CA2500151A1 - Ttk protein kinase gene for diagnosing and treating non-small cell lung cancers - Google Patents
Ttk protein kinase gene for diagnosing and treating non-small cell lung cancers Download PDFInfo
- Publication number
- CA2500151A1 CA2500151A1 CA002500151A CA2500151A CA2500151A1 CA 2500151 A1 CA2500151 A1 CA 2500151A1 CA 002500151 A CA002500151 A CA 002500151A CA 2500151 A CA2500151 A CA 2500151A CA 2500151 A1 CA2500151 A1 CA 2500151A1
- Authority
- CA
- Canada
- Prior art keywords
- nsc
- protein
- lung cancer
- small cell
- cell lung
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000002154 non-small cell lung carcinoma Diseases 0.000 title claims abstract description 218
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 title claims abstract description 213
- 101000659223 Homo sapiens Dual specificity protein kinase TTK Proteins 0.000 title description 2
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 583
- 238000000034 method Methods 0.000 claims abstract description 168
- 230000014509 gene expression Effects 0.000 claims abstract description 164
- 150000001875 compounds Chemical class 0.000 claims abstract description 126
- 102000004169 proteins and genes Human genes 0.000 claims description 330
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 226
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 209
- 229920001184 polypeptide Polymers 0.000 claims description 198
- 210000004027 cell Anatomy 0.000 claims description 189
- 238000012360 testing method Methods 0.000 claims description 98
- 102000040430 polynucleotide Human genes 0.000 claims description 88
- 108091033319 polynucleotide Proteins 0.000 claims description 88
- 239000002157 polynucleotide Substances 0.000 claims description 88
- 108020004999 messenger RNA Proteins 0.000 claims description 83
- 239000000203 mixture Substances 0.000 claims description 56
- 230000001105 regulatory effect Effects 0.000 claims description 56
- 108020004414 DNA Proteins 0.000 claims description 49
- 230000027455 binding Effects 0.000 claims description 48
- 230000000694 effects Effects 0.000 claims description 46
- 108020004459 Small interfering RNA Proteins 0.000 claims description 41
- 238000012216 screening Methods 0.000 claims description 41
- 125000003729 nucleotide group Chemical group 0.000 claims description 39
- 239000002773 nucleotide Substances 0.000 claims description 38
- 101000883798 Homo sapiens Probable ATP-dependent RNA helicase DDX53 Proteins 0.000 claims description 36
- 102100038236 Probable ATP-dependent RNA helicase DDX53 Human genes 0.000 claims description 36
- 239000012472 biological sample Substances 0.000 claims description 36
- 239000012634 fragment Substances 0.000 claims description 35
- 239000000523 sample Substances 0.000 claims description 32
- 239000013598 vector Substances 0.000 claims description 26
- 239000003550 marker Substances 0.000 claims description 25
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- 230000004071 biological effect Effects 0.000 claims description 24
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 22
- 150000001413 amino acids Chemical class 0.000 claims description 19
- 230000001939 inductive effect Effects 0.000 claims description 18
- 238000001514 detection method Methods 0.000 claims description 17
- 229960005486 vaccine Drugs 0.000 claims description 17
- 239000004480 active ingredient Substances 0.000 claims description 16
- 230000005809 anti-tumor immunity Effects 0.000 claims description 16
- 230000007423 decrease Effects 0.000 claims description 16
- 238000009396 hybridization Methods 0.000 claims description 16
- 239000003112 inhibitor Substances 0.000 claims description 16
- 230000000692 anti-sense effect Effects 0.000 claims description 15
- 108700008625 Reporter Genes Proteins 0.000 claims description 13
- 230000000295 complement effect Effects 0.000 claims description 13
- 230000002103 transcriptional effect Effects 0.000 claims description 13
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 11
- 239000003153 chemical reaction reagent Substances 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 210000004369 blood Anatomy 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 239000013604 expression vector Substances 0.000 claims description 8
- 238000012258 culturing Methods 0.000 claims description 6
- 239000003623 enhancer Substances 0.000 claims description 5
- 206010036790 Productive cough Diseases 0.000 claims description 4
- 210000003802 sputum Anatomy 0.000 claims description 4
- 208000024794 sputum Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 230000002062 proliferating effect Effects 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 241000282414 Homo sapiens Species 0.000 abstract description 60
- 235000018102 proteins Nutrition 0.000 description 323
- 239000002299 complementary DNA Substances 0.000 description 130
- 206010028980 Neoplasm Diseases 0.000 description 49
- 208000011317 telomere syndrome Diseases 0.000 description 42
- 150000007523 nucleic acids Chemical class 0.000 description 39
- 102000039446 nucleic acids Human genes 0.000 description 38
- 108020004707 nucleic acids Proteins 0.000 description 38
- 201000011510 cancer Diseases 0.000 description 37
- 239000000047 product Substances 0.000 description 32
- 102000005962 receptors Human genes 0.000 description 32
