EP0721328A4 - Camptothecin formulations - Google Patents

Camptothecin formulations

Info

Publication number
EP0721328A4
EP0721328A4 EP94929892A EP94929892A EP0721328A4 EP 0721328 A4 EP0721328 A4 EP 0721328A4 EP 94929892 A EP94929892 A EP 94929892A EP 94929892 A EP94929892 A EP 94929892A EP 0721328 A4 EP0721328 A4 EP 0721328A4
Authority
EP
European Patent Office
Prior art keywords
camptothecin formulations
camptothecin
formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94929892A
Other languages
German (de)
French (fr)
Other versions
EP0721328A1 (en
Inventor
Panayiotis Peri Constantinides
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0721328A1 publication Critical patent/EP0721328A1/en
Publication of EP0721328A4 publication Critical patent/EP0721328A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP94929892A 1993-09-27 1994-09-27 Camptothecin formulations Withdrawn EP0721328A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12720893A 1993-09-27 1993-09-27
PCT/US1994/010898 WO1995008986A1 (en) 1993-09-27 1994-09-27 Camptothecin formulations
US127208 1998-07-31

Publications (2)

Publication Number Publication Date
EP0721328A1 EP0721328A1 (en) 1996-07-17
EP0721328A4 true EP0721328A4 (en) 1997-09-17

Family

ID=22428860

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94929892A Withdrawn EP0721328A4 (en) 1993-09-27 1994-09-27 Camptothecin formulations

Country Status (3)

