CN104582711B - 诱导心肌梗塞的修复再生的多能性干细胞 - Google Patents

诱导心肌梗塞的修复再生的多能性干细胞 Download PDF

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CN104582711B
CN104582711B CN201380043649.5A CN201380043649A CN104582711B CN 104582711 B CN104582711 B CN 104582711B CN 201380043649 A CN201380043649 A CN 201380043649A CN 104582711 B CN104582711 B CN 104582711B
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cells
negative
pluripotent stem
muse
stem cells
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CN104582711A (zh
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吉田正顺
港口信也
出泽真理
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National University Legal Person Northeast University
Gifu University NUC
Clio Inc
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National University Legal Person Northeast University
Gifu University NUC
Clio Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
CN201380043649.5A 2012-08-17 2013-08-15 诱导心肌梗塞的修复再生的多能性干细胞 Active CN104582711B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2012-181029 2012-08-17
JP2012181029 2012-08-17
PCT/JP2013/054049 WO2014027474A1 (ja) 2012-08-17 2013-02-19 心筋梗塞の修復再生を誘導する多能性幹細胞
JPPCT/JP2013/054049 2013-02-19
PCT/JP2013/071981 WO2014027684A1 (ja) 2012-08-17 2013-08-15 心筋梗塞の修復再生を誘導する多能性幹細胞

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CN104582711A CN104582711A (zh) 2015-04-29
CN104582711B true CN104582711B (zh) 2019-12-06

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US (3) US9844570B2 (enExample)
EP (2) EP3659612B1 (enExample)
JP (1) JP5968442B2 (enExample)
KR (1) KR101730052B1 (enExample)
CN (1) CN104582711B (enExample)
AU (1) AU2013303492B2 (enExample)
CA (1) CA2882239C (enExample)
DK (1) DK2886123T3 (enExample)
ES (1) ES2767182T3 (enExample)
IN (1) IN2015DN01616A (enExample)
PL (1) PL2886123T3 (enExample)
PT (1) PT2886123T (enExample)
SG (2) SG11201501185WA (enExample)
WO (2) WO2014027474A1 (enExample)

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WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
JP2015160820A (ja) * 2014-02-26 2015-09-07 株式会社Ｃｌｉｏ 慢性腎障害治療のための多能性幹細胞
JP6452107B2 (ja) 2014-09-05 2019-01-16 国立大学法人 東京大学 糖尿病性皮膚潰瘍治療のための多能性幹細胞
WO2016168993A1 (en) 2015-04-22 2016-10-27 Innolife Co., Ltd. Methods of tissue repair and regeneration
JP6770673B2 (ja) * 2016-02-26 2020-10-21 国立大学法人東海国立大学機構 急性心筋梗塞の予後マーカー及びその利用
CA3029505A1 (en) * 2016-07-01 2018-01-04 Tohoku University Prophylactic or therapeutic agent for organ fibrosis
EP3492091B1 (en) * 2016-07-29 2021-07-14 Tohoku University "muse" cells as prophylactic or therapeutic agent for aneurysm
JP7045670B2 (ja) * 2016-08-03 2022-04-01 皓 矢吹 多能性幹細胞による虚血再灌流肺障害の軽減及び治療
CN109661461B (zh) * 2016-08-03 2024-05-24 株式会社生命科学研究院 在体外分化诱导多能性干细胞的方法
SG11201900983TA (en) * 2016-08-03 2019-03-28 Univ Nagoya Nat Univ Corp Amelioration and treatment of chronic lung disease using pluripotent stem cells
CN106822899B (zh) * 2017-03-10 2020-11-27 北京大学 一种通过抑制自噬促进心肌再生的药物
CN111225676A (zh) * 2017-10-17 2020-06-02 国立大学法人广岛大学 诱导骨软骨修复的多能性干细胞
JP7102666B2 (ja) * 2018-01-25 2022-07-20 国立大学法人東海国立大学機構 Ｍｕｓｅ細胞動員剤及び心筋障害への利用
JP7072777B2 (ja) * 2018-07-03 2022-05-23 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
CN110302212A (zh) * 2019-07-17 2019-10-08 陶正博 一种用于治疗急性心肌梗死的细胞制剂及其制备方法
KR102791419B1 (ko) 2019-08-19 2025-04-08 세루아쿠시아 가부시키가이샤 세포 함유 의약 조성물
EP4026551A1 (en) * 2019-09-05 2022-07-13 Tohoku University Therapeutic agent for myocarditis
JPWO2021085639A1 (enExample) * 2019-10-31 2021-05-06
WO2021201286A1 (ja) 2020-04-02 2021-10-07 国立大学法人東北大学 ハイポテンシャル多能性幹細胞
TWI825446B (zh) * 2020-08-14 2023-12-11 中國醫藥大學 醫藥組合物治療組織缺血狀況之用途
JP2021073305A (ja) * 2021-02-09 2021-05-13 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
CN119198334A (zh) * 2024-10-31 2024-12-27 北京大学深圳研究生院 一种心肌梗死边界区组织鉴定方法

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JP5103626B2 (ja) 2005-01-27 2012-12-19 財団法人ヒューマンサイエンス振興財団 間葉系幹細胞を含む細胞シート
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WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞

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US9844570B2 (en) 2017-12-19
WO2014027474A1 (ja) 2014-02-20
US20190307806A1 (en) 2019-10-10
PT2886123T (pt) 2020-01-22
EP2886123A4 (en) 2016-06-22
EP2886123A1 (en) 2015-06-24
CN104582711A (zh) 2015-04-29
AU2013303492A1 (en) 2015-03-12
CA2882239A1 (en) 2014-02-20
SG10201800829XA (en) 2018-03-28
IN2015DN01616A (enExample) 2015-07-03
EP2886123B1 (en) 2019-10-23
EP3659612B1 (en) 2023-06-07
JPWO2014027684A1 (ja) 2016-07-28
EP3659612A1 (en) 2020-06-03
WO2014027684A1 (ja) 2014-02-20
KR101730052B1 (ko) 2017-04-25
US20180050067A1 (en) 2018-02-22
DK2886123T3 (da) 2020-01-27
KR20150043482A (ko) 2015-04-22
JP5968442B2 (ja) 2016-08-10
US10376544B2 (en) 2019-08-13
US20150196600A1 (en) 2015-07-16
ES2767182T3 (es) 2020-06-16
CA2882239C (en) 2018-05-22
PL2886123T3 (pl) 2020-05-18
AU2013303492B2 (en) 2017-02-16
US10639335B2 (en) 2020-05-05
SG11201501185WA (en) 2015-05-28

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