- 108020003175 receptors Proteins 0.000 description 32
- 239000004055 small Interfering RNA Substances 0.000 description 27
- 108090000994 Catalytic RNA Proteins 0.000 description 25
- 102000053642 Catalytic RNA Human genes 0.000 description 25
- 108091092562 ribozyme Proteins 0.000 description 25
- 208000020816 lung neoplasm Diseases 0.000 description 24
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 23
- 201000005202 lung cancer Diseases 0.000 description 23
- 238000011282 treatment Methods 0.000 description 22
- 102000014914 Carrier Proteins Human genes 0.000 description 21
- 108091008324 binding proteins Proteins 0.000 description 20
- 210000001519 tissue Anatomy 0.000 description 19
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 18
- 235000001014 amino acid Nutrition 0.000 description 18
- 238000000018 DNA microarray Methods 0.000 description 17
- 239000000427 antigen Substances 0.000 description 17
- 102000036639 antigens Human genes 0.000 description 17
- 108091007433 antigens Proteins 0.000 description 17
- 239000000074 antisense oligonucleotide Substances 0.000 description 17
- 238000012230 antisense oligonucleotides Methods 0.000 description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 17
- 230000006870 function Effects 0.000 description 17
- 108091000080 Phosphotransferase Proteins 0.000 description 15
- 201000010099 disease Diseases 0.000 description 15
- 102000020233 phosphotransferase Human genes 0.000 description 15
- 108091034117 Oligonucleotide Proteins 0.000 description 14
- 210000004443 dendritic cell Anatomy 0.000 description 14
- 238000009472 formulation Methods 0.000 description 14
- 230000036961 partial effect Effects 0.000 description 14
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 13
- 210000001744 T-lymphocyte Anatomy 0.000 description 13
- 230000006698 induction Effects 0.000 description 13
- 230000002401 inhibitory effect Effects 0.000 description 13
- 238000003752 polymerase chain reaction Methods 0.000 description 12
- 102000004316 Oxidoreductases Human genes 0.000 description 11
- 108090000854 Oxidoreductases Proteins 0.000 description 11
- 210000000349 chromosome Anatomy 0.000 description 11
- 238000011109 contamination Methods 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 102000037865 fusion proteins Human genes 0.000 description 11
- 108020001507 fusion proteins Proteins 0.000 description 11
- 230000001225 therapeutic effect Effects 0.000 description 11
- 101710088194 Dehydrogenase Proteins 0.000 description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 description 10
- 230000000875 corresponding effect Effects 0.000 description 10
- 230000001419 dependent effect Effects 0.000 description 10
- 239000000843 powder Substances 0.000 description 10
- 239000003826 tablet Substances 0.000 description 10
- 210000004881 tumor cell Anatomy 0.000 description 10
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 9
- 108700020796 Oncogene Proteins 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- 230000012010 growth Effects 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 239000013074 reference sample Substances 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 9
- 241000796533 Arna Species 0.000 description 8
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 8
- -1 NSC 893 Chemical compound 0.000 description 8
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 8
- 230000002265 prevention Effects 0.000 description 8
- 230000014616 translation Effects 0.000 description 8
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 7
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 7
- 102000037054 SLC-Transporter Human genes 0.000 description 7
- 108091006207 SLC-Transporter Proteins 0.000 description 7
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 7
- 230000003247 decreasing effect Effects 0.000 description 7
- 238000004393 prognosis Methods 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 238000013518 transcription Methods 0.000 description 7
- 230000035897 transcription Effects 0.000 description 7
- 238000013519 translation Methods 0.000 description 7
- 102000005720 Glutathione transferase Human genes 0.000 description 6
- 108010070675 Glutathione transferase Proteins 0.000 description 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 6
- 102000005741 Metalloproteases Human genes 0.000 description 6
- 108010006035 Metalloproteases Proteins 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 102000001708 Protein Isoforms Human genes 0.000 description 6
- 108010029485 Protein Isoforms Proteins 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 238000013459 approach Methods 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 230000004663 cell proliferation Effects 0.000 description 6
- 239000000284 extract Substances 0.000 description 6
- 230000004927 fusion Effects 0.000 description 6
- 238000009169 immunotherapy Methods 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 6
- 238000001262 western blot Methods 0.000 description 6
- 108091006146 Channels Proteins 0.000 description 5
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 5
- 108090000365 Cytochrome-c oxidases Proteins 0.000 description 5
- 102000003886 Glycoproteins Human genes 0.000 description 5
- 108090000288 Glycoproteins Proteins 0.000 description 5
- 231100000002 MTT assay Toxicity 0.000 description 5