Country Link
EP (1) EP0721328A4 (en)
JP (1) JPH09504517A (en)
WO (1) WO1995008986A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115099A (en) * 1994-10-14 1999-04-11 Upjohn Co Lyophilizate of phospholipid complex of water insoluble camptothecins
US5827533A (en) * 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
NZ503293A (en) * 1997-09-16 2002-09-27 Nexstar Pharmaceuticals Inc Liposomal camptothecin formulations also comprising at least one phospholipid
US6726925B1 (en) 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
US6200598B1 (en) * 1998-06-18 2001-03-13 Duke University Temperature-sensitive liposomal formulation
ATE238039T1 (en) * 1998-09-16 2003-05-15 Alza Corp TOPOISOMERASE INHIBITORS ENCLOSED IN LIPOSOMES
ATE286741T1 (en) * 1999-01-27 2005-01-15 Telik Inc THERAPEUTIC COMPOSITIONS CONTAINING GLUTATHIONE ANALOGUES
US7311924B2 (en) 1999-04-01 2007-12-25 Hana Biosciences, Inc. Compositions and methods for treating cancer
ATE309786T1 (en) 2000-06-30 2005-12-15 Inex Pharmaceuticals Corp LIPOSOMAL ANTINEOPLASTIC DRUGS AND USES THEREOF
US7452550B2 (en) 2000-06-30 2008-11-18 Hana Biosciences, Inc. Liposomal antineoplastic drugs and uses thereof
AU7833601A (en) 2000-07-31 2002-02-13 Daniel L Sparks Charged lipid compositions and methods for their use
EA006741B1 (en) * 2000-11-09 2006-04-28 Неофарм, Инк. Peptide composition comprising camptothecin derivative (variants), method for manufacturing thereof and use
EP1372571A4 (en) * 2001-03-20 2006-06-07 New Century Pharmaceuticals Method and compositions for optimizing blood and tissue stability of camptothecin and other albumin-binding therapeutic compounds
DE10157994A1 (en) * 2001-05-25 2003-01-02 G O T Therapeutics Gmbh Liposomally encapsulated hydrophobic active ingredients with a high active ingredient content> 50% and methods for producing pharmaceutical preparations which comprise liposomally encapsulated hydrophobic active ingredients
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
GB0207653D0 (en) * 2002-04-03 2002-05-15 Lamellar Therapeutics Ltd Methods of using lamellar bodies for therapeutic purposes
EP1393719A1 (en) * 2002-08-23 2004-03-03 Munich Biotech AG Camptothecin-carboxylate formulations
EP1553924B1 (en) * 2002-06-26 2010-12-08 MediGene AG Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system
ATE397091T1 (en) 2003-05-30 2008-06-15 Univ Chicago METHODS AND COMPOSITIONS FOR PREDICTING IRINOTECANTOXICITY
JP2007522085A (en) * 2003-06-27 2007-08-09 スミスクライン・ビーチャム・コーポレイション Stabilized topotecan liposome compositions and methods
GB0322448D0 (en) 2003-09-25 2003-10-29 Lamellar Therapeutics Ltd Using lamellar bodies to modify linear biological macro molecules
EP1750673B1 (en) 2004-05-17 2009-12-02 Tekmira Pharmaceuticals Corporation Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
CN100356919C (en) * 2004-05-31 2007-12-26 上海医药工业研究院 Hydroxycamptothecin liposome and its preparation
ES2594621T3 (en) 2004-06-01 2016-12-21 Kabushiki Kaisha Yakult Honsha Irinotecan Preparation
EP1759699B1 (en) * 2004-06-18 2016-01-20 Kabushiki Kaisha Yakult Honsha Liposome preparation containing slightly water-soluble camptothecin
CA2584279C (en) * 2004-11-05 2015-01-27 Index Pharmaceuticals Corporation Compositions and methods for stabilizing liposomal drug formulations
EP1676568A1 (en) * 2004-12-30 2006-07-05 Merckle Gmbh Particles comprising phospholipids, process of preparation and use as medicament
US8206750B2 (en) 2005-03-24 2012-06-26 Cerenis Therapeutics Holding S.A. Charged lipoprotein complexes and their uses
EP3721943A1 (en) 2009-12-23 2020-10-14 Novartis AG Lipids, lipid compositions and methods of using them
CN102516258B (en) * 2011-11-11 2014-06-25 正大天晴药业集团股份有限公司 Water-soluble vitamin E derivative modified fat-soluble anti-cancer drug compound and preparation, preparation method and application of compound
WO2014015016A1 (en) * 2012-07-18 2014-01-23 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
KR102186116B1 (en) 2012-11-20 2020-12-03 스펙트럼 파마슈티컬즈 인크 Improved method for the preparation of liposome encapsulated vincristine for therapeutic use
AU2014224205C1 (en) 2013-03-08 2019-04-04 Novartis Ag Lipids and lipid compositions for the delivery of active agents
EP3083579B1 (en) 2013-12-19 2022-01-26 Novartis AG Lipids and lipid compositions for the delivery of active agents
ES2774968T3 (en) 2013-12-19 2020-07-23 Novartis Ag Lipids and lipid compositions for the administration of active agents
US10342761B2 (en) 2014-07-16 2019-07-09 Novartis Ag Method of encapsulating a nucleic acid in a lipid nanoparticle host
JP6731912B2 (en) 2014-09-05 2020-07-29 ノバルティス アーゲー Lipids and lipid compositions for delivery of active substances
TWI678213B (en) 2015-07-22 2019-12-01 美商史倍壯製藥公司 A ready-to-use formulation for vincristine sulfate liposome injection
PL439632A1 (en) * 2021-11-23 2023-05-29 Uniwersytet Warszawski Lipid drug carrier, a pharmaceutical formulation, uses thereof and method for producing a lipid drug carrier, a carrier prepared by such method and its applications

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026253A1 (en) * 1993-05-19 1994-11-24 The Liposome Company, Inc. Liposome having a multicomponent bilayer which contains a bioactive agent as an integral component of the bilayer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721612A (en) * 1984-04-12 1988-01-26 The Liposome Company, Inc. Steroidal liposomes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026253A1 (en) * 1993-05-19 1994-11-24 The Liposome Company, Inc. Liposome having a multicomponent bilayer which contains a bioactive agent as an integral component of the bilayer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9508986A1 *

Also Published As

Publication number Publication date
EP0721328A1 (en) 1996-07-17
WO1995008986A1 (en) 1995-04-06
JPH09504517A (en) 1997-05-06

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Legal Events

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