904332 A CA 2904332A CA 2904332 A1 CA2904332 A1 CA 2904332A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
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| US201361783491P | 2013-03-14 | 2013-03-14 | |
| US61/783,491 | 2013-03-14 | ||
| PCT/US2014/020801 WO2014158900A1 (en) | 2013-03-14 | 2014-03-05 | Insulin-incretin conjugates |
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| CA2904332A1 true CA2904332A1 (en) | 2014-10-02 |
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| EP (1) | EP2970511B1 (enExample) |
| JP (1) | JP6538645B2 (enExample) |
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| CN (1) | CN105324397B (enExample) |
| AU (1) | AU2014241743B2 (enExample) |
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| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| RU2652783C2 (ru) | 2012-12-21 | 2018-05-03 | Санофи | Двойные агонисты glp1/gip или тройные агонисты glp1/gip/глюкагона |
| KR20150131213A (ko) | 2013-03-14 | 2015-11-24 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 인슐린-인크레틴 접합체들 |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| ES2822994T3 (es) | 2014-09-24 | 2021-05-05 | Univ Indiana Res & Tech Corp | Conjugados de incretina-insulina |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| CN108026157B (zh) | 2015-08-25 | 2022-11-25 | 诺和诺德股份有限公司 | 新型胰岛素衍生物及其医学用途 |
| WO2017074798A2 (en) | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | Long-acting co-agonists of the glucagon and glp-1 receptors |
| EP3430033A4 (en) * | 2016-03-18 | 2019-11-20 | Merck Sharp & Dohme Corp. | CONJUGATES OF INSULIN-INCRETIN |
| EP3448417B1 (en) * | 2016-04-26 | 2025-11-12 | Merck Sharp & Dohme LLC | Insulin dimer-incretin conjugates |
| MA45727A (fr) | 2016-07-22 | 2019-05-29 | Walter & Eliza Hall Inst Medical Res | Analogues de l'insuline |
| ES2944544T3 (es) | 2017-02-03 | 2023-06-22 | Univ Vanderbilt | Sistemas, composiciones y métodos para el tratamiento de la diabetes |
| EP3624828B1 (en) * | 2017-05-18 | 2024-08-07 | Merck Sharp & Dohme LLC | Pharmaceutical formulation comprising incretin-insulin conjugates |
| EP3658574A1 (en) | 2017-07-28 | 2020-06-03 | The Trustees of Princeton University | Fusion tags for recombinant protein expression |
| CA3071686A1 (en) | 2017-08-17 | 2019-02-21 | Novo Nordisk A/S | Novel acylated insulin analogues and uses thereof |
| CA3097939A1 (en) | 2018-05-04 | 2019-11-07 | Novo Nordisk A/S | Gip derivatives and uses thereof |
| WO2019243502A1 (en) * | 2018-06-21 | 2019-12-26 | Novo Nordisk A/S | Novel compounds for treatment of obesity |
| MX2021006972A (es) * | 2018-12-11 | 2021-08-16 | Sanofi Sa | Conjugados de insulina. |
| US12435116B2 (en) | 2019-10-16 | 2025-10-07 | Clarence Hurt | Compounds, compositions, methods, and uses for treating insulin resistance, type 2 diabetes and metabolic syndrome |
| IL319162A (en) | 2019-12-11 | 2025-04-01 | Novo Nordisk As | New insulin analogs and their use |
| CN117487026A (zh) * | 2020-07-24 | 2024-02-02 | 江苏晟斯生物制药有限公司 | 胰岛素-Fc融合蛋白及其应用 |
| WO2022094146A1 (en) | 2020-10-28 | 2022-05-05 | The Trustees Of Princeton University | Methods of converting precursor proteins to mature proteins using kex2 proteases |
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2014
- 2014-03-05 KR KR1020157028780A patent/KR20150131213A/ko not_active Abandoned
- 2014-03-05 RU RU2015143472A patent/RU2678134C2/ru not_active IP Right Cessation
- 2014-03-05 CN CN201480027381.0A patent/CN105324397B/zh not_active Expired - Fee Related
- 2014-03-05 US US14/774,357 patent/US20160024169A1/en not_active Abandoned
- 2014-03-05 CA CA2904332A patent/CA2904332A1/en not_active Abandoned
- 2014-03-05 JP JP2016500671A patent/JP6538645B2/ja not_active Expired - Fee Related
- 2014-03-05 WO PCT/US2014/020801 patent/WO2014158900A1/en not_active Ceased
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- 2014-03-05 EP EP14773636.7A patent/EP2970511B1/en not_active Not-in-force
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Also Published As
| Publication number | Publication date |
|---|---|
| CN105324397A (zh) | 2016-02-10 |
| EP2970511A1 (en) | 2016-01-20 |
| US10696726B2 (en) | 2020-06-30 |
| AU2014241743B2 (en) | 2018-07-05 |
| US20180194827A1 (en) | 2018-07-12 |
| BR112015023071A2 (pt) | 2017-07-18 |
| US20160024169A1 (en) | 2016-01-28 |
| JP6538645B2 (ja) | 2019-07-03 |
| CN105324397B (zh) | 2020-01-14 |
| WO2014158900A1 (en) | 2014-10-02 |
| JP2016512255A (ja) | 2016-04-25 |
| AU2014241743A1 (en) | 2015-09-17 |
| EP2970511B1 (en) | 2020-09-30 |
| KR20150131213A (ko) | 2015-11-24 |
| RU2678134C2 (ru) | 2019-01-23 |
| EP2970511A4 (en) | 2016-03-23 |
| RU2015143472A (ru) | 2017-04-28 |
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