- 238000000134 MTT assay Methods 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 5
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 5
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 5
- 102000001253 Protein Kinase Human genes 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 230000004913 activation Effects 0.000 description 5
- 210000003719 b-lymphocyte Anatomy 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 230000022131 cell cycle Effects 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 210000005265 lung cell Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 5
- 210000003470 mitochondria Anatomy 0.000 description 5
- 108060006633 protein kinase Proteins 0.000 description 5
- 230000004083 survival effect Effects 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 4
- SUCPTJIDWIPYDE-UHFFFAOYSA-N 5-(2,2-dimethylpropyl)nonan-5-ol Chemical compound CCCCC(O)(CC(C)(C)C)CCCC SUCPTJIDWIPYDE-UHFFFAOYSA-N 0.000 description 4
- 108090000197 Clusterin Proteins 0.000 description 4
- 102100031780 Endonuclease Human genes 0.000 description 4
- 108091006027 G proteins Proteins 0.000 description 4
- 102000030782 GTP binding Human genes 0.000 description 4
- 108091000058 GTP-Binding Proteins 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 102000018697 Membrane Proteins Human genes 0.000 description 4
- 108010052285 Membrane Proteins Proteins 0.000 description 4
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 4
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 4
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 4
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 4
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 4
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 4
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 4
- 208000009956 adenocarcinoma Diseases 0.000 description 4
- 238000001042 affinity chromatography Methods 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 4
- 230000010261 cell growth Effects 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 230000002759 chromosomal effect Effects 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 4
- 235000018417 cysteine Nutrition 0.000 description 4
- 210000002919 epithelial cell Anatomy 0.000 description 4
- 239000007850 fluorescent dye Substances 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 238000001114 immunoprecipitation Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 206010061289 metastatic neoplasm Diseases 0.000 description 4
- 230000035772 mutation Effects 0.000 description 4
- 108010055837 phosphocarrier protein HPr Proteins 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 230000002194 synthesizing effect Effects 0.000 description 4
- 238000010396 two-hybrid screening Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 108010085238 Actins Proteins 0.000 description 3
- 102000007469 Actins Human genes 0.000 description 3
- 241000428352 Amma Species 0.000 description 3
- 101710145634 Antigen 1 Proteins 0.000 description 3
- 101100465060 Arabidopsis thaliana PRK4 gene Proteins 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 102000055006 Calcitonin Human genes 0.000 description 3
- 108060001064 Calcitonin Proteins 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 102000003780 Clusterin Human genes 0.000 description 3
- 108020004635 Complementary DNA Proteins 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 101001031598 Dictyostelium discoideum Probable serine/threonine-protein kinase fhkC Proteins 0.000 description 3
- 102100021160 Dual specificity protein phosphatase 9 Human genes 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102100035218 Epidermal growth factor receptor kinase substrate 8-like protein 2 Human genes 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000282326 Felis catus Species 0.000 description 3
- 102100034294 Glutathione synthetase Human genes 0.000 description 3
- 108010033040 Histones Proteins 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 101000924727 Homo sapiens Alternative prion protein Proteins 0.000 description 3
- 101000968556 Homo sapiens Dual specificity protein phosphatase 9 Proteins 0.000 description 3
- 101000876686 Homo sapiens Epidermal growth factor receptor kinase substrate 8-like protein 2 Proteins 0.000 description 3
- 101001069973 Homo sapiens Glutathione synthetase Proteins 0.000 description 3
- 101000591312 Homo sapiens Putative MORF4 family-associated protein 1-like protein UPP Proteins 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 description 3
- 102100026632 Mimecan Human genes 0.000 description 3
- 108700026244 Open Reading Frames Proteins 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 3
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 3
- 102100034096 Putative MORF4 family-associated protein 1-like protein UPP Human genes 0.000 description 3
- 108010000605 Ribosomal Proteins Proteins 0.000 description 3
- 102000002278 Ribosomal Proteins Human genes 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 229920002684 Sepharose Polymers 0.000 description 3
- 102100023153 Sodium- and chloride-dependent creatine transporter 1 Human genes 0.000 description 3
- 108091081024 Start codon Proteins 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 239000000556 agonist Substances 0.000 description 3
