CA2778837C - Thin film processing apparatuses for adjustable volume accommodation - Google Patents
Thin film processing apparatuses for adjustable volume accommodation Download PDFInfo
- Publication number
- CA2778837C CA2778837C CA2778837A CA2778837A CA2778837C CA 2778837 C CA2778837 C CA 2778837C CA 2778837 A CA2778837 A CA 2778837A CA 2778837 A CA2778837 A CA 2778837A CA 2778837 C CA2778837 C CA 2778837C
- Authority
- CA
- Canada
- Prior art keywords
- slide
- liquid
- curved portion
- cover
- platen assembly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000012545 processing Methods 0.000 title claims abstract description 218
- 239000010409 thin film Substances 0.000 title description 11
- 230000004308 accommodation Effects 0.000 title description 3
- 239000000126 substance Substances 0.000 claims abstract description 41
- 230000000717 retained effect Effects 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims description 242
- 239000002699 waste material Substances 0.000 claims description 104
- 238000000034 method Methods 0.000 claims description 71
- 230000007246 mechanism Effects 0.000 claims description 45
- 239000000463 material Substances 0.000 claims description 30
- 238000005096 rolling process Methods 0.000 claims description 24
- 230000000712 assembly Effects 0.000 claims description 18
- 238000000429 assembly Methods 0.000 claims description 18
- 238000010438 heat treatment Methods 0.000 claims description 16
- 230000009471 action Effects 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 239000012530 fluid Substances 0.000 abstract description 182
- 239000000758 substrate Substances 0.000 abstract description 150
- 239000012472 biological sample Substances 0.000 abstract description 10
- 239000000523 sample Substances 0.000 description 80
- 239000003153 chemical reaction reagent Substances 0.000 description 76
- 238000010186 staining Methods 0.000 description 34
- 230000008569 process Effects 0.000 description 31
- 238000001816 cooling Methods 0.000 description 19
- 210000001519 tissue Anatomy 0.000 description 19
- 239000003112 inhibitor Substances 0.000 description 15
- 239000010410 layer Substances 0.000 description 14
- 238000011049 filling Methods 0.000 description 13
- 230000002209 hydrophobic effect Effects 0.000 description 11
- 230000003068 static effect Effects 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- -1 stains Substances 0.000 description 10
- 238000000576 coating method Methods 0.000 description 9
- 238000011534 incubation Methods 0.000 description 9
- 238000011068 loading method Methods 0.000 description 9
- 239000012528 membrane Substances 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 8
- 239000010408 film Substances 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 8
- 239000004033 plastic Substances 0.000 description 8
- 229920003023 plastic Polymers 0.000 description 8
- GVVXWEKLOLROBR-UHFFFAOYSA-N 4-bromo-6-tert-butyl-3-hydroxy-6-methylpyran-2,5-dione Chemical compound CC(C)(C)C1(C)OC(=O)C(O)=C(Br)C1=O GVVXWEKLOLROBR-UHFFFAOYSA-N 0.000 description 7
- 239000012790 adhesive layer Substances 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 7
- 238000007901 in situ hybridization Methods 0.000 description 7
- 230000005499 meniscus Effects 0.000 description 7
- 230000002745 absorbent Effects 0.000 description 6
- 239000002250 absorbent Substances 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 230000003750 conditioning effect Effects 0.000 description 6
- 238000011109 contamination Methods 0.000 description 6
- 239000012636 effector Substances 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 238000003364 immunohistochemistry Methods 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000012188 paraffin wax Substances 0.000 description 6
- 239000000872 buffer Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 238000003892 spreading Methods 0.000 description 5
- 230000007480 spreading Effects 0.000 description 5
- 238000012546 transfer Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- 238000007726 management method Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000002033 PVDF binder Substances 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 description 3
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 229920001774 Perfluoroether Polymers 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000002055 immunohistochemical effect Effects 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 238000002493 microarray Methods 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 239000012454 non-polar solvent Substances 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 239000002798 polar solvent Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000005382 thermal cycling Methods 0.000 description 2
