CA2692506C - Pyrimidyl cyclopentanes as akt protein kinase inhibitors - Google Patents
Pyrimidyl cyclopentanes as akt protein kinase inhibitors Download PDFInfo
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- CA2692506C CA2692506C CA2692506A CA2692506A CA2692506C CA 2692506 C CA2692506 C CA 2692506C CA 2692506 A CA2692506 A CA 2692506A CA 2692506 A CA2692506 A CA 2692506A CA 2692506 C CA2692506 C CA 2692506C
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- A61P17/00—Drugs for dermatological disorders
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Rheumatology (AREA)
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- Psychiatry (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
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| US94814707P | 2007-07-05 | 2007-07-05 | |
| US60/948,147 | 2007-07-05 | ||
| PCT/US2008/069147 WO2009006569A1 (en) | 2007-07-05 | 2008-07-03 | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
Publications (2)
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| CA2692506A1 CA2692506A1 (en) | 2009-01-08 |
| CA2692506C true CA2692506C (en) | 2015-11-24 |
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| CA2692506A Expired - Fee Related CA2692506C (en) | 2007-07-05 | 2008-07-03 | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
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| US (1) | US8377937B2 (OSRAM) |
| EP (2) | EP2404907B1 (OSRAM) |
| JP (2) | JP5542282B2 (OSRAM) |
| KR (2) | KR101624361B1 (OSRAM) |
| CN (1) | CN101918373B (OSRAM) |
| AT (1) | ATE522509T1 (OSRAM) |
| AU (1) | AU2008272832B2 (OSRAM) |
| BR (1) | BRPI0813993A2 (OSRAM) |
| CA (1) | CA2692506C (OSRAM) |
| ES (1) | ES2533557T3 (OSRAM) |
| IL (1) | IL202617A0 (OSRAM) |
| MX (1) | MX2009014013A (OSRAM) |
| SI (1) | SI2173723T1 (OSRAM) |
| WO (1) | WO2009006569A1 (OSRAM) |
| ZA (1) | ZA200908901B (OSRAM) |
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| BRPI0813999A2 (pt) * | 2007-07-05 | 2019-10-01 | Array Biopharma Inc | ciclopentanos de pirimidil como inibidores de akt proteína cinase |
| US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
| US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| JP5608097B2 (ja) | 2008-01-08 | 2014-10-15 | アレイ バイオファーマ、インコーポレイテッド | キナーゼ阻害薬としてのピロロピリジン |
| AU2009204019B2 (en) | 2008-01-09 | 2014-02-20 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor |
| US8372842B2 (en) | 2008-01-09 | 2013-02-12 | Array Biopharma Inc. | Pyrazolopyridines as kinase inhibitors |
| EP2250155B1 (en) | 2008-01-09 | 2013-07-03 | Array Biopharma, Inc. | 5h-cyclopenta[d]pyrimidines as akt protein kinase inhibitors |
| GB201110546D0 (en) * | 2011-06-22 | 2011-08-03 | Imp Innovations Ltd | Compositions |
| ES2588878T3 (es) * | 2012-05-17 | 2016-11-07 | Array Biopharma, Inc. | Proceso para preparar compuestos de ciclopentilpirimidina hidroxilada |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| JP2019537585A (ja) | 2016-10-28 | 2019-12-26 | アイカーン スクール オブ メディスン アット マウント シナイ | Ｅｚｈ２媒介性がんを治療するための組成物および方法 |
| CA3045037A1 (en) | 2016-12-08 | 2018-06-14 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating cdk4/6-mediated cancer |
| AU2019231689A1 (en) * | 2018-03-06 | 2020-09-24 | Icahn School Of Medicine At Mount Sinai | Serine threonine kinase (AKT) degradation / disruption compounds and methods of use |
