CA2509982C - Indoles n-arylsulfonyl-3-substitues presentant une affinite pour le recepteur de la serotonine, methode de preparation et composition pharmaceutique contenant ces indoles - Google Patents

Indoles n-arylsulfonyl-3-substitues presentant une affinite pour le recepteur de la serotonine, methode de preparation et composition pharmaceutique contenant ces indoles Download PDF

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CA2509982C
CA2509982C CA2509982A CA2509982A CA2509982C CA 2509982 C CA2509982 C CA 2509982C CA 2509982 A CA2509982 A CA 2509982A CA 2509982 A CA2509982 A CA 2509982A CA 2509982 C CA2509982 C CA 2509982C
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indole
ylmethyl
methylpiperazin
bromo
methoxybenzenesulfonyl
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CA2509982A1 (fr
Inventor
Venkata Satya Nirogi Ramakrishna
Vikas Shreekrishna Shirsath
Rama Sastri Kambhampati
Venkata Satya Veerabhadra Vadlamudi Rao
Venkateswarlu Jasti
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Suven Life Sciences Ltd
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Suven Life Sciences Ltd
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    • C—CHEMISTRY; METALLURGY
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Child & Adolescent Psychology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés d'indoles N-arylsulfonyl-3-substitués, leurs dérivés, analogues, formes tautomères, stéréoisomères, formes géométriques, N-oxydes, polymorphes, sels pharmaceutiquement acceptables, solvates pharmaceutiquement acceptables, et des compositions pharmaceutiquement acceptables contenant ces composés. L'invention concerne en particulier de nouveaux composés d'indoles N-arylsulfonyl-3-substitués de formule générale (I), leurs dérivés, analogues, formes tautomères, stéréoisomères, polymorphes, sels pharmaceutiquement acceptables, solvates pharmaceutiquement acceptables, et des compositions pharmaceutiquement acceptables contenant ces composés. L'invention concerne en outre la méthode de préparation de composés de formule générale (I), des compositions pharmaceutiques contenant ces composés, et l'utilisation de ces composés et compositions en médecine. L'invention concerne enfin de nouveaux intermédiaires intervenant dans ces composés et compositions et leur méthode de préparation.
CA2509982A 2002-11-28 2003-06-05 Indoles n-arylsulfonyl-3-substitues presentant une affinite pour le recepteur de la serotonine, methode de preparation et composition pharmaceutique contenant ces indoles Expired - Lifetime CA2509982C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN884MA2002 2002-11-28
IN884/MAS/2002 2002-11-28
PCT/IN2003/000209 WO2004048330A1 (fr) 2002-11-28 2003-06-05 Indoles n-arylsulfonyl-3-substitues presentant une affinite pour le recepteur de la serotonine, methode de preparation et composition pharmaceutique contenant ces indoles

Publications (2)

Publication Number Publication Date
CA2509982A1 CA2509982A1 (fr) 2004-06-10
CA2509982C true CA2509982C (fr) 2011-11-08

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CA2509982A Expired - Lifetime CA2509982C (fr) 2002-11-28 2003-06-05 Indoles n-arylsulfonyl-3-substitues presentant une affinite pour le recepteur de la serotonine, methode de preparation et composition pharmaceutique contenant ces indoles

Country Status (22)

Country Link
US (1) US7875605B2 (fr)
EP (1) EP1581492B1 (fr)
JP (1) JP4559230B2 (fr)
KR (1) KR100818508B1 (fr)
CN (2) CN1720225B (fr)
AT (1) ATE401307T1 (fr)
AU (1) AU2003237599B2 (fr)
BR (2) BRPI0318799B8 (fr)
CA (1) CA2509982C (fr)
CY (1) CY1108786T1 (fr)
DE (1) DE60322266D1 (fr)
DK (1) DK1581492T3 (fr)
EA (1) EA011320B1 (fr)
ES (1) ES2310243T3 (fr)
HK (2) HK1133002A1 (fr)
MX (1) MXPA05005701A (fr)
NO (2) NO330341B1 (fr)
NZ (2) NZ540840A (fr)
PT (1) PT1581492E (fr)
SI (1) SI1581492T1 (fr)
WO (1) WO2004048330A1 (fr)
ZA (1) ZA200504043B (fr)

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DE602004021031D1 (de) 2004-01-02 2009-06-18 Suven Life Sciences Ltd Neue indenoä2,1-aüindene und isoindolä2,1-aüindol
EP1917255A2 (fr) 2005-07-29 2008-05-07 F. Hoffmann-Roche AG Derives de indol-3-yl-carbonyl-piperidine et piperazine
WO2007020653A1 (fr) * 2005-08-12 2007-02-22 Suven Life Sciences Limited Dérivés de thioéther en tant que ligands 5-ht6 fonctionnels
DK1919896T3 (da) 2005-08-12 2010-04-19 Suven Life Sciences Ltd Aminoarylsulfonamidderivater, som funktionelle 5-HT6-ligander
KR101250820B1 (ko) 2005-08-16 2013-04-04 수벤 라이프 사이언시스 리미티드 개선된 로사르탄 제조 방법
MX2009006077A (es) * 2007-01-08 2009-06-17 Suven Life Sciences Ltd Compuestos de 5-(heterociclil)alquil-n-(arilsulfonil)indol y su uso como ligandos de la 5-hidroxitriptamina6.
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WO2008144263A1 (fr) * 2007-05-18 2008-11-27 The Ohio State University Research Foundation Agents antitumoraux efficaces dérivés de l'indole-3-carbinole
ES2370680T3 (es) 2007-10-26 2011-12-21 Suven Life Sciences Limited Compuestos de aminoarilsulfonamida y su empleo como ligandos de 5-ht6.
SI2346847T1 (sl) 2008-09-17 2013-10-30 Suven Life Sciences Limited Spojine aril sulfonamid aminov in njihova uporaba kot 5-HT6 ligandi
WO2010032257A1 (fr) 2008-09-17 2010-03-25 Suven Life Sciences Limited Composés arylindolylsulfonamides et leur utilisation en tant que ligands de 5-ht<sb>6</sb>
CA2770724A1 (fr) * 2009-08-10 2011-02-17 Galenea Corporation Composes d'indole inhibant 5-ht
US8153680B2 (en) * 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
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CN102093149A (zh) * 2010-12-08 2011-06-15 天津理工大学 一种促进氰基快速水解制备羧酸类化合物的方法
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JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物
KR101534136B1 (ko) * 2013-06-11 2015-07-07 이화여자대학교 산학협력단 인돌 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 5-ht6 수용체 관련 질환의 예방 또는 치료용 약학적 조성물
RS56323B1 (sr) 2013-12-02 2017-12-29 Suven Life Sciences Ltd Proces za masovnu proizvodnju monohidrata 1-[(2-bromofenil)sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indol dimezilata
EP3083588B1 (fr) 2013-12-20 2020-12-09 Sunshine Lake Pharma Co., Ltd. Composés hétérocycliques aromatiques et leur utilisation dans les produits pharmaceutiques
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