CA2575753A1 - Muteins of fibroblast growth factor 21 - Google Patents

Muteins of fibroblast growth factor 21 Download PDF

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Publication number
CA2575753A1
CA2575753A1 CA002575753A CA2575753A CA2575753A1 CA 2575753 A1 CA2575753 A1 CA 2575753A1 CA 002575753 A CA002575753 A CA 002575753A CA 2575753 A CA2575753 A CA 2575753A CA 2575753 A1 CA2575753 A1 CA 2575753A1
Authority
CA
Canada
Prior art keywords
mutein
leucine
fgf
cys
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002575753A
Other languages
English (en)
French (fr)
Inventor
Christopher Carl Frye
Lihua Huang
Radmila Micanovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2575753A1 publication Critical patent/CA2575753A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002575753A 2004-09-02 2005-07-26 Muteins of fibroblast growth factor 21 Abandoned CA2575753A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60680504P 2004-09-02 2004-09-02
US60/606,805 2004-09-02
PCT/US2005/026398 WO2006028595A2 (en) 2004-09-02 2005-07-26 Muteins of fibroblast growth factor 21

Publications (1)

Publication Number Publication Date
CA2575753A1 true CA2575753A1 (en) 2006-03-16

Family

ID=36036790

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002575753A Abandoned CA2575753A1 (en) 2004-09-02 2005-07-26 Muteins of fibroblast growth factor 21

Country Status (21)

Country Link
US (1) US7582607B2 (enExample)
EP (2) EP1789442B1 (enExample)
JP (1) JP4809352B2 (enExample)
KR (1) KR100854198B1 (enExample)
CN (1) CN101010338B (enExample)
AT (1) ATE444307T1 (enExample)
AU (1) AU2005283025B2 (enExample)
BR (1) BRPI0514790A (enExample)
CA (1) CA2575753A1 (enExample)
DE (1) DE602005016946D1 (enExample)
DK (1) DK1789442T3 (enExample)
EA (1) EA011390B1 (enExample)
ES (1) ES2332057T3 (enExample)
HR (1) HRP20090597T1 (enExample)
IL (1) IL181573A0 (enExample)
MX (1) MX2007002616A (enExample)
NO (1) NO20071327L (enExample)
PL (1) PL1789442T3 (enExample)
PT (1) PT1789442E (enExample)
SI (1) SI1789442T1 (enExample)
WO (1) WO2006028595A2 (enExample)

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US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
JP2008507294A (ja) 2004-07-26 2008-03-13 ダウ グローバル テクノロジーズ インコーポレイティド 菌株遺伝子操作による改善されたタンパク質発現のための方法
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US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2615172A1 (en) 2007-04-27 2013-07-17 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
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US9120871B2 (en) 2009-01-23 2015-09-01 Novo Nordisk A/S Process for preparing FGF21 with low degree of O-glycosylation
CN102361647B (zh) 2009-01-23 2018-02-16 诺沃-诺迪斯克有限公司 具有白蛋白结合剂a‑b‑c‑d‑e‑的fgf21衍生物及其应用
BRPI1011404B1 (pt) * 2009-05-05 2022-05-03 Amgen Inc Polipeptídeos mutantes fgf21, polipeptídeo de fusão, multímero, composição farmacêutica, ácido nucleico isolado, vetor e célula hospedeira
AU2010246038A1 (en) * 2009-05-05 2011-12-01 Amgen Inc. FGF21 mutants and uses thereof
WO2011154349A2 (en) 2010-06-08 2011-12-15 Novo Nordisk A/S Fgf21 analogues and derivatives
EP2443145A1 (en) 2009-06-17 2012-04-25 Amgen, Inc Chimeric fgf19 polypeptides and uses thereof
CN101993485B (zh) 2009-08-20 2013-04-17 重庆富进生物医药有限公司 促胰岛素分泌肽类似物同源二聚体及其用途
JP2013512672A (ja) * 2009-12-02 2013-04-18 アムジエン・インコーポレーテツド ヒトＦＧＦＲ１ｃ、ヒトβ−クロト−、ならびにヒトＦＧＦＲ１ｃおよびヒトβ−クロト−の両方に結合する結合タンパク質
UA109888C2 (uk) * 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
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Family Cites Families (12)

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CA2173750C (en) * 1994-08-12 2011-03-22 Irving Boime Single-chain forms of the glycoprotein hormone quartet
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Also Published As

Publication number Publication date
JP4809352B2 (ja) 2011-11-09
NO20071327L (no) 2007-05-29
ES2332057T3 (es) 2010-01-25
EA200700533A1 (ru) 2007-08-31
IL181573A0 (en) 2007-07-04
CN101010338B (zh) 2011-06-15
PT1789442E (pt) 2009-11-11
KR20070050454A (ko) 2007-05-15
BRPI0514790A (pt) 2008-06-24
EP1789442A2 (en) 2007-05-30
CN101010338A (zh) 2007-08-01
ATE444307T1 (de) 2009-10-15
PL1789442T3 (pl) 2010-02-26
US7582607B2 (en) 2009-09-01
DE602005016946D1 (de) 2009-11-12
SI1789442T1 (sl) 2010-01-29
HRP20090597T1 (hr) 2009-12-31
EP2161281A1 (en) 2010-03-10
DK1789442T3 (da) 2009-11-16
WO2006028595A2 (en) 2006-03-16
EA011390B1 (ru) 2009-02-27
AU2005283025A1 (en) 2006-03-16
US20080103096A1 (en) 2008-05-01
WO2006028595A3 (en) 2007-01-18
AU2005283025B2 (en) 2011-06-30
KR100854198B1 (ko) 2008-08-26
JP2008511323A (ja) 2008-04-17
EP1789442B1 (en) 2009-09-30
MX2007002616A (es) 2007-05-16

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EEER Examination request
FZDE Discontinued

Effective date: 20130726