- 210000004102 animal cell Anatomy 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 230000003305 autocrine Effects 0.000 description 3
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 3
- 229960004015 calcitonin Drugs 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 230000003833 cell viability Effects 0.000 description 3
- 108010007169 creatine transporter Proteins 0.000 description 3
- 230000001086 cytosolic effect Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 230000003511 endothelial effect Effects 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 230000009422 growth inhibiting effect Effects 0.000 description 3
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000002493 microarray Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000002246 oncogenic effect Effects 0.000 description 3
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 3
- 102000014187 peptide receptors Human genes 0.000 description 3
- 108010011903 peptide receptors Proteins 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 238000002416 scanning tunnelling spectroscopy Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000035939 shock Effects 0.000 description 3
- 108010088201 squamous cell carcinoma-related antigen Proteins 0.000 description 3
- 150000003431 steroids Chemical class 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000375 suspending agent Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 210000005253 yeast cell Anatomy 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- UYSQHMXRROFKRN-UHFFFAOYSA-N (2,4-dimethylphenyl)-phenylmethanone Chemical compound CC1=CC(C)=CC=C1C(=O)C1=CC=CC=C1 UYSQHMXRROFKRN-UHFFFAOYSA-N 0.000 description 2
- TZOVOULUMXXLOJ-UHFFFAOYSA-N 1-methyl-4-[(4-methylphenyl)disulfanyl]benzene Chemical compound C1=CC(C)=CC=C1SSC1=CC=C(C)C=C1 TZOVOULUMXXLOJ-UHFFFAOYSA-N 0.000 description 2
- 102100038794 17-beta-hydroxysteroid dehydrogenase type 6 Human genes 0.000 description 2
- AWAHTDIOUIVENZ-UHFFFAOYSA-N 2,2-dipropylpentanenitrile Chemical compound CCCC(CCC)(CCC)C#N AWAHTDIOUIVENZ-UHFFFAOYSA-N 0.000 description 2
- ZVSCENGNXWPDPL-UHFFFAOYSA-N 2-methyl-2-phenylpropan-1-ol Chemical compound OCC(C)(C)C1=CC=CC=C1 ZVSCENGNXWPDPL-UHFFFAOYSA-N 0.000 description 2
- NQCQVNHLNXCSPY-UHFFFAOYSA-N 3-chloropropyl 4-methylbenzenesulfonate Chemical compound CC1=CC=C(S(=O)(=O)OCCCCl)C=C1 NQCQVNHLNXCSPY-UHFFFAOYSA-N 0.000 description 2
- DVNYTAVYBRSTGK-UHFFFAOYSA-N 5-aminoimidazole-4-carboxamide Chemical compound NC(=O)C=1N=CNC=1N DVNYTAVYBRSTGK-UHFFFAOYSA-N 0.000 description 2
- 102100021324 5-azacytidine-induced protein 2 Human genes 0.000 description 2
- DCBJCKDOZLTTDW-UHFFFAOYSA-N 5-chloropentan-1-ol Chemical compound OCCCCCCl DCBJCKDOZLTTDW-UHFFFAOYSA-N 0.000 description 2
- MHPUGCYGQWGLJL-UHFFFAOYSA-N 5-methyl-hexanoic acid Chemical compound CC(C)CCCC(O)=O MHPUGCYGQWGLJL-UHFFFAOYSA-N 0.000 description 2
- 102100035988 60S ribosomal protein L39 Human genes 0.000 description 2
- 102100024643 ATP-binding cassette sub-family D member 1 Human genes 0.000 description 2
- 108091006112 ATPases Proteins 0.000 description 2
- 108010059616 Activins Proteins 0.000 description 2
- 102000005606 Activins Human genes 0.000 description 2
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 2
- 101710186708 Agglutinin Proteins 0.000 description 2
- 102000005602 Aldo-Keto Reductases Human genes 0.000 description 2
- 108010084469 Aldo-Keto Reductases Proteins 0.000 description 2
- 102100024092 Aldo-keto reductase family 1 member C4 Human genes 0.000 description 2
- 108090000531 Amidohydrolases Proteins 0.000 description 2
- 102000004092 Amidohydrolases Human genes 0.000 description 2
- 102100036439 Amyloid beta precursor protein binding family B member 1 Human genes 0.000 description 2
- 102100034605 Atrial natriuretic peptide receptor 3 Human genes 0.000 description 2
- 241000271566 Aves Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 108010015087 Basic Amino Acid Transport Systems Proteins 0.000 description 2
- 102000001733 Basic Amino Acid Transport Systems Human genes 0.000 description 2
- 102100024154 Cadherin-13 Human genes 0.000 description 2
- 102000005701 Calcium-Binding Proteins Human genes 0.000 description 2
- 108010045403 Calcium-Binding Proteins Proteins 0.000 description 2
- 108010052500 Calgranulin A Proteins 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 208000005623 Carcinogenesis Diseases 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 102100026772 Cell cycle control protein 50A Human genes 0.000 description 2
- 102100038099 Cell division cycle protein 20 homolog Human genes 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 108010077544 Chromatin Proteins 0.000 description 2
- 102100038602 Chromatin assembly factor 1 subunit A Human genes 0.000 description 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
- 102000005870 Coenzyme A Ligases Human genes 0.000 description 2
- 102100030501 Coiled-coil domain-containing protein 180 Human genes 0.000 description 2
- 241001550206 Colla Species 0.000 description 2
- 102100024335 Collagen alpha-1(VII) chain Human genes 0.000 description 2
- 102100024203 Collagen alpha-1(XIV) chain Human genes 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 2
- 102000016917 Complement C1 Human genes 0.000 description 2
- 108010028774 Complement C1 Proteins 0.000 description 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 2
