UA112155C2 - Розкладаний видалюваний імплантат для безперервного вивільнення активної сполуки - Google Patents

Розкладаний видалюваний імплантат для безперервного вивільнення активної сполуки Download PDF

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Publication number
UA112155C2
UA112155C2 UAA201206035A UAA201206035A UA112155C2 UA 112155 C2 UA112155 C2 UA 112155C2 UA A201206035 A UAA201206035 A UA A201206035A UA A201206035 A UAA201206035 A UA A201206035A UA 112155 C2 UA112155 C2 UA 112155C2
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UA
Ukraine
Prior art keywords
microparticles
tube
polymer
complex
implant according
Prior art date
Application number
UAA201206035A
Other languages
English (en)
Ukrainian (uk)
Inventor
Дебора М. Шачтер
Лівен Ельвір Колетт Берт
Гюнтер Краус
Кьюанг Зханг
Іксоо Чін
Original Assignee
ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі filed Critical ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі
Publication of UA112155C2 publication Critical patent/UA112155C2/uk

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148Materials at least partially resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
UAA201206035A 2009-12-21 2010-12-20 Розкладаний видалюваний імплантат для безперервного вивільнення активної сполуки UA112155C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28837309P 2009-12-21 2009-12-21
PCT/EP2010/070246 WO2011080141A2 (en) 2009-12-21 2010-12-20 Degradable removable implant for the sustained release of an active compound

Publications (1)

Publication Number Publication Date
UA112155C2 true UA112155C2 (uk) 2016-08-10

Family

ID=43743502

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201206035A UA112155C2 (uk) 2009-12-21 2010-12-20 Розкладаний видалюваний імплантат для безперервного вивільнення активної сполуки

Country Status (18)

Country Link
US (3) US8784858B2 (OSRAM)
EP (1) EP2515877B1 (OSRAM)
JP (1) JP5950825B2 (OSRAM)
KR (1) KR101798430B1 (OSRAM)
CN (1) CN102740837B (OSRAM)
AU (1) AU2010338425B2 (OSRAM)
BR (1) BR112012015114B1 (OSRAM)
CA (1) CA2784530C (OSRAM)
ES (1) ES2600878T3 (OSRAM)
IL (1) IL219685B (OSRAM)
MX (1) MX2012007210A (OSRAM)
MY (1) MY163383A (OSRAM)
NZ (1) NZ600156A (OSRAM)
RU (1) RU2593790C2 (OSRAM)
SG (1) SG181759A1 (OSRAM)
UA (1) UA112155C2 (OSRAM)
WO (1) WO2011080141A2 (OSRAM)
ZA (1) ZA201204583B (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014205252A2 (en) * 2013-06-20 2014-12-24 Mercy Medical Research Institute Extended release drug-delivery contact lenses and methods of making
CN107073169B (zh) 2014-08-15 2022-03-08 约翰·霍普金斯大学技术创业公司 用于组织修复的复合材料
WO2016149561A1 (en) * 2015-03-17 2016-09-22 Oak Crest Institute Of Science Subdermal implants for the sustained delivery of water-soluble drugs
US11779435B2 (en) 2015-08-26 2023-10-10 Flexscrewdriver I.K.E. Dental screwdriver
CN106702597B (zh) * 2016-12-20 2019-06-18 华南理工大学 一种核-壳结构纳米纤维膜及其制备方法和应用
BR112020000506A2 (pt) * 2017-07-11 2020-07-14 Sustained Nano Systems Llc formulações farmacêuticas hipercomprimidas
AU2019265839B2 (en) 2018-05-09 2025-04-24 The Johns Hopkins University Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
AU2019267711B2 (en) 2018-05-09 2025-04-17 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
CN112423739A (zh) * 2018-05-16 2021-02-26 斯贝洛克斯公司 过敏性鼻炎药物输送植入物
KR20210060631A (ko) * 2018-10-16 2021-05-26 리써치 트라이앵글 인스티튜트 피하 생분해성 저장소 디바이스
CN115697304A (zh) * 2020-04-07 2023-02-03 三角研究所 用于能够生物降解的皮下储存器装置的多药配制物
WO2021229111A1 (es) * 2020-05-12 2021-11-18 Laboratorios Farmacéuticos Rovi, S.A. Procedimiento para la purificación de partículas poliméricas termoplásticas biodegradables para uso médico y/o farmacéutico

