CA2784530C - Degradable removable implant for the sustained release of an active compound - Google Patents
Degradable removable implant for the sustained release of an active compound Download PDFInfo
- Publication number
- CA2784530C CA2784530C CA2784530A CA2784530A CA2784530C CA 2784530 C CA2784530 C CA 2784530C CA 2784530 A CA2784530 A CA 2784530A CA 2784530 A CA2784530 A CA 2784530A CA 2784530 C CA2784530 C CA 2784530C
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- Prior art keywords
- microparticles
- implant
- tube
- polymer
- poly
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Landscapes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28837309P | 2009-12-21 | 2009-12-21 | |
| US61/288,373 | 2009-12-21 | ||
| PCT/EP2010/070246 WO2011080141A2 (en) | 2009-12-21 | 2010-12-20 | Degradable removable implant for the sustained release of an active compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2784530A1 CA2784530A1 (en) | 2011-07-07 |
| CA2784530C true CA2784530C (en) | 2018-05-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2784530A Active CA2784530C (en) | 2009-12-21 | 2010-12-20 | Degradable removable implant for the sustained release of an active compound |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8784858B2 (OSRAM) |
| EP (1) | EP2515877B1 (OSRAM) |
| JP (1) | JP5950825B2 (OSRAM) |
| KR (1) | KR101798430B1 (OSRAM) |
| CN (1) | CN102740837B (OSRAM) |
| AU (1) | AU2010338425B2 (OSRAM) |
| BR (1) | BR112012015114B1 (OSRAM) |
| CA (1) | CA2784530C (OSRAM) |
| ES (1) | ES2600878T3 (OSRAM) |
| IL (1) | IL219685B (OSRAM) |
| MX (1) | MX2012007210A (OSRAM) |
| MY (1) | MY163383A (OSRAM) |
| NZ (1) | NZ600156A (OSRAM) |
| RU (1) | RU2593790C2 (OSRAM) |
| SG (1) | SG181759A1 (OSRAM) |
| UA (1) | UA112155C2 (OSRAM) |
| WO (1) | WO2011080141A2 (OSRAM) |
| ZA (1) | ZA201204583B (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014205252A2 (en) * | 2013-06-20 | 2014-12-24 | Mercy Medical Research Institute | Extended release drug-delivery contact lenses and methods of making |
| EP3180042B8 (en) | 2014-08-15 | 2025-03-12 | The Johns Hopkins University | Composite material for tissue restoration |
| WO2016149561A1 (en) * | 2015-03-17 | 2016-09-22 | Oak Crest Institute Of Science | Subdermal implants for the sustained delivery of water-soluble drugs |
| US11779435B2 (en) | 2015-08-26 | 2023-10-10 | Flexscrewdriver I.K.E. | Dental screwdriver |
| CN106702597B (zh) * | 2016-12-20 | 2019-06-18 | 华南理工大学 | 一种核-壳结构纳米纤维膜及其制备方法和应用 |
| BR112020000506A2 (pt) | 2017-07-11 | 2020-07-14 | Sustained Nano Systems Llc | formulações farmacêuticas hipercomprimidas |
| KR20210034544A (ko) | 2018-05-09 | 2021-03-30 | 더 존스 홉킨스 유니버시티 | 향상된 연조직 대체 및 재생을 위한 나노섬유-하이드로겔 복합재료 |
| CN112384258A (zh) | 2018-05-09 | 2021-02-19 | 约翰·霍普金斯大学 | 用于细胞和组织递送的纳米纤维-水凝胶复合物 |
| CN112423739A (zh) * | 2018-05-16 | 2021-02-26 | 斯贝洛克斯公司 | 过敏性鼻炎药物输送植入物 |
| EP3866761A4 (en) * | 2018-10-16 | 2022-08-10 | Research Triangle Institute | SUBCUTANEOUS BIODEGRADABLE RESERVOIR DEVICE |
| WO2021207329A1 (en) * | 2020-04-07 | 2021-10-14 | Research Triangle Institute | Multi-drug formulations for subcutaneous biodegradable reservoir device |