- 102000003849 Cytochrome P450 Human genes 0.000 description 2
- 102100039924 Cytochrome b-c1 complex subunit 1, mitochondrial Human genes 0.000 description 2
- 102100036035 Cytochrome c oxidase copper chaperone Human genes 0.000 description 2
- 230000004544 DNA amplification Effects 0.000 description 2
- 230000004568 DNA-binding Effects 0.000 description 2
- 101800001224 Disintegrin Proteins 0.000 description 2
- 102100038191 Double-stranded RNA-specific editase 1 Human genes 0.000 description 2
- 101150029707 ERBB2 gene Proteins 0.000 description 2
- 108010042407 Endonucleases Proteins 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 102000001534 GDP dissociation inhibitor Human genes 0.000 description 2
- 102100039556 Galectin-4 Human genes 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- BPDVTFBJZNBHEU-HGNGGELXSA-N Glu-Ala-His Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 BPDVTFBJZNBHEU-HGNGGELXSA-N 0.000 description 2
- 102000042092 Glucose transporter family Human genes 0.000 description 2
- 108091052347 Glucose transporter family Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- 108010092964 Guanine Nucleotide Dissociation Inhibitors Proteins 0.000 description 2
- 108010067218 Guanine Nucleotide Exchange Factors Proteins 0.000 description 2
- 102000016285 Guanine Nucleotide Exchange Factors Human genes 0.000 description 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 2
- 108010013476 HLA-A24 Antigen Proteins 0.000 description 2
- 108010050568 HLA-DM antigens Proteins 0.000 description 2
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 description 2
- 102100022123 Hepatocyte nuclear factor 1-beta Human genes 0.000 description 2
- 101000895045 Homo sapiens 5-azacytidine-induced protein 2 Proteins 0.000 description 2
- 101000928670 Homo sapiens Amyloid beta precursor protein binding family B member 1 Proteins 0.000 description 2
- 101000924488 Homo sapiens Atrial natriuretic peptide receptor 3 Proteins 0.000 description 2
- 101000910814 Homo sapiens Cell cycle control protein 50A Proteins 0.000 description 2
- 101000772631 Homo sapiens Coiled-coil domain-containing protein 180 Proteins 0.000 description 2
- 101000909498 Homo sapiens Collagen alpha-1(VII) chain Proteins 0.000 description 2
- 101000875933 Homo sapiens Cytochrome c oxidase copper chaperone Proteins 0.000 description 2
- 101000742223 Homo sapiens Double-stranded RNA-specific editase 1 Proteins 0.000 description 2
- 101000608765 Homo sapiens Galectin-4 Proteins 0.000 description 2
- 101001001473 Homo sapiens Importin subunit alpha-4 Proteins 0.000 description 2
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 2
- 101001090688 Homo sapiens Lymphocyte cytosolic protein 2 Proteins 0.000 description 2
- 101001018100 Homo sapiens Lysozyme C Proteins 0.000 description 2
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 2
- 101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 description 2
- 101000735223 Homo sapiens Palmdelphin Proteins 0.000 description 2
- 101000734537 Homo sapiens Pyridoxal-dependent decarboxylase domain-containing protein 1 Proteins 0.000 description 2
- 101000609349 Homo sapiens Pyrroline-5-carboxylate reductase 3 Proteins 0.000 description 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 2
- 101000630197 Homo sapiens Rho GTPase-activating protein SYDE1 Proteins 0.000 description 2
- 101000886098 Homo sapiens Rho guanine nucleotide exchange factor 40 Proteins 0.000 description 2
- 101000813777 Homo sapiens Splicing factor ESS-2 homolog Proteins 0.000 description 2
- 101000692109 Homo sapiens Syndecan-2 Proteins 0.000 description 2
- 101000711846 Homo sapiens Transcription factor SOX-9 Proteins 0.000 description 2
- 101000964478 Homo sapiens Zinc finger and BTB domain-containing protein 17 Proteins 0.000 description 2
- 101000976608 Homo sapiens Zinc finger protein 408 Proteins 0.000 description 2
- 101710146024 Horcolin Proteins 0.000 description 2
- 108010072462 Hydroxymethyl and Formyl Transferases Proteins 0.000 description 2
- 102000006933 Hydroxymethyl and Formyl Transferases Human genes 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 102100036187 Importin subunit alpha-4 Human genes 0.000 description 2
- 102100025390 Integrin beta-2 Human genes 0.000 description 2
- 102100037795 Interleukin-6 receptor subunit beta Human genes 0.000 description 2
- 102100023424 Kinesin-like protein KIF2C Human genes 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 102100027454 Laminin subunit beta-2 Human genes 0.000 description 2
- 101710189395 Lectin Proteins 0.000 description 2
- 102000004856 Lectins Human genes 0.000 description 2
- 108090001090 Lectins Proteins 0.000 description 2
- 240000007472 Leucaena leucocephala Species 0.000 description 2
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 2
- 108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 description 2
- 102100034709 Lymphocyte cytosolic protein 2 Human genes 0.000 description 2
- 102100033468 Lysozyme C Human genes 0.000 description 2
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 description 2
- 102100025354 Macrophage mannose receptor 1 Human genes 0.000 description 2
- 108010031099 Mannose Receptor Proteins 0.000 description 2
- 101710179758 Mannose-specific lectin Proteins 0.000 description 2
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 2
