EA020339B1 - Nmda рецепторные антагонисты для лечения нейропсихиатрических расстройств - Google Patents

Info

Publication number

EA020339B1

EA020339B1 EA201071291A EA201071291A EA020339B1 EA 020339 B1 EA020339 B1 EA 020339B1 EA 201071291 A EA201071291 A EA 201071291A EA 201071291 A EA201071291 A EA 201071291A EA 020339 B1 EA020339 B1 EA 020339B1

Authority

EA

Eurasian Patent Office

Prior art keywords

phenyl

compound

piperazin

alkyl

hydroxy

Prior art date

2008-05-09

Links

• Espacenet
• Global Dossier
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• 238000011282 treatment Methods 0.000 title abstract description 30
• 229940127523 NMDA Receptor Antagonists Drugs 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 301
• -1 1-(4-chlorophenyl)-3-(4-hydroxyphenoxy)propyl Chemical group 0.000 claims abstract description 192
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 71
• 238000000034 method Methods 0.000 claims abstract description 71
• 150000003839 salts Chemical class 0.000 claims abstract description 21
• 150000002148 esters Chemical class 0.000 claims abstract description 10
• 125000000217 alkyl group Chemical group 0.000 claims description 82
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 56
• 229910052739 hydrogen Inorganic materials 0.000 claims description 40
• 229910052698 phosphorus Inorganic materials 0.000 claims description 28
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 20
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 19
• 229910052799 carbon Inorganic materials 0.000 claims description 18
• 208000020401 Depressive disease Diseases 0.000 claims description 15
• 125000003118 aryl group Chemical group 0.000 claims description 15
• 125000001072 heteroaryl group Chemical group 0.000 claims description 14
• 208000024714 major depressive disease Diseases 0.000 claims description 13
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 13
• 229910052760 oxygen Inorganic materials 0.000 claims description 11
• 125000000623 heterocyclic group Chemical group 0.000 claims description 9
• 239000013256 coordination polymer Substances 0.000 claims description 7
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
• 239000003795 chemical substances by application Substances 0.000 claims description 6
• 239000003937 drug carrier Substances 0.000 claims description 6
• 125000002877 alkyl aryl group Chemical group 0.000 claims description 5
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 5
• 239000000460 chlorine Substances 0.000 claims description 4
• 239000012634 fragment Substances 0.000 claims description 4
• IRFHMTUHTBSEBK-QGZVFWFLSA-N tert-butyl n-[(2s)-2-(2,5-difluorophenyl)-3-quinolin-3-ylpropyl]carbamate Chemical compound C1([C@H](CC=2C=C3C=CC=CC3=NC=2)CNC(=O)OC(C)(C)C)=CC(F)=CC=C1F IRFHMTUHTBSEBK-QGZVFWFLSA-N 0.000 claims description 3
• 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 2
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
• 239000013543 active substance Substances 0.000 claims description 2
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