| WO2021229111A1 (es) * | 2020-05-12 | 2021-11-18 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento para la purificación de partículas poliméricas termoplásticas biodegradables para uso médico y/o farmacéutico |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5182111A (en) * | 1987-11-17 | 1993-01-26 | Boston University Research Foundation | In vivo delivery of active factors by co-cultured cell implants |
| US5837747A (en) * | 1991-10-29 | 1998-11-17 | Vivorx, Inc. | Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release |
| US5651900A (en) | 1994-03-07 | 1997-07-29 | The Regents Of The University Of California | Microfabricated particle filter |
| US5645684A (en) | 1994-03-07 | 1997-07-08 | The Regents Of The University Of California | Multilayer high vertical aspect ratio thin film structures |
| US5660680A (en) | 1994-03-07 | 1997-08-26 | The Regents Of The University Of California | Method for fabrication of high vertical aspect ratio thin film structures |
| US5798042A (en) | 1994-03-07 | 1998-08-25 | Regents Of The University Of California | Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters |
| WO1995024472A1 (en) | 1994-03-07 | 1995-09-14 | The Regents Of The University Of California | Microfabricated capsules for isolation of cell transplants |
| US7033603B2 (en) | 1999-08-06 | 2006-04-25 | Board Of Regents The University Of Texas | Drug releasing biodegradable fiber for delivery of therapeutics |
| WO2001010421A1 (en) | 1999-08-06 | 2001-02-15 | Board Of Regents, The University Of Texas System | Drug releasing biodegradable fiber implant |
| CA2386850C (en) | 1999-10-06 | 2010-03-30 | Piet Tom Bert Paul Wigerinck | Hexahydrofuro[2,3-b]furan-3-yl-n-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor |
| TW200800298A (en) | 2000-01-27 | 2008-01-01 | Zentaris Ag | Compressed microparticles for dry injection |
| US20040115268A1 (en) * | 2000-04-26 | 2004-06-17 | Control Delivery Systems, Inc. | Systemic delivery of antiviral agents |
| DE10050199A1 (de) * | 2000-10-11 | 2002-04-25 | Ethicon Gmbh | Flächiges Implantat mit im Ultraschall detektierbaren Elementen |
| AU2002305079B8 (en) * | 2001-05-11 | 2006-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Immune modulation device for use in animals |
| MY169670A (en) | 2003-09-03 | 2019-05-08 | Tibotec Pharm Ltd | Combinations of a pyrimidine containing nnrti with rt inhibitors |
| US7497855B2 (en) | 2002-09-04 | 2009-03-03 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
| US20040156878A1 (en) * | 2003-02-11 | 2004-08-12 | Alireza Rezania | Implantable medical device seeded with mammalian cells and methods of treatment |
| TWI457136B (zh) * | 2005-04-04 | 2014-10-21 | Tibotec Pharm Ltd | Ｈｉｖ-感染之預防 |
| JP2008538754A (ja) | 2005-04-11 | 2008-11-06 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ | 薬剤を含んだ所定のレイヤパターンを有する複層構造体 |
| US20060252049A1 (en) | 2005-05-04 | 2006-11-09 | Shuler Richard O | Growth-promoting and immunizing subcutaneous implant |
| US7261529B2 (en) | 2005-09-07 | 2007-08-28 | Southwest Research Institute | Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents |
| ME01617B (me) * | 2006-01-20 | 2014-09-20 | Janssen R&D Ireland | Dugotrajno tretiranje hiv-infekcije s tcm278 |
| US20080081064A1 (en) * | 2006-09-28 | 2008-04-03 | Surmodics, Inc. | Implantable Medical Device with Apertures for Delivery of Bioactive Agents |
