CA2840149C - Methods and nucleic acids for determining the prognosis of a cancer subject - Google Patents

Methods and nucleic acids for determining the prognosis of a cancer subject Download PDF

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Publication number
CA2840149C
CA2840149C CA2840149A CA2840149A CA2840149C CA 2840149 C CA2840149 C CA 2840149C CA 2840149 A CA2840149 A CA 2840149A CA 2840149 A CA2840149 A CA 2840149A CA 2840149 C CA2840149 C CA 2840149C
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Prior art keywords
prognosis
determining
nucleic acids
methods
cancer subject
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CA2840149A
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English (en)
French (fr)
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CA2840149A1 (en
Inventor
Joern Lewin
Manuel Krispin
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Epigenomics AG
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Epigenomics AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2840149A 2011-07-08 2012-07-09 Methods and nucleic acids for determining the prognosis of a cancer subject Active CA2840149C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161505919P 2011-07-08 2011-07-08
US61/505,919 2011-07-08
PCT/EP2012/063436 WO2013007702A1 (en) 2011-07-08 2012-07-09 Methods and nucleic acids for determining the prognosis of a cancer subject

Publications (2)

Publication Number Publication Date
CA2840149A1 CA2840149A1 (en) 2013-01-17
CA2840149C true CA2840149C (en) 2021-10-26

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Family Applications (1)

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CA2840149A Active CA2840149C (en) 2011-07-08 2012-07-09 Methods and nucleic acids for determining the prognosis of a cancer subject

Country Status (21)

Country Link
US (4) US10626462B2 (enExample)
EP (1) EP2729579B1 (enExample)
JP (1) JP6397762B2 (enExample)
KR (1) KR102046668B1 (enExample)
CN (2) CN108048573A (enExample)
AU (1) AU2012282528B2 (enExample)
BR (1) BR112014000443B1 (enExample)
CA (1) CA2840149C (enExample)
DK (1) DK2729579T3 (enExample)
EA (1) EA034232B1 (enExample)
ES (1) ES2654561T3 (enExample)
HR (1) HRP20180001T1 (enExample)
HU (1) HUE036036T2 (enExample)
IL (1) IL230303B (enExample)
LT (1) LT2729579T (enExample)
MX (1) MX358117B (enExample)
NO (1) NO2729579T3 (enExample)
PH (1) PH12014500063A1 (enExample)
SI (1) SI2729579T1 (enExample)
WO (1) WO2013007702A1 (enExample)
ZA (1) ZA201400089B (enExample)

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CN106148501A (zh) * 2015-04-23 2016-11-23 博诚研究中心 一种检测Septin9基因甲基化的试剂盒及其应用
WO2017009322A1 (en) * 2015-07-15 2017-01-19 Universiteit Gent Probes and a methylation in situ hybridization assay
WO2017043497A1 (ja) * 2015-09-08 2017-03-16 国立大学法人山口大学 大腸腫瘍の有無を検査する方法
EP4528275A3 (en) 2016-08-10 2025-05-14 Grail, Inc. Methods of preparing dual-indexed dna libraries for bisulfite conversion sequencing
KR102601593B1 (ko) 2017-04-19 2023-11-13 싱글레라 제노믹스, 인코포레이티드 라이브러리 제작 및 서열 분석을 위한 조성물 및 방법
CN107385056A (zh) * 2017-08-10 2017-11-24 上海时代基因医学科技有限公司 一种检测SEPT9基因不同Cpg岛甲基化的试剂盒及应用
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EP3717502B1 (en) * 2017-11-29 2025-04-23 The Regents of The University of Michigan Compositions and methods for characterizing cancer
CN108796080B (zh) * 2018-06-06 2022-06-07 苏州唯善生物科技有限公司 用于结直肠癌诊断、检测或筛查的引物和探针组
CN109055552A (zh) * 2018-08-23 2018-12-21 北京迈基诺基因科技股份有限公司 检测Septin9基因启动子是否甲基化的方法及其专用成套试剂
CN112195243A (zh) * 2020-09-22 2021-01-08 北京华大吉比爱生物技术有限公司 一种检测多基因甲基化的试剂盒及其应用
KR102404750B1 (ko) * 2021-10-14 2022-06-07 주식회사 엔도믹스 세포 유리 dna를 이용한 대장암 진단을 위한 메틸화 마커 유전자 및 이의 용도
CN114561452A (zh) * 2022-03-10 2022-05-31 天津市人民医院 mSEPT9作为预测结直肠癌患者术后复发风险标志物及用于评价化疗方案有效性的应用
KR102559496B1 (ko) * 2022-04-26 2023-07-25 연세대학교 산학협력단 핵산의 메틸화 여부 확인용 조성물 및 핵산의 메틸화 여부를 확인하는 방법
CN115248313A (zh) * 2022-08-03 2022-10-28 中山市人民医院 肠癌外周血免疫细胞m5C标志物的应用
CN115029462B (zh) * 2022-08-10 2022-11-08 中国农业科学院农业质量标准与检测技术研究所 一种动植物疫病的核酸标准物质、形貌模拟方法及其应用
CA3268032A1 (en) * 2022-09-23 2024-03-28 Flagship Pioneering Innovations Vi, Llc NUCLEIC ACID AMPLIFICATION PROCESSES
WO2024107441A1 (en) * 2022-11-14 2024-05-23 Trustees Of Dartmouth College Systemic biomarkers for the dynamic assessment of tumor burden and treatment efficacy in high grade gliomas

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Also Published As

Publication number Publication date
ES2654561T3 (es) 2018-02-14
AU2012282528B2 (en) 2017-04-13
NO2729579T3 (enExample) 2018-03-03
WO2013007702A1 (en) 2013-01-17
PH12014500063A1 (en) 2014-02-17
IL230303B (en) 2018-05-31
US20150031021A1 (en) 2015-01-29
CA2840149A1 (en) 2013-01-17
SI2729579T1 (en) 2018-07-31
HRP20180001T1 (hr) 2018-03-09
CN108048573A (zh) 2018-05-18
US20250101527A1 (en) 2025-03-27
JP6397762B2 (ja) 2018-09-26
CN103732759A (zh) 2014-04-16
KR102046668B1 (ko) 2019-11-19
BR112014000443A2 (pt) 2017-02-14
US20220243277A1 (en) 2022-08-04
KR20140044385A (ko) 2014-04-14
DK2729579T3 (en) 2018-01-08
LT2729579T (lt) 2018-02-26
US10626462B2 (en) 2020-04-21
EA201400117A1 (ru) 2014-06-30
EP2729579B1 (en) 2017-10-04
US20200308656A1 (en) 2020-10-01
ZA201400089B (en) 2022-03-30
MX358117B (es) 2018-08-06
US11261499B2 (en) 2022-03-01
HUE036036T2 (hu) 2018-06-28
JP2014520520A (ja) 2014-08-25
EA034232B1 (ru) 2020-01-20
AU2012282528A1 (en) 2014-01-23
EP2729579A1 (en) 2014-05-14
US12110558B2 (en) 2024-10-08
BR112014000443B1 (pt) 2021-03-23
MX2014000116A (es) 2014-03-27

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