ATE292961T1 - Zur wirkstoffabgabe an zielorten im darm fähige zubereitung - Google Patents

Zur wirkstoffabgabe an zielorten im darm fähige zubereitung

Info

Publication number
ATE292961T1
ATE292961T1 AT99931535T AT99931535T ATE292961T1 AT E292961 T1 ATE292961 T1 AT E292961T1 AT 99931535 T AT99931535 T AT 99931535T AT 99931535 T AT99931535 T AT 99931535T AT E292961 T1 ATE292961 T1 AT E292961T1
Authority
AT
Austria
Prior art keywords
intestine
medicinal substance
site
preparation
intestinal
Prior art date
Application number
AT99931535T
Other languages
English (en)
Inventor
Takashi Ishibashi
Hiroaki Kubo
Hiroyuki Yoshino
Masakazu Mizobe
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Application granted granted Critical
Publication of ATE292961T1 publication Critical patent/ATE292961T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99931535T 1998-07-28 1999-07-26 Zur wirkstoffabgabe an zielorten im darm fähige zubereitung ATE292961T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21167898 1998-07-28
PCT/JP1999/003989 WO2000006128A1 (fr) 1998-07-28 1999-07-26 Preparation capable de liberer un medicament au niveau d'un site cible dans l'intestin

Publications (1)

Publication Number Publication Date
ATE292961T1 true ATE292961T1 (de) 2005-04-15

Family

ID=16609788

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99931535T ATE292961T1 (de) 1998-07-28 1999-07-26 Zur wirkstoffabgabe an zielorten im darm fähige zubereitung

Country Status (9)