| JP2021527666A (ja) | 2018-06-21 | 2021-10-14 | アイカーン スクール オブ メディスン アット マウント シナイ | Ｗｄ４０反復ドメインタンパク質５（ｗｄｒ５）分解／破壊化合物および使用の方法 |
| CN114423463B (zh) | 2019-05-06 | 2025-09-26 | 西奈山伊坎医学院 | 作为hpk1的降解剂的异双功能化合物 |
| CN118530260A (zh) * | 2020-03-17 | 2024-08-23 | 江苏恒瑞医药股份有限公司 | 稠合二环类衍生物、其制备方法及其在医药上的应用 |
| CN113444110B (zh) * | 2020-03-25 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 四氢吡咯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| US12103924B2 (en) | 2020-06-01 | 2024-10-01 | Icahn School Of Medicine At Mount Sinai | Mitogen-activated protein kinase kinase (MEK) degradation compounds and methods of use |
| US20250145641A1 (en) | 2021-09-17 | 2025-05-08 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Fused bicyclic derivative, pharmaceutically acceptable salt, crystal form thereof and preparation method therefor |
| CN116514739B (zh) * | 2023-05-09 | 2025-07-22 | 天津绿菱气体股份有限公司 | 一种1,4-二甲基哌嗪及其制备方法 |
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-
2008
- 2008-07-03 EP EP11169324.8A patent/EP2404907B1/en active Active
- 2008-07-03 EP EP08781340.8A patent/EP2173723B3/en active Active
- 2008-07-03 AU AU2008272832A patent/AU2008272832B2/en not_active Ceased
- 2008-07-03 KR KR1020107002547A patent/KR101624361B1/ko not_active Expired - Fee Related
- 2008-07-03 CN CN2008801058708A patent/CN101918373B/zh active Active
- 2008-07-03 WO PCT/US2008/069147 patent/WO2009006569A1/en not_active Ceased
- 2008-07-03 JP JP2010515270A patent/JP5542282B2/ja active Active
- 2008-07-03 US US12/667,850 patent/US8377937B2/en active Active
- 2008-07-03 AT AT08781340T patent/ATE522509T1/de not_active IP Right Cessation
- 2008-07-03 ES ES11169324.8T patent/ES2533557T3/es active Active
- 2008-07-03 SI SI200830441T patent/SI2173723T1/sl unknown
- 2008-07-03 BR BRPI0813993-8A patent/BRPI0813993A2/pt not_active Application Discontinuation
- 2008-07-03 MX MX2009014013A patent/MX2009014013A/es not_active Application Discontinuation
- 2008-07-03 CA CA2692506A patent/CA2692506C/en not_active Expired - Fee Related
- 2008-07-03 KR KR1020157020348A patent/KR20150091196A/ko not_active Ceased
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2009
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2009006569A1 (en) | 2009-01-08 |
| KR20100029846A (ko) | 2010-03-17 |
| HK1166078A1 (en) | 2012-10-19 |
| SI2173723T1 (sl) | 2011-12-30 |
| US20110160221A1 (en) | 2011-06-30 |
| ES2533557T3 (es) | 2015-04-13 |
| CN101918373B (zh) | 2013-06-05 |
| JP2014040489A (ja) | 2014-03-06 |
| RU2010103811A (ru) | 2011-08-10 |
| AU2008272832A1 (en) | 2009-01-08 |
| EP2173723A1 (en) | 2010-04-14 |
| ZA200908901B (en) | 2011-10-26 |
| CA2692506A1 (en) | 2009-01-08 |
| ATE522509T1 (de) | 2011-09-15 |
| EP2173723B3 (en) | 2014-11-19 |
| US8377937B2 (en) | 2013-02-19 |
| BRPI0813993A2 (pt) | 2015-06-16 |
| KR20150091196A (ko) | 2015-08-07 |
| EP2173723B1 (en) | 2011-08-31 |
| AU2008272832B2 (en) | 2014-02-20 |
| EP2404907B1 (en) | 2015-01-14 |
| JP2010532387A (ja) | 2010-10-07 |
| CN101918373A (zh) | 2010-12-15 |
| IL202617A0 (en) | 2010-06-30 |
| JP5542282B2 (ja) | 2014-07-09 |
| KR101624361B1 (ko) | 2016-05-25 |
| HK1136832A1 (en) | 2010-07-09 |
| MX2009014013A (es) | 2010-01-28 |
| EP2404907A1 (en) | 2012-01-11 |
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