CA2616366A1

CA2616366A1 - Novel pharmaceutical compounds

Novel pharmaceutical compounds Download PDF

Info

Publication number: CA2616366A1
Authority: CA; Canada
Prior art keywords: compound; deuterium; medicament; prodrug; hydrogen
Prior art date: 2005-07-29
Legal status : Abandoned

Application number

CA002616366A

Other languages

English (en)

French (fr)

Inventor

Roger Tung

Current Assignee

Concert Pharmaceuticals Inc

Original Assignee

Individual

Priority date

2005-07-29

Filing date

2006-07-28

Publication date

2007-02-08

2006-07-28 Application filed by Individual filed Critical Individual

2007-02-08 Publication of CA2616366A1 publication Critical patent/CA2616366A1/en

Status Abandoned legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 300
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229910052739 hydrogen Inorganic materials 0.000 claims abstract description 81
239000001257 hydrogen Substances 0.000 claims abstract description 81
238000000034 method Methods 0.000 claims abstract description 73
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 58
125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 29
201000010099 disease Diseases 0.000 claims abstract description 19
125000001153 fluoro group Chemical group F* 0.000 claims abstract description 13
101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 claims abstract 2
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229910052805 deuterium Inorganic materials 0.000 claims description 159
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 157
239000003814 drug Substances 0.000 claims description 94
229940002612 prodrug Drugs 0.000 claims description 67
239000000651 prodrug Substances 0.000 claims description 67
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 53
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