Country Link
US (1) US6638534B1 (de)
EP (1) EP1101490B1 (de)
KR (1) KR100501022B1 (de)
CN (1) CN1163223C (de)
AT (1) ATE292961T1 (de)
AU (1) AU4800999A (de)
CA (1) CA2338780C (de)
DE (1) DE69924735T2 (de)
WO (1) WO2000006128A1 (de)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432448B1 (en) * 1999-02-08 2002-08-13 Fmc Corporation Edible coating composition
US6723342B1 (en) 1999-02-08 2004-04-20 Fmc Corporation Edible coating composition
TR200300731T2 (tr) 2000-11-28 2004-08-23 Fmc Corporation Yenebilir PGA kaplama bileşimi
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
CA2480826C (fr) 2002-04-09 2012-02-07 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s)
IL164221A0 (en) 2002-04-09 2005-12-18 Flamel Tech Sa Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillim
US20030220351A1 (en) * 2002-05-24 2003-11-27 Gilbert Gonzales Enteric coated caffeine tablet
US20060188563A1 (en) * 2003-03-27 2006-08-24 Hisamitsu Pharmaceutical Co., Inc. Medicinal oral preparations for colon delivery, medicinal oral preparations for treating colon cancer and medicinal oral preparations for treating colitis
US7825106B2 (en) 2003-09-03 2010-11-02 Agi Therapeutics Ltd. Modified release formulations and methods of treating inflammatory bowel disease
US7737133B2 (en) 2003-09-03 2010-06-15 Agi Therapeutics Ltd. Formulations and methods of treating inflammatory bowel disease
EP1680100A4 (de) 2003-11-04 2012-08-08 Supernus Pharmaceuticals Inc Zusammensetzungen aus quartärem ammonium mit biologisch verfügbaren verstärkern
EP1680110B1 (de) 2003-11-04 2011-01-05 Supernus Pharmaceuticals, Inc. Einmal tägliche dosierformen von trospium
US20050175695A1 (en) 2003-11-25 2005-08-11 Catherine Castan Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
WO2005074598A2 (en) 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use
AT500144A1 (de) * 2004-03-05 2005-11-15 Sanochemia Pharmazeutika Ag Tolperison enthaltende, pharmazeutische zubereitung mit steuerbarer wirkstofffreisetzung zur oralen verabreichung
WO2005105050A1 (en) * 2004-04-28 2005-11-10 Procarrier, Inc. Oral formulation for delivery of poorly absorbed drugs
KR20050104152A (ko) * 2004-04-28 2005-11-02 최승호 경구용 약물의 흡수를 증진하는 약제학적 조성물
WO2006004795A2 (en) 2004-06-25 2006-01-12 The Johns Hopkins University Angiogenesis inhibitors
FR2878159B1 (fr) * 2004-11-24 2008-10-17 Flamel Technologies Sa Medicament oral a liberation modifiee d'au moins un principe actif sous forme multimicrocapsulaire
US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
AU2005320547B2 (en) 2004-12-27 2009-02-05 Eisai R & D Management Co., Ltd. Method for stabilizing anti-dementia drug
EP1912635B1 (de) * 2005-07-29 2014-03-05 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Verwendung von chk2-kinasehemmern zur krebsbehandlung
KR20080047375A (ko) 2005-07-29 2008-05-28 콘서트 파마슈티컬즈, 인크. 약제 화합물
US20070154413A1 (en) * 2005-12-30 2007-07-05 Nolan Lee Phillips Dentifrices comprising biogenic silica materials
US20070154412A1 (en) * 2005-12-30 2007-07-05 Nolan Lee Phillips Dentifrices comprising biogenic silica materials
US20070196399A1 (en) * 2006-02-21 2007-08-23 Shin-Etsu Chemical Co., Ltd. Enteric-coated preparation covered with enteric coating material for site-specific delivery of drug to site within the small intestine
DK2489350T3 (en) 2006-03-17 2014-03-03 Univ Johns Hopkins Med N-hydroxylsulfonamidderivater as new physiologically useful nitroxyldonorer
KR20090034385A (ko) * 2006-07-19 2009-04-07 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 염증성 장질환을 치료하기 위한 5-아미노살리실산 함유 약제 및 인지질의 제제
US20080159967A1 (en) * 2006-12-27 2008-07-03 Fultz William C Dentifrices comprising biogenic silica materials and at least one calcium phosphate
US20080159968A1 (en) * 2006-12-27 2008-07-03 Fultz William C Dentifrices comprising biogenic silica materials and calcium carbonate
ES2531002T3 (es) 2007-01-19 2015-03-09 Xcovery Inc Compuestos inhibidores de quinasa
EP2190814B1 (de) 2007-09-26 2017-02-01 The Johns Hopkins University N-hydroxylsulfonamidderivate als neue physiologisch nützliche nitroxyl-spender
CN104945309B (zh) 2008-05-07 2019-06-04 卡尔迪奥克斯尔制药公司 作为硝酰基供体的新亚硝基化合物及其用途
PL2303018T3 (pl) 2008-06-19 2016-06-30 Xcovery Holdings Inc Podstawione związki pirydazynokarboksyamidowe jako związki będące inhibitorami kinazy
