AU2013303492B2 - Pluripotent stem cell that induces repair and regeneration after myocardial infarction - Google Patents

Pluripotent stem cell that induces repair and regeneration after myocardial infarction Download PDF

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Publication number
AU2013303492B2
AU2013303492B2 AU2013303492A AU2013303492A AU2013303492B2 AU 2013303492 B2 AU2013303492 B2 AU 2013303492B2 AU 2013303492 A AU2013303492 A AU 2013303492A AU 2013303492 A AU2013303492 A AU 2013303492A AU 2013303492 B2 AU2013303492 B2 AU 2013303492B2
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AU
Australia
Prior art keywords
cells
negative
pluripotent stem
muse
stem cells
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Ceased
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AU2013303492A
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English (en)
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AU2013303492A1 (en
Inventor
Mari Dezawa
Shinya Minatoguchi
Masanori Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tohoku University
Gifu University
Clio Inc
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Tohoku University
Gifu University
Clio Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
AU2013303492A 2012-08-17 2013-08-15 Pluripotent stem cell that induces repair and regeneration after myocardial infarction Ceased AU2013303492B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2012181029 2012-08-17
JP2012-181029 2012-08-17
AUPCT/JP2013/054049 2013-02-19
PCT/JP2013/054049 WO2014027474A1 (ja) 2012-08-17 2013-02-19 心筋梗塞の修復再生を誘導する多能性幹細胞
PCT/JP2013/071981 WO2014027684A1 (ja) 2012-08-17 2013-08-15 心筋梗塞の修復再生を誘導する多能性幹細胞

Publications (2)

Publication Number Publication Date
AU2013303492A1 AU2013303492A1 (en) 2015-03-12
AU2013303492B2 true AU2013303492B2 (en) 2017-02-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013303492A Ceased AU2013303492B2 (en) 2012-08-17 2013-08-15 Pluripotent stem cell that induces repair and regeneration after myocardial infarction

Country Status (14)

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US (3) US9844570B2 (enExample)
EP (2) EP3659612B1 (enExample)
JP (1) JP5968442B2 (enExample)
KR (1) KR101730052B1 (enExample)
CN (1) CN104582711B (enExample)
AU (1) AU2013303492B2 (enExample)
CA (1) CA2882239C (enExample)
DK (1) DK2886123T3 (enExample)
ES (1) ES2767182T3 (enExample)
IN (1) IN2015DN01616A (enExample)
PL (1) PL2886123T3 (enExample)
PT (1) PT2886123T (enExample)
SG (2) SG11201501185WA (enExample)
WO (2) WO2014027474A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11419899B2 (en) 2016-07-29 2022-08-23 Tohoku University Method of treating aortic aneurysm using muse cells

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WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
JP2015160820A (ja) * 2014-02-26 2015-09-07 株式会社Ｃｌｉｏ 慢性腎障害治療のための多能性幹細胞
JP6452107B2 (ja) * 2014-09-05 2019-01-16 国立大学法人 東京大学 糖尿病性皮膚潰瘍治療のための多能性幹細胞
WO2016168993A1 (en) * 2015-04-22 2016-10-27 Innolife Co., Ltd. Methods of tissue repair and regeneration
JP6770673B2 (ja) * 2016-02-26 2020-10-21 国立大学法人東海国立大学機構 急性心筋梗塞の予後マーカー及びその利用
US20190201455A1 (en) * 2016-07-01 2019-07-04 Tohoku University Prophylactic or therapeutic agent for organ fibrosis
US11920180B2 (en) 2016-08-03 2024-03-05 Tohoku University Method for inducing differentiation of pluripotent stem cells in vitro
SG11201900983TA (en) * 2016-08-03 2019-03-28 Univ Nagoya Nat Univ Corp Amelioration and treatment of chronic lung disease using pluripotent stem cells
CA3032925A1 (en) * 2016-08-03 2018-02-08 Life Science Institute, Inc. Alleviation and treatment of ischemia reperfusion-induced lung injury using pluripotent stem cells
CN106822899B (zh) * 2017-03-10 2020-11-27 北京大学 一种通过抑制自噬促进心肌再生的药物
WO2019078262A1 (ja) * 2017-10-17 2019-04-25 国立大学法人広島大学 骨軟骨修復を誘導する多能性幹細胞
JP7102666B2 (ja) * 2018-01-25 2022-07-20 国立大学法人東海国立大学機構 Ｍｕｓｅ細胞動員剤及び心筋障害への利用
JP7072777B2 (ja) * 2018-07-03 2022-05-23 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
CN110302212A (zh) * 2019-07-17 2019-10-08 陶正博 一种用于治疗急性心肌梗死的细胞制剂及其制备方法
US12460182B2 (en) 2019-08-19 2025-11-04 Cellaxia Inc. Cell-containing pharmaceutical composition
CA3153237A1 (en) * 2019-09-05 2021-03-11 Tohoku University Therapeutic agent for myocarditis
CA3156700A1 (en) 2019-10-31 2021-05-06 Life Science Institute, Inc. Therapy for interstitial cystitis by pluripotent stem cells
US20230203436A1 (en) 2020-04-02 2023-06-29 Tohoku University High-potential pluripotent stem cells
TWI825446B (zh) * 2020-08-14 2023-12-11 中國醫藥大學 醫藥組合物治療組織缺血狀況之用途
JP2021073305A (ja) * 2021-02-09 2021-05-13 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
CN119198334A (zh) * 2024-10-31 2024-12-27 北京大学深圳研究生院 一种心肌梗死边界区组织鉴定方法

