CA2577233C - Pharmaceutical composition containing angiotensin ii antagonist - Google Patents
Pharmaceutical composition containing angiotensin ii antagonist Download PDFInfo
- Publication number
- CA2577233C CA2577233C CA002577233A CA2577233A CA2577233C CA 2577233 C CA2577233 C CA 2577233C CA 002577233 A CA002577233 A CA 002577233A CA 2577233 A CA2577233 A CA 2577233A CA 2577233 C CA2577233 C CA 2577233C
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- Prior art keywords
- activity
- methyl
- group
- ethoxy
- compound
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 23
- 229940123413 Angiotensin II antagonist Drugs 0.000 title description 3
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title description 3
- 150000003839 salts Chemical class 0.000 claims abstract description 100
- 150000001875 compounds Chemical class 0.000 claims abstract description 90
- 101800000733 Angiotensin-2 Proteins 0.000 claims abstract description 44
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 claims abstract description 44
- 229950006323 angiotensin ii Drugs 0.000 claims abstract description 44
- 102000005862 Angiotensin II Human genes 0.000 claims abstract 6
- 239000000203 mixture Substances 0.000 claims description 46
- 230000003042 antagnostic effect Effects 0.000 claims description 33
- HTQMVQVXFRQIKW-UHFFFAOYSA-N candesartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=NN1 HTQMVQVXFRQIKW-UHFFFAOYSA-N 0.000 claims description 21
- KGSXMPPBFPAXLY-UHFFFAOYSA-N azilsartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NOC(=O)N1 KGSXMPPBFPAXLY-UHFFFAOYSA-N 0.000 claims description 13
- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims description 2
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- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims description 2
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- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims description 2
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- 229960002855 simvastatin Drugs 0.000 claims description 2
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 2
- BCPWNYREAURMOP-UHFFFAOYSA-N ethyl 2-ethoxy-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate Chemical compound C1=2C(C(=O)OCC)=CC=CC=2N=C(OCC)N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=NN1 BCPWNYREAURMOP-UHFFFAOYSA-N 0.000 claims 2
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- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 62
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- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical group N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 20
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- 206010020772 Hypertension Diseases 0.000 description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 18
- 241000894007 species Species 0.000 description 18
- MWAWVTYQASXVJZ-QGZVFWFLSA-N (5r)-5-[3-[4-[[2-(furan-2-yl)-5-methyl-1,3-oxazol-4-yl]methoxy]-3-methoxyphenyl]propyl]-1,3-oxazolidine-2,4-dione Chemical compound C=1C=C(OCC2=C(OC(=N2)C=2OC=CC=2)C)C(OC)=CC=1CCC[C@H]1OC(=O)NC1=O MWAWVTYQASXVJZ-QGZVFWFLSA-N 0.000 description 16
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- FDJCVHVKXFIEPJ-JCNFZFLDSA-N Delapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N(CC(O)=O)C1CC2=CC=CC=C2C1)CC1=CC=CC=C1 FDJCVHVKXFIEPJ-JCNFZFLDSA-N 0.000 description 10
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002650637A CA2650637A1 (en) | 1996-04-05 | 1997-04-03 | Pharmaceutical composition containing angiotensin ii antagonist |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8391796 | 1996-04-05 | ||
| JP8/83917 | 1996-04-05 | ||