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5837747A (en) * 1991-10-29 1998-11-17 Vivorx, Inc. Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
EP0749474A4 (en) 1994-03-07 1997-09-17 Univ California MICRO-MADE CAPSULES FOR INSULATING CELL TRANSPLANTS
US5651900A (en) 1994-03-07 1997-07-29 The Regents Of The University Of California Microfabricated particle filter
US5645684A (en) 1994-03-07 1997-07-08 The Regents Of The University Of California Multilayer high vertical aspect ratio thin film structures
US5660680A (en) 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
US5798042A (en) 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US7033603B2 (en) 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
WO2001010421A1 (en) 1999-08-06 2001-02-15 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
DE60039244D1 (de) 1999-10-06 2008-07-31 Tibotec Pharm Ltd HEXAHYDROFUROi2,3-B FURAN-3-YL-N- 3-i(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO -1-BENZYL-2-HYDROXYPROPYL CARBAMAT ALS RETROVIRUSPROTEASEHEMMER
TW200800298A (en) 2000-01-27 2008-01-01 Zentaris Ag Compressed microparticles for dry injection
US20040115268A1 (en) * 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
DE10050199A1 (de) * 2000-10-11 2002-04-25 Ethicon Gmbh Flächiges Implantat mit im Ultraschall detektierbaren Elementen
WO2002092054A2 (en) * 2001-05-11 2002-11-21 Ortho-Mcneil Pharmaceutical, Inc. Immune modulation device for use in animals
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
AU2003278766A1 (en) 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
US20040156878A1 (en) 2003-02-11 2004-08-12 Alireza Rezania Implantable medical device seeded with mammalian cells and methods of treatment
TWI457136B (zh) 2005-04-04 2014-10-21 Tibotec Pharm Ltd Hiv-感染之預防
EP1872390A2 (en) 2005-04-11 2008-01-02 The Board of Trustees of the Leland Stanford Junior University Multi-layer structure having a predetermined layer pattern including an agent
US20060252049A1 (en) 2005-05-04 2006-11-09 Shuler Richard O Growth-promoting and immunizing subcutaneous implant
US7261529B2 (en) 2005-09-07 2007-08-28 Southwest Research Institute Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
DK1981506T6 (da) * 2006-01-20 2021-06-14 Janssen Sciences Ireland Unlimited Co Langtidsbehandling af hiv-infektion med tcm278
US20080081064A1 (en) 2006-09-28 2008-04-03 Surmodics, Inc. Implantable Medical Device with Apertures for Delivery of Bioactive Agents
RU2448958C2 (ru) * 2007-06-12 2012-04-27 Консерт Фармасьютикалз, Инк. Производные азапептидов
US20090123508A1 (en) * 2007-10-04 2009-05-14 Boston Scientific Scimed, Inc. Implantable Drug Depot for Intrathecal Drug Delivery System for Pain Management
WO2010047819A1 (en) * 2008-10-24 2010-04-29 Concert Pharmaceuticals, Inc. Hydroxyethylamino sulfonamide derivatives
NZ593950A (en) 2008-12-24 2013-08-30 Janssen R & D Ireland Implantable devices for treating hiv

Also Published As

Publication number Publication date
NZ600156A (en) 2015-01-30
BR112012015114A2 (pt) 2020-09-01
US20140296799A1 (en) 2014-10-02
IL219685A0 (en) 2012-07-31
US20120277690A1 (en) 2012-11-01
KR101798430B1 (ko) 2017-11-16
JP5950825B2 (ja) 2016-07-13
JP2013514971A (ja) 2013-05-02
SG181759A1 (en) 2012-07-30
AU2010338425A1 (en) 2012-06-07
BR112012015114B1 (pt) 2023-01-10
KR20120101084A (ko) 2012-09-12
WO2011080141A3 (en) 2012-03-08
US8784858B2 (en) 2014-07-22
US20200330654A1 (en) 2020-10-22
ES2600878T3 (es) 2017-02-13
US10744235B2 (en) 2020-08-18
CN102740837B (zh) 2017-06-06
CA2784530A1 (en) 2011-07-07
ZA201204583B (en) 2022-03-30
EP2515877B1 (en) 2016-08-10
WO2011080141A2 (en) 2011-07-07
EP2515877A2 (en) 2012-10-31
AU2010338425B2 (en) 2015-07-23
CN102740837A (zh) 2012-10-17
US11395867B2 (en) 2022-07-26
CA2784530C (en) 2018-05-22
MY163383A (en) 2017-09-15
MX2012007210A (es) 2012-07-23
RU2012131282A (ru) 2014-01-27
RU2593790C2 (ru) 2016-08-10
IL219685B (en) 2019-03-31

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