CA2882239C - Pluripotent stem cell that induces repair and regeneration after myocardial infarction - Google Patents

Pluripotent stem cell that induces repair and regeneration after myocardial infarction Download PDF

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Publication number
CA2882239C
CA2882239C CA2882239A CA2882239A CA2882239C CA 2882239 C CA2882239 C CA 2882239C CA 2882239 A CA2882239 A CA 2882239A CA 2882239 A CA2882239 A CA 2882239A CA 2882239 C CA2882239 C CA 2882239C
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Prior art keywords
cells
negative
cell preparation
pluripotent stem
myocardial infarction
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CA2882239A
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English (en)
French (fr)
Other versions
CA2882239A1 (en
Inventor
Masanori Yoshida
Shinya Minatoguchi
Mari Dezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tohoku University
Life Science Institute Ltd
Tokai National Higher Education and Research System
Original Assignee
Tohoku University
Gifu University
Clio Inc
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Publication of CA2882239A1 publication Critical patent/CA2882239A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
CA2882239A 2012-08-17 2013-08-15 Pluripotent stem cell that induces repair and regeneration after myocardial infarction Active CA2882239C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2012181029 2012-08-17
JP2012-181029 2012-08-17
PCT/JP2013/054049 WO2014027474A1 (ja) 2012-08-17 2013-02-19 心筋梗塞の修復再生を誘導する多能性幹細胞
JPPCT/JP2013/054049 2013-02-19
PCT/JP2013/071981 WO2014027684A1 (ja) 2012-08-17 2013-08-15 心筋梗塞の修復再生を誘導する多能性幹細胞

Publications (2)

Publication Number Publication Date
CA2882239A1 CA2882239A1 (en) 2014-02-20
CA2882239C true CA2882239C (en) 2018-05-22

Family

ID=50685515

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2882239A Active CA2882239C (en) 2012-08-17 2013-08-15 Pluripotent stem cell that induces repair and regeneration after myocardial infarction

Country Status (14)