- 239000012780 transparent material Substances 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- 108020003215 DNA Probes Proteins 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 241001510071 Pyrrhocoridae Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000002920 hazardous waste Substances 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229920000092 linear low density polyethylene Polymers 0.000 description 1
- 239000004707 linear low-density polyethylene Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000012120 mounting media Substances 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000012858 resilient material Substances 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000004018 waxing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26126709P | 2009-11-13 | 2009-11-13 | |
| US61/261,267 | 2009-11-13 | ||
| PCT/US2010/056752 WO2011060387A1 (en) | 2009-11-13 | 2010-11-15 | Thin film processing apparatuses for adjustable volume accommodation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2778837A1 CA2778837A1 (en) | 2011-05-19 |
| CA2778837C true CA2778837C (en) | 2016-01-19 |
Family
ID=43992102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2778837A Expired - Fee Related CA2778837C (en) | 2009-11-13 | 2010-11-15 | Thin film processing apparatuses for adjustable volume accommodation |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8911815B2 (en, 2012) |
| EP (1) | EP2499500B1 (en, 2012) |
| JP (2) | JP5611363B2 (en, 2012) |
| KR (1) | KR101358549B1 (en, 2012) |
| CN (1) | CN102687023B (en, 2012) |
| AU (1) | AU2010320039B2 (en, 2012) |
| BR (1) | BR112012011181A2 (en, 2012) |
| CA (1) | CA2778837C (en, 2012) |
| IL (1) | IL219086A (en, 2012) |
| IN (1) | IN2012DN03245A (en, 2012) |
| WO (1) | WO2011060387A1 (en, 2012) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11249095B2 (en) | 2002-04-15 | 2022-02-15 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| US7468161B2 (en) | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| DE102009032703A1 (de) * | 2009-07-09 | 2011-01-13 | Mtu Aero Engines Gmbh | Vorrichtung und Verfahren zum Anordnen eines Bauteils an einem Bauteilträger |
| US20140152801A1 (en) | 2009-10-28 | 2014-06-05 | Alentic Microscience Inc. | Detecting and Using Light Representative of a Sample |
| US9075225B2 (en) | 2009-10-28 | 2015-07-07 | Alentic Microscience Inc. | Microscopy imaging |
| CA2778725C (en) | 2009-10-28 | 2019-04-30 | Alentic Microscience Inc. | Microscopy imaging |
| US10509216B2 (en) * | 2012-12-26 | 2019-12-17 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for aligning slides |
| IN2012DN03245A (en, 2012) | 2009-11-13 | 2015-10-23 | Ventana Med Syst Inc | |
| US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| US9498791B2 (en) | 2009-11-13 | 2016-11-22 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| DK2625502T3 (en) * | 2010-10-06 | 2018-12-17 | Biocare Medical Llc | Method and system for efficient processing of biological samples |
| CN107478484B (zh) | 2010-11-10 | 2021-03-30 | 罗氏血液诊断股份有限公司 | 制备用于检查的生物标本的自动化系统及方法 |
| US9945763B1 (en) | 2011-02-18 | 2018-04-17 | Biocare Medical, Llc | Methods and systems for immunohistochemistry heat retrieval of biological samples |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| US8932543B2 (en) * | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
| CA2855511C (en) * | 2011-11-16 | 2021-03-09 | Leica Biosystems Melbourne Pty Ltd | Cover member, method and treatment module for treating a biological sample on a substrate |
| EP2780688B1 (en) | 2011-11-16 | 2022-09-14 | Leica Biosystems Melbourne Pty Ltd | Biological sample treatment apparatus |
| JP6272296B2 (ja) * | 2012-04-06 | 2018-01-31 | ヴェンタナ メディカル システムズ， インク． | 懸濁された細胞成分を均質に分布させるための方法と装置 |
| ITRM20120436A1 (it) * | 2012-09-13 | 2014-03-14 | System Optimal Solution S R L | Elemento per la realizzazione di repliche di indagini superficiali di materiali e metodo atto a realizzare tali indagini |
| ES2969390T3 (es) | 2012-10-08 | 2024-05-17 | Ventana Med Syst Inc | Procedimientos y kits para clarificar muestras pigmentadas |
| WO2014060483A1 (en) | 2012-10-17 | 2014-04-24 | Spatial Transcriptomics Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| US9989448B2 (en) | 2012-12-26 | 2018-06-05 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
| US11274998B2 (en) | 2012-12-26 | 2022-03-15 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
| BR112015015413A2 (pt) * | 2012-12-26 | 2017-07-11 | Ventana Med Syst Inc | aparelho de aquecimento de lâmina, método para aquecer um espécime biológico conduzido em uma lâmina e sistema para aquecer uma lâmina portadora de espécime |
| KR101727844B1 (ko) * | 2012-12-26 | 2017-04-17 | 벤타나 메디컬 시스템즈, 인코포레이티드 | 자동 검체 프로세싱 시스템들 및 검체 지탱 현미경 슬라이드들을 정렬 및 운반하는 방법들 |
| BR112015015366A2 (pt) * | 2012-12-26 | 2017-07-11 | Ventana Med Syst Inc | aparelho automatizado para processamento de lâmina e método para distribuir líquido em uma lâmina de microscópio |
| BR112015015383A2 (pt) * | 2012-12-26 | 2017-07-11 | Ventana Med Syst Inc | aparelho de processamento de lâmina, sistema para processar um espécime conduzido por uma lâmina, métodos para processar um espécime biológico conduzido por uma lâmina e para processar um espécime em uma lâmina |
| HK1213986A1 (zh) * | 2012-12-26 | 2016-07-15 | Ventana Medical Systems, Inc. | 可相對物和具有可相對物的自動樣品處理系統 |
| US10502666B2 (en) | 2013-02-06 | 2019-12-10 | Alentic Microscience Inc. | Sample processing improvements for quantitative microscopy |
| USD728120S1 (en) | 2013-03-15 | 2015-04-28 | Ventana Medical Systems, Inc. | Arcuate member for moving liquids along a microscope slide |
| HK1211695A1 (en) | 2013-04-05 | 2016-05-27 | 罗氏血液诊断股份有限公司 | Automated systems and methods for preparing biological specimens for examination |
| US9790465B2 (en) | 2013-04-30 | 2017-10-17 | Corning Incorporated | Spheroid cell culture well article and methods thereof |
| WO2014210223A1 (en) | 2013-06-25 | 2014-12-31 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
| EP3014330B1 (en) | 2013-06-26 | 2024-01-03 | Alentic Microscience Inc. | Sample processing improvements for microscopy |
| WO2015086531A1 (en) | 2013-12-13 | 2015-06-18 | Ventana Medical Systems, Inc. | Automated processing systems and methods of thermally processing microscope slides |
| WO2015086484A1 (en) | 2013-12-13 | 2015-06-18 | Ventana Medical Systems, Inc. | Automated histological processing of biological specimens and associated technology |
| JP6232138B2 (ja) | 2013-12-13 | 2017-11-15 | ベンタナ メディカル システムズ， インコーポレイテッド | 生物学的試料の組織学的処理のための染色試薬および他の液体ならびに関連技術 |
| CN106461688B (zh) * | 2014-03-31 | 2018-06-12 | 文塔纳医疗系统公司 | 自动化标本处理系统和显微镜载玻片的多步处理 |
| EP3161448A1 (en) * | 2014-06-27 | 2017-05-03 | Ventana Medical Systems, Inc. | Automated specimen processing systems and methods of detecting specimen-bearing microscope slides |
| CN104280280B (zh) * | 2014-10-13 | 2016-12-07 | 赵烨梁 | 一种微漏进样法制备单分子样品的装置 |
| WO2016069930A1 (en) | 2014-10-29 | 2016-05-06 | Corning Incorporated | Microwell design and fabrication for generation of cell culture aggregates |
| EP3212759A1 (en) | 2014-10-29 | 2017-09-06 | Corning Incorporated | Cell culture insert |
| US10209166B2 (en) | 2014-11-18 | 2019-02-19 | Alfonso Heras | System and method for processing biological specimens |
| JP2018512560A (ja) | 2015-02-27 | 2018-05-17 | ベンタナ メディカル システムズ， インコーポレイテッド | アッセイ反応コントローラマガジン |
| WO2016162309A1 (en) | 2015-04-10 | 2016-10-13 | Spatial Transcriptomics Ab | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| JPWO2016190111A1 (ja) * | 2015-05-26 | 2018-03-15 | オリンパス株式会社 | 検体染色装置および検体染色方法 |
| EP3317636B1 (en) | 2015-07-02 | 2023-01-18 | Ventana Medical Systems, Inc. | Opposables incorporating fluid control elements and automated specimen processing systems |
| CN105092865B (zh) * | 2015-07-23 | 2017-07-18 | 爱威科技股份有限公司 | 试纸条淋样槽、淋样系统、干化分析仪及其淋样与清洗方法 |
| CA2995204A1 (en) | 2015-08-10 | 2017-02-16 | Essenlix Corp. | Bio/chemical assay devices and methods for simplified steps, small samples, accelerated speed, and ease-of-use |
| JP6594528B2 (ja) | 2015-09-14 | 2019-10-23 | エッセンリックス コーポレーション | 蒸気凝縮液、特に呼気凝縮液を採取し分析する装置及びシステム、並びにそれらの使用方法 |
| HK1254633A1 (zh) | 2015-09-14 | 2019-07-26 | Essenlix Corporation | 用於分析样品，尤其是血液，的装置和系统以及使用它的方法 |
| ITUB20155913A1 (it) * | 2015-11-26 | 2017-05-26 | Delcon S R L | Apparecchiatura e metodo per la colorazione di vetrini |
| WO2017114750A1 (en) | 2015-12-28 | 2017-07-06 | Ventana Medical Systems, Inc. | Opposables incorporating onboard reagents and automated specimen processing systems |
| CN109073517A (zh) | 2016-04-27 | 2018-12-21 | 文塔纳医疗系统公司 | 用于实时体积控制的系统和方法 |
| DE102016225885B4 (de) * | 2016-12-21 | 2023-12-21 | Prime23 GmbH | Vorrichtung und Verfahren zum Benetzen von biologischem Material |
| CN110312473B (zh) | 2016-12-21 | 2023-04-07 | 艾森利克斯公司 | 用于认证样本的装置和方法及其使用 |
| CN111246945A (zh) * | 2017-02-07 | 2020-06-05 | Essenlix公司 | 压缩开放流测定和使用 |
| CN118347819A (zh) * | 2017-02-08 | 2024-07-16 | 爱威科技股份有限公司 | 一种样本染色装置 |
| CN119000153A (zh) | 2017-02-08 | 2024-11-22 | 上海宜晟生物科技有限公司 | 样品分析装置及其使用 |
| US11927560B2 (en) | 2017-02-08 | 2024-03-12 | Essenlix Corporation | Bio/chemical material extraction and assay |
| CN110741240A (zh) | 2017-02-08 | 2020-01-31 | Essenlix公司 | 通过控制温度的分子操作和检测 |
| CA3052809A1 (en) | 2017-02-08 | 2018-08-23 | Essenlix Corporation | Qmax assays and applications |