| CA002241466A CA2241466C (en) | 1996-04-05 | 1997-04-03 | Pharmaceutical composition containing angiotensin ii antagonist |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA002241466A Division CA2241466C (en) | 1996-04-05 | 1997-04-03 | Pharmaceutical composition containing angiotensin ii antagonist |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA002650637A Division CA2650637A1 (en) | 1996-04-05 | 1997-04-03 | Pharmaceutical composition containing angiotensin ii antagonist |
Publications (2)
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| CA2577233A1 CA2577233A1 (en) | 1997-10-16 |
| CA2577233C true CA2577233C (en) | 2009-08-18 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CA002241466A Expired - Fee Related CA2241466C (en) | 1996-04-05 | 1997-04-03 | Pharmaceutical composition containing angiotensin ii antagonist |
| CA002577233A Expired - Fee Related CA2577233C (en) | 1996-04-05 | 1997-04-03 | Pharmaceutical composition containing angiotensin ii antagonist |
| CA002650637A Abandoned CA2650637A1 (en) | 1996-04-05 | 1997-04-03 | Pharmaceutical composition containing angiotensin ii antagonist |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA002241466A Expired - Fee Related CA2241466C (en) | 1996-04-05 | 1997-04-03 | Pharmaceutical composition containing angiotensin ii antagonist |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002650637A Abandoned CA2650637A1 (en) | 1996-04-05 | 1997-04-03 | Pharmaceutical composition containing angiotensin ii antagonist |
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| EP (4) | EP0914158B2 (cs) |
| JP (2) | JPH09323940A (cs) |
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| AU (1) | AU713277B2 (cs) |
| BR (1) | BR9708517A (cs) |
| CA (3) | CA2241466C (cs) |
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| PT (1) | PT914158E (cs) |
| RU (1) | RU2188013C2 (cs) |
| SI (1) | SI0914158T2 (cs) |
| SK (1) | SK283348B6 (cs) |
| WO (1) | WO1997037688A2 (cs) |
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| US6268392B1 (en) * | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| EP0835106A4 (en) * | 1995-06-30 | 1998-09-30 | Merck & Co Inc | METHOD FOR TREATING KIDNEY DISEASES USING AN ACE INHIBITOR AND AII ANTAGONIST |
| NZ286920A (en) * | 1995-07-03 | 1997-06-24 | Sankyo Co | Use of combination of hmg-coa reductase inhibitors and of insulin sensitizers for the prevention/treatment of arteriosclerosis or xanthoma |
| PT914158E (pt) * | 1996-04-05 | 2002-11-29 | Takeda Chemical Industries Ltd | Combinacao farmaceutica que incorpora um composto que possui actividade antagonista da angiotensina ii e um composto que aumenta a sensibilidade a insulina |
| DE69731840T2 (de) | 1996-07-15 | 2005-08-04 | Sankyo Co., Ltd. | Pharmazeutische Zusammensetzungen enthaltend CS-866 und Insulinresistenz verbessernde Mittel und deren Verwendung zur Behandlung von Arteriosklerose und Xanthom |
| JP2008094852A (ja) * | 1996-07-15 | 2008-04-24 | Daiichi Sankyo Co Ltd | 医薬 |
| CA2300813A1 (en) * | 1997-08-21 | 1999-03-04 | Hiroyuki Odaka | Anti-inflammatory agent |
| US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| CA2355293C (en) | 1998-12-23 | 2005-08-16 | Orphan Medical, Inc. | Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy |
| US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
| AU3073700A (en) * | 1999-01-19 | 2000-08-07 | Sankyo Company Limited | Troglitazone-containing medicinal compositions for inhibiting apoptosis |
| GB0001662D0 (en) | 1999-02-06 | 2000-03-15 | Zeneca Ltd | Pharmaceutical compositions |
| US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| EP1197223B1 (en) | 1999-04-28 | 2005-02-16 | Takeda Pharmaceutical Company Limited | Preventives / remedies / progression inhibitors for simplex retinopathy or preproliferating retinopathy |
| DE60037192T2 (de) * | 1999-07-21 | 2008-05-15 | Takeda Pharmaceutical Co. Ltd. | Mittel zur verbesserung der erkrankungen nach zerebralen durchblutungsstörungen sowie zur verhinderung deren fortschreitens |