CN102239149B (zh) 2008-10-06 2015-05-13 约翰·霍普金斯大学 喹啉化合物作为血管新生、人类甲硫氨酰氨肽酶、以及sirt1的抑制剂,以及治疗病症的方法
EP2255794A1 (de) 2009-05-29 2010-12-01 H e x a l Aktiengesellschaft Magensaftresistenter Überzug
MX2012001178A (es) * 2009-07-30 2012-03-07 Evonik Roehm Gmbh Composicion que consta de un material polimerico anionico y la sal de un acido monocarboxilico saturado que tiene 6 a 22 atomos de carbono.
WO2011063339A1 (en) * 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
US9018411B2 (en) * 2009-12-07 2015-04-28 Cardioxyl Pharmaceuticals, Inc. Bis-acylated hydroxylamine derivatives
MX2012006349A (es) * 2009-12-07 2012-10-03 Cardioxyl Pharmaceuticals Inc Derivados de n-aciloxisulfonamida y n-hidroxi-n-acilsulfonamida.
EP2568973A2 (de) 2010-05-11 2013-03-20 Sensient Colors LLC Folienbeschichtungszusammensetzung und verfahren zu deren herstellung und verwendung
US9126947B2 (en) 2010-10-08 2015-09-08 Xcovery Holding Company Llc Substituted pyridazine carboxamide compounds
MX2013008946A (es) 2011-02-03 2013-10-25 Lupin Ltd Composiciones farmaceuticas orales de bepotastina de liberacion controlada.
KR102061537B1 (ko) 2011-10-17 2020-01-03 더 존스 홉킨스 유니버시티 Ｈｎｏ 공여체들로서의 하이드록실아민으로 치환된 멜드럼산, 바르비투르산 및 피라졸론 유도체들
BRPI1106900A2 (pt) * 2011-12-26 2013-11-05 Ems Sa Composição farmacêutica sólida compreendendo antibótico da familia das quinolonas e processo de sua obtenção
AU2013240289B2 (en) 2012-03-29 2018-01-25 Therabiome, Llc Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix
BR112014026453A2 (pt) * 2012-04-23 2017-06-27 Cadila Healthcare Ltd composição farmacêutica de liberação retardada, processo para o preparo de uma composição farmacêutica compreendendo salsalato e método de tratar sinais e sintomas de artrite reumatóide, osteoartrite e desordens reumáticas relacionadas
EP2914579A1 (de) 2012-11-01 2015-09-09 The Johns Hopkins University Gesteuerte hno-freisetzung durch intramolekulare zyklisierungseliminierung
RU2676277C2 (ru) 2013-01-18 2018-12-27 Кардиоксил Фармасьютикалз, Инк. Доноры нитроксила с улучшенным терапевтическим индексом
NZ711298A (en) 2013-03-14 2021-07-30 Therabiome Llc Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents
KR20210156320A (ko) 2013-04-07 2021-12-24 더 브로드 인스티튜트, 인코퍼레이티드 개인맞춤화 신생물 백신을 위한 조성물 및 방법
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
AU2014368898B2 (en) 2013-12-20 2020-06-11 Dana-Farber Cancer Institute, Inc. Combination therapy with neoantigen vaccine
ES2734060T3 (es) 2014-01-17 2019-12-04 Cardioxyl Pharmaceuticals Inc Donadores de nitroxilo de N-hidroximetanosulfonamida
FR3018689B1 (fr) * 2014-03-20 2017-04-28 Centre Hospitalier Univ De Clermont Ferrand Inhibiteurs de l'acetylcholinesterase d'action centrale pour la prevention et/ou le traitement des neuropathies chimio-induites et leurs symptomes, compositions, utilisations, methodes et trousse correspondantes.
ES2749682T3 (es) 2014-05-27 2020-03-23 Cardioxyl Pharmaceuticals Inc Derivados de pirazolona como donadores de nitroxilo
US9464061B2 (en) 2014-05-27 2016-10-11 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives
EP3148983A1 (de) 2014-05-27 2017-04-05 The Johns Hopkins University N-hydroxylaminobarbitursäure-derivate als nitroxyldonatoren
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
WO2016100975A1 (en) 2014-12-19 2016-06-23 Massachsetts Institute Ot Technology Molecular biomarkers for cancer immunotherapy
EP3237399B1 (de) 2014-12-23 2022-11-30 Avalo Therapeutics, Inc. Verbindungen, zusammensetzungen und verfahren
EP3288556A4 (de) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Oral zerfallende zusammensetzungen
EP3297660A2 (de) 2015-05-20 2018-03-28 The Broad Institute Inc. Gemeinsam genutzte neoantigene
JP2018516947A (ja) 2015-06-09 2018-06-28 レクサン ファーマシューティカルズ インコーポレイテッド フルオロシクロペンテニルシトシンの使用および調製のプロセス
KR20180049015A (ko) 2015-09-04 2018-05-10 렉산 파마슈티컬스, 인코포레이티드 퀴녹살리닐-피페라진아미드의 사용 방법
WO2017184590A1 (en) 2016-04-18 2017-10-26 The Broad Institute Inc. Improved hla epitope prediction
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
PL3509591T3 (pl) 2016-10-03 2022-01-31 Highlightll Pharmaceutical (Hainan) Co., Ltd. Nowe selektywne inhibitory Jak1 i ich zastosowanie
US11549149B2 (en) 2017-01-24 2023-01-10 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