Country Link
US (3) US9844570B2 (enExample)
EP (2) EP3659612B1 (enExample)
JP (1) JP5968442B2 (enExample)
KR (1) KR101730052B1 (enExample)
CN (1) CN104582711B (enExample)
AU (1) AU2013303492B2 (enExample)
CA (1) CA2882239C (enExample)
DK (1) DK2886123T3 (enExample)
ES (1) ES2767182T3 (enExample)
IN (1) IN2015DN01616A (enExample)
PL (1) PL2886123T3 (enExample)
PT (1) PT2886123T (enExample)
SG (2) SG11201501185WA (enExample)
WO (2) WO2014027474A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
JP2015160820A (ja) * 2014-02-26 2015-09-07 株式会社Ｃｌｉｏ 慢性腎障害治療のための多能性幹細胞
JP6452107B2 (ja) * 2014-09-05 2019-01-16 国立大学法人 東京大学 糖尿病性皮膚潰瘍治療のための多能性幹細胞
WO2016168993A1 (en) * 2015-04-22 2016-10-27 Innolife Co., Ltd. Methods of tissue repair and regeneration
JP6770673B2 (ja) * 2016-02-26 2020-10-21 国立大学法人東海国立大学機構 急性心筋梗塞の予後マーカー及びその利用
US20190201455A1 (en) * 2016-07-01 2019-07-04 Tohoku University Prophylactic or therapeutic agent for organ fibrosis
WO2018021515A1 (ja) * 2016-07-29 2018-02-01 国立大学法人東北大学 血管障害の予防又は治療剤
US11920180B2 (en) 2016-08-03 2024-03-05 Tohoku University Method for inducing differentiation of pluripotent stem cells in vitro
SG11201900983TA (en) * 2016-08-03 2019-03-28 Univ Nagoya Nat Univ Corp Amelioration and treatment of chronic lung disease using pluripotent stem cells
CA3032925A1 (en) * 2016-08-03 2018-02-08 Life Science Institute, Inc. Alleviation and treatment of ischemia reperfusion-induced lung injury using pluripotent stem cells
CN106822899B (zh) * 2017-03-10 2020-11-27 北京大学 一种通过抑制自噬促进心肌再生的药物
WO2019078262A1 (ja) * 2017-10-17 2019-04-25 国立大学法人広島大学 骨軟骨修復を誘導する多能性幹細胞
JP7102666B2 (ja) * 2018-01-25 2022-07-20 国立大学法人東海国立大学機構 Ｍｕｓｅ細胞動員剤及び心筋障害への利用
JP7072777B2 (ja) * 2018-07-03 2022-05-23 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
CN110302212A (zh) * 2019-07-17 2019-10-08 陶正博 一种用于治疗急性心肌梗死的细胞制剂及其制备方法
US12460182B2 (en) 2019-08-19 2025-11-04 Cellaxia Inc. Cell-containing pharmaceutical composition
CA3153237A1 (en) * 2019-09-05 2021-03-11 Tohoku University Therapeutic agent for myocarditis
CA3156700A1 (en) 2019-10-31 2021-05-06 Life Science Institute, Inc. Therapy for interstitial cystitis by pluripotent stem cells
US20230203436A1 (en) 2020-04-02 2023-06-29 Tohoku University High-potential pluripotent stem cells
TWI825446B (zh) * 2020-08-14 2023-12-11 中國醫藥大學 醫藥組合物治療組織缺血狀況之用途
JP2021073305A (ja) * 2021-02-09 2021-05-13 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
CN119198334A (zh) * 2024-10-31 2024-12-27 北京大学深圳研究生院 一种心肌梗死边界区组织鉴定方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4543193A (en) * 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
WO1999003973A1 (en) * 1997-07-14 1999-01-28 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
ATE382681T1 (de) * 1998-07-31 2008-01-15 Genzyme Corp Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
WO2002009650A2 (en) 2000-07-31 2002-02-07 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
WO2002057430A2 (en) 2001-01-20 2002-07-25 Cardion Ag Pluripotent adult stem cells derived from regenerative tissue
EP1412479A4 (en) 2001-07-12 2004-07-28 Geron Corp CELLS WITH CARDIOMYOCYTE GENERATION PRODUCED FROM HUMAN PLURIPOTENT STEM CELLS
WO2006080434A1 (ja) * 2005-01-27 2006-08-03 Japan Health Sciences Foundation 間葉系幹細胞を含む細胞シート
EP2206724A1 (en) 2005-12-13 2010-07-14 Kyoto University Nuclear reprogramming factor
CN101517069A (zh) * 2006-07-13 2009-08-26 塞拉帝思股份公司 由人类胚泡来源的干细胞衍生的多能心脏前体细胞新种群
WO2009046058A1 (en) * 2007-10-01 2009-04-09 University Of Miami A method to amplify cardiac stem cells in vitro and in vivo
JP5394932B2 (ja) 2007-11-02 2014-01-22 日本ケミカルリサーチ株式会社 ヒト間葉系幹細胞含有医薬組成物
JP5564679B2 (ja) 2009-04-16 2014-07-30 公益財団法人ヒューマンサイエンス振興財団 心筋細胞分化誘導促進剤およびその使用方法
US9550975B2 (en) * 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
TWI523947B (zh) * 2010-10-18 2016-03-01 尚翔股份有限公司 人類多能性類胚胎幹細胞先驅細胞
WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞

Also Published As

Publication number Publication date
US9844570B2 (en) 2017-12-19
JP5968442B2 (ja) 2016-08-10
US20150196600A1 (en) 2015-07-16
EP2886123A1 (en) 2015-06-24
EP2886123A4 (en) 2016-06-22
IN2015DN01616A (enExample) 2015-07-03
CN104582711B (zh) 2019-12-06
DK2886123T3 (da) 2020-01-27
ES2767182T3 (es) 2020-06-16
US10376544B2 (en) 2019-08-13
JPWO2014027684A1 (ja) 2016-07-28
KR20150043482A (ko) 2015-04-22
EP3659612B1 (en) 2023-06-07
EP3659612A1 (en) 2020-06-03
CN104582711A (zh) 2015-04-29
PL2886123T3 (pl) 2020-05-18
AU2013303492A1 (en) 2015-03-12
SG11201501185WA (en) 2015-05-28
AU2013303492B2 (en) 2017-02-16
SG10201800829XA (en) 2018-03-28
KR101730052B1 (ko) 2017-04-25
US20180050067A1 (en) 2018-02-22
EP2886123B1 (en) 2019-10-23
US10639335B2 (en) 2020-05-05
CA2882239A1 (en) 2014-02-20
WO2014027684A1 (ja) 2014-02-20
US20190307806A1 (en) 2019-10-10
WO2014027474A1 (ja) 2014-02-20
PT2886123T (pt) 2020-01-22

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