MX344302B - Compuestos de quinazolina sustituidos con alquino y metodos uso. - Google Patents
Compuestos de quinazolina sustituidos con alquino y metodos uso.Info
- Publication number
- MX344302B MX344302B MX2013010016A MX2013010016A MX344302B MX 344302 B MX344302 B MX 344302B MX 2013010016 A MX2013010016 A MX 2013010016A MX 2013010016 A MX2013010016 A MX 2013010016A MX 344302 B MX344302 B MX 344302B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- substituted quinazoline
- alkyne substituted
- quinazoline compound
- compounds
- Prior art date
Links
- 150000001345 alkine derivatives Chemical group 0.000 title abstract 2
- -1 quinazoline compound Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 230000002427 irreversible effect Effects 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161449088P | 2011-03-04 | 2011-03-04 | |
| PCT/US2012/027614 WO2012122058A2 (en) | 2011-03-04 | 2012-03-02 | Alkyne substituted quinazoline compound and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013010016A MX2013010016A (es) | 2013-11-20 |
| MX344302B true MX344302B (es) | 2016-12-13 |
Family
ID=46798728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013010016A MX344302B (es) | 2011-03-04 | 2012-03-02 | Compuestos de quinazolina sustituidos con alquino y metodos uso. |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US9090588B2 (enExample) |
| EP (1) | EP2680850B1 (enExample) |
| JP (1) | JP6006242B2 (enExample) |
| KR (4) | KR20210043016A (enExample) |
| CN (1) | CN103998040B (enExample) |
| AU (3) | AU2012225693A1 (enExample) |
| BR (1) | BR112013022552B1 (enExample) |
| CA (1) | CA2828713C (enExample) |
| IL (1) | IL228072A (enExample) |
| MX (1) | MX344302B (enExample) |
| RU (1) | RU2013144571A (enExample) |
| SG (3) | SG10201913982WA (enExample) |
| TW (1) | TWI617556B (enExample) |
| WO (1) | WO2012122058A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201913982WA (en) | 2011-03-04 | 2020-03-30 | Newgen Therapeutics Inc | Alkyne Substituted Quinazoline Compound And Methods Of Use |
| CN102918029B (zh) | 2011-05-17 | 2015-06-17 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
| US9371292B2 (en) * | 2011-07-27 | 2016-06-21 | Shanghai Pharmaceuticals Holdings Co., Ltd. | Quinazoline derivative, preparation method therefor, intermediate, composition and application thereof |
| TWI609012B (zh) | 2013-04-28 | 2017-12-21 | 廣東東陽光藥業有限公司 | 氨基喹唑啉類衍生物及其鹽和使用方法 |
| CN103254183B (zh) * | 2013-05-10 | 2015-11-11 | 苏州明锐医药科技有限公司 | 阿法替尼的制备方法 |
| CN103254156B (zh) * | 2013-05-10 | 2015-08-26 | 苏州明锐医药科技有限公司 | 阿法替尼中间体的制备方法 |
| JP6983661B2 (ja) * | 2015-12-24 | 2021-12-17 | 協和キリン株式会社 | α、β不飽和アミド化合物 |
| DE102016224889B4 (de) * | 2016-12-14 | 2019-11-07 | Airbus Defence and Space GmbH | Verfahren zur Vorbeugung einer Ablösung einer Fluidströmung, Strömungskörpersystem und Luftfahrzeug |
| US11083492B2 (en) * | 2018-06-06 | 2021-08-10 | Lifetech Scientific (Shenzhen) Co., Ltd | Method for implanting an interventional medical device |
| US10973321B2 (en) | 2018-09-04 | 2021-04-13 | Steelcase Inc. | Workspace system and components and method for the use thereof |
| MX2021003517A (es) | 2018-09-25 | 2021-08-16 | Black Diamond Therapeutics Inc | Composiciones de inhibidor de tirosina quinasa, metodos de fabricacion y metodos de uso. |
| AU2020328598A1 (en) * | 2019-08-15 | 2022-03-03 | Black Diamond Therapeutics, Inc. | Alkynyl quinazoline compounds |
| CN113527215B (zh) * | 2020-04-17 | 2023-12-05 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、制备方法及其应用 |
| TWI820414B (zh) * | 2020-04-17 | 2023-11-01 | 大陸商北京賽特明強醫藥科技有限公司 | 喹唑啉類化合物、製備方法及其應用 |
| AU2021368798A1 (en) * | 2020-11-02 | 2023-05-18 | Black Diamond Therapeutics, Inc. | Method of treating cancers with alkyne substituted quinazoline derivatives |
| WO2024179451A1 (zh) * | 2023-03-02 | 2024-09-06 | 江苏康缘药业股份有限公司 | 一种炔基取代的喹唑啉化合物的晶型、其制备方法和应用 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4062881A (en) | 1974-07-26 | 1977-12-13 | Cincinnati Milacron Chemicals, Inc. | Sulfide containing tin stabilizers |
| US4343940A (en) | 1979-02-13 | 1982-08-10 | Mead Johnson & Company | Anti-tumor quinazoline compounds |
