CA2526534C - Compounds and methods for delivery of prostacyclin analogs - Google Patents

Compounds and methods for delivery of prostacyclin analogs Download PDF

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Publication number
CA2526534C
CA2526534C CA2526534A CA2526534A CA2526534C CA 2526534 C CA2526534 C CA 2526534C CA 2526534 A CA2526534 A CA 2526534A CA 2526534 A CA2526534 A CA 2526534A CA 2526534 C CA2526534 C CA 2526534C
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Prior art keywords
treprostinil
compound
groups
group
substituted
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Expired - Lifetime
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CA2526534A
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English (en)
French (fr)
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CA2526534A1 (en
Inventor
Ken Phares
David Mottola
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United Therapeutics Corp
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United Therapeutics Corp
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Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp
Priority to CA2736406A priority Critical patent/CA2736406C/en
Publication of CA2526534A1 publication Critical patent/CA2526534A1/en
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    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
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    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C07C59/13—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups containing rings
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C51/41—Preparation of salts of carboxylic acids
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    • C07C59/40—Unsaturated compounds
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    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
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CA2526534A 2003-05-22 2004-05-24 Compounds and methods for delivery of prostacyclin analogs Expired - Lifetime CA2526534C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2736406A CA2736406C (en) 2003-05-22 2004-05-24 Compositions comprising diethanolamine salts of trepostinil in the treatment of pulmonary hypertension and other cardiovascular diseases

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47240703P 2003-05-22 2003-05-22
US60/472,407 2003-05-22
PCT/US2004/016401 WO2005007081A2 (en) 2003-05-22 2004-05-24 Compounds and methods for delivery of prostacyclin analogs

Related Child Applications (1)

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CA2736406A Division CA2736406C (en) 2003-05-22 2004-05-24 Compositions comprising diethanolamine salts of trepostinil in the treatment of pulmonary hypertension and other cardiovascular diseases

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CA2526534A1 CA2526534A1 (en) 2005-01-27
CA2526534C true CA2526534C (en) 2011-07-12

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Family Applications (4)

Application Number Title Priority Date Filing Date
CA2526534A Expired - Lifetime CA2526534C (en) 2003-05-22 2004-05-24 Compounds and methods for delivery of prostacyclin analogs
CA2851309A Expired - Lifetime CA2851309C (en) 2003-05-22 2004-05-24 Compositions comprising diethanolamine salts of treprostinil in the treatment of pulmonary hypertension and other cardiovascular diseases
CA2959852A Abandoned CA2959852A1 (en) 2003-05-22 2004-05-24 Compounds and methods for delivery of prostacyclin analogs
CA2736406A Expired - Lifetime CA2736406C (en) 2003-05-22 2004-05-24 Compositions comprising diethanolamine salts of trepostinil in the treatment of pulmonary hypertension and other cardiovascular diseases

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CA2851309A Expired - Lifetime CA2851309C (en) 2003-05-22 2004-05-24 Compositions comprising diethanolamine salts of treprostinil in the treatment of pulmonary hypertension and other cardiovascular diseases
CA2959852A Abandoned CA2959852A1 (en) 2003-05-22 2004-05-24 Compounds and methods for delivery of prostacyclin analogs
CA2736406A Expired - Lifetime CA2736406C (en) 2003-05-22 2004-05-24 Compositions comprising diethanolamine salts of trepostinil in the treatment of pulmonary hypertension and other cardiovascular diseases

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US (19) US7417070B2 (https=)
EP (2) EP1628654B2 (https=)
JP (2) JP5043433B2 (https=)
KR (1) KR101072339B1 (https=)
CN (4) CN101265226B (https=)
CA (4) CA2526534C (https=)
ES (2) ES2670872T3 (https=)
WO (1) WO2005007081A2 (https=)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10214983A1 (de) * 2002-04-04 2004-04-08 TransMIT Gesellschaft für Technologietransfer mbH Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen
CN101265226B (zh) * 2003-05-22 2013-04-24 联合治疗公司 化合物和释放前列环素类似物的方法
CA2549801C (en) * 2003-12-16 2012-10-16 United Therapeutics Corporation Use of treprostinil to improve kidney functions
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