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 2
- 102100030417 Matrilysin Human genes 0.000 description 2
- 102000000440 Melanoma-associated antigen Human genes 0.000 description 2
- 108050008953 Melanoma-associated antigen Proteins 0.000 description 2
- 102000002151 Microfilament Proteins Human genes 0.000 description 2
- 108010040897 Microfilament Proteins Proteins 0.000 description 2
- 108091013859 Mimecan Proteins 0.000 description 2
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 2
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 2
- 108010063954 Mucins Proteins 0.000 description 2
- 241000699660 Mus musculus Species 0.000 description 2
- 108091008758 NR0A5 Proteins 0.000 description 2
- 206010029260 Neuroblastoma Diseases 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 238000000636 Northern blotting Methods 0.000 description 2
- 102000007999 Nuclear Proteins Human genes 0.000 description 2
- 108010089610 Nuclear Proteins Proteins 0.000 description 2
- 102100023258 Nucleoside diphosphate kinase B Human genes 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 102100035005 Palmdelphin Human genes 0.000 description 2
- 108020002230 Pancreatic Ribonuclease Proteins 0.000 description 2
- 102000005891 Pancreatic ribonuclease Human genes 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 2
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 102100029811 Protein S100-A11 Human genes 0.000 description 2
- 102100032442 Protein S100-A8 Human genes 0.000 description 2
- 102100029333 Pterin-4-alpha-carbinolamine dehydratase Human genes 0.000 description 2
- 102100034759 Pyridoxal-dependent decarboxylase domain-containing protein 1 Human genes 0.000 description 2
- 102000009609 Pyrophosphatases Human genes 0.000 description 2
- 108010009413 Pyrophosphatases Proteins 0.000 description 2
- 102100039448 Pyrroline-5-carboxylate reductase 3 Human genes 0.000 description 2
- 108010010469 Qa-SNARE Proteins Proteins 0.000 description 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 2
- 108091030071 RNAI Proteins 0.000 description 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 2
- 102100026203 Rho GTPase-activating protein SYDE1 Human genes 0.000 description 2
- 102100039653 Rho guanine nucleotide exchange factor 40 Human genes 0.000 description 2
- 102000004389 Ribonucleoproteins Human genes 0.000 description 2
- 108010081734 Ribonucleoproteins Proteins 0.000 description 2
- 102100030053 Secreted frizzled-related protein 3 Human genes 0.000 description 2
- 108700032475 Sex-Determining Region Y Proteins 0.000 description 2
- 102100022978 Sex-determining region Y protein Human genes 0.000 description 2
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 2
- 102100036325 Sterol 26-hydroxylase, mitochondrial Human genes 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 102100026087 Syndecan-2 Human genes 0.000 description 2
- 102100037219 Syntenin-1 Human genes 0.000 description 2
- 108091008874 T cell receptors Proteins 0.000 description 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 2
- 102100034204 Transcription factor SOX-9 Human genes 0.000 description 2
- 102000009322 Tudor domains Human genes 0.000 description 2
- 108050000178 Tudor domains Proteins 0.000 description 2
- 108010005656 Ubiquitin Thiolesterase Proteins 0.000 description 2
- 102100025038 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Human genes 0.000 description 2
- 108010020277 WD repeat containing planar cell polarity effector Proteins 0.000 description 2
- 241000269368 Xenopus laevis Species 0.000 description 2
- 102100040761 Zinc finger and BTB domain-containing protein 17 Human genes 0.000 description 2
- 102100023554 Zinc finger protein 408 Human genes 0.000 description 2
- HMNZFMSWFCAGGW-XPWSMXQVSA-N [3-[hydroxy(2-hydroxyethoxy)phosphoryl]oxy-2-[(e)-octadec-9-enoyl]oxypropyl] (e)-octadec-9-enoate Chemical compound CCCCCCCC\C=C\CCCCCCCC(=O)OCC(COP(O)(=O)OCCO)OC(=O)CCCCCCC\C=C\CCCCCCCC HMNZFMSWFCAGGW-XPWSMXQVSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 239000000488 activin Substances 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 239000000910 agglutinin Substances 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 210000000436 anus Anatomy 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 108010056708 bcr-abl Fusion Proteins Proteins 0.000 description 2
- 102000004441 bcr-abl Fusion Proteins Human genes 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 230000036952 cancer formation Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 239000003183 carcinogenic agent Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 239000013592 cell lysate Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 210000003483 chromatin Anatomy 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 235000017471 coenzyme Q10 Nutrition 0.000 description 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000001973 epigenetic effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000010195 expression analysis Methods 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 230000009368 gene silencing by RNA Effects 0.000 description 2
- 238000010353 genetic engineering Methods 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
- 102000028718 growth factor binding proteins Human genes 0.000 description 2