Citations (5)

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US5827735A (en) * 1992-06-22 1998-10-27 Morphogen Pharmaceuticals, Inc. Pluripotent mesenchymal stem cells and methods of use thereof
WO2002057430A2 (en) * 2001-01-20 2002-07-25 Cardion Ag Pluripotent adult stem cells derived from regenerative tissue
WO2009046058A1 (en) * 2007-10-01 2009-04-09 University Of Miami A method to amplify cardiac stem cells in vitro and in vivo
WO2011007900A1 (ja) * 2009-07-15 2011-01-20 Dezawa Mari 生体組織から単離できる多能性幹細胞
US20120094380A1 (en) * 2010-10-18 2012-04-19 Sunshine Biotech Inc. Human multipotent embryonic stem cell-like progenitor cells

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WO1999003973A1 (en) * 1997-07-14 1999-01-28 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
ATE382681T1 (de) * 1998-07-31 2008-01-15 Genzyme Corp Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
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EP1412479A4 (en) 2001-07-12 2004-07-28 Geron Corp CELLS WITH CARDIOMYOCYTE GENERATION PRODUCED FROM HUMAN PLURIPOTENT STEM CELLS
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JP5564679B2 (ja) 2009-04-16 2014-07-30 公益財団法人ヒューマンサイエンス振興財団 心筋細胞分化誘導促進剤およびその使用方法
WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞

Patent Citations (5)

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US5827735A (en) * 1992-06-22 1998-10-27 Morphogen Pharmaceuticals, Inc. Pluripotent mesenchymal stem cells and methods of use thereof
WO2002057430A2 (en) * 2001-01-20 2002-07-25 Cardion Ag Pluripotent adult stem cells derived from regenerative tissue
WO2009046058A1 (en) * 2007-10-01 2009-04-09 University Of Miami A method to amplify cardiac stem cells in vitro and in vivo
WO2011007900A1 (ja) * 2009-07-15 2011-01-20 Dezawa Mari 生体組織から単離できる多能性幹細胞
US20120094380A1 (en) * 2010-10-18 2012-04-19 Sunshine Biotech Inc. Human multipotent embryonic stem cell-like progenitor cells

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11419899B2 (en) 2016-07-29 2022-08-23 Tohoku University Method of treating aortic aneurysm using muse cells

Also Published As

Publication number Publication date
US9844570B2 (en) 2017-12-19
JP5968442B2 (ja) 2016-08-10
US20150196600A1 (en) 2015-07-16
EP2886123A1 (en) 2015-06-24
EP2886123A4 (en) 2016-06-22
IN2015DN01616A (enExample) 2015-07-03
CN104582711B (zh) 2019-12-06
DK2886123T3 (da) 2020-01-27
ES2767182T3 (es) 2020-06-16
US10376544B2 (en) 2019-08-13
JPWO2014027684A1 (ja) 2016-07-28
KR20150043482A (ko) 2015-04-22
CA2882239C (en) 2018-05-22
EP3659612B1 (en) 2023-06-07
EP3659612A1 (en) 2020-06-03
CN104582711A (zh) 2015-04-29
PL2886123T3 (pl) 2020-05-18
AU2013303492A1 (en) 2015-03-12
SG11201501185WA (en) 2015-05-28
SG10201800829XA (en) 2018-03-28
KR101730052B1 (ko) 2017-04-25
US20180050067A1 (en) 2018-02-22
EP2886123B1 (en) 2019-10-23
US10639335B2 (en) 2020-05-05
CA2882239A1 (en) 2014-02-20
WO2014027684A1 (ja) 2014-02-20
US20190307806A1 (en) 2019-10-10
WO2014027474A1 (ja) 2014-02-20
PT2886123T (pt) 2020-01-22

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