ES2965337T3 (es) * 2017-11-23 2024-04-12 Medac Ges Fuer Klinische Spezialpraeparate Mbh Composición farmacéutica para administración oral que contiene sulfasalazina y/o una sal orgánica de sulfasalazina, proceso de producción y uso
EP3489222A1 (de) 2017-11-23 2019-05-29 medac Gesellschaft für klinische Spezialpräparate mbH Sulfasalazinesalze, herstellungsverfahren und verwendungen
KR20210006353A (ko) 2018-05-04 2021-01-18 톨리스 상피 세포 및 골수 세포 모두를 활성화시키는 tlr3 리간드
US20210382068A1 (en) 2018-10-02 2021-12-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
WO2020131586A2 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Methods for identifying neoantigens
EP3949959A4 (de) * 2019-04-04 2022-05-11 Daegu-Gyeongbuk Medical Innovation Foundation Pharmazeutische zusammensetzung mit trimebutin oder einem pharmazeutisch akzeptablen salz davon als wirkstoff zur vorbeugung oder behandlung von krebs
EP3955923A1 (de) 2019-04-18 2022-02-23 The Regents Of The University Of Michigan Kombination mit checkpoint-inhibitoren zur behandlung von krebs
JP2023510158A (ja) 2019-12-27 2023-03-13 エヴェロ バイオサイエンシズ，インコーポレーテッド 細菌及び微生物細胞外小胞を含有する固形剤形
TW202140051A (zh) 2020-01-17 2021-11-01 美商艾弗洛生物科技股份有限公司 具有改善的崩散譜之固體劑型
KR20230004619A (ko) 2020-04-17 2023-01-06 에벨로 바이오사이언시즈, 인크. 붕해 프로파일이 개선된 고체 투여 형태
AU2021280261A1 (en) 2020-05-26 2023-01-19 Dionis Therapeutics, Inc. Nucleic acid artificial mini-proteome libraries
WO2021248093A1 (en) 2020-06-05 2021-12-09 Henry Ford Health System Daclatasvir for use in treating lung and prostate cancer
MX2023003089A (es) 2020-09-18 2023-05-09 Evelo Biosciences Inc Formas farmaceuticas solidas de bacterias.
TW202227111A (zh) 2020-09-21 2022-07-16 美商艾弗洛生物科技股份有限公司 具有改善的崩散譜之固體劑型
KR20230127985A (ko) 2020-10-29 2023-09-01 에벨로 바이오사이언시즈, 인크. 스피룰리나 성분을 포함하는 조성물
JP2024501481A (ja) 2020-12-14 2024-01-12 エヴェロ バイオサイエンシズ，インコーポレーテッド 細胞外小胞調製物
EP4267554A1 (de) 2020-12-22 2023-11-01 Mekanistic Therapeutics LLC Substituierte aminobenzylheteroarylverbindungen als egfr- und/oder pi3k-hemmer
EP4267154A1 (de) 2020-12-22 2023-11-01 Evelo Biosciences, Inc. Zusammensetzungen mit tierhämoglobin
WO2022164806A1 (en) 2021-01-26 2022-08-04 Evelo Biosciences, Inc. Prevotella extracellular vesicle preparations
EP4297762A1 (de) 2021-02-26 2024-01-03 Evelo Biosciences, Inc. Zusammensetzungen und verfahren zur reduzierung der cytokinexpression
WO2022187578A1 (en) 2021-03-05 2022-09-09 Evelo Biosciences, Inc. Solid dosage forms
WO2022189861A1 (en) 2021-03-08 2022-09-15 Tollys Carbohydrate conjugates of tlr3 ligands and uses thereof
KR20240006543A (ko) 2021-04-08 2024-01-15 에벨로 바이오사이언시즈, 인크. 박테리아를 함유하는 약학적 조성물
WO2022221183A1 (en) 2021-04-12 2022-10-20 Evelo Biosciences, Inc. Fournierella extracellular vesicle preparations
WO2022251166A2 (en) 2021-05-25 2022-12-01 Evelo Biosciences, Inc. Bacterial compositions comprising soy hemoglobin
WO2023016321A1 (zh) 2021-08-10 2023-02-16 贝达药业股份有限公司 恩沙替尼或其盐在治疗携带met 14外显子跳跃突变的疾病中的用途
EP4404921A1 (de) 2021-09-24 2024-07-31 Evelo Biosciences, Inc. Feste darreichungsformen mit bakterien und mikrobiellen extrazellulären vesikeln
EP4426829A1 (de) 2021-11-01 2024-09-11 Dana-Farber Cancer Institute, Inc. Biologisch ausgewählte bibliotheken künstlicher miniproteome von nukleinsäuren
WO2023114300A1 (en) 2021-12-14 2023-06-22 Evelo Biosciences, Inc. Fournierella massiliensis bacteria extracellular vesicle preparations
WO2023114293A1 (en) 2021-12-14 2023-06-22 Evelo Biosciences, Inc. Extracellular vesicle assays
WO2023114295A1 (en) 2021-12-14 2023-06-22 Evelo Biosciences, Inc. Veillonella parvula bacteria extracellular vesicle preparations
WO2023146843A1 (en) 2022-01-25 2023-08-03 Evelo Biosciences, Inc. Extracellular vesicle compositions and methods of use
WO2023183396A1 (en) 2022-03-22 2023-09-28 Evelo Biosciences, Inc. Compositions and methods of treating inflammation using prevotella histicola
WO2023200837A1 (en) 2022-04-13 2023-10-19 Evelo Biosciences, Inc. Compositions and methods of treating inflammation using prevotella histicola
WO2023239728A1 (en) 2022-06-07 2023-12-14 Evelo Biosciences, Inc. Compositions and methods of treating inflammation using prevotella histicola extracellular vesicles
WO2024102226A1 (en) 2022-10-14 2024-05-16 Evelo Biosciences, Inc. Methods for assaying drug substances and drug products by using cell lines with nf-kb- inducible reporter genes

