CA2904184C - Lipids and lipid compositions for the delivery of active agents - Google Patents

Lipids and lipid compositions for the delivery of active agents Download PDF

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Publication number
CA2904184C
CA2904184C CA2904184A CA2904184A CA2904184C CA 2904184 C CA2904184 C CA 2904184C CA 2904184 A CA2904184 A CA 2904184A CA 2904184 A CA2904184 A CA 2904184A CA 2904184 C CA2904184 C CA 2904184C
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Prior art keywords
bis
lipid
mmol
methyl
dimethylamino
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CA2904184A
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English (en)
French (fr)
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CA2904184A1 (en
Inventor
Jeremy Lee BARYZA
Rohan Eric John Beckwith
Keith Bowman
Crystal BYERS
Tanzina Fazal
Gabriel Grant GAMBER
Cameron Chuck-Munn LEE
Ritesh Bhanudasji Tichkule
Chandra Vargeese
Shuangxi Wang
Laura West
Thomas ZABAWA
Junping Zhao
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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EP3608308B1 (en) 2021-07-21
TW201442999A (zh) 2014-11-16
JP6781202B2 (ja) 2020-11-04
US20160106842A1 (en) 2016-04-21
AU2018279005B2 (en) 2020-06-25
JP6352950B2 (ja) 2018-07-04
CA2904184A1 (en) 2014-09-12
AU2014224205C1 (en) 2019-04-04
BR112015021791A2 (pt) 2017-07-18
CN105164102B (zh) 2017-12-15
AU2014224205A1 (en) 2015-10-01
WO2014136086A1 (en) 2014-09-12
US10124065B2 (en) 2018-11-13
ES2887254T3 (es) 2021-12-22
MX2015011955A (es) 2016-04-07
KR20150126015A (ko) 2015-11-10
JP2016514109A (ja) 2016-05-19
EP3608308A1 (en) 2020-02-12
MX377255B (es) 2025-03-07
CN105164102A (zh) 2015-12-16
KR102255108B1 (ko) 2021-05-24
AU2014224205B2 (en) 2018-10-04
EA030650B1 (ru) 2018-09-28
EP2964608B1 (en) 2019-08-28
EP2964608A1 (en) 2016-01-13
JP2018184402A (ja) 2018-11-22
CN107879960B (zh) 2021-06-22
US20180369386A1 (en) 2018-12-27
US10792361B2 (en) 2020-10-06

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