| GB2160201B (en) | 1984-06-14 | 1988-05-11 | Wyeth John & Brother Ltd | Quinazoline and cinnoline derivatives |
| DE68917485T2 (de) | 1988-01-23 | 1995-02-09 | Kyowa Hakko Kogyo Kk | Pyridazinon-Derivate und diese enthaltende pharmazeutische Zubereitungen. |
| US5053227A (en) | 1989-03-22 | 1991-10-01 | Cygnus Therapeutic Systems | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith |
| US5721237A (en) | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| JP3089901B2 (ja) | 1993-07-20 | 2000-09-18 | 株式会社豊田自動織機製作所 | クラッチレス圧縮機における動力伝達構造 |
| WO1995024190A2 (en) | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
| GB9405355D0 (en) | 1994-03-18 | 1994-05-04 | Lucas Ind Plc | Vibrating element transducer |
| AU5108196A (en) | 1995-03-20 | 1996-10-08 | Dr. Karl Thomae Gmbh | Imidazoquinazolines, drugs containing these compounds, their use and process for their preparation |
| EP2163546B1 (en) | 1995-03-30 | 2016-06-01 | Pfizer Products Inc. | Quinazoline derivatives |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| AU716993B2 (en) | 1995-05-12 | 2000-03-16 | Neurogen Corporation | Novel deazapurine derivatives; a new class of CRF1 specific ligands |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| CA2222545A1 (en) | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Quinazolines and pharmaceutical compositions |
| DK0831829T3 (da) | 1995-06-07 | 2003-12-15 | Pfizer | Heterocykliske, ringkondenserede pyrimidinderivater |
| TR199800012T1 (xx) | 1995-07-06 | 1998-04-21 | Novartis Ag | Piroloprimidinler ve preparasyon i�in tatbikler. |
| GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| GB9520822D0 (en) | 1995-10-11 | 1995-12-13 | Wellcome Found | Therapeutically active compounds |
| AU2522197A (en) | 1996-04-16 | 1997-11-07 | Ube Industries, Ltd. | Hydrazine compounds, process for the preparation thereof, and insecticides for agricultural and horticultural use |
| EP0912559B1 (en) | 1996-07-13 | 2002-11-06 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| US6225318B1 (en) | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
| CN1126743C (zh) | 1998-07-30 | 2003-11-05 | 惠氏 | 取代的喹唑啉的衍生物 |
| UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
| US6627634B2 (en) | 2000-04-08 | 2003-09-30 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them |
| MXPA02012681A (es) | 2000-06-30 | 2003-04-25 | Glaxo Group Ltd | Compuestos de sales de ditosilato de quinazolina. |
| IL155029A0 (en) | 2000-10-27 | 2003-10-31 | Novartis Ag | Treatment of gastrointestinal stromal tumors |
| DE10063435A1 (de) | 2000-12-20 | 2002-07-04 | Boehringer Ingelheim Pharma | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| CN1264824C (zh) * | 2001-02-21 | 2006-07-19 | 三菱制药株式会社 | 喹唑啉衍生物 |
| TWI324597B (en) | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
| GB0215823D0 (en) * | 2002-07-09 | 2002-08-14 | Astrazeneca Ab | Quinazoline derivatives |
| EP1521747B1 (en) | 2002-07-15 | 2018-09-05 | Symphony Evolution, Inc. | Receptor-type kinase modulators and methods of use |
| DE10349113A1 (de) | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| JP4353903B2 (ja) | 2005-01-07 | 2009-10-28 | 東京エレクトロン株式会社 | クラスタツールの処理システム |
| CN101203494A (zh) | 2005-05-25 | 2008-06-18 | 惠氏公司 | 合成经取代3-氰基喹啉和其中间物的方法 |
| WO2007054550A1 (en) * | 2005-11-11 | 2007-05-18 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
| EP1981863B1 (en) | 2006-01-26 | 2012-10-10 | Boehringer Ingelheim International GmbH | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
| CN100345856C (zh) | 2006-03-10 | 2007-10-31 | 武汉化工学院 | 一种制备葡萄糖醛酸内酯的酯化及结晶工艺方法 |
| US8604044B2 (en) | 2006-09-11 | 2013-12-10 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| JP2010522707A (ja) | 2007-03-29 | 2010-07-08 | エフ．ホフマン−ラ ロシュ アーゲー | 抗ウイルス性複素環化合物 |
| CN101584696A (zh) | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | 包含喹唑啉衍生物的组合物及制备方法、用途 |
| US8735409B2 (en) | 2009-12-21 | 2014-05-27 | Qiang Zhang | Quinazoline derivatives |
| US20120195857A1 (en) | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| CN102382106A (zh) | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