- 108091009353 growth factor binding proteins Proteins 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 235000014304 histidine Nutrition 0.000 description 2
- 102000053563 human MYC Human genes 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 108010028309 kalinin Proteins 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000002523 lectin Substances 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 229940040145 liniment Drugs 0.000 description 2
- 239000000865 liniment Substances 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 102000033952 mRNA binding proteins Human genes 0.000 description 2
- 108091000373 mRNA binding proteins Proteins 0.000 description 2
- 102100031622 mRNA decay activator protein ZFP36 Human genes 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 238000010208 microarray analysis Methods 0.000 description 2
- 230000002438 mitochondrial effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- SJSZBOAQWPKFMU-UHFFFAOYSA-N n-(1-acetamidoethyl)acetamide Chemical compound CC(=O)NC(C)NC(C)=O SJSZBOAQWPKFMU-UHFFFAOYSA-N 0.000 description 2
- 210000004940 nucleus Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000010647 peptide synthesis reaction Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 108010078587 pseudouridylate synthetase Proteins 0.000 description 2
- 108010014186 ras Proteins Proteins 0.000 description 2
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000002207 retinal effect Effects 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 210000002460 smooth muscle Anatomy 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 206010041823 squamous cell carcinoma Diseases 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 102100029783 tRNA pseudouridine synthase A Human genes 0.000 description 2
- 229940126585 therapeutic drug Drugs 0.000 description 2
- 229910052721 tungsten Inorganic materials 0.000 description 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 2
- 229940035936 ubiquinone Drugs 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 229910052727 yttrium Inorganic materials 0.000 description 2
- XUHRVZXFBWDCFB-QRTDKPMLSA-N (3R)-4-[[(3S,6S,9S,12R,15S,18R,21R,24R,27R,28R)-12-(3-amino-3-oxopropyl)-6-[(2S)-butan-2-yl]-3-(2-carboxyethyl)-18-(hydroxymethyl)-28-methyl-9,15,21,24-tetrakis(2-methylpropyl)-2,5,8,11,14,17,20,23,26-nonaoxo-1-oxa-4,7,10,13,16,19,22,25-octazacyclooctacos-27-yl]amino]-3-[[(2R)-2-[[(3S)-3-hydroxydecanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid Chemical compound CCCCCCC[C@H](O)CC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H]1[C@@H](C)OC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC1=O)[C@@H](C)CC XUHRVZXFBWDCFB-QRTDKPMLSA-N 0.000 description 1
- CHIQFWSFQDADKY-ILYVXUQDSA-N (8r,9s,13s,14s,16r)-16-azido-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-one Chemical compound C1C[C@]2(C)C(=O)[C@H](N=[N+]=[N-])C[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 CHIQFWSFQDADKY-ILYVXUQDSA-N 0.000 description 1
- SSAYTINUCCRGDR-OWOJBTEDSA-N (e)-3-pyridin-4-ylprop-2-enoic acid Chemical compound OC(=O)\C=C\C1=CC=NC=C1 SSAYTINUCCRGDR-OWOJBTEDSA-N 0.000 description 1
- FEWLNYSYJNLUOO-UHFFFAOYSA-N 1-Piperidinecarboxaldehyde Chemical compound O=CN1CCCCC1 FEWLNYSYJNLUOO-UHFFFAOYSA-N 0.000 description 1
- NILQLFBWTXNUOE-UHFFFAOYSA-N 1-aminocyclopentanecarboxylic acid Chemical compound OC(=O)C1(N)CCCC1 NILQLFBWTXNUOE-UHFFFAOYSA-N 0.000 description 1
- JBMTUXVKTGBMLE-UHFFFAOYSA-N 1-methylpyrazolo[3,4-d]pyrimidin-4-amine Chemical compound N1=CN=C2N(C)N=CC2=C1N JBMTUXVKTGBMLE-UHFFFAOYSA-N 0.000 description 1
- 102100031236 11-beta-hydroxysteroid dehydrogenase type 2 Human genes 0.000 description 1
- 102100030489 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Human genes 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- BSYJHYLAMMJNRC-UHFFFAOYSA-N 2,4,4-trimethylpentan-2-ol Chemical compound CC(C)(C)CC(C)(C)O BSYJHYLAMMJNRC-UHFFFAOYSA-N 0.000 description 1
- YTOPFCCWCSOHFV-UHFFFAOYSA-N 2,6-dimethyl-4-tridecylmorpholine Chemical compound CCCCCCCCCCCCCN1CC(C)OC(C)C1 YTOPFCCWCSOHFV-UHFFFAOYSA-N 0.000 description 1
- ZXCIEWBDUAPBJF-MUUNZHRXSA-N 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C ZXCIEWBDUAPBJF-MUUNZHRXSA-N 0.000 description 1
- AFZJELJKFJSQGN-UHFFFAOYSA-N 2-chloro-1,3-oxazole-4-carboxylic acid Chemical compound OC(=O)C1=COC(Cl)=N1 AFZJELJKFJSQGN-UHFFFAOYSA-N 0.000 description 1
- 108010030844 2-methylcitrate synthase Proteins 0.000 description 1
- 102100025425 2-oxoglutarate and iron-dependent oxygenase JMJD4 Human genes 0.000 description 1
- AMQVHASIFJZFOS-UHFFFAOYSA-N 3-[(4-chlorophenyl)-(4-hydroxy-2-oxochromen-3-yl)methyl]-4-hydroxychromen-2-one Chemical compound O=C1OC=2C=CC=CC=2C(O)=C1C(C=1C(OC2=CC=CC=C2C=1O)=O)C1=CC=C(Cl)C=C1 AMQVHASIFJZFOS-UHFFFAOYSA-N 0.000 description 1
- 108010077268 3-hydroxyisobutyryl-CoA hydrolase Proteins 0.000 description 1
- 102100034767 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Human genes 0.000 description 1
- 102100026105 3-ketoacyl-CoA thiolase, mitochondrial Human genes 0.000 description 1
- JEWXYDDSLPIBBO-UHFFFAOYSA-N 3-methyl-3-octanol Chemical compound CCCCCC(C)(O)CC JEWXYDDSLPIBBO-UHFFFAOYSA-N 0.000 description 1
- 102100022031 39S ribosomal protein L23, mitochondrial Human genes 0.000 description 1
- 101710180042 39kDa core protein Proteins 0.000 description 1
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 1