| TWI290470B (en) | 1999-12-01 | 2007-12-01 | Sankyo Co | The composition for treating glaucoma |
| HUP0301057A3 (en) * | 2000-02-18 | 2004-01-28 | Takeda Pharmaceutical | Angiotenzin ii antagonist heterocyclic compound an their use for preparation of tnf-alpha inhibitors |
| US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| US20060089389A1 (en) | 2000-08-22 | 2006-04-27 | Malcolm Allison | Combination |
| AR033390A1 (es) * | 2000-08-22 | 2003-12-17 | Novartis Ag | Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes |
| EP1314425A4 (en) * | 2000-08-30 | 2004-06-02 | Sankyo Co | MEDICINAL COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF HEART FAILURE |
| EP1370210A4 (en) * | 2001-02-07 | 2004-08-18 | Mclean Hospital Corp | HYPOCHOLESTEROLEMIANTS USED TO TREAT PSYCHOLOGICAL AND COGNITIVE DISORDERS |
| US20030078190A1 (en) * | 2001-05-25 | 2003-04-24 | Weinberg Marc S. | Methods for tissue protection using highly effective inhibition of the renin-angiotensin system |
| GB0113570D0 (en) | 2001-06-04 | 2001-07-25 | Hewlett Packard Co | Audio-form presentation of text messages |
| EP1413315A4 (en) * | 2001-08-03 | 2006-08-16 | Takeda Pharmaceutical | DRUGS WITH CONTINUOUS RELEASE |
| JP4484427B2 (ja) * | 2001-12-03 | 2010-06-16 | 武田薬品工業株式会社 | インスリン抵抗性改善剤 |
| US20050032854A1 (en) * | 2001-12-03 | 2005-02-10 | Kiminori Kawahara | Insulin resistance improving agents |
| MY131170A (en) | 2002-03-28 | 2007-07-31 | Nissan Chemical Ind Ltd | Therapeutic agent for glomerular disease |
| US20030229007A1 (en) * | 2002-05-30 | 2003-12-11 | Roberto Levi | Form of human renin and its use as a target in treatments for cardiac ischemia and arrhythmia |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US7232828B2 (en) | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| EP1545540A2 (en) * | 2002-08-21 | 2005-06-29 | Merck & Co., Inc. | Combination therapy using a dual ppar alpha/gamma agonist and an angiotensin ii type i receptor antagonist |
| US7582662B2 (en) * | 2002-12-27 | 2009-09-01 | Takeda Pharmaceutical Company Limited | Body weight gain inhibitor |
| DE10301371A1 (de) * | 2003-01-16 | 2004-08-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische Kombination zur Prophylaxe oder Therapie von kardiovaskulären, kardiopulmonalen, pulmonalen oder renalen Krankheiten |
| KR20050092119A (ko) * | 2003-01-16 | 2005-09-20 | 베링거 인겔하임 인터내셔날 게엠베하 | 심혈관 질환, 심폐 질환, 폐 질환 또는 신장 질환을예방하거나 치료하기 위한 약제학적 배합물 |
| JPWO2005011736A1 (ja) * | 2003-07-30 | 2006-09-14 | 株式会社 東北テクノアーチ | アルツハイマー病の予防および／または治療剤 |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| GB0322552D0 (en) | 2003-09-26 | 2003-10-29 | Astrazeneca Uk Ltd | Therapeutic treatment |
| US20050250734A1 (en) * | 2003-11-07 | 2005-11-10 | The Procter & Gamble Company | Compositions, kits, and methods for the treatment of conditions associated with elevated cholesterol levels |
| WO2005070398A2 (en) * | 2004-01-23 | 2005-08-04 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of candesartan cilexetil stabilized with co-solvents |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| US20060039890A1 (en) * | 2004-08-20 | 2006-02-23 | Renshaw Perry F | Treatment of psychological and cognitive disorders using a cholesterol -lowering agent in combination with an antidepressant |
| CA2583768A1 (en) * | 2004-10-07 | 2006-04-13 | Takeda Pharmaceutical Company Limited | Agent for prophylaxis or treatment of metabolic syndrome |
| ATE518526T1 (de) * | 2005-01-26 | 2011-08-15 | Lek Pharmaceuticals | Neue pharmazeutische zusammensetzung mit candesartan-cilexetil als lipophile kristalline substanz |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| JP4795362B2 (ja) * | 2005-03-30 | 2011-10-19 | 武田薬品工業株式会社 | ベンズイミダゾール誘導体およびその用途 |
