RS56323B1 - Proces za masovnu proizvodnju monohidrata 1-[(2-bromofenil)sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indol dimezilata - Google Patents
Proces za masovnu proizvodnju monohidrata 1-[(2-bromofenil)sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indol dimezilataInfo
- Publication number
- RS56323B1 RS56323B1 RS20170853A RSP20170853A RS56323B1 RS 56323 B1 RS56323 B1 RS 56323B1 RS 20170853 A RS20170853 A RS 20170853A RS P20170853 A RSP20170853 A RS P20170853A RS 56323 B1 RS56323 B1 RS 56323B1
- Authority
- RS
- Serbia
- Prior art keywords
- methyl
- bromophenyl
- piperazinyl
- sulfonyl
- methoxy
- Prior art date
Links
- XKDCUJBWVGDNSH-UHFFFAOYSA-N 1-(2-bromophenyl)sulfonyl-5-methoxy-3-[(4-methylpiperazin-1-yl)methyl]indole;methanesulfonic acid;hydrate Chemical compound O.CS(O)(=O)=O.CS(O)(=O)=O.C12=CC(OC)=CC=C2N(S(=O)(=O)C=2C(=CC=CC=2)Br)C=C1CN1CCN(C)CC1 XKDCUJBWVGDNSH-UHFFFAOYSA-N 0.000 title 1
- 238000011031 large-scale manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14725245.6A EP3077375B1 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| PCT/IN2014/000109 WO2015083179A1 (en) | 2013-12-02 | 2014-02-20 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
| IN5537CH2013 IN2013CH05537A (sr) | 2013-12-02 | 2014-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS56323B1 true RS56323B1 (sr) | 2017-12-29 |
Family
ID=54199404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20170853A RS56323B1 (sr) | 2013-12-02 | 2014-02-20 | Proces za masovnu proizvodnju monohidrata 1-[(2-bromofenil)sulfonil]-5-metoksi-3-[(4-metil-1-piperazinil)metil]-1h-indol dimezilata |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9540321B2 (sr) |
| EP (1) | EP3077375B1 (sr) |
| JP (1) | JP6151453B2 (sr) |
| KR (1) | KR101808792B1 (sr) |
| CN (1) | CN105814020B (sr) |
| AP (1) | AP2016009224A0 (sr) |
| AU (1) | AU2014358682B2 (sr) |
| BR (1) | BR112016010788B1 (sr) |
| CA (1) | CA2929309C (sr) |
| CY (1) | CY1119298T1 (sr) |
| DK (1) | DK3077375T3 (sr) |
| EA (1) | EA028038B1 (sr) |
| ES (1) | ES2638856T3 (sr) |
| HK (1) | HK1226396B (sr) |
| HR (1) | HRP20171245T1 (sr) |
| HU (1) | HUE036008T2 (sr) |
| IL (1) | IL245619B (sr) |
| IN (1) | IN2013CH05537A (sr) |
| LT (1) | LT3077375T (sr) |
| ME (1) | ME02843B (sr) |
| MX (1) | MX364930B (sr) |
| NZ (1) | NZ719671A (sr) |
| PL (1) | PL3077375T3 (sr) |
| PT (1) | PT3077375T (sr) |
| RS (1) | RS56323B1 (sr) |
| SI (1) | SI3077375T1 (sr) |
| WO (1) | WO2015083179A1 (sr) |
| ZA (1) | ZA201602954B (sr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3458040B1 (en) | 2016-05-18 | 2021-01-27 | Suven Life Sciences Limited | Combination of pure 5-ht6 receptor antagonists with nmda receptor antagonist |
| BR112018073410A2 (pt) * | 2016-05-18 | 2019-03-19 | Suven Life Sciences Limited | combinação de antagonistas, uso da combinação, método para o tratamento, composto, método para o tratamento de doença de alzheimer e composição farmacêutica |
| CN109069468A (zh) * | 2016-05-18 | 2018-12-21 | 苏文生命科学有限公司 | 纯5-ht6受体拮抗剂与乙酰胆碱酯酶抑制剂的组合 |
| US20210346374A1 (en) * | 2016-10-03 | 2021-11-11 | Suven Life Sciences Limited | Pharmaceutical compositions of 5-ht6 receptor antagonist |
