CA2828713C - Alkyne substituted quinazoline compounds and methods of use - Google Patents

Alkyne substituted quinazoline compounds and methods of use Download PDF

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Publication number
CA2828713C
CA2828713C CA2828713A CA2828713A CA2828713C CA 2828713 C CA2828713 C CA 2828713C CA 2828713 A CA2828713 A CA 2828713A CA 2828713 A CA2828713 A CA 2828713A CA 2828713 C CA2828713 C CA 2828713C
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CA
Canada
Prior art keywords
compound
cancer
salt
solvate
chloro
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Active
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CA2828713A
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English (en)
French (fr)
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CA2828713A1 (en
Inventor
Wang Shen
Aimin Zhang
Jack Maung
Xiaoling Zheng
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NewGen Therapeutics Inc
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NewGen Therapeutics Inc
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Publication of CA2828713A1 publication Critical patent/CA2828713A1/en
Application granted granted Critical
Publication of CA2828713C publication Critical patent/CA2828713C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2828713A 2011-03-04 2012-03-02 Alkyne substituted quinazoline compounds and methods of use Active CA2828713C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161449088P 2011-03-04 2011-03-04
US61/449,088 2011-03-04
PCT/US2012/027614 WO2012122058A2 (en) 2011-03-04 2012-03-02 Alkyne substituted quinazoline compound and methods of use

Publications (2)

Publication Number Publication Date
CA2828713A1 CA2828713A1 (en) 2012-09-13
CA2828713C true CA2828713C (en) 2022-08-16

Family

ID=46798728

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2828713A Active CA2828713C (en) 2011-03-04 2012-03-02 Alkyne substituted quinazoline compounds and methods of use

Country Status (14)

Country Link
US (5) US9090588B2 (enExample)
EP (1) EP2680850B1 (enExample)
JP (1) JP6006242B2 (enExample)
KR (4) KR102061743B1 (enExample)
CN (1) CN103998040B (enExample)
AU (3) AU2012225693A1 (enExample)
BR (1) BR112013022552B1 (enExample)
CA (1) CA2828713C (enExample)
IL (1) IL228072A (enExample)
MX (1) MX344302B (enExample)
RU (1) RU2013144571A (enExample)
SG (3) SG10201913982WA (enExample)
TW (1) TWI617556B (enExample)
WO (1) WO2012122058A2 (enExample)

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KR102061743B1 (ko) 2011-03-04 2020-01-03 뉴젠 세러퓨틱스 인코포레이티드 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
CN102918029B (zh) 2011-05-17 2015-06-17 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
CN102898386B (zh) * 2011-07-27 2015-07-29 上海医药集团股份有限公司 喹唑啉衍生物、其制备方法、中间体、组合物及其应用
TWI609012B (zh) 2013-04-28 2017-12-21 廣東東陽光藥業有限公司 氨基喹唑啉類衍生物及其鹽和使用方法
CN103254183B (zh) * 2013-05-10 2015-11-11 苏州明锐医药科技有限公司 阿法替尼的制备方法
CN103254156B (zh) * 2013-05-10 2015-08-26 苏州明锐医药科技有限公司 阿法替尼中间体的制备方法
JP6983661B2 (ja) * 2015-12-24 2021-12-17 協和キリン株式会社 α、β不飽和アミド化合物
DE102016224889B4 (de) * 2016-12-14 2019-11-07 Airbus Defence and Space GmbH Verfahren zur Vorbeugung einer Ablösung einer Fluidströmung, Strömungskörpersystem und Luftfahrzeug
US11083492B2 (en) * 2018-06-06 2021-08-10 Lifetech Scientific (Shenzhen) Co., Ltd Method for implanting an interventional medical device
US10973321B2 (en) 2018-09-04 2021-04-13 Steelcase Inc. Workspace system and components and method for the use thereof
KR20210137422A (ko) 2018-09-25 2021-11-17 블랙 다이아몬드 테라퓨틱스, 인코포레이티드 티로신 키나아제 억제제로서의 퀴나졸린 유도체, 조성물, 이들의 제조 방법 및 이들의 용도
CN119390683A (zh) * 2019-08-15 2025-02-07 黑钻治疗公司 炔基喹唑啉化合物
CN113527215B (zh) * 2020-04-17 2023-12-05 北京赛特明强医药科技有限公司 一种喹唑啉类化合物、制备方法及其应用
TWI820414B (zh) * 2020-04-17 2023-11-01 大陸商北京賽特明強醫藥科技有限公司 喹唑啉類化合物、製備方法及其應用
TWI910256B (zh) * 2020-11-02 2026-01-01 美商黑鑽醫療公司 使用經炔取代之喹唑啉衍生物類以治療癌症之方法
WO2024179451A1 (zh) * 2023-03-02 2024-09-06 江苏康缘药业股份有限公司 一种炔基取代的喹唑啉化合物的晶型、其制备方法和应用

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Also Published As

Publication number Publication date
JP2014518544A (ja) 2014-07-31
US20180093975A1 (en) 2018-04-05
KR20140020955A (ko) 2014-02-19
US11524956B2 (en) 2022-12-13
IL228072A (en) 2016-08-31
US9090588B2 (en) 2015-07-28
CA2828713A1 (en) 2012-09-13
AU2018267622B2 (en) 2020-05-14
AU2017200984A1 (en) 2017-03-02
US20210047303A1 (en) 2021-02-18
SG10201913982WA (en) 2020-03-30
MX2013010016A (es) 2013-11-20
IL228072A0 (en) 2013-09-30
JP6006242B2 (ja) 2016-10-12
EP2680850A4 (en) 2015-01-28
WO2012122058A3 (en) 2014-04-24
WO2012122058A2 (en) 2012-09-13
BR112013022552B1 (pt) 2021-11-23
SG193291A1 (en) 2013-10-30
RU2013144571A (ru) 2015-04-10
US20190382382A1 (en) 2019-12-19
US20160031860A1 (en) 2016-02-04
KR20210043016A (ko) 2021-04-20
EP2680850A2 (en) 2014-01-08
AU2018267622A1 (en) 2018-12-13
TWI617556B (zh) 2018-03-11
CN103998040A (zh) 2014-08-20
MX344302B (es) 2016-12-13
SG10201601711SA (en) 2016-04-28
CN103998040B (zh) 2017-03-29
KR20220031732A (ko) 2022-03-11
KR102061743B1 (ko) 2020-01-03
US20140128417A1 (en) 2014-05-08
EP2680850B1 (en) 2018-05-23
BR112013022552A2 (pt) 2016-12-06
AU2012225693A1 (en) 2013-09-19
KR20200003933A (ko) 2020-01-10
TW201249835A (en) 2012-12-16

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