| CA2677661A1 (en) | 2007-02-07 | 2008-08-14 | Kyowa Hakko Kirin Co., Ltd. | Tricyclic compounds |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| JP5283632B2 (ja) * | 2007-03-28 | 2013-09-04 | 武田薬品工業株式会社 | ベンズイミダゾール−７−カルボキシレート誘導体およびｐＨ調整剤を含有する固形医薬組成物 |
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| LT2838512T (lt) | 2012-04-18 | 2018-11-12 | GrĆ¼nenthal GmbH | Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| EP2873422A4 (en) * | 2012-07-10 | 2015-12-30 | Takeda Pharmaceutical | PHARMACEUTICAL PREPARATION FOR INJECTION |
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| JP6445537B2 (ja) | 2013-05-29 | 2018-12-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | １個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形 |
| US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| HK1224189A1 (zh) | 2013-11-26 | 2017-08-18 | Grünenthal GmbH | 通过低温研磨制备粉状药物组合物 |
| US20150320690A1 (en) | 2014-05-12 | 2015-11-12 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
| MX2016015417A (es) | 2014-05-26 | 2017-02-22 | Gruenenthal Gmbh | Multiparticulas protegidas contra vertido de dosis etanolico. |
| CA2983642A1 (en) | 2015-04-24 | 2016-10-27 | Grunenthal Gmbh | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
| JP2018526414A (ja) | 2015-09-10 | 2018-09-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0238580B2 (ja) * | 1981-06-02 | 1990-08-31 | Takeda Chemical Industries Ltd | Bariooruaminnonnchikanjudotai*sonoseizohooyobyoto |
| CA2016710A1 (en) * | 1989-05-15 | 1990-11-15 | Prasun K. Chakravarty | Substituted benzimidazoles as angiotensin ii antagonists |
| ES2059121T5 (es) * | 1990-02-09 | 2000-12-01 | Upjohn Co | Uso de agentes sensibilizantes de la insulina para tratar la hipertension. |
| US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| DK0527879T3 (da) * | 1990-05-11 | 1997-07-14 | Pfizer | Synergistiske terapeutiske præparater og fremgangsmåder. |
| US5298497A (en) * | 1990-05-15 | 1994-03-29 | E. R. Squibb & Sons, Inc. | Method for preventing onset of hypertension employing a cholesterol lowering drug |
| CA2040865C (en) * | 1990-05-15 | 2002-07-23 | James L. Bergey | Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor |
| ATE177634T1 (de) * | 1990-12-14 | 1999-04-15 | Smithkline Beecham Corp | Angiotensin-ii-rezeptor blockierende zusammensetzungen |
| AU1256692A (en) * | 1991-02-06 | 1992-09-07 | Schering Corporation | Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor |
| EP0503838A3 (en) * | 1991-03-08 | 1992-10-07 | Merck & Co. Inc. | Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists |
| US5162340A (en) * | 1991-05-10 | 1992-11-10 | Merck & Co., Inc. | Substituted 1-(2h)-isoquinolinones bearing acidic functional groups as angiotensin ii antagonists |
| HU9203780D0 (en) * | 1991-12-12 | 1993-03-29 | Sandoz Ag | Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them |
| JPH07505646A (ja) * | 1992-04-13 | 1995-06-22 | ゼネカ・リミテッド | 神経伝達速度の減損を伴う障害，特に糖尿病性ニューロパシーに対するアンギオテンシンｉｉアンタゴニスト |
| US5266583A (en) * | 1992-09-01 | 1993-11-30 | Merck & Co., Inc. | Angitotensin II antagonist |
| DE4315349A1 (de) * | 1992-10-06 | 1994-11-10 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5300668A (en) * | 1993-03-10 | 1994-04-05 | Pfizer Inc. | Certain esters of 1-(4-X-methylphenyl)cyclopent-3-ene-1-carboxylic acid, wherein X is a trialkylsilyloxy, bromo or hydroxy group, as intermediates |
| JP3057471B2 (ja) * | 1993-06-07 | 2000-06-26 | 武田薬品工業株式会社 | アンジオテンシンｉｉ介在性諸疾患の予防または治療剤 |
| CA2125251C (en) * | 1993-06-07 | 2005-04-26 | Yoshiyuki Inada | A pharmaceutical composition for angiotensin ii-mediated diseases |
| EP0629408A1 (en) * | 1993-06-16 | 1994-12-21 | LABORATOIRES MERCK, SHARP & DOHME-CHIBRET | Combination of angiotensin converting enzyme inhibitors and AII antagonists |