| SG10201913982WA (en) | 2011-03-04 | 2020-03-30 | Newgen Therapeutics Inc | Alkyne Substituted Quinazoline Compound And Methods Of Use |
| CN102918029B (zh) | 2011-05-17 | 2015-06-17 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
-
2012
- 2012-03-02 SG SG10201913982WA patent/SG10201913982WA/en unknown
- 2012-03-02 CN CN201280011384.6A patent/CN103998040B/zh active Active
- 2012-03-02 KR KR1020217010767A patent/KR20210043016A/ko not_active Ceased
- 2012-03-02 KR KR1020197038395A patent/KR20200003933A/ko not_active Ceased
- 2012-03-02 WO PCT/US2012/027614 patent/WO2012122058A2/en not_active Ceased
- 2012-03-02 SG SG10201601711SA patent/SG10201601711SA/en unknown
- 2012-03-02 AU AU2012225693A patent/AU2012225693A1/en not_active Abandoned
- 2012-03-02 KR KR1020227006071A patent/KR20220031732A/ko not_active Ceased
- 2012-03-02 MX MX2013010016A patent/MX344302B/es active IP Right Grant
- 2012-03-02 RU RU2013144571/04A patent/RU2013144571A/ru not_active Application Discontinuation
- 2012-03-02 BR BR112013022552-1A patent/BR112013022552B1/pt active IP Right Grant
- 2012-03-02 KR KR1020137026199A patent/KR102061743B1/ko active Active
- 2012-03-02 CA CA2828713A patent/CA2828713C/en active Active
- 2012-03-02 JP JP2013556664A patent/JP6006242B2/ja active Active
- 2012-03-02 SG SG2013066352A patent/SG193291A1/en unknown
- 2012-03-02 US US14/002,983 patent/US9090588B2/en active Active
- 2012-03-02 EP EP12754325.4A patent/EP2680850B1/en active Active
- 2012-03-03 TW TW101107247A patent/TWI617556B/zh active
-
2013
- 2013-08-22 IL IL228072A patent/IL228072A/en active IP Right Grant
-
2015
- 2015-06-19 US US14/745,308 patent/US20160031860A1/en not_active Abandoned
-
2017
- 2017-02-14 AU AU2017200984A patent/AU2017200984A1/en not_active Abandoned
- 2017-08-11 US US15/675,438 patent/US20180093975A1/en not_active Abandoned
-
2018
- 2018-11-22 AU AU2018267622A patent/AU2018267622B2/en active Active
-
2019
- 2019-01-18 US US16/252,458 patent/US20190382382A1/en not_active Abandoned
-
2020
- 2020-03-27 US US16/833,020 patent/US11524956B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX344302B (es) | Compuestos de quinazolina sustituidos con alquino y metodos uso. | |
| PH12019501321B1 (en) | Use of pyrazolopyrimidine derivatives for the treatment of pi3k-delta related disorders | |
| TN2014000138A1 (en) | Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases. | |
| MX2014005928A (es) | Inhibidores ciclicos de glutaminasa. | |
| MX2014002836A (es) | Derivados de aminopirimidina para usarse como moduladores de la actividad de cinasa. | |
| IN2014MN02082A (enExample) | ||
| MX344335B (es) | Derivados de benzonitrilo como inhibidores de cinasa. | |
| EA201391390A1 (ru) | Циклопропиламины в качестве ингибиторов lsd | |
| BR112015000399A2 (pt) | derivados de pirazolil pirimidina | |
| PH12015500064A1 (en) | Imidazotriazinecarbonitriles useful as kinase inhibitors | |
| PT3418281T (pt) | Pirazolo[1,5-a]pirimidinas úteis como inibidores da quinase atr para o tratamento de doenças de cancro | |
| MX2013011329A (es) | Combinaciones de compuestos inhibidores de akt y erlotinib y metodos de uso. | |
| PH12014500373A1 (en) | Amino quinazolines as kinase inhibitors | |
| MX355088B (es) | Inhibidores de tienopirimidina de proteina cinasa c atipica. | |
| UA111075C2 (uk) | Триазолопіридинові сполуки як інгібітори кінази рім | |
| MX346095B (es) | Nuevas imidazol-aminas como moduladores de la actividad de cinasas. | |
| PH12015500363A1 (en) | Prodrugs of amino quinazoline kinase inhibitor | |
| TN2015000120A1 (en) | Oxazolidin-2-one-pyrimidine derivatives | |
| PH12016500735B1 (en) | Substituted pyrimidine compounds and their use as syk inhibitors | |
| MX2015013414A (es) | N-(2-ciano heterociclil)pirazolo piridonas como inhibidores de janus quinasa. | |
| SG10201900954SA (en) | Heterocycles as Modulators of Kinase Activity | |
| MX2014007364A (es) | Nuevas carboxamidas heterociclicas como modulares de la activadad de cinasas. | |
| MX360001B (es) | Compuestos de acrilamida como ligandos receptores de histamina h3. | |
| MX2016010268A (es) | Pirimidinimidazolaminas como modulares de actividad de cinasa. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |