CA2743850C - Variants of activin iib receptor polypeptides and uses thereof - Google Patents

Variants of activin iib receptor polypeptides and uses thereof Download PDF

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Publication number
CA2743850C
CA2743850C CA2743850A CA2743850A CA2743850C CA 2743850 C CA2743850 C CA 2743850C CA 2743850 A CA2743850 A CA 2743850A CA 2743850 A CA2743850 A CA 2743850A CA 2743850 C CA2743850 C CA 2743850C
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Prior art keywords
polypeptide
seq
protein
activin
subject
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Expired - Fee Related
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CA2743850A
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English (en)
French (fr)
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CA2743850A1 (en
Inventor
Jeonghoon Sun
Lei-Ting Tony Tam
Mark Leo Michaels
Thomas C. Boone
Rohini Deshpande
Yue-Sheng Li
Hq Han
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Amgen Inc
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Amgen Inc
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Priority to CA2997971A priority Critical patent/CA2997971A1/en
Publication of CA2743850A1 publication Critical patent/CA2743850A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
CA2743850A 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof Expired - Fee Related CA2743850C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2997971A CA2997971A1 (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US20025008P 2008-11-26 2008-11-26
US61/200,250 2008-11-26
US25906009P 2009-11-06 2009-11-06
US61/259,060 2009-11-06
PCT/US2009/006252 WO2010062383A2 (en) 2008-11-26 2009-11-24 Stabilized receptor polypeptides and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2997971A Division CA2997971A1 (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
CA2743850A1 CA2743850A1 (en) 2010-06-03
CA2743850C true CA2743850C (en) 2018-04-17

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ID=41693455

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CA2743850A Expired - Fee Related CA2743850C (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof
CA2997971A Abandoned CA2997971A1 (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof

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CA2997971A Abandoned CA2997971A1 (en) 2008-11-26 2009-11-24 Variants of activin iib receptor polypeptides and uses thereof

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US (5) US8410043B2 (enExample)
EP (2) EP3101029B1 (enExample)
JP (3) JP5611222B2 (enExample)
KR (3) KR20170105124A (enExample)
CN (2) CN102245634B (enExample)
AR (1) AR074397A1 (enExample)
AU (1) AU2009320364B2 (enExample)
BR (1) BRPI0920962A2 (enExample)
CA (2) CA2743850C (enExample)
CL (1) CL2011001239A1 (enExample)
CO (1) CO6382163A2 (enExample)
CR (2) CR20160443A (enExample)
CY (1) CY1118754T1 (enExample)
DK (1) DK2370463T3 (enExample)
EA (2) EA201791940A3 (enExample)
ES (1) ES2600491T3 (enExample)
HR (1) HRP20161450T1 (enExample)
HU (1) HUE032090T2 (enExample)
IL (2) IL212773A (enExample)
LT (1) LT2370463T (enExample)
MA (1) MA32936B1 (enExample)
ME (1) ME02652B (enExample)
MX (1) MX2011005505A (enExample)
MY (1) MY159483A (enExample)
NZ (2) NZ604818A (enExample)
PE (2) PE20150680A1 (enExample)
PL (1) PL2370463T3 (enExample)
PT (1) PT2370463T (enExample)
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SG (2) SG10201703067QA (enExample)
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SM (1) SMT201600417B (enExample)
TN (1) TN2011000238A1 (enExample)
TW (1) TWI486166B (enExample)
UA (1) UA107921C2 (enExample)
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