CA2604032C - Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses - Google Patents

Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses Download PDF

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CA2604032C
CA2604032C CA2604032A CA2604032A CA2604032C CA 2604032 C CA2604032 C CA 2604032C CA 2604032 A CA2604032 A CA 2604032A CA 2604032 A CA2604032 A CA 2604032A CA 2604032 C CA2604032 C CA 2604032C
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antigen
homodimer
antibody
fab
treating
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CA2604032A1 (en
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Chien-Hsing Chang
David M. Goldenberg
William J. Mcbride
Edmund A. Rossi
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IBC Pharmaceuticals Inc
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IBC Pharmaceuticals Inc
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/65Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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CA2604032A 2005-04-06 2006-03-24 Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses Active CA2604032C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US66860305P 2005-04-06 2005-04-06
US60/668,603 2005-04-06
US72829205P 2005-10-19 2005-10-19
US60/728,292 2005-10-19
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