| EP0635263A3 (en) * | 1993-06-28 | 1995-09-27 | American Cyanamid Co | Angiotensin II antagonists (AII) as inhibitors of the growth of adipose tissue. |
| CA2186606A1 (en) * | 1994-03-29 | 1995-10-05 | Edward B. Nelson | Treatment of atherosclerosis with angiotensin ii receptor blocking imidazoles |
| GB9406573D0 (en) * | 1994-03-31 | 1994-05-25 | Merck Sharp & Dohme | Medicaments |
| FR2733911B1 (fr) * | 1995-05-09 | 1998-05-29 | Takeda Chemical Industries Ltd | Composition pharmaceutique pour maladies renales ou cardio-vasculaires |
| FR2735365B1 (fr) * | 1995-06-14 | 1997-09-05 | Sanofi Sa | Utilisation d'un antagoniste de l'angiotensine ii et d'un derive du benzofurane pour la preparation d'un medicament utile dans le traitement des affections cardiovasculaires |
| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| EP0835106A4 (en) * | 1995-06-30 | 1998-09-30 | Merck & Co Inc | METHOD FOR TREATING KIDNEY DISEASES USING AN ACE INHIBITOR AND AII ANTAGONIST |
| NZ286920A (en) * | 1995-07-03 | 1997-06-24 | Sankyo Co | Use of combination of hmg-coa reductase inhibitors and of insulin sensitizers for the prevention/treatment of arteriosclerosis or xanthoma |
| PT914158E (pt) * | 1996-04-05 | 2002-11-29 | Takeda Chemical Industries Ltd | Combinacao farmaceutica que incorpora um composto que possui actividade antagonista da angiotensina ii e um composto que aumenta a sensibilidade a insulina |
-
1997
- 1997-04-03 PT PT97914592T patent/PT914158E/pt unknown
- 1997-04-03 PL PL97329188A patent/PL189066B1/pl not_active IP Right Cessation
- 1997-04-03 EP EP97914592A patent/EP0914158B2/en not_active Expired - Lifetime
- 1997-04-03 RU RU98119885/14A patent/RU2188013C2/ru not_active IP Right Cessation
- 1997-04-03 KR KR1020057007489A patent/KR20050047560A/ko not_active Ceased
- 1997-04-03 CA CA002241466A patent/CA2241466C/en not_active Expired - Fee Related
- 1997-04-03 DE DE69713890T patent/DE69713890T3/de not_active Expired - Lifetime
- 1997-04-03 ES ES97914592T patent/ES2175385T5/es not_active Expired - Lifetime
- 1997-04-03 KR KR1019980706462A patent/KR19990087076A/ko not_active Ceased
- 1997-04-03 CN CN97193515A patent/CN1215338A/zh active Pending
- 1997-04-03 PL PL367915A patent/PL193365B1/pl not_active IP Right Cessation
- 1997-04-03 WO PCT/JP1997/001149 patent/WO1997037688A2/en active IP Right Grant
- 1997-04-03 CA CA002577233A patent/CA2577233C/en not_active Expired - Fee Related
- 1997-04-03 EP EP10173392A patent/EP2253327A1/en not_active Withdrawn
- 1997-04-03 BR BR9708517A patent/BR9708517A/pt not_active IP Right Cessation
- 1997-04-03 AT AT97914592T patent/ATE220333T1/de active
- 1997-04-03 AU AU21780/97A patent/AU713277B2/en not_active Ceased
- 1997-04-03 CZ CZ0288698A patent/CZ297941B6/cs not_active IP Right Cessation
- 1997-04-03 EP EP01124024A patent/EP1192951A3/en not_active Withdrawn
- 1997-04-03 EP EP07009568A patent/EP1813286A3/en not_active Withdrawn
- 1997-04-03 SI SI9730391T patent/SI0914158T2/sl unknown
- 1997-04-03 SK SK1278-98A patent/SK283348B6/sk not_active IP Right Cessation
- 1997-04-03 DK DK97914592T patent/DK0914158T4/da active
- 1997-04-03 NZ NZ330774A patent/NZ330774A/xx not_active IP Right Cessation
- 1997-04-03 CA CA002650637A patent/CA2650637A1/en not_active Abandoned
- 1997-04-03 US US08/836,784 patent/US6107323A/en not_active Expired - Lifetime
- 1997-04-04 JP JP9086484A patent/JPH09323940A/ja active Pending
-
1998
- 1998-09-07 NO NO19984123A patent/NO321388B1/no not_active IP Right Cessation
-
2000
- 2000-04-18 US US09/551,546 patent/US6432996B1/en not_active Expired - Fee Related
-
2002
- 2002-10-22 CY CY0200060A patent/CY2300B1/xx unknown
-
2008
- 2008-04-21 JP JP2008110085A patent/JP2008195736A/ja active Pending
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