| CN110998325B (zh) | 2017-02-09 | 2024-08-16 | 上海宜晟生物科技有限公司 | 扩增测定 |
| CA3053114A1 (en) | 2017-02-09 | 2018-08-16 | Essenlix Corporation | Assay using different spacing heights |
| EP3662259A4 (en) | 2017-02-09 | 2021-08-25 | Essenlix Corporation | COLORIMETRIC TESTS |
| US12017218B2 (en) * | 2017-02-15 | 2024-06-25 | International Business Machines Corporation | Hybrid microfluidics devices |
| JP2020508043A (ja) | 2017-02-15 | 2020-03-19 | エッセンリックス コーポレーション | 急速な温度変化を伴うアッセイ |
| CN120195095A (zh) | 2017-02-16 | 2025-06-24 | 上海宜晟生物科技有限公司 | 采用纹理化表面的测定方法及装置 |
| WO2018182757A1 (en) | 2017-03-31 | 2018-10-04 | X-Zell Inc. | Automatic slide staining and cooling systems |
| US12064771B2 (en) | 2017-05-23 | 2024-08-20 | Essenlix Corporation | Rapid sample temperature changing for assaying |
| WO2018215844A2 (en) * | 2017-05-26 | 2018-11-29 | Ventana Medical Systems, Inc. | Non-contact, on-slide fluid mixing |
| US12181472B2 (en) | 2017-06-12 | 2024-12-31 | Essenlix Corporation | Homogeneous assay |
| US11857970B2 (en) | 2017-07-14 | 2024-01-02 | Corning Incorporated | Cell culture vessel |
| JP7245222B2 (ja) | 2017-07-14 | 2023-03-23 | コーニング インコーポレイテッド | 手動又は自動で培地を交換するための３ｄ細胞培養容器 |
| CN112689758B (zh) | 2017-08-01 | 2025-03-28 | 上海宜晟生物科技有限公司 | 检查药物对微生物影响的装置和方法 |
| US11280706B2 (en) | 2017-08-01 | 2022-03-22 | Essenlix Corporation | Dilution calibration |
| CN111492222A (zh) | 2017-08-01 | 2020-08-04 | Essenlix公司 | 样品收集、保持和测定 |
| CN111094966B (zh) * | 2017-09-21 | 2023-07-11 | 浜松光子学株式会社 | 试样支撑体 |
| US11393561B2 (en) | 2017-10-13 | 2022-07-19 | Essenlix Corporation | Devices and methods for authenticating a medical test and use of the same |
| WO2019082293A1 (ja) * | 2017-10-25 | 2019-05-02 | 株式会社日立ハイテクノロジーズ | 生物組織試料の作成方法、及び生物組織片試料の観察方法 |
| US10807095B2 (en) | 2017-10-26 | 2020-10-20 | Essenlix Corporation | Making and tracking assay card |
| US11237113B2 (en) | 2017-10-26 | 2022-02-01 | Essenlix Corporation | Rapid pH measurement |
| US11609224B2 (en) | 2017-10-26 | 2023-03-21 | Essenlix Corporation | Devices and methods for white blood cell analyses |
| US11648551B2 (en) | 2017-12-12 | 2023-05-16 | Essenlix Corporation | Sample manipulation and assay with rapid temperature change |
| WO2019118936A2 (en) | 2017-12-14 | 2019-06-20 | Essenlix Corporation | Devices, systems, and methods for monitoring hair |
| JP7449862B2 (ja) | 2017-12-24 | 2024-03-14 | ヴェンタナ メディカル システムズ， インク． | エオシン染色技術 |
| CA3086716A1 (en) | 2017-12-24 | 2019-06-27 | Ventana Medical Systems, Inc. | Phenol-free acid-fast staining composition and use thereof |
| JP2021510894A (ja) | 2018-01-11 | 2021-04-30 | ベンタナ メディカル システムズ， インコーポレイテッド | 曇り止めバーコード・リーダ |
| US11156606B2 (en) | 2018-01-11 | 2021-10-26 | Essenlix Corporation | Homogeneous assay (II) |
| EP3649226B1 (en) | 2018-07-13 | 2022-04-06 | Corning Incorporated | Microcavity dishes with sidewall including liquid medium delivery surface |
| JP7171696B2 (ja) | 2018-07-13 | 2022-11-15 | コーニング インコーポレイテッド | 相互接続されたウェルを有するマイクロプレートを備えた流体デバイス |
| CN111051493B (zh) | 2018-07-13 | 2023-11-03 | 康宁股份有限公司 | 具有稳定器装置的细胞培养容器 |
| WO2020016127A2 (en) | 2018-07-16 | 2020-01-23 | Ventana Medical Systems, Inc. | Automated slide processing systems, consumable slide processing modules, and reagent cartridges |
| WO2020016113A1 (en) | 2018-07-16 | 2020-01-23 | Ventana Medical Systems, Inc. | Microscope slide processing systems, consumable stainer modules, and methods of using the same |
| US11885952B2 (en) | 2018-07-30 | 2024-01-30 | Essenlix Corporation | Optics, device, and system for assaying and imaging |
| WO2020123319A2 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Methods of using master / copy arrays for spatial detection |
| EP3841370B1 (en) * | 2018-12-20 | 2024-05-08 | Leica Biosystems Melbourne Pty Ltd | A slide output module |
| MX392907B (es) * | 2019-02-21 | 2025-03-20 | Jesùs Raùl Beltran Ramìrez | Aparato para el procesamiento inmunohistoquímico de múltiples muestras histológicas |
| US11712177B2 (en) | 2019-08-12 | 2023-08-01 | Essenlix Corporation | Assay with textured surface |
| WO2021075000A1 (ja) * | 2019-10-16 | 2021-04-22 | 株式会社日立ハイテク | 貼付方法、観察方法、貼付条件推定システム、切片作製装置、顕微鏡用スライドの製造方法、顕微鏡用スライド及びサーバ |
| US12157124B2 (en) | 2019-11-06 | 2024-12-03 | 10X Genomics, Inc. | Imaging system hardware |
| US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
| US11846643B2 (en) * | 2020-03-27 | 2023-12-19 | Alpha Technologies Services Llc | Test sample handling system with rotary carousel |
| DE102020204670A1 (de) * | 2020-04-14 | 2021-10-14 | Prime23 GmbH | Vorrichtung und Verfahren zum Benetzen von biologischen Material mit wenigstens einer Flüssigkeit sowie eine Halteeinrichtung |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| ES2981265T3 (es) | 2020-06-08 | 2024-10-08 | 10X Genomics Inc | Métodos para determinar un margen quirúrgico y métodos de uso del mismo |
| EP4164796A4 (en) | 2020-06-10 | 2024-03-06 | 10x Genomics, Inc. | LIQUID DISPENSING METHOD |
| WO2022061150A2 (en) | 2020-09-18 | 2022-03-24 | 10X Geonomics, Inc. | Sample handling apparatus and image registration methods |
| EP4121555A1 (en) | 2020-12-21 | 2023-01-25 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| EP4348330A4 (en) * | 2021-05-27 | 2025-05-07 | Scopio Labs Ltd. | COVER SLIDE MOUNTING SYSTEMS AND METHODS |
| WO2022256503A1 (en) | 2021-06-03 | 2022-12-08 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| WO2023091750A1 (en) * | 2021-11-19 | 2023-05-25 | Cornell University | Surface-patterned, omniphobic tiles (spots), fabrication, loading, and use thereof |
| EP4305195A2 (en) | 2021-12-01 | 2024-01-17 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| WO2023122033A1 (en) | 2021-12-20 | 2023-06-29 | 10X Genomics, Inc. | Self-test for pathology/histology slide imaging device |
| WO2024107736A2 (en) * | 2022-11-15 | 2024-05-23 | Waters Technologies Corporation | Pressed and mixed thin film enzymatic reactor and methods of making the same |
| WO2024237277A1 (ja) * | 2023-05-18 | 2024-11-21 | 株式会社Ｓｃｒｅｅｎホールディングス | 標本封入方法および標本封入装置 |
| WO2025024557A1 (en) * | 2023-07-25 | 2025-01-30 | Ruby Robotics Inc | Staining methods for automated systems |
Family Cites Families (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3551023A (en) | 1969-01-17 | 1970-12-29 | Ibm | Pathology specimen processing method and article |
| US3556633A (en) | 1969-01-17 | 1971-01-19 | Winifred Liu Mutschmann | Specimen carrying slide with runoff trough |
| US3672745A (en) | 1970-06-29 | 1972-06-27 | Propper Mfg Co Inc | Bevelled edge microscope slide |
| GB1457137A (en) | 1973-08-16 | 1976-12-01 | Wyeth John & Brother Ltd | Apparatus for handling coverslips |
| FR2263502B1 (en, 2012) * | 1974-03-06 | 1976-12-10 | Ass Ctre Transfusion San | |
| US3961346A (en) | 1975-01-30 | 1976-06-01 | Miles Laboratories, Inc. | Liquid inspection slide |
| US4023949A (en) | 1975-08-04 | 1977-05-17 | Schlom Leslie A | Evaporative refrigeration system |
| SE403940B (sv) | 1976-02-26 | 1978-09-11 | Cytologiska Centrallab | Sett och anordning for maskinell applicering av teckplattor pa med preparat for mikroskopisk undersokning forsedda objektglas |
| US4146414A (en) | 1977-05-09 | 1979-03-27 | Cytologiska Centrallaboratoriet Ab | Method for applying cover-slips to slides carrying specimens for microscopic examination |
| US4203797A (en) | 1977-05-09 | 1980-05-20 | Cytologiska Centrallaboratoriet Ab | Method of and apparatus for applying cover-slips to slides carrying specimens for microscopic examination |
| US4418527A (en) | 1980-04-21 | 1983-12-06 | Schlom Leslie A | Precooler for gas turbines |
| US4359013A (en) | 1980-09-08 | 1982-11-16 | Prevo Donald L | Device for spreading monolayered films |
| US4392450A (en) | 1981-02-12 | 1983-07-12 | Prevo Donald L | Device for spreading monolayered films |
| US4336765A (en) | 1981-06-12 | 1982-06-29 | Coughlin Vincent D | Vacuum work piece holder |
| JPS58140457U (ja) * | 1982-03-18 | 1983-09-21 | 明星電気株式会社 | 顕微鏡標本作成装置の試料固定機構 |
| JPS5840519A (ja) * | 1981-09-03 | 1983-03-09 | Meisei Electric Co Ltd | 顕微鏡用標本の封入方法 |
| US4428793A (en) | 1981-08-25 | 1984-01-31 | Meisei Electric Co., Ltd. | Preparation method for a microscopic specimen and a device therefor |
| US4597982A (en) | 1982-03-18 | 1986-07-01 | Delameter William D | Method for processing flexible sheets |
| US5023187A (en) | 1985-09-13 | 1991-06-11 | Fisher Scientific Company | Method and device for accelerated treatment of thin sample on surface |
| US4731335A (en) | 1985-09-13 | 1988-03-15 | Fisher Scientific Company | Method for treating thin samples on a surface employing capillary flow |
| US4790640A (en) | 1985-10-11 | 1988-12-13 | Nason Frederic L | Laboratory slide |
| US5002736A (en) | 1987-03-31 | 1991-03-26 | Fisher Scientific Co. | Microscope slide and slide assembly |
| US4849340A (en) | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| GB8722902D0 (en) | 1987-09-30 | 1987-11-04 | Shandon Southern Prod | Tissue &c processing |
| US5503803A (en) | 1988-03-28 | 1996-04-02 | Conception Technologies, Inc. | Miniaturized biological assembly |
| US4911782A (en) | 1988-03-28 | 1990-03-27 | Cyto-Fluidics, Inc. | Method for forming a miniaturized biological assembly |
| US5188963A (en) | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
| US5281516A (en) | 1988-08-02 | 1994-01-25 | Gene Tec Corporation | Temperature control apparatus and method |
| US5346672A (en) | 1989-11-17 | 1994-09-13 | Gene Tec Corporation | Devices for containing biological specimens for thermal processing |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| WO1991015826A1 (en) | 1990-03-30 | 1991-10-17 | Neuromedical Systems, Inc. | Automated cytological specimen classification system and method |
| US5075079A (en) | 1990-05-21 | 1991-12-24 | Technicon Instruments Corporation | Slide analysis system |
| US5273905A (en) | 1991-02-22 | 1993-12-28 | Amoco Corporation | Processing of slide mounted material |
| US5189751A (en) | 1991-03-21 | 1993-03-02 | Gemtech, Inc. | Vibrating toothbrush using a magnetic driver |
| JP3320444B2 (ja) | 1992-04-06 | 2002-09-03 | 株式会社千代田製作所 | 染色装置用ノズル洗浄装置 |
| US5256241A (en) | 1992-08-28 | 1993-10-26 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Method for controlling protein crystallization |
| NO179729C (no) | 1992-12-11 | 1996-12-04 | Oeystein H Ljungmann | Apparat for automatisk påklebing av dekkglass på objektglass |
| US5364790A (en) | 1993-02-16 | 1994-11-15 | The Perkin-Elmer Corporation | In situ PCR amplification system |
| JP3292765B2 (ja) * | 1993-07-30 | 2002-06-17 | 株式会社千代田製作所 | 顕微鏡標本の染色方法とその装置 |
| AUPM352194A0 (en) | 1994-01-25 | 1994-02-17 | Australian Biomedical Corporation Limited | Instrument for automatically applying coverslips and method |
| AUPN038995A0 (en) | 1995-01-05 | 1995-01-27 | Australian Biomedical Corporation Limited | Method and apparatus for human or animal cell sample treatment |
| GB9506312D0 (en) | 1995-03-28 | 1995-05-17 | Medical Res Council | Improvements in or relating to sample processing |
| AUPN357495A0 (en) | 1995-06-15 | 1995-07-06 | Australian Biomedical Corporation Limited | Coverslip pick-up and laydown apparatus |
| JPH0943118A (ja) * | 1995-07-31 | 1997-02-14 | Aloka Co Ltd | 生物組織の処理装置 |
| GB9518129D0 (en) | 1995-09-06 | 1995-11-08 | Zynocyte Ltd | Stain and capillary slide |
| US5650332A (en) * | 1995-11-14 | 1997-07-22 | Coulter International Corp. | Method for the preparation of microscope slides |
| JP3947226B2 (ja) * | 1996-01-16 | 2007-07-18 | デュレル・コーポレーション | ロールコーティングされたｅｌパネル |
| AUPN762196A0 (en) | 1996-01-17 | 1996-02-08 | Australian Biomedical Corporation Limited | Specimen preparation apparatus |
| AUPN923596A0 (en) * | 1996-04-12 | 1996-05-09 | Australian Biomedical Corporation Limited | Method and apparatus for treatment of human or animal cell samples |
| WO1997042496A1 (en) | 1996-05-06 | 1997-11-13 | Helena Laboratories Corporation | A system for the application of samples on a substrate__________ |
| JP3419430B2 (ja) | 1996-08-21 | 2003-06-23 | 日本電子株式会社 | 生化学自動分析装置における試薬注入攪拌装置 |
| JP3753526B2 (ja) | 1996-12-18 | 2006-03-08 | サクラ精機株式会社 | 顕微鏡標本のカバーガラス貼着方法と装置 |
| US6703247B1 (en) | 1996-12-23 | 2004-03-09 | American Registry Of Pathology | Apparatus and methods for efficient processing of biological samples on slides |
| AUPO439496A0 (en) * | 1996-12-24 | 1997-01-23 | Australian Biomedical Corporation Pty. Ltd. | Smearer mechanism |
| JPH10197424A (ja) * | 1997-01-14 | 1998-07-31 | Chiyoda Manufacturing Co Ltd | 顕微鏡標本のカバーガラス取付け方法及び装置 |
| US6489171B1 (en) | 1997-04-18 | 2002-12-03 | Cell Marque Corporation | Chemical dispensing system and method |
| US5812312A (en) | 1997-09-04 | 1998-09-22 | Lorincz; Andrew Endre | Microscope slide |
| US6239906B1 (en) | 1997-09-04 | 2001-05-29 | Andrew E. Lorincz | Flexible microscope slide |
| US6567214B2 (en) | 1997-09-04 | 2003-05-20 | Andrew E. Lorincz | Microscope slide having culture media and method for use |
| US6486947B2 (en) | 1998-07-22 | 2002-11-26 | Ljl Biosystems, Inc. | Devices and methods for sample analysis |
| AU1752499A (en) | 1997-12-23 | 1999-07-19 | Dako A/S | Cartridge device for processing a sample mounted on a surface of a support member |
| US6083759A (en) | 1997-12-30 | 2000-07-04 | University Of Hawaii | Blood smearing cassette |
| US6037168A (en) | 1997-12-31 | 2000-03-14 | Cytonix Corporation | Microbiological assembly comprising resealable closure means |
| JPH11202215A (ja) * | 1998-01-09 | 1999-07-30 | Chiyoda Mfg Co Ltd | 顕微鏡標本のカバーガラス貼着方法と装置 |
| US6589650B1 (en) | 2000-08-07 | 2003-07-08 | 3M Innovative Properties Company | Microscope cover slip materials |
| CN100403008C (zh) * | 1998-02-27 | 2008-07-16 | 文塔纳医疗系统公司 | 对组织样品进行处理的方法及装置 |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| EP1066502A1 (en) | 1998-03-24 | 2001-01-10 | Biogenex Laboratories | Automated staining apparatus |
| US6180314B1 (en) | 1998-05-27 | 2001-01-30 | Becton, Dickinson And Company | Method for preparing thin liquid samples for microscopic analysis |
| US6358475B1 (en) | 1998-05-27 | 2002-03-19 | Becton, Dickinson And Company | Device for preparing thin liquid for microscopic analysis |
| NO986025D0 (no) * | 1998-12-21 | 1998-12-21 | Torstein Ljungmann | Maskin for automatisk pÕklebing av dekkglass pÕ objektglass |
| US6544798B1 (en) | 1999-02-26 | 2003-04-08 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
| US6568447B1 (en) | 1999-05-11 | 2003-05-27 | Kabushiki Kaisha Tiyoda Seisakusho | Cover glass adhering device |
| US6474386B2 (en) | 1999-08-25 | 2002-11-05 | Kabushiki Kaisha Tiyoda Seisakusho | Cover glass adhering device |
| US6403931B1 (en) | 1999-10-07 | 2002-06-11 | Ventana Medical Systems, Inc. | Slide heater calibrator and temperature converter apparatus and method |
| US6690470B1 (en) | 1999-11-04 | 2004-02-10 | Arcturus Engineering, Inc. | Automated laser capture microdissection |
| USD445909S1 (en) | 1999-11-11 | 2001-07-31 | Hemocue Ab | Cuvette |
| NO310385B1 (no) | 1999-11-17 | 2001-06-25 | Torstein Ljungmann | Anordning for automatisk påklebing av dekkglass på objektglass |
| WO2001062372A1 (en) | 2000-02-23 | 2001-08-30 | Schlom, Leslie | A heat exchanger for cooling and for a pre-cooler for turbine intake air conditioning |
| USD464141S1 (en) | 2000-10-17 | 2002-10-08 | Acon Laboratories, Inc. | Test device platform |
| US6717657B2 (en) | 2001-01-02 | 2004-04-06 | Becton, Dickinson And Company | Apparatus for measuring the volume of individual red blood cells |
| US6544793B2 (en) | 2001-04-27 | 2003-04-08 | Becton, Dickinson And Company | Method for calibrating a sample analyzer |
| US6485918B1 (en) | 2001-07-02 | 2002-11-26 | Packard Bioscience Corporation | Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate |
| DE10144048B4 (de) | 2001-09-07 | 2012-09-20 | Leica Mikrosysteme Gmbh | Vorrichtung und Verfahren zum Handhaben von Deckgläsern für Objektträger |
| US7425306B1 (en) | 2001-09-11 | 2008-09-16 | Ventana Medical Systems, Inc. | Slide heater |
| US20030087292A1 (en) | 2001-10-04 | 2003-05-08 | Shiping Chen | Methods and systems for promoting interactions between probes and target molecules in fluid in microarrays |
| US7468161B2 (en) * | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
| ES2307962T3 (es) | 2002-04-26 | 2008-12-01 | Ventana Medical Systems, Inc. | Metodo y aparato para colocar cubreobjetos automaticamente. |
| CA2482763C (en) * | 2002-04-26 | 2008-07-29 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having fixed slide platforms |
| US7919308B2 (en) | 2002-06-14 | 2011-04-05 | Agilent Technologies, Inc. | Form in place gaskets for assays |
| AU2003240295A1 (en) | 2002-06-20 | 2004-01-06 | Vision Biosystems Limited | Biological reaction apparatus with draining mechanism |
| AUPS309002A0 (en) * | 2002-06-20 | 2002-07-11 | Vision Biosystems Limited | A covertile for a substrate |
| US7063758B2 (en) * | 2002-07-29 | 2006-06-20 | Three Bond Co., Ltd. | Laminating apparatus and laminating method |
| US7452712B2 (en) | 2002-07-30 | 2008-11-18 | Applied Biosystems Inc. | Sample block apparatus and method of maintaining a microcard on a sample block |
| USD495806S1 (en) | 2002-08-08 | 2004-09-07 | Exiqon A/S | Slide for use in chemical or biochemical procedures |
| US7186383B2 (en) | 2002-09-27 | 2007-03-06 | Ast Management Inc. | Miniaturized fluid delivery and analysis system |
| US20040082058A1 (en) | 2002-10-29 | 2004-04-29 | Arthur Schleifer | Array hybridization apparatus and method for making uniform sample volumes |
| US7850912B2 (en) | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
| WO2004083824A1 (en) | 2003-03-20 | 2004-09-30 | Dakocytomation Denmark A/S | System for establishing a sample cover on a substrate |
| US7468160B2 (en) | 2003-12-05 | 2008-12-23 | Agilent Technologies, Inc. | Devices and methods for performing array based assays |
| JP4871737B2 (ja) | 2003-12-23 | 2012-02-08 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 平坦な表面の効率的な薄膜液体処理のための方法および装置 |
| EP1771730B1 (en) | 2004-07-23 | 2014-08-20 | Ventana Medical Systems, Inc. | Method and apparatus for applying fluids to a biological sample |
| DE102004037848B4 (de) | 2004-08-04 | 2007-03-29 | Advalytix Ag | Probenträgerwaschbehälter, Probenträgerwaschstation, System zum Waschen von Probenträgern und Verfahren zum Waschen von Probenträgern |
| US7481980B2 (en) | 2004-09-08 | 2009-01-27 | Intavis Bioanalytical Instruments Ag | Device for staining and hybridization reactions |
| US7300804B2 (en) | 2004-11-15 | 2007-11-27 | Beckman Coulter, Inc. | Method and apparatus for controlling the uniform smearing of a biological liquid over a substrate |
| CA2623235A1 (en) * | 2005-04-21 | 2006-11-02 | Celerus Diagnostics, Inc. | Method and apparatus for automated rapid immunohistochemistry |
| JP4607703B2 (ja) * | 2005-08-22 | 2011-01-05 | 東芝機械株式会社 | 薄切片標本作製方法 |
