CA2722776A1 - Nmda receptor antagonists for the treatment of neuropsychiatric disorders - Google Patents
Nmda receptor antagonists for the treatment of neuropsychiatric disorders Download PDFInfo
- Publication number
- CA2722776A1 CA2722776A1 CA2722776A CA2722776A CA2722776A1 CA 2722776 A1 CA2722776 A1 CA 2722776A1 CA 2722776 A CA2722776 A CA 2722776A CA 2722776 A CA2722776 A CA 2722776A CA 2722776 A1 CA2722776 A1 CA 2722776A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- phenyl
- compound
- piperazin
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000008215 water for injection Substances 0.000 description 1
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- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- MJIBOYFUEIDNPI-HBNMXAOGSA-L zinc 5-[2,3-dihydroxy-5-[(2R,3R,4S,5R,6S)-4,5,6-tris[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]-2-[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxymethyl]oxan-3-yl]oxycarbonylphenoxy]carbonyl-3-hydroxybenzene-1,2-diolate Chemical class [Zn++].Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c([O-])c([O-])c2)c1 MJIBOYFUEIDNPI-HBNMXAOGSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12709808P | 2008-05-09 | 2008-05-09 | |
| US61/127,098 | 2008-05-09 | ||
| PCT/US2009/043502 WO2009137843A2 (en) | 2008-05-09 | 2009-05-11 | Nmda receptor antagonists for the treatment of neuropsychiatric disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2722776A1 true CA2722776A1 (en) | 2009-11-12 |
Family
ID=41265475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2722776A Abandoned CA2722776A1 (en) | 2008-05-09 | 2009-05-11 | Nmda receptor antagonists for the treatment of neuropsychiatric disorders |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20110160223A1 (https=) |
| EP (1) | EP2296658A4 (https=) |
| JP (1) | JP2011520815A (https=) |
| KR (1) | KR20110016891A (https=) |
| CN (1) | CN102762207A (https=) |
| AU (1) | AU2009244082A1 (https=) |
| BR (1) | BRPI0912362A2 (https=) |
| CA (1) | CA2722776A1 (https=) |
| CO (1) | CO6341558A2 (https=) |
| EA (1) | EA020339B1 (https=) |
| IL (1) | IL208895A0 (https=) |
| MX (1) | MX2010012186A (https=) |
| NZ (1) | NZ589764A (https=) |
| SG (1) | SG195568A1 (https=) |
| WO (1) | WO2009137843A2 (https=) |
| ZA (1) | ZA201007958B (https=) |
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| MX2012008721A (es) | 2010-02-16 | 2012-08-17 | Pfizer | (r)-4-((4-((4-(tetrahidrofuran-3-iloxi)benzo[d]isoxazol-3-iloxi)m etil) tetrahidro-2h-piran-4-ol, un agonista pacial de receptores 5-ht4. |
| HRP20230747T1 (hr) | 2011-09-08 | 2024-01-05 | Sage Therapeutics, Inc. | Neuroaktivni steroidi, pripravci i njihova uporaba |
| JP6345651B2 (ja) * | 2012-05-09 | 2018-06-20 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ヘテロアリール化合物及びその使用方法 |
| WO2013170072A2 (en) * | 2012-05-09 | 2013-11-14 | Neurop, Inc. | Compounds for the treatment of neurological disorders |
| US8974365B2 (en) * | 2012-11-25 | 2015-03-10 | Steven Richard Devore Best | Treatment of thalamocortical dysrhythmia |
| SMT201800657T1 (it) | 2013-03-13 | 2019-01-11 | Sage Therapeutics Inc | Steroidi neuroattivi e loro metodi di utilizzo |
| WO2014210456A1 (en) | 2013-06-28 | 2014-12-31 | Emory University | Pyrazoline dihydroquinolones, pharmaceutical compositions, and uses |
| WO2015195967A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| SG11201702799UA (en) * | 2014-10-07 | 2017-05-30 | Sage Therapeutics Inc | Neuroactive compounds and methods of use thereof |
| US10752588B2 (en) | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
| WO2016100940A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
| MX382122B (es) | 2015-07-06 | 2025-03-13 | Sage Therapeutics Inc | Oxiesteroles y metodos de uso de los mismos. |
| PL3319611T3 (pl) | 2015-07-06 | 2021-07-12 | Sage Therapeutics, Inc. | Oksysterole i sposoby ich stosowania |
| AU2016289965B2 (en) | 2015-07-06 | 2021-09-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| EP3383429B1 (en) | 2015-11-30 | 2020-10-14 | INSERM - Institut National de la Santé et de la Recherche Médicale | Nmdar antagonists for the treatment of tumor angiogenesis |
| EP3436022B1 (en) | 2016-04-01 | 2022-03-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2018009867A1 (en) | 2016-07-07 | 2018-01-11 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| PT3519422T (pt) | 2016-09-30 | 2022-12-05 | Sage Therapeutics Inc | Oxisteróis substituídos em c7 e métodos como moduladores nmda |
| CA3041088C (en) | 2016-10-18 | 2024-05-21 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| DK4105223T3 (da) | 2016-10-18 | 2025-07-07 | Sage Therapeutics Inc | Oxysteroler og fremgangsmåder til anvendelse deraf |
| CN109803656B (zh) * | 2017-10-09 | 2021-08-31 | 华南农业大学 | 一种抗白色念珠菌的化合物及其制备方法和应用 |
| US11981652B2 (en) | 2018-03-28 | 2024-05-14 | Emory University | GluN2C/D subunit selective antagonists of the N-methyl-D-aspartate receptor |
| JP2021529732A (ja) | 2018-06-27 | 2021-11-04 | クレキシオ バイオサイエンシーズ エルティーディー． | 大うつ病性障害の処置方法 |
| KR20210074275A (ko) | 2018-10-05 | 2021-06-21 | 클렉시오 바이오사이언시스 리미티드 | 주요 우울 장애를 치료하기 위한 에스케타민의 복용 요법 |
| US12364672B2 (en) | 2018-10-11 | 2025-07-22 | Clexio Biosciences Ltd. | Esketamine for use in treating major depressive disorder |
| WO2021137147A1 (en) | 2019-12-30 | 2021-07-08 | Clexio Biosciences Ltd. | Dosage regime with esketamine for treating major depressive disorder |
| JP2023507926A (ja) | 2019-12-30 | 2023-02-28 | クレキシオ バイオサイエンシーズ エルティーディー． | 神経精神状態または神経学的状態を治療するためのエスケタミンを用いた投与計画 |
| CN114539129B (zh) * | 2020-11-18 | 2023-06-09 | 上海中医药大学附属龙华医院 | 烯丙胺类双功能化合物及其用途 |
| CN118019541A (zh) * | 2021-09-02 | 2024-05-10 | 埃默里大学 | 在酸性pH下具有增强的效力的N-甲基-D-天冬氨酸受体的GLUN2B-亚基选择性拮抗剂 |
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| JPS54130587A (en) * | 1978-03-30 | 1979-10-09 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| DE2960178D1 (en) * | 1978-06-06 | 1981-04-09 | Hoechst Ag | New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation |
| DE2824677A1 (de) * | 1978-06-06 | 1979-12-20 | Hoechst Ag | Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung |
| JPS55162774A (en) * | 1979-06-06 | 1980-12-18 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| JPS5646812A (en) * | 1979-09-27 | 1981-04-28 | Otsuka Pharmaceut Co Ltd | Central nervous system depressant |
| JPS5649362A (en) * | 1979-09-28 | 1981-05-02 | Otsuka Pharmaceut Co Ltd | Thiocarbostyril derivative |
| JPS5649361A (en) * | 1979-09-28 | 1981-05-02 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
| JPS579769A (en) * | 1980-06-23 | 1982-01-19 | Otsuka Pharmaceut Co Ltd | 2-benzimidazolinone derivative |
| JPS58203968A (ja) * | 1982-05-21 | 1983-11-28 | Otsuka Pharmaceut Co Ltd | イソカルボスチリル誘導体 |
| DE3442570A1 (de) * | 1984-11-22 | 1986-05-22 | Hoechst Ag, 6230 Frankfurt | Neue substituierte phenylpiperazinderivate, verfahren zu deren herstellung und die verwendung substituierter phenylpiperazinderivate als aggressionshemmer fuer tiere |
| JPS62252783A (ja) * | 1986-02-13 | 1987-11-04 | ワ−ナ−−ランバ−ト・コンパニ− | ベンズ複素環式化合物 |
| GB9005318D0 (en) * | 1990-03-09 | 1990-05-02 | Isis Innovation | Antiarrhythmic agents |
| ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| TW498067B (en) * | 1996-07-19 | 2002-08-11 | Hoffmann La Roche | 4-hydroxy-piperidine derivatives |
| DE69830045T2 (de) * | 1997-10-31 | 2006-01-12 | Daiichi Suntory Pharma Co., Ltd. | Arylpiperidinopropanol und Arylpiperazinopropanol Derivate und dieselbe ent- haltende Pharmazeutika |
| IL145584A0 (en) * | 2000-10-02 | 2002-06-30 | Pfizer Prod Inc | Nmda nr2b antagonists for treatment |
| AU2001296994A1 (en) * | 2000-10-06 | 2002-04-15 | Regents Of The University Of California | Nmda receptor channel blocker with neuroprotective activity |
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| EP1436258A4 (en) * | 2001-03-08 | 2005-03-23 | Univ Emory | PH VALVE DEPENDENT NMDA RECEPTOR ANTAGONISTS |
| DE10248925A1 (de) * | 2002-10-15 | 2004-04-29 | Proteosys Ag | Neue Verbindungen mit dopaminerger und/oder serotoninerger Aktivität |
| EP1626722A1 (en) * | 2003-05-16 | 2006-02-22 | Pfizer Products Inc. | Method for enhancing cognition using ziprasidone |
| EP2260844A1 (en) * | 2003-05-27 | 2010-12-15 | Merz Pharma GmbH & Co. KGaA | Combination of an NMDA Receptor Antagonist and a Selective Serotonin Reuptake Inhibitor for the Treatment of Depression and other Mood Disorders |
| HUP0401526A2 (en) * | 2004-07-29 | 2006-04-28 | Richter Gedeon Vegyeszet | Aryloxy acetic acid amide derivatives, pharmaceutical compositions comprising thereof, methods for their preparation and their use |
| EP1791569A4 (en) * | 2004-08-23 | 2009-12-16 | Univ Emory | Improved selection of-ph dependent compounds for in vivo therapy |
| WO2007006738A2 (en) * | 2005-07-12 | 2007-01-18 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising 2 , 3-disubstituted tropanes for the treatment of disorders of sexual desire |
| AR055203A1 (es) * | 2005-08-31 | 2007-08-08 | Otsuka Pharma Co Ltd | Derivados de benzotiofeno con propiedades antipsicoticas |
| EP2520567A3 (en) * | 2006-02-23 | 2012-12-12 | Shionogi & Co., Ltd. | Nitrogen-containing heterocycle derivatives substituted with cyclic group |
| WO2008020306A2 (en) * | 2006-08-18 | 2008-02-21 | Pfizer Products Inc. | Isoindole derivatives |
| KR20100045983A (ko) * | 2007-06-29 | 2010-05-04 | 에모리 유니버시티 | 신경보호를 위한 ｎｍｄａ 수용체 길항물질 |
-
2009
- 2009-05-11 NZ NZ589764A patent/NZ589764A/xx not_active IP Right Cessation
- 2009-05-11 WO PCT/US2009/043502 patent/WO2009137843A2/en not_active Ceased
- 2009-05-11 CA CA2722776A patent/CA2722776A1/en not_active Abandoned
- 2009-05-11 AU AU2009244082A patent/AU2009244082A1/en not_active Abandoned
- 2009-05-11 JP JP2011508724A patent/JP2011520815A/ja active Pending
- 2009-05-11 MX MX2010012186A patent/MX2010012186A/es not_active Application Discontinuation
- 2009-05-11 KR KR1020107025739A patent/KR20110016891A/ko not_active Ceased
- 2009-05-11 EA EA201071291A patent/EA020339B1/ru not_active IP Right Cessation
- 2009-05-11 CN CN2009801184245A patent/CN102762207A/zh active Pending
- 2009-05-11 SG SG2013077359A patent/SG195568A1/en unknown
- 2009-05-11 EP EP09743829.5A patent/EP2296658A4/en not_active Withdrawn
- 2009-05-11 BR BRPI0912362A patent/BRPI0912362A2/pt not_active IP Right Cessation
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2010
- 2010-10-24 IL IL208895A patent/IL208895A0/en unknown
- 2010-11-02 US US12/938,138 patent/US20110160223A1/en not_active Abandoned
- 2010-11-05 ZA ZA2010/07958A patent/ZA201007958B/en unknown
- 2010-11-16 CO CO10143058A patent/CO6341558A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0912362A2 (pt) | 2015-10-06 |
| CN102762207A (zh) | 2012-10-31 |
| US20110160223A1 (en) | 2011-06-30 |
| EA020339B1 (ru) | 2014-10-30 |
| JP2011520815A (ja) | 2011-07-21 |
| ZA201007958B (en) | 2011-07-27 |
| KR20110016891A (ko) | 2011-02-18 |
| EP2296658A4 (en) | 2014-01-15 |
| MX2010012186A (es) | 2011-02-22 |
| EP2296658A2 (en) | 2011-03-23 |
| NZ589764A (en) | 2012-10-26 |
| WO2009137843A2 (en) | 2009-11-12 |
| EA201071291A3 (ru) | 2014-02-28 |
| IL208895A0 (en) | 2011-01-31 |
| CO6341558A2 (es) | 2011-11-21 |
| SG195568A1 (en) | 2013-12-30 |
| AU2009244082A1 (en) | 2009-11-12 |
| WO2009137843A9 (en) | 2010-03-11 |
| EA201071291A2 (ru) | 2011-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140124 |
|
| FZDE | Discontinued |
Effective date: 20160511 |