CA2609716C - Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile - Google Patents

Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile Download PDF

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Publication number
CA2609716C
CA2609716C CA2609716A CA2609716A CA2609716C CA 2609716 C CA2609716 C CA 2609716C CA 2609716 A CA2609716 A CA 2609716A CA 2609716 A CA2609716 A CA 2609716A CA 2609716 C CA2609716 C CA 2609716C
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CA
Canada
Prior art keywords
process according
formula
acid
compound
reaction
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Active
Application number
CA2609716A
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English (en)
French (fr)
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CA2609716A1 (en
Inventor
Didier Philippe Robert Schils
Alfred Elisabeth Stappers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Sciences Ireland ULC
Original Assignee
Tibotec Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Tibotec Pharmaceuticals Ltd filed Critical Tibotec Pharmaceuticals Ltd
Publication of CA2609716A1 publication Critical patent/CA2609716A1/en
Application granted granted Critical
Publication of CA2609716C publication Critical patent/CA2609716C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA2609716A 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile Active CA2609716C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05104531.8 2005-05-26
EP05104531 2005-05-26
US68599305P 2005-05-31 2005-05-31
US60/685,993 2005-05-31
PCT/EP2006/062606 WO2006125809A1 (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile

Publications (2)

Publication Number Publication Date
CA2609716A1 CA2609716A1 (en) 2006-11-30
CA2609716C true CA2609716C (en) 2014-10-14

Family

ID=35822492

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2609716A Active CA2609716C (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile

Country Status (19)

Country Link
US (2) US8101752B2 (https=)
EP (1) EP1888537B1 (https=)
JP (2) JP5148483B2 (https=)
CN (1) CN101248051B (https=)
AU (1) AU2006251163C1 (https=)
BR (1) BRPI0611038B8 (https=)
CA (1) CA2609716C (https=)
DK (1) DK1888537T3 (https=)
ES (1) ES2437202T3 (https=)
HR (1) HRP20131133T1 (https=)
IN (1) IN2014DN04588A (https=)
ME (1) ME01612B (https=)
MX (1) MX2007014881A (https=)
PL (1) PL1888537T3 (https=)
PT (1) PT1888537E (https=)
RS (1) RS53062B (https=)
RU (1) RU2458056C2 (https=)
SI (1) SI1888537T1 (https=)
WO (1) WO2006125809A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006251163C1 (en) * 2005-05-26 2012-07-12 Janssen Sciences Ireland Uc Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile
WO2012125993A1 (en) 2011-03-17 2012-09-20 Teva Pharmaceutical Industries Ltd. Solid state forms of rilpivirine base, and rilipivirine salts
MX351340B (es) 2012-03-13 2017-10-11 Octapharma Ag Proceso mejorado para la produccion de fibrinogeno y fibrinogeno producido por este.
CN103058936B (zh) * 2013-01-23 2016-01-06 宁波九胜创新医药科技有限公司 4-[(4-氯-2-嘧啶基)氨基]苯腈的制备方法
CN103193719B (zh) * 2013-04-08 2015-07-22 宁波九胜创新医药科技有限公司 一种4-[(4-羟基-2-嘧啶基)氨基]苯腈的制备方法
CN114933567B (zh) * 2022-04-29 2023-07-11 武汉工程大学 一种2-甲硫基-4-嘧啶酮的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63502B1 (en) 1989-04-21 1995-05-03 Zeneca Ltd Aminopyrimidine derivatives useful for treating cardiovascular disorders
DE3923979A1 (de) 1989-07-20 1991-01-24 Merck Patent Gmbh Verfahren zur herstellung von aromatischen nitrilen
RU2037483C1 (ru) * 1989-07-20 1995-06-19 Мерк Патент Гмбх Способ получения замещенных ароматических нитрилов
CZ299380B6 (cs) * 1998-03-27 2008-07-09 Janssen Pharmaceutica N. V. Pyrimidinová sloucenina, použití této slouceniny pro prípravu léciva, farmaceutický prostredek tutoslouceninu obsahující, zpusob prípravy tohoto prostredku a uvedené slouceniny a kombinace a produktuvedenou slouceninu obsahující
HRP20080359B1 (hr) * 1998-11-10 2016-01-01 Janssen Pharmaceutica N.V. PIRIMIDINI KOJI INHIBIRAJU REPLIKACIJU HIV-a
CA2384188C (en) * 1999-09-24 2008-06-17 Janssen Pharmaceutica N.V. Antiviral compositions
JP4969010B2 (ja) * 2000-05-08 2012-07-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｈｉｖ複製阻害性ピリミジンのプロドラッグ
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
MXPA04004178A (es) * 2001-11-01 2004-09-06 Janssen Pharmaceutica Nv Heteroarilaminas como inhibidores de glucogeno cintasa cinasa 3beta.
KR101140785B1 (ko) * 2002-08-09 2012-05-03 얀센 파마슈티카 엔.브이. 4-〔〔4-〔〔4-（2-시아노에테닐）-2,6-디메틸페닐〕아미노〕-2-피리미디닐〕아미노〕벤조니트릴의 제조방법
EP1673348B1 (en) * 2003-09-30 2009-04-01 Janssen Pharmaceutica N.V. Benzoimidazole compounds
AU2006251163C1 (en) * 2005-05-26 2012-07-12 Janssen Sciences Ireland Uc Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile

Also Published As

Publication number Publication date
US8101752B2 (en) 2012-01-24
CN101248051B (zh) 2013-07-17
PT1888537E (pt) 2013-11-26
ES2437202T3 (es) 2014-01-09
BRPI0611038A2 (pt) 2010-08-10
JP2008545680A (ja) 2008-12-18
CN101248051A (zh) 2008-08-20
CA2609716A1 (en) 2006-11-30
AU2006251163A1 (en) 2006-11-30
EP1888537A1 (en) 2008-02-20
RU2458056C2 (ru) 2012-08-10
RU2007148968A (ru) 2009-07-10
HK1123551A1 (en) 2009-06-19
JP2013040194A (ja) 2013-02-28
DK1888537T3 (da) 2013-12-09
BRPI0611038B8 (pt) 2022-10-25
BRPI0611038B1 (pt) 2022-02-08
WO2006125809A1 (en) 2006-11-30
US8618291B2 (en) 2013-12-31
ME01612B (me) 2014-09-20
PL1888537T3 (pl) 2014-02-28
AU2006251163B2 (en) 2012-03-08
US20120083606A1 (en) 2012-04-05
RS53062B (sr) 2014-04-30
US20080171878A1 (en) 2008-07-17
AU2006251163C1 (en) 2012-07-12
EP1888537B1 (en) 2013-09-11
JP5148483B2 (ja) 2013-02-20
IN2014DN04588A (https=) 2015-07-10
SI1888537T1 (sl) 2014-01-31
JP5580385B2 (ja) 2014-08-27
HRP20131133T1 (hr) 2014-01-03
MX2007014881A (es) 2008-02-15

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