CA2856127C - Mutants of hydantoinase - Google Patents
Mutants of hydantoinase Download PDFInfo
- Publication number
- CA2856127C CA2856127C CA2856127A CA2856127A CA2856127C CA 2856127 C CA2856127 C CA 2856127C CA 2856127 A CA2856127 A CA 2856127A CA 2856127 A CA2856127 A CA 2856127A CA 2856127 C CA2856127 C CA 2856127C
- Authority
- CA
- Canada
- Prior art keywords
- seq
- hydantoinase
- amino acid
- hydantoin
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/227—Tryptophan
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/009—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving hydantoins or carbamoylamino compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
- C12Y305/02002—Dihydropyrimidinase (3.5.2.2), i.e. hydantoinase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11189395 | 2011-11-16 | ||
| EP11189395.4 | 2011-11-16 | ||
| PCT/EP2012/072891 WO2013072486A1 (en) | 2011-11-16 | 2012-11-16 | Mutants of hydantoinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2856127A1 CA2856127A1 (en) | 2013-05-23 |
| CA2856127C true CA2856127C (en) | 2021-04-06 |
Family
ID=47189946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2856127A Active CA2856127C (en) | 2011-11-16 | 2012-11-16 | Mutants of hydantoinase |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9957536B2 (2) |
| EP (1) | EP2780451B1 (2) |
| JP (1) | JP6279478B2 (2) |
| KR (1) | KR102027201B1 (2) |
| CN (2) | CN104053772A (2) |
| BR (1) | BR112014011664A2 (2) |
| CA (1) | CA2856127C (2) |
| DK (1) | DK2780451T3 (2) |
| ES (1) | ES2652387T3 (2) |
| IN (1) | IN2014KN00866A (2) |
| PL (1) | PL2780451T3 (2) |
| WO (1) | WO2013072486A1 (2) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112175929A (zh) * | 2020-10-10 | 2021-01-05 | 山西大学 | 一种重组海因消旋酶工程菌及其构建方法和用途 |
| EP4105335A1 (en) | 2021-06-16 | 2022-12-21 | Evonik Operations GmbH | Enzymatic method for the production of l-glufosinate p-alkyl esters |
| CN114686465B (zh) * | 2021-11-21 | 2024-03-22 | 宁波酶赛生物工程有限公司 | 一种水解酶和一种(r)-(-)-3-(氨甲酰甲基)-5-甲基己酸的合成方法 |
| MX2024011087A (es) | 2022-03-14 | 2024-09-23 | Evonik Operations Gmbh | Metodo enzimatico para la produccion de p-esteres de l-glufosinato. |
| WO2023222226A1 (en) | 2022-05-19 | 2023-11-23 | Evonik Operations Gmbh | Enzymatic method for producing l-glufosinate |
| WO2023222227A1 (en) | 2022-05-19 | 2023-11-23 | Evonik Operations Gmbh | Enzymatic method for producing l-glufosinate |
| WO2023232225A1 (en) | 2022-05-31 | 2023-12-07 | Evonik Operations Gmbh | Enzymatic method for the diastereoselective production of l-glufosinate p-esters |
| CN120699948B (zh) * | 2025-07-15 | 2026-04-21 | 上海奥萝拉医药科技有限公司 | 海因酶突变体及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5391189A (en) * | 1976-12-30 | 1978-08-10 | Kanegafuchi Chem Ind Co Ltd | Preparation of d-n-carbamoyl-alpha-amino acids |
| JPS6225990A (ja) * | 1986-07-19 | 1987-02-03 | Kanegafuchi Chem Ind Co Ltd | Ｄ−α−アミノ酸類の製造方法 |
| DE4316928C2 (de) | 1993-05-19 | 1995-03-16 | Degussa | Neue Mikroorganismen, deren Verwendung und Verfahren zur Herstellung von L-alpha-Aminosäuren |
| US6524837B1 (en) * | 1999-03-29 | 2003-02-25 | California Institute Of Technology | Hydantoinase variants with improved properties and their use for the production of amino acids |
| DE10114999A1 (de) | 2001-03-26 | 2002-10-10 | Degussa | D-Carbamoylase aus Arthrobacter crystallopoietes DSM 20117 |
| DE10155928A1 (de) | 2001-11-15 | 2003-06-12 | Degussa | recA-negativer und rhaB-negativer Mikroorganismus |
| CN1260347C (zh) * | 2002-05-13 | 2006-06-21 | 中国人民解放军军事医学科学院生物工程研究所 | 一株产乙内酰脲酶系的节杆菌 |
| DE10251184A1 (de) * | 2002-11-04 | 2004-05-13 | Degussa Ag | Mutanten zur Herstellung von D-Aminosäuren |
| JP2007189949A (ja) | 2006-01-19 | 2007-08-02 | Kaneka Corp | 新規ヒダントイナーゼ及び光学活性アミノ酸誘導体の製造方法 |
-
2012
- 2012-11-16 BR BR112014011664A patent/BR112014011664A2/pt not_active IP Right Cessation
- 2012-11-16 CA CA2856127A patent/CA2856127C/en active Active
- 2012-11-16 CN CN201280067105.8A patent/CN104053772A/zh active Pending
- 2012-11-16 CN CN201811207287.XA patent/CN109468304B/zh not_active Expired - Fee Related
- 2012-11-16 KR KR1020147012821A patent/KR102027201B1/ko not_active Expired - Fee Related
- 2012-11-16 IN IN866KON2014 patent/IN2014KN00866A/en unknown
- 2012-11-16 DK DK12787447.7T patent/DK2780451T3/en active
- 2012-11-16 PL PL12787447T patent/PL2780451T3/pl unknown
- 2012-11-16 JP JP2014541685A patent/JP6279478B2/ja not_active Expired - Fee Related
- 2012-11-16 WO PCT/EP2012/072891 patent/WO2013072486A1/en not_active Ceased
- 2012-11-16 EP EP12787447.7A patent/EP2780451B1/en active Active
- 2012-11-16 ES ES12787447.7T patent/ES2652387T3/es active Active
- 2012-11-16 US US14/357,028 patent/US9957536B2/en active Active
-
2018
- 2018-04-13 US US15/952,377 patent/US10822627B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN109468304A (zh) | 2019-03-15 |
| ES2652387T3 (es) | 2018-02-01 |
| CA2856127A1 (en) | 2013-05-23 |
| DK2780451T3 (en) | 2018-01-02 |
| US10822627B2 (en) | 2020-11-03 |
| EP2780451A1 (en) | 2014-09-24 |
| US20150056667A1 (en) | 2015-02-26 |
| KR20140092835A (ko) | 2014-07-24 |
| US9957536B2 (en) | 2018-05-01 |
| US20180237814A1 (en) | 2018-08-23 |
| BR112014011664A2 (pt) | 2017-05-09 |
| CN109468304B (zh) | 2022-04-19 |
| KR102027201B1 (ko) | 2019-10-01 |
| JP2014533497A (ja) | 2014-12-15 |
| JP6279478B2 (ja) | 2018-02-14 |
| IN2014KN00866A (2) | 2015-10-02 |
| EP2780451B1 (en) | 2017-09-20 |
| CN104053772A (zh) | 2014-09-17 |
| WO2013072486A1 (en) | 2013-05-23 |
| PL2780451T3 (pl) | 2018-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20171101 |
|
| H11 | Ip right ceased following rejected request for revival |
Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED Effective date: 20250516 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20251008 |