CA2585974C - Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof - Google Patents

Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof Download PDF

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Publication number
CA2585974C
CA2585974C CA2585974A CA2585974A CA2585974C CA 2585974 C CA2585974 C CA 2585974C CA 2585974 A CA2585974 A CA 2585974A CA 2585974 A CA2585974 A CA 2585974A CA 2585974 C CA2585974 C CA 2585974C
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lpei
cross
linked
biodegradable
water
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Expired - Lifetime
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CA2585974A
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English (en)
French (fr)
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CA2585974A1 (en
Inventor
Gregory Slobodkin
Majed Matar
Jason Fewell
Khursheed Anwer
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CLSN LABORATORIES Inc
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CLSN LABORATORIES Inc
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA2585974A 2004-11-03 2005-11-03 Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof Expired - Lifetime CA2585974C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/981,135 2004-11-03
US10/981,135 US8057821B2 (en) 2004-11-03 2004-11-03 Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
PCT/US2005/039779 WO2006052649A2 (en) 2004-11-03 2005-11-03 Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof

Publications (2)

Publication Number Publication Date
CA2585974A1 CA2585974A1 (en) 2006-05-18
CA2585974C true CA2585974C (en) 2017-07-04

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CA2585974A Expired - Lifetime CA2585974C (en) 2004-11-03 2005-11-03 Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof

Country Status (7)

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US (2) US8057821B2 (enExample)
EP (1) EP1807054A4 (enExample)
JP (1) JP5436779B2 (enExample)
KR (1) KR101208192B1 (enExample)
CN (1) CN101094652B (enExample)
CA (1) CA2585974C (enExample)
WO (1) WO2006052649A2 (enExample)

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US8057821B2 (en) 2011-11-15
US20120009145A1 (en) 2012-01-12
JP5436779B2 (ja) 2014-03-05
US8445017B2 (en) 2013-05-21
WO2006052649A2 (en) 2006-05-18
US20060093674A1 (en) 2006-05-04
JP2008519128A (ja) 2008-06-05
CN101094652A (zh) 2007-12-26
KR101208192B1 (ko) 2012-12-04
KR20070085500A (ko) 2007-08-27
WO2006052649A3 (en) 2006-09-14

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