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2921883A (en) * 1957-05-03 1960-01-19 Smith Kline French Lab Novel coating material for medicaments
DE2336218C3 (de) * 1973-07-17 1985-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Orale Arzneiform
WO1981002671A1 (en) 1980-03-20 1981-10-01 Ferring Farma Lab Pharmaceutical composition and method for the treatment of colitis ulcerosa and crohn's disease by oral administration
EP0064485B1 (de) * 1981-04-27 1985-07-24 Aktiebolaget Hässle Pharmazeutisches Präparat
ZA825384B (en) 1981-07-31 1983-05-25 Tillott J B Ltd Orally administrable pharmaceutical compositions
US4755387A (en) 1985-03-21 1988-07-05 The Procter & Gamble Company Therapeutic particles
EP0425699B1 (de) 1989-05-11 1994-08-17 Chugai Seiyaku Kabushiki Kaisha Mundzubereitung zur verabreichung an bestimmter stelle des darmes
IE61651B1 (en) * 1990-07-04 1994-11-16 Zambon Spa Programmed release oral solid pharmaceutical dosage form
JP2773959B2 (ja) 1990-07-10 1998-07-09 信越化学工業株式会社 大腸内放出性固形製剤
JPH06256166A (ja) 1993-01-06 1994-09-13 ▲寛▼治 ▲高▼田 薬物放出制御製剤
JPH072650A (ja) * 1993-06-18 1995-01-06 Tanabe Seiyaku Co Ltd 放出部位制御型製剤
JP2917799B2 (ja) * 1994-03-11 1999-07-12 田辺製薬株式会社 消化管内適所放出型製剤
JPH08143476A (ja) 1994-11-18 1996-06-04 Japan Tobacco Inc 薬物放出制御膜及び固形製剤
JPH10120571A (ja) 1996-10-22 1998-05-12 Sato Yakuhin Kogyo Kk 塩酸ジルチアゼム徐放性製剤
JP3047325B2 (ja) 1997-01-07 2000-05-29 謙二 徳永 品質劣化を抑制したローヤルゼリー錠剤の製造方法

