CA2695583A1 - Novel activators of glucokinase - Google Patents

Novel activators of glucokinase Download PDF

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Publication number
CA2695583A1
CA2695583A1 CA2695583A CA2695583A CA2695583A1 CA 2695583 A1 CA2695583 A1 CA 2695583A1 CA 2695583 A CA2695583 A CA 2695583A CA 2695583 A CA2695583 A CA 2695583A CA 2695583 A1 CA2695583 A1 CA 2695583A1
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Canada
Prior art keywords
optionally substituted
alkyl
group
aryl
atoms
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CA2695583A
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English (en)
French (fr)
Inventor
Feng Tian
Qun Dang
G. Sridhar Prasad
Wenyu Li
Brett C. Bookser
Nicholas Brian Raffaele
Mark D. Erion
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Metabasis Therapeutics Inc
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Individual
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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/06—Antihyperlipidemics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
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    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4021—Esters of aromatic acids (P-C aromatic linkage)
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    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
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CN106279283A (zh) 2017-01-04
EP2185570B1 (en) 2014-03-19
US10174062B2 (en) 2019-01-08
US20110294758A1 (en) 2011-12-01
CN101821276A (zh) 2010-09-01
EP2185570A2 (en) 2010-05-19
BRPI0815557A2 (pt) 2015-02-18
US20170096440A1 (en) 2017-04-06
EP2185570A4 (en) 2011-02-09
US8940927B2 (en) 2015-01-27
WO2009023718A3 (en) 2009-04-16
JP5572549B2 (ja) 2014-08-13
WO2009023718A2 (en) 2009-02-19
CN101821276B (zh) 2016-08-31
US20150119365A1 (en) 2015-04-30
MX2010001784A (es) 2010-03-15
US9522926B2 (en) 2016-12-20

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