CA2834033C - Methods for the production of ansamitocins - Google Patents

Methods for the production of ansamitocins Download PDF

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Publication number
CA2834033C
CA2834033C CA2834033A CA2834033A CA2834033C CA 2834033 C CA2834033 C CA 2834033C CA 2834033 A CA2834033 A CA 2834033A CA 2834033 A CA2834033 A CA 2834033A CA 2834033 C CA2834033 C CA 2834033C
Authority
CA
Canada
Prior art keywords
ansamitocins
ansamitocin
culture medium
crystallization
culturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2834033A
Other languages
English (en)
French (fr)
Other versions
CA2834033A1 (en
Inventor
Cynthia Kuo
Graham S. Byng
Wayne C. Widdison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunogen Inc
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36692550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2834033(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of CA2834033A1 publication Critical patent/CA2834033A1/en
Application granted granted Critical
Publication of CA2834033C publication Critical patent/CA2834033C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2834033A 2005-01-19 2005-12-12 Methods for the production of ansamitocins Expired - Lifetime CA2834033C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/037,104 US7432088B2 (en) 2003-05-08 2005-01-19 Methods for the production of ansamitocins
US11/037,104 2005-01-19
CA2595024A CA2595024C (en) 2005-01-19 2005-12-12 Methods for the production of ansamitocins

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2595024A Division CA2595024C (en) 2005-01-19 2005-12-12 Methods for the production of ansamitocins

Publications (2)

Publication Number Publication Date
CA2834033A1 CA2834033A1 (en) 2006-07-27
CA2834033C true CA2834033C (en) 2017-01-24

Family

ID=36692550

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2595024A Expired - Lifetime CA2595024C (en) 2005-01-19 2005-12-12 Methods for the production of ansamitocins
CA2834033A Expired - Lifetime CA2834033C (en) 2005-01-19 2005-12-12 Methods for the production of ansamitocins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2595024A Expired - Lifetime CA2595024C (en) 2005-01-19 2005-12-12 Methods for the production of ansamitocins

Country Status (27)

Country Link
US (1) US7432088B2 (enExample)
EP (2) EP2514828B1 (enExample)
JP (1) JP5106120B2 (enExample)
KR (3) KR20120099734A (enExample)
CN (2) CN101103120A (enExample)
AU (1) AU2005325166B2 (enExample)
BR (1) BRPI0519624B8 (enExample)
CA (2) CA2595024C (enExample)
CR (1) CR9228A (enExample)
CY (1) CY1121372T1 (enExample)
DK (1) DK2514828T3 (enExample)
EA (1) EA012524B1 (enExample)
ES (1) ES2710875T3 (enExample)
HK (1) HK1211985A1 (enExample)
HU (1) HUE042312T2 (enExample)
IL (2) IL183918A (enExample)
LT (1) LT2514828T (enExample)
MX (1) MX2007008069A (enExample)
NO (1) NO342876B1 (enExample)
NZ (2) NZ583446A (enExample)
PL (1) PL2514828T3 (enExample)
PT (1) PT2514828T (enExample)
SG (1) SG158905A1 (enExample)
SI (1) SI2514828T1 (enExample)
TR (1) TR201901647T4 (enExample)
WO (1) WO2006078368A1 (enExample)
ZA (1) ZA200704918B (enExample)

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US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
WO2007044576A1 (en) * 2005-10-07 2007-04-19 Steward Environmental Solutions, Llc Method to remove an agent using a magnetic carrier
US20070135629A1 (en) * 2005-12-08 2007-06-14 Millennium Pharmaceuticals, Inc. Isolation of ansamitocins
EP2046470A2 (en) * 2006-07-10 2009-04-15 Sicor, Inc. Apparatus for the separation of a resin from a reaction mixture
CN100420754C (zh) * 2006-10-26 2008-09-24 浙江海正药业股份有限公司 一种制备蒽莎姆菌素的方法
CN101711284A (zh) 2007-01-25 2010-05-19 达娜-法勃肿瘤研究所 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
ES2542152T3 (es) 2007-03-15 2015-07-31 Ludwig Institute For Cancer Research Ltd. Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas
JP5469600B2 (ja) 2007-07-16 2014-04-16 ジェネンテック， インコーポレイテッド 抗ＣＤ７９ｂ抗体及びイムノコンジュゲートとその使用方法
SG183044A1 (en) 2007-07-16 2012-08-30 Genentech Inc Humanized anti-cd79b antibodies and immunoconjugatesand methods of use
WO2009023265A1 (en) 2007-08-14 2009-02-19 Ludwig Institute For Cancer Research Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof
UA106586C2 (uk) 2008-01-31 2014-09-25 Дженентек, Інк. Анти-cd79b антитіла, і імунокон'югати та способи їх застосування
KR20160125535A (ko) 2008-03-18 2016-10-31 제넨테크, 인크. 항-ｈｅｒ２ 항체-약물 접합체와 화학요법제의 병용물, 및 사용 방법
CN101319241B (zh) * 2008-07-17 2011-03-30 上海交通大学 安丝菌素的固体发酵方法
BRPI1012676A2 (pt) 2009-04-01 2016-04-05 Genentech Inc anticorpos anti-fcrh5 e imunoconjugados e métodos de uso
AR079256A1 (es) 2009-12-04 2012-01-04 Genentech Inc Metodo para el tratamiento del cancer de mama metastasico con trastuzumab-mcc-dm1
CN101921817A (zh) * 2010-09-07 2010-12-22 上海交通大学 安莎霉素发酵产量提高方法
CA2816426A1 (en) 2010-11-17 2012-06-07 Genentech, Inc. Alaninyl maytansinol antibody conjugates
US8852435B2 (en) * 2011-11-29 2014-10-07 Therapeutics Proteins International, LLC Purification and separation treatment assembly (PASTA) for biological products
CN103255184B (zh) * 2012-02-15 2016-01-27 百奥泰生物科技(广州)有限公司 生产安丝菌素的发酵培养基
CN103805648B (zh) * 2012-11-13 2017-09-15 百奥泰生物科技(广州)有限公司 高产安丝菌素发酵工艺
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
TWI541022B (zh) 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
TW201711702A (zh) 2015-06-04 2017-04-01 應克隆公司 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法
CN113607945B (zh) 2015-07-07 2025-01-28 豪夫迈·罗氏有限公司 抗HER2抗体-药物缀合物和Bcl-2抑制剂的组合疗法
CN105907681B (zh) * 2016-05-30 2019-11-19 苏州康聚生物科技有限公司 一种高产安丝菌素p-3的突变株及安丝菌素p-3的制备方法
CN110234348B (zh) 2016-12-16 2024-06-25 蓝鳍生物医药公司 抗-含cub结构域蛋白1(cdcp1)抗体、抗体药物缀合物及其使用方法
CN108276427A (zh) * 2018-01-14 2018-07-13 常州大学 一种安丝菌素p-3的提取与分离纯化方法
CN108330113B (zh) * 2018-03-08 2019-05-28 山东省医药生物技术研究中心（山东省病毒研究所） 一株高底物专一性酰基转移酶的珍贵束丝放线菌及其应用
CN113444106A (zh) * 2020-03-25 2021-09-28 重庆乾泰生物医药有限公司 一种高纯度安丝菌素的制备方法
CN112630368A (zh) * 2020-12-18 2021-04-09 卓和药业集团有限公司 安丝菌素含量的高效液相色谱检测分析方法
CN117597450A (zh) * 2021-06-18 2024-02-23 杭州中美华东制药有限公司 安丝菌素p-3的提纯方法
CN115477658A (zh) * 2022-10-12 2022-12-16 道中道（菏泽）制药有限公司 一种有效降低安丝菌素p-3杂质的结晶方法

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JPS6016236B2 (ja) 1977-11-18 1985-04-24 武田薬品工業株式会社 抗生物質ｃ―１５００３ ｐ―３の製造法
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Also Published As

Publication number Publication date
EP2514828A3 (en) 2013-07-03
ZA200704918B (en) 2008-11-26
CA2595024A1 (en) 2006-07-27
HUE042312T2 (hu) 2019-06-28
EA012524B1 (ru) 2009-10-30
CA2834033A1 (en) 2006-07-27
JP2008526267A (ja) 2008-07-24
JP5106120B2 (ja) 2012-12-26
PT2514828T (pt) 2019-02-15
NO342876B1 (no) 2018-08-20
IL183918A0 (en) 2007-10-31
BRPI0519624B1 (pt) 2021-01-19
CN104745655A (zh) 2015-07-01
CN101103120A (zh) 2008-01-09
BRPI0519624B8 (pt) 2021-05-25
CR9228A (es) 2008-03-31
TR201901647T4 (tr) 2019-02-21
KR20120099734A (ko) 2012-09-11
DK2514828T3 (en) 2019-03-11
AU2005325166B2 (en) 2012-02-02
MX2007008069A (es) 2007-08-21
CY1121372T1 (el) 2020-05-29
PL2514828T3 (pl) 2019-04-30
CA2595024C (en) 2014-02-04
SI2514828T1 (sl) 2019-03-29
WO2006078368A1 (en) 2006-07-27
HK1211985A1 (en) 2016-06-03
LT2514828T (lt) 2019-02-25
KR20130051019A (ko) 2013-05-16
ES2710875T3 (es) 2019-04-29
EP1838863A1 (en) 2007-10-03
IL215686A0 (en) 2011-11-30
KR20070099576A (ko) 2007-10-09
EP2514828A2 (en) 2012-10-24
EP1838863A4 (en) 2011-10-05
EA200701310A1 (ru) 2008-06-30
US7432088B2 (en) 2008-10-07
NO20074222L (no) 2007-10-18
KR101515873B1 (ko) 2015-04-29
IL183918A (en) 2013-07-31
NZ555437A (en) 2010-04-30
IL215686A (en) 2013-07-31
BRPI0519624A2 (pt) 2009-02-25
AU2005325166A1 (en) 2006-07-27
NZ583446A (en) 2011-08-26
EP2514828B1 (en) 2018-11-14
SG158905A1 (en) 2010-02-26
US20050170475A1 (en) 2005-08-04

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Effective date: 20131121