CA2609716C - Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile - Google Patents

Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile Download PDF

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Publication number
CA2609716C
CA2609716C CA2609716A CA2609716A CA2609716C CA 2609716 C CA2609716 C CA 2609716C CA 2609716 A CA2609716 A CA 2609716A CA 2609716 A CA2609716 A CA 2609716A CA 2609716 C CA2609716 C CA 2609716C
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CA
Canada
Prior art keywords
process according
formula
acid
compound
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2609716A
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English (en)
French (fr)
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CA2609716A1 (en
Inventor
Didier Philippe Robert Schils
Alfred Elisabeth Stappers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Sciences Ireland ULC
Original Assignee
Tibotec Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35822492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2609716(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharmaceuticals Ltd filed Critical Tibotec Pharmaceuticals Ltd
Publication of CA2609716A1 publication Critical patent/CA2609716A1/en
Application granted granted Critical
Publication of CA2609716C publication Critical patent/CA2609716C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA2609716A 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile Active CA2609716C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05104531 2005-05-26
EP05104531.8 2005-05-26
US68599305P 2005-05-31 2005-05-31
US60/685,993 2005-05-31
PCT/EP2006/062606 WO2006125809A1 (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino benzonitrile

Publications (2)

Publication Number Publication Date
CA2609716A1 CA2609716A1 (en) 2006-11-30
CA2609716C true CA2609716C (en) 2014-10-14

Family

ID=35822492

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2609716A Active CA2609716C (en) 2005-05-26 2006-05-24 Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile

Country Status (19)

Country Link
US (2) US8101752B2 (OSRAM)
EP (1) EP1888537B1 (OSRAM)
JP (2) JP5148483B2 (OSRAM)
CN (1) CN101248051B (OSRAM)
AU (1) AU2006251163C1 (OSRAM)
BR (1) BRPI0611038B8 (OSRAM)
CA (1) CA2609716C (OSRAM)
DK (1) DK1888537T3 (OSRAM)
ES (1) ES2437202T3 (OSRAM)
HR (1) HRP20131133T1 (OSRAM)
IN (1) IN2014DN04588A (OSRAM)
ME (1) ME01612B (OSRAM)
MX (1) MX2007014881A (OSRAM)
PL (1) PL1888537T3 (OSRAM)
PT (1) PT1888537E (OSRAM)
RS (1) RS53062B (OSRAM)
RU (1) RU2458056C2 (OSRAM)
SI (1) SI1888537T1 (OSRAM)
WO (1) WO2006125809A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2609716C (en) * 2005-05-26 2014-10-14 Tibotec Pharmaceuticals Ltd. Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile
WO2012125993A1 (en) 2011-03-17 2012-09-20 Teva Pharmaceutical Industries Ltd. Solid state forms of rilpivirine base, and rilipivirine salts
EP2825555B1 (en) 2012-03-13 2017-07-12 Octapharma AG Mproved process for production of fibrinogen and fibrinogen produced thereby
CN103058936B (zh) * 2013-01-23 2016-01-06 宁波九胜创新医药科技有限公司 4-[(4-氯-2-嘧啶基)氨基]苯腈的制备方法
CN103193719B (zh) * 2013-04-08 2015-07-22 宁波九胜创新医药科技有限公司 一种4-[(4-羟基-2-嘧啶基)氨基]苯腈的制备方法
CN114933567B (zh) * 2022-04-29 2023-07-11 武汉工程大学 一种2-甲硫基-4-嘧啶酮的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63502B1 (en) * 1989-04-21 1995-05-03 Zeneca Ltd Aminopyrimidine derivatives useful for treating cardiovascular disorders
DE3923979A1 (de) 1989-07-20 1991-01-24 Merck Patent Gmbh Verfahren zur herstellung von aromatischen nitrilen
RU2037483C1 (ru) * 1989-07-20 1995-06-19 Мерк Патент Гмбх Способ получения замещенных ароматических нитрилов
HU230522B1 (hu) * 1998-03-27 2016-10-28 Janssen Pharmaceutica N.V HIV-gátló pirimidinszármazékok
HU227453B1 (en) * 1998-11-10 2011-06-28 Janssen Pharmaceutica Nv Hiv replication inhibiting pyrimidines, and pharmaceutical compositions containing them
SI1225874T1 (sl) * 1999-09-24 2006-06-30 Janssen Pharmaceutica Nv Protivirusne trdne disperzije
ES2559273T3 (es) * 2000-05-08 2016-02-11 Janssen Pharmaceutica Nv Profármacos de pirimidinas que inhiben la replicación del VIH
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
IL161662A0 (en) * 2001-11-01 2004-09-27 Janssen Pharmaceutica Nv Heteroaryl amines as glycogen synthase kinase 3 beta inhibitors (gsk3 inhibitors)
CN101481356B (zh) * 2002-08-09 2012-07-11 詹森药业有限公司 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
ES2323178T3 (es) * 2003-09-30 2009-07-08 Janssen Pharmaceutica Nv Compuestos de benzoimidazol.
CA2609716C (en) * 2005-05-26 2014-10-14 Tibotec Pharmaceuticals Ltd. Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile

Also Published As

Publication number Publication date
CN101248051A (zh) 2008-08-20
ME01612B (me) 2014-09-20
AU2006251163C1 (en) 2012-07-12
JP2008545680A (ja) 2008-12-18
EP1888537B1 (en) 2013-09-11
BRPI0611038B8 (pt) 2022-10-25
HRP20131133T1 (hr) 2014-01-03
BRPI0611038A2 (pt) 2010-08-10
DK1888537T3 (da) 2013-12-09
BRPI0611038B1 (pt) 2022-02-08
JP5580385B2 (ja) 2014-08-27
US20080171878A1 (en) 2008-07-17
RS53062B (sr) 2014-04-30
MX2007014881A (es) 2008-02-15
AU2006251163A1 (en) 2006-11-30
PL1888537T3 (pl) 2014-02-28
US8618291B2 (en) 2013-12-31
ES2437202T3 (es) 2014-01-09
US20120083606A1 (en) 2012-04-05
RU2458056C2 (ru) 2012-08-10
JP2013040194A (ja) 2013-02-28
JP5148483B2 (ja) 2013-02-20
CN101248051B (zh) 2013-07-17
US8101752B2 (en) 2012-01-24
CA2609716A1 (en) 2006-11-30
RU2007148968A (ru) 2009-07-10
EP1888537A1 (en) 2008-02-20
WO2006125809A1 (en) 2006-11-30
IN2014DN04588A (OSRAM) 2015-07-10
PT1888537E (pt) 2013-11-26
AU2006251163B2 (en) 2012-03-08
SI1888537T1 (sl) 2014-01-31
HK1123551A1 (en) 2009-06-19

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