| MD3518905T2 (ro) * | 2016-10-03 | 2021-09-30 | Suven Life Sciences Ltd | Compoziții farmaceutice de antagonist al 5-HT6 |
| US20210338661A1 (en) | 2017-07-03 | 2021-11-04 | Suven Life Sciences Limited | New uses of a pure 5-ht 6 receptor antagonist |
| US20220409614A1 (en) | 2019-12-02 | 2022-12-29 | Suven Life Sciences Limited | Treating behavioral and psychological symptoms in dementia patients |
| KR20220110518A (ko) | 2019-12-02 | 2022-08-08 | 수벤 라이프 사이언시스 리미티드 | 치매 환자의 행동 및 심리적 증상 치료 |
| CN111362859B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| CN111362858B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
| CN111233737B (zh) * | 2020-03-16 | 2021-05-11 | 东莞市东阳光新药研发有限公司 | 芳杂环类衍生物的盐及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2749846B1 (fr) * | 1996-06-17 | 1998-09-11 | Pf Medicament | Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique |
| AU2003237599B2 (en) * | 2002-11-28 | 2009-06-18 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| AU2003292510B2 (en) * | 2002-12-18 | 2009-04-23 | Suven Life Sciences Limited | Tetracyclic 3-substituted indoles having serotonin receptor affinity |
| MX2008015899A (es) * | 2006-06-12 | 2009-04-01 | Novartis Ag | Procedimiento para hacer sales de n-hidroxi-3-[4-[[[2-(2-metil-1h- indol-3-il)etil]amino]metil]fenil]-2e-2-propenamida. |
-
2014
- 2014-02-20 KR KR1020167013965A patent/KR101808792B1/ko active IP Right Grant
- 2014-02-20 AP AP2016009224A patent/AP2016009224A0/en unknown
- 2014-02-20 PT PT147252456T patent/PT3077375T/pt unknown
- 2014-02-20 HU HUE14725245A patent/HUE036008T2/hu unknown
- 2014-02-20 RS RS20170853A patent/RS56323B1/sr unknown
- 2014-02-20 PL PL14725245T patent/PL3077375T3/pl unknown
- 2014-02-20 ES ES14725245.6T patent/ES2638856T3/es active Active
- 2014-02-20 JP JP2016535680A patent/JP6151453B2/ja active Active
- 2014-02-20 DK DK14725245.6T patent/DK3077375T3/en active
- 2014-02-20 EA EA201691161A patent/EA028038B1/ru unknown
- 2014-02-20 CN CN201480065601.9A patent/CN105814020B/zh active Active
- 2014-02-20 ME MEP-2017-193A patent/ME02843B/me unknown
- 2014-02-20 EP EP14725245.6A patent/EP3077375B1/en active Active
- 2014-02-20 WO PCT/IN2014/000109 patent/WO2015083179A1/en active Application Filing
- 2014-02-20 NZ NZ719671A patent/NZ719671A/en unknown
- 2014-02-20 US US15/100,489 patent/US9540321B2/en active Active
- 2014-02-20 MX MX2016006629A patent/MX364930B/es active IP Right Grant
- 2014-02-20 BR BR112016010788-8A patent/BR112016010788B1/pt active IP Right Grant
- 2014-02-20 CA CA2929309A patent/CA2929309C/en active Active
- 2014-02-20 LT LTEP14725245.6T patent/LT3077375T/lt unknown
- 2014-02-20 AU AU2014358682A patent/AU2014358682B2/en active Active
- 2014-02-20 IN IN5537CH2013 patent/IN2013CH05537A/en unknown
- 2014-02-20 SI SI201430348T patent/SI3077375T1/sl unknown
-
2016
- 2016-05-03 ZA ZA2016/02954A patent/ZA201602954B/en unknown
- 2016-05-11 IL IL245619A patent/IL245619B/en active IP Right Grant
- 2016-12-23 HK HK16114655A patent/HK1226396B/zh unknown
-
2017
- 2017-08-16 HR HRP20171245TT patent/HRP20171245T1/hr unknown
- 2017-08-28 CY CY20171100904T patent/CY1119298T1/el unknown
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