Also Published As

Publication number Publication date
CN1311667A (zh) 2001-09-05
US6638534B1 (en) 2003-10-28
AU4800999A (en) 2000-02-21
KR100501022B1 (ko) 2005-07-18
EP1101490A1 (de) 2001-05-23
EP1101490B1 (de) 2005-04-13
KR20010074757A (ko) 2001-08-09
DE69924735D1 (de) 2005-05-19
WO2000006128A1 (fr) 2000-02-10
CA2338780A1 (en) 2000-02-10
EP1101490A4 (de) 2002-04-03
CA2338780C (en) 2007-01-02
DE69924735T2 (de) 2006-01-19
CN1163223C (zh) 2004-08-25

Similar Documents

Publication Publication Date Title
ATE292961T1 (de) Zur wirkstoffabgabe an zielorten im darm fähige zubereitung
KR0138651B1 (ko) 치아질환을 경감시키는데 유용한 개선된 상분리-미소봉입된 제약학적 조성물
ATE285228T1 (de) Arzneistoffverabreichungsystem zur verzögerten, völlstandigen wirkstoffabgabe im verdauungstrakt
ATE260649T1 (de) Pharmazeutische formulierung und dosierform bestehend aus polysacchariden zur kontrollierten wirkstoff-freisetzung im dickdarm
ATE225165T1 (de) Im unteren teil des verdauungstrakts freisetzende pharmazeutische zubereitung in form einer beschichteten kapsel
ATE238774T1 (de) Darreichungsform zur verzögerten, vollständigen wirkstoffabgabe im verdauungstrakt
IL161628A0 (en) Pharmaceutical dosage form with multiple coatings
ES2162874T3 (es) Composicion farmaceutica para hacer llegar medicamentos hasta el colon.
ATE213936T1 (de) Pharmazeutische dosisform mit mehrfacher darmlöslicher polymerbeschichtung zur wirkstoffabgabe im kolon
ATE193439T1 (de) Kontrolliertes pharmazeutisches präparat zur gezielten freisetzung eines medizinischen wirkstoffes im intestinaltrakt
KR880013586A (ko) 고체상태성질을 가진 제거 가능한 기질을 포함하는 투약기
BR9914384A (pt) Dispositivo e método para liberação de um agente ativo em aerossol aos pulmões de um paciente humano
BR9908893A (pt) Composição polimérica lìquida para a liberação controlada de substâncias bioativas hidrofóbicas, e, processo para a liberação controlada de uma substância bioativa hidrofóbica em um animal, incluindo o ser humano
CA2359812A1 (en) Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures
IL118240A (en) Oral coated capsule dosage form of omega-3 polyunsaturated acid for release of the acid in the intestine
NZ235807A (en) Controlled release pellet formulation (core coated with or comprising a glucocorticosteroid, and a polymeric outer coating); capsules containing pellets; and use in treating bowel disease
PT96921B (pt) Dispositivo de libertacao intermitente
ATE366119T1 (de) Chitosanpulver enthaltende feste zubereitungen und verfahren zu deren herstellung
FR2845289B1 (fr) Spheroides, procede de preparation et compositions pharmaceutiques.
ES2053528T3 (es) Composicion farmaceutica que comprende un medicamento y un polimero hinchable en agua.
US20080286348A1 (en) Secured transdermal delivery system
PL88997B1 (de)
IT1244867B (it) Forma farmaceutica a rilascio rapido ritardato
TH13953A (th) ฟิล์มตัวนำส่งยาใช้เฉพาะที่ในการบำบัดโรคปริทันต์
IT1244037B (it) Forma farmaceutica a rilascio selettivo nel colon

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties