CA2607281C - Anti-cd19 antibody therapy for autoimmune disease - Google Patents
Anti-cd19 antibody therapy for autoimmune disease Download PDFInfo
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- CA2607281C CA2607281C CA2607281A CA2607281A CA2607281C CA 2607281 C CA2607281 C CA 2607281C CA 2607281 A CA2607281 A CA 2607281A CA 2607281 A CA2607281 A CA 2607281A CA 2607281 C CA2607281 C CA 2607281C
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
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- Endocrinology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67909505P | 2005-05-05 | 2005-05-05 | |
| US60/679,095 | 2005-05-05 | ||
| PCT/US2006/017402 WO2006121852A2 (en) | 2005-05-05 | 2006-05-05 | Anti-cd19 antibody therapy for autoimmune disease |
Publications (2)
| Publication Number | Publication Date |
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| CA2607281A1 CA2607281A1 (en) | 2006-11-16 |
| CA2607281C true CA2607281C (en) | 2023-10-03 |
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ID=37397123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2607281A Active CA2607281C (en) | 2005-05-05 | 2006-05-05 | Anti-cd19 antibody therapy for autoimmune disease |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20060263357A1 (OSRAM) |
| EP (2) | EP1885755A4 (OSRAM) |
| JP (2) | JP5047947B2 (OSRAM) |
| AU (1) | AU2006244445B2 (OSRAM) |
| CA (1) | CA2607281C (OSRAM) |
| WO (1) | WO2006121852A2 (OSRAM) |
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| US20070249008A1 (en) * | 2004-07-16 | 2007-10-25 | Ziad Mallat | Cardiovascular Prognostic and Diagnostic Marker |
| KR101289537B1 (ko) * | 2005-02-15 | 2013-07-31 | 듀크 유니버시티 | 항-ｃｄ19 항체 및 종양학에서 이의 용도 |
| US8444973B2 (en) | 2005-02-15 | 2013-05-21 | Duke University | Anti-CD19 antibodies and uses in B cell disorders |
| US20060280738A1 (en) * | 2005-06-08 | 2006-12-14 | Tedder Thomas F | Anti-CD19 antibody therapy for transplantation |
| CN101198698B (zh) | 2005-03-31 | 2014-03-19 | 中外制药株式会社 | 通过调节多肽缔合制备多肽的方法 |
| KR20080032097A (ko) * | 2005-06-20 | 2008-04-14 | 메다렉스, 인코포레이티드 | 씨디19 항체 및 그의 용도 |
| EP3056568B1 (en) | 2006-03-31 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| JP5144499B2 (ja) | 2006-03-31 | 2013-02-13 | 中外製薬株式会社 | 二重特異性抗体を精製するための抗体改変方法 |
| EP1884571A1 (en) * | 2006-07-31 | 2008-02-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of spla2 activity for the diagnosis of a cardiovascular event |
| HRP20140331T1 (hr) | 2006-08-14 | 2014-05-09 | Xencor, Inc. | Optimizirana antitijela usmjerena na cd19 |
| MX2009002414A (es) | 2006-09-08 | 2009-05-20 | Medimmune Llc | Anticuerpos anti-cd19 humanizados y su uso en el tratamiento de oncologia, transplante y enfermedad autoinmunitaria. |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| RU2526512C2 (ru) | 2007-09-26 | 2014-08-20 | Чугаи Сейяку Кабусики Кайся | Модифицированная константная область антитела |
| PT2211904T (pt) | 2007-10-19 | 2016-11-02 | Seattle Genetics Inc | Agentes de ligação a cd19 e seus usos |
| US9669057B2 (en) | 2008-04-25 | 2017-06-06 | Duke University | Regulatory B cells and their uses |
| EP2899209A1 (en) * | 2008-04-29 | 2015-07-29 | Abbvie Inc. | Dual Variable Domain Immunoglobulins and uses thereof |
| EP2297208A4 (en) | 2008-06-03 | 2012-07-11 | Abbott Lab | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES |
| BRPI0913406A2 (pt) | 2008-06-03 | 2018-01-09 | Abbott Lab | imunoglobulinas de domínio variável duplo e usos das mesmas |
| US8822645B2 (en) * | 2008-07-08 | 2014-09-02 | Abbvie Inc. | Prostaglandin E2 dual variable domain immunoglobulins and uses thereof |
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2006
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- 2006-05-05 JP JP2008510254A patent/JP5047947B2/ja active Active
- 2006-05-05 EP EP10159451A patent/EP2221316A1/en not_active Withdrawn
- 2006-05-05 CA CA2607281A patent/CA2607281C/en active Active
- 2006-05-05 WO PCT/US2006/017402 patent/WO2006121852A2/en not_active Ceased
- 2006-05-05 AU AU2006244445A patent/AU2006244445B2/en active Active
- 2006-05-05 US US11/429,545 patent/US20060263357A1/en not_active Abandoned
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2008
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2012
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Also Published As
| Publication number | Publication date |
|---|---|
| JP5047947B2 (ja) | 2012-10-10 |
| US20100158901A1 (en) | 2010-06-24 |
| AU2006244445A1 (en) | 2006-11-16 |
| EP1885755A2 (en) | 2008-02-13 |
| EP2221316A1 (en) | 2010-08-25 |
| WO2006121852A3 (en) | 2007-02-08 |
| WO2006121852A2 (en) | 2006-11-16 |
| JP2008540447A (ja) | 2008-11-20 |
| AU2006244445B2 (en) | 2013-04-18 |
| US20060263357A1 (en) | 2006-11-23 |
| CA2607281A1 (en) | 2006-11-16 |
| JP2012211143A (ja) | 2012-11-01 |
| EP1885755A4 (en) | 2009-07-29 |
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