EA201791940A2 - Варианты полипептидов рецептора iib активина и их использование - Google Patents

Варианты полипептидов рецептора iib активина и их использование

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Publication number
EA201791940A2
EA201791940A2 EA201791940A EA201791940A EA201791940A2 EA 201791940 A2 EA201791940 A2 EA 201791940A2 EA 201791940 A EA201791940 A EA 201791940A EA 201791940 A EA201791940 A EA 201791940A EA 201791940 A2 EA201791940 A2 EA 201791940A2
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EA
Eurasian Patent Office
Prior art keywords
polypeptides
options
activin
iib receptor
activin iib
Prior art date
Application number
EA201791940A
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English (en)
Other versions
EA201791940A3 (ru
Inventor
Цзюнхун Сунь
Лей-Тин Тони Там
Марк Лео Майклз
Томас С. Бун
Рохини Дешпанд
Юэ-Шэн Ли
Хк Хань
Original Assignee
Амген Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41693455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201791940(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Амген Инк. filed Critical Амген Инк.
Publication of EA201791940A2 publication Critical patent/EA201791940A2/ru
Publication of EA201791940A3 publication Critical patent/EA201791940A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

Настоящее изобретение представляет полипептиды стабилизированного рецептора активина IIB и белки, способные на связывание и ингибирование активностей активина A, миостатина, РДФ-11. Настоящее изобретение также представляет полинуклеотиды, векторы и клетки хозяина, способные к продуцированию стабилизированных полипептидов или протеинов. Кроме того представлены композиции и способы для лечения мышечной дистрофии и метаболических нарушений.
EA201791940A 2008-11-26 2009-11-24 Варианты полипептидов рецептора iib активина и их использование EA201791940A3 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20025008P 2008-11-26 2008-11-26
US25906009P 2009-11-06 2009-11-06

Publications (2)

Publication Number Publication Date
EA201791940A2 true EA201791940A2 (ru) 2018-01-31
EA201791940A3 EA201791940A3 (ru) 2018-04-30

Family

ID=41693455

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201791940A EA201791940A3 (ru) 2008-11-26 2009-11-24 Варианты полипептидов рецептора iib активина и их использование
EA201100832A EA201100832A1 (ru) 2008-11-26 2009-11-24 Варианты полипептидов рецептора iib активина и их применение

Family Applications After (1)

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EA201100832A EA201100832A1 (ru) 2008-11-26 2009-11-24 Варианты полипептидов рецептора iib активина и их применение

Country Status (38)

Country Link
US (5) US8410043B2 (ru)
EP (2) EP3101029B1 (ru)
JP (3) JP5611222B2 (ru)
KR (3) KR101720143B1 (ru)
CN (2) CN104371024A (ru)
AR (1) AR074397A1 (ru)
AU (1) AU2009320364B2 (ru)
BR (1) BRPI0920962A2 (ru)
CA (2) CA2743850C (ru)
CL (1) CL2011001239A1 (ru)
CO (1) CO6382163A2 (ru)
CR (2) CR20160443A (ru)
CY (1) CY1118754T1 (ru)
DK (1) DK2370463T3 (ru)
EA (2) EA201791940A3 (ru)
ES (1) ES2600491T3 (ru)
HK (1) HK1162545A1 (ru)
HR (1) HRP20161450T1 (ru)
HU (1) HUE032090T2 (ru)
IL (2) IL212773A (ru)
LT (1) LT2370463T (ru)
MA (1) MA32936B1 (ru)
ME (1) ME02652B (ru)
MX (1) MX2011005505A (ru)
MY (1) MY159483A (ru)
NZ (2) NZ627111A (ru)
PE (2) PE20120206A1 (ru)
PL (1) PL2370463T3 (ru)
PT (1) PT2370463T (ru)
RS (1) RS55369B1 (ru)
SG (2) SG171813A1 (ru)
SI (1) SI2370463T1 (ru)
SM (1) SMT201600417B (ru)
TN (1) TN2011000238A1 (ru)
TW (1) TWI486166B (ru)
UA (1) UA107921C2 (ru)
WO (1) WO2010062383A2 (ru)
ZA (1) ZA201104648B (ru)

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