| US20100031757A1 (en) | 2006-04-26 | 2010-02-11 | Quantifoil Instruments Gmbh | sample handling device for and a method of handling a sample |
| USD569990S1 (en) | 2006-09-28 | 2008-05-27 | Millennium Sciences | Microscope slide assembly |
| US20110217731A1 (en) | 2008-06-16 | 2011-09-08 | Mayo Foundation For Medical Education And Research | Pathology sample processing workstation |
| ES2608716T3 (es) | 2008-12-08 | 2017-04-12 | Sunstar Inc. | Accionador lineal |
| WO2010074917A1 (en) | 2008-12-24 | 2010-07-01 | Ventana Medical Systems, Inc. | Microscope-slide dryer |
| US9498791B2 (en) | 2009-11-13 | 2016-11-22 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| IN2012DN03245A (en, 2012) | 2009-11-13 | 2015-10-23 | Ventana Med Syst Inc | |
| WO2011139978A1 (en) | 2010-05-04 | 2011-11-10 | Ventana Medical Systems, Inc. | Moving meniscus rinsing and mixing in cell staining |
| USD645971S1 (en) | 2010-05-11 | 2011-09-27 | Claros Diagnostics, Inc. | Sample cassette |
| US20110305842A1 (en) | 2010-06-11 | 2011-12-15 | Ventana Medical Systems, Inc. | Floatable opposables for applying fluids to process biological samples |
| US20150031071A1 (en) | 2012-03-01 | 2015-01-29 | Victorious Medical Systems Aps | Method and System for Distributing and Agitating an Amount of Liquid Over a Microscope Slide |
| HK1213986A1 (zh) | 2012-12-26 | 2016-07-15 | Ventana Medical Systems, Inc. | 可相對物和具有可相對物的自動樣品處理系統 |
| BR112015015366A2 (pt) | 2012-12-26 | 2017-07-11 | Ventana Med Syst Inc | aparelho automatizado para processamento de lâmina e método para distribuir líquido em uma lâmina de microscópio |
| USD728120S1 (en) | 2013-03-15 | 2015-04-28 | Ventana Medical Systems, Inc. | Arcuate member for moving liquids along a microscope slide |
-
2010
- 2010-11-15 IN IN3245DEN2012 patent/IN2012DN03245A/en unknown
- 2010-11-15 US US13/509,785 patent/US8911815B2/en active Active
- 2010-11-15 KR KR1020127012234A patent/KR101358549B1/ko not_active Expired - Fee Related
- 2010-11-15 CA CA2778837A patent/CA2778837C/en not_active Expired - Fee Related
- 2010-11-15 EP EP10830875.0A patent/EP2499500B1/en active Active
- 2010-11-15 BR BR112012011181-7A patent/BR112012011181A2/pt not_active IP Right Cessation
- 2010-11-15 AU AU2010320039A patent/AU2010320039B2/en not_active Ceased
- 2010-11-15 JP JP2012539061A patent/JP5611363B2/ja not_active Expired - Fee Related
- 2010-11-15 CN CN201080051170.2A patent/CN102687023B/zh not_active Expired - Fee Related
- 2010-11-15 WO PCT/US2010/056752 patent/WO2011060387A1/en active Application Filing
-
2012
- 2012-04-05 IL IL219086A patent/IL219086A/en not_active IP Right Cessation
-
2014
- 2014-09-02 JP JP2014177783A patent/JP5923145B2/ja not_active Expired - Fee Related
- 2014-11-14 US US14/542,518 patent/US9618430B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20150071833A1 (en) | 2015-03-12 |
| CN102687023B (zh) | 2016-01-06 |
| JP2015007646A (ja) | 2015-01-15 |
| JP5923145B2 (ja) | 2016-05-24 |
| US9618430B2 (en) | 2017-04-11 |
| IL219086A0 (en) | 2012-06-28 |
| IN2012DN03245A (en, 2012) | 2015-10-23 |
| EP2499500A4 (en) | 2016-01-06 |
| KR101358549B1 (ko) | 2014-02-05 |
| KR20120107074A (ko) | 2012-09-28 |
| HK1175845A1 (zh) | 2013-07-12 |
| JP5611363B2 (ja) | 2014-10-22 |
| EP2499500B1 (en) | 2020-12-30 |
| US20130052331A1 (en) | 2013-02-28 |
| AU2010320039A1 (en) | 2012-05-03 |
| CA2778837A1 (en) | 2011-05-19 |
| US8911815B2 (en) | 2014-12-16 |
| BR112012011181A2 (pt) | 2020-10-13 |
| AU2010320039B2 (en) | 2013-08-15 |
| CN102687023A (zh) | 2012-09-19 |
| JP2013511048A (ja) | 2013-03-28 |
| EP2499500A1 (en) | 2012-09-19 |
| IL219086A (en) | 2017-10-31 |
| WO2011060387A1 (en) | 2011-05-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9618430B2 (en) | Thin film processing apparatuses for adjustable volume accommodation | |
| US9989448B2 (en) | Specimen processing systems and methods for holding slides | |
| EP2938996B1 (en) | Automated specimen processing systems and methods of using the same | |
| EP2938994B1 (en) | Specimen processing systems and methods for aligning slides | |
| EP2939030B1 (en) | Specimen processing systems and method for uniformly heating slides | |
| WO2011002779A2 (en) | Methods and apparatuses for applying and removing fluids for processing biological samples | |
| US10509216B2 (en) | Specimen processing systems and methods for aligning slides | |
| US12104994B2 (en) | Specimen processing systems and methods for holding slides | |
| CA2890819C (en) | Specimen processing systems and methods for moderating evaporation | |
| HK1175845B (en) | Thin film processing apparatuses for adjustable volume accommodation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20191115 |