CY1118754T1 - Μια σταθεροποιημενη παραλλαγη υποδοχεα ακτιβινης ιιb - Google Patents

Μια σταθεροποιημενη παραλλαγη υποδοχεα ακτιβινης ιιb

Info

Publication number
CY1118754T1
CY1118754T1 CY20161101175T CY161101175T CY1118754T1 CY 1118754 T1 CY1118754 T1 CY 1118754T1 CY 20161101175 T CY20161101175 T CY 20161101175T CY 161101175 T CY161101175 T CY 161101175T CY 1118754 T1 CY1118754 T1 CY 1118754T1
Authority
CY
Cyprus
Prior art keywords
stabilized
activate receptors
stabilized line
iib
present
Prior art date
Application number
CY20161101175T
Other languages
English (en)
Inventor
Jeonghoon Sun
Lei-Ting Tony Tam
Mark Leo Michaels
Thomas C Boone
Rohini Deshpande
Yue-Sheng Li
Hq Han
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41693455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1118754(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of CY1118754T1 publication Critical patent/CY1118754T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P5/26—Androgens
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

Η παρούσα εφεύρεση παρέχει πολυπεπτίδια σταθεροποιημένων υποδοχέων ακτιβίνης ΙΙΒ και πρωτεΐνες που έχουν τη δυνατότητα να συνδέονται με και να αναστέλλουν τη δράση της ακτιβίνης Α, της μυοστατίνης ή του GDF-11. Η παρούσα εφεύρεση παρέχει επίσης πολυνουκλεοτίδια, φορείς και κύτταρα ξενιστές που έχουν τη δυνατότητα παραγωγής των σταθεροποιημένων πολυπεπτιδίων και πρωτεϊνών. Παρέχονται επίσης συνθέσεις και μέθοδοι για τη θεραπευτική αντιμετώπιση παθήσεων εξασθένησης των μυών και μεταβολικών διαταραχών.
CY20161101175T 2008-11-26 2016-11-16 Μια σταθεροποιημενη παραλλαγη υποδοχεα ακτιβινης ιιb CY1118754T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20025008P 2008-11-26 2008-11-26
US25906009P 2009-11-06 2009-11-06
PCT/US2009/006252 WO2010062383A2 (en) 2008-11-26 2009-11-24 Stabilized receptor polypeptides and uses thereof

Publications (1)

Publication Number Publication Date
CY1118754T1 true CY1118754T1 (el) 2017-07-12

Family

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US (5) US8410043B2 (el)
EP (2) EP2370463B1 (el)
JP (3) JP5611222B2 (el)
KR (3) KR101720143B1 (el)
CN (2) CN104371024A (el)
AR (1) AR074397A1 (el)
AU (1) AU2009320364B2 (el)
BR (1) BRPI0920962A2 (el)
CA (2) CA2997971A1 (el)
CL (1) CL2011001239A1 (el)
CO (1) CO6382163A2 (el)
CR (2) CR20160443A (el)
CY (1) CY1118754T1 (el)
DK (1) DK2370463T3 (el)
EA (2) EA201791940A3 (el)
ES (1) ES2600491T3 (el)
HK (1) HK1162545A1 (el)
HR (1) HRP20161450T1 (el)
HU (1) HUE032090T2 (el)
IL (2) IL212773A (el)
LT (1) LT2370463T (el)
MA (1) MA32936B1 (el)
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MX (1) MX2011005505A (el)
MY (1) MY159483A (el)
NZ (2) NZ627111A (el)
PE (2) PE20150680A1 (el)
PL (1) PL2370463T3 (el)
PT (1) PT2370463T (el)
RS (1) RS55369B1 (el)
SG (2) SG171813A1 (el)
SI (1) SI2370463T1 (el)
SM (1) SMT201600417B (el)
TN (1) TN2011000238A1 (el)
TW (1) TWI486166B (el)
UA (1) UA107921C2 (el)
WO (1) WO2010062383A2 (el)
ZA (1) ZA201104648B (el)

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