| CA2692028C (en) * | 2007-06-12 | 2013-06-04 | Concert Pharmaceuticals, Inc. | Azapeptide derivatives |
| WO2009046299A2 (en) | 2007-10-04 | 2009-04-09 | Boston Scientific Scimed, Inc | Implantable drug depot for intrathecal drug delivery system for pain management |
| WO2010047819A1 (en) * | 2008-10-24 | 2010-04-29 | Concert Pharmaceuticals, Inc. | Hydroxyethylamino sulfonamide derivatives |
| JP5612602B2 (ja) | 2008-12-24 | 2014-10-22 | ヤンセン・アールアンドデイ・アイルランド | Ｈｉｖ処置用の移植可能デバイス |
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2010
- 2010-12-20 AU AU2010338425A patent/AU2010338425B2/en active Active
- 2010-12-20 BR BR112012015114-2A patent/BR112012015114B1/pt not_active IP Right Cessation
- 2010-12-20 WO PCT/EP2010/070246 patent/WO2011080141A2/en not_active Ceased
- 2010-12-20 MX MX2012007210A patent/MX2012007210A/es active IP Right Grant
- 2010-12-20 CN CN201080058303.9A patent/CN102740837B/zh not_active Expired - Fee Related
- 2010-12-20 ES ES10803585.8T patent/ES2600878T3/es active Active
- 2010-12-20 SG SG2012044541A patent/SG181759A1/en unknown
- 2010-12-20 EP EP10803585.8A patent/EP2515877B1/en active Active
- 2010-12-20 KR KR1020127016179A patent/KR101798430B1/ko active Active
- 2010-12-20 JP JP2012543843A patent/JP5950825B2/ja active Active
- 2010-12-20 NZ NZ600156A patent/NZ600156A/en not_active IP Right Cessation
- 2010-12-20 RU RU2012131282/15A patent/RU2593790C2/ru active
- 2010-12-20 CA CA2784530A patent/CA2784530C/en active Active
- 2010-12-20 MY MYPI2012002730A patent/MY163383A/en unknown
- 2010-12-20 UA UAA201206035A patent/UA112155C2/uk unknown
- 2010-12-20 US US13/515,380 patent/US8784858B2/en active Active
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2012
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- 2012-06-20 ZA ZA2012/04583A patent/ZA201204583B/en unknown
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2014
- 2014-06-10 US US14/300,607 patent/US10744235B2/en active Active
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2020
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Also Published As
| Publication number | Publication date |
|---|---|
| US20120277690A1 (en) | 2012-11-01 |
| US20140296799A1 (en) | 2014-10-02 |
| CN102740837B (zh) | 2017-06-06 |
| MX2012007210A (es) | 2012-07-23 |
| NZ600156A (en) | 2015-01-30 |
| UA112155C2 (uk) | 2016-08-10 |
| US8784858B2 (en) | 2014-07-22 |
| US11395867B2 (en) | 2022-07-26 |
| ZA201204583B (en) | 2022-03-30 |
| EP2515877B1 (en) | 2016-08-10 |
| RU2012131282A (ru) | 2014-01-27 |
| KR20120101084A (ko) | 2012-09-12 |
| ES2600878T3 (es) | 2017-02-13 |
| AU2010338425B2 (en) | 2015-07-23 |
| JP5950825B2 (ja) | 2016-07-13 |
| US10744235B2 (en) | 2020-08-18 |
| KR101798430B1 (ko) | 2017-11-16 |
| SG181759A1 (en) | 2012-07-30 |
| CN102740837A (zh) | 2012-10-17 |
| BR112012015114B1 (pt) | 2023-01-10 |
| RU2593790C2 (ru) | 2016-08-10 |
| CA2784530A1 (en) | 2011-07-07 |
| AU2010338425A1 (en) | 2012-06-07 |
| BR112012015114A2 (pt) | 2020-09-01 |
| WO2011080141A3 (en) | 2012-03-08 |
| MY163383A (en) | 2017-09-15 |
| JP2013514971A (ja) | 2013-05-02 |
| IL219685B (en) | 2019-03-31 |
| EP2515877A2 (en) | 2012-10-31 |
| IL219685A0 (en) | 2012-07-31 |
| US20200330654A1 (en) | 2020-10-22 |
| WO2011080141A2 (en) | 2011-07-07 |
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