- YTBRNEUEFCNVHC-UHFFFAOYSA-N 4,4'-dichlorobiphenyl Chemical compound C1=CC(Cl)=CC=C1C1=CC=C(Cl)C=C1 YTBRNEUEFCNVHC-UHFFFAOYSA-N 0.000 description 1
- VDQZABQVXYELSI-UHFFFAOYSA-N 4-(2-methylbutan-2-yl)cyclohexan-1-ol Chemical compound CCC(C)(C)C1CCC(O)CC1 VDQZABQVXYELSI-UHFFFAOYSA-N 0.000 description 1
- VJXRKZJMGVSXPX-UHFFFAOYSA-N 4-ethylpyridine Chemical compound CCC1=CC=NC=C1 VJXRKZJMGVSXPX-UHFFFAOYSA-N 0.000 description 1
- 102100037710 40S ribosomal protein S21 Human genes 0.000 description 1
- 102100031928 40S ribosomal protein S29 Human genes 0.000 description 1
- 102100027271 40S ribosomal protein SA Human genes 0.000 description 1
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 description 1
- NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 description 1
- 102000004023 5-Lipoxygenase-Activating Proteins Human genes 0.000 description 1
- 108090000411 5-Lipoxygenase-Activating Proteins Proteins 0.000 description 1
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 description 1
- QAJYCQZQLVENRZ-UHFFFAOYSA-N 6-chloropyridin-3-amine Chemical compound NC1=CC=C(Cl)N=C1 QAJYCQZQLVENRZ-UHFFFAOYSA-N 0.000 description 1
- 102100021927 60S ribosomal protein L27a Human genes 0.000 description 1
- 102100022048 60S ribosomal protein L36 Human genes 0.000 description 1
- 101710187872 60S ribosomal protein L36 Proteins 0.000 description 1
- 102100026802 72 kDa type IV collagenase Human genes 0.000 description 1
- 102100033824 A-kinase anchor protein 12 Human genes 0.000 description 1
- 102100024379 AF4/FMR2 family member 1 Human genes 0.000 description 1
- 102100033347 AP-2 complex subunit beta Human genes 0.000 description 1
- 102100037651 AP-2 complex subunit sigma Human genes 0.000 description 1
- 102100027573 ATP synthase subunit alpha, mitochondrial Human genes 0.000 description 1
- 102100032922 ATP-dependent 6-phosphofructokinase, muscle type Human genes 0.000 description 1
- 102100032787 ATPase family AAA domain-containing protein 3A Human genes 0.000 description 1
- 101710126783 Acetyl-hydrolase Proteins 0.000 description 1
- 108020005296 Acid Ceramidase Proteins 0.000 description 1
- 102100024005 Acid ceramidase Human genes 0.000 description 1
- 102100039819 Actin, alpha cardiac muscle 1 Human genes 0.000 description 1
- 102100036732 Actin, aortic smooth muscle Human genes 0.000 description 1
- 102100022454 Actin, gamma-enteric smooth muscle Human genes 0.000 description 1
- 101710197633 Actin-1 Proteins 0.000 description 1
- 102100020961 Actin-binding LIM protein 3 Human genes 0.000 description 1
- 108010005254 Activating Transcription Factors Proteins 0.000 description 1
- 102000005869 Activating Transcription Factors Human genes 0.000 description 1
- 102000010651 Adaptor Protein Complex 1 Human genes 0.000 description 1
- 108010077847 Adaptor Protein Complex 1 Proteins 0.000 description 1
- 108010077852 Adaptor Protein Complex 2 Proteins 0.000 description 1
- 102000010650 Adaptor Protein Complex 2 Human genes 0.000 description 1
- 102100036664 Adenosine deaminase Human genes 0.000 description 1
- 102100035990 Adenosine receptor A2a Human genes 0.000 description 1
- 102100020925 Adenosylhomocysteinase Human genes 0.000 description 1
- 102100036791 Adhesion G protein-coupled receptor L2 Human genes 0.000 description 1
- 208000005676 Adrenogenital syndrome Diseases 0.000 description 1
- 201000011452 Adrenoleukodystrophy Diseases 0.000 description 1
- 102100029599 Advanced glycosylation end product-specific receptor Human genes 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 102100036457 Akirin-1 Human genes 0.000 description 1
- 102100027211 Albumin Human genes 0.000 description 1
- 101710187578 Alcohol dehydrogenase 1 Proteins 0.000 description 1
- 102100034035 Alcohol dehydrogenase 1A Human genes 0.000 description 1
- 102100034042 Alcohol dehydrogenase 1C Human genes 0.000 description 1
- 101710187573 Alcohol dehydrogenase 2 Proteins 0.000 description 1
- 101710187571 Alcohol dehydrogenase 3 Proteins 0.000 description 1
- 101710133776 Alcohol dehydrogenase class-3 Proteins 0.000 description 1
- 102000052030 Aldehyde Dehydrogenase 1 Family Human genes 0.000 description 1
- 101710196131 Aldehyde dehydrogenase 1 Proteins 0.000 description 1
- 102100026605 Aldehyde dehydrogenase, dimeric NADP-preferring Human genes 0.000 description 1
- 102100026446 Aldo-keto reductase family 1 member C1 Human genes 0.000 description 1
- 101710117294 Aldo-keto reductase family 1 member C1 Proteins 0.000 description 1
- 102100024090 Aldo-keto reductase family 1 member C3 Human genes 0.000 description 1
- 101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 description 1
- 102100034044 All-trans-retinol dehydrogenase [NAD(+)] ADH1B Human genes 0.000 description 1
- 101710193111 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Proteins 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 108010074725 Alpha,alpha-trehalose phosphorylase Proteins 0.000 description 1
- 102100033879 Alpha-amylase 1A Human genes 0.000 description 1
- 102100031090 Alpha-catulin Human genes 0.000 description 1
- 102100040743 Alpha-crystallin B chain Human genes 0.000 description 1
- 102100038910 Alpha-enolase Human genes 0.000 description 1
- 108010033760 Amphiregulin Proteins 0.000 description 1
- 102000007299 Amphiregulin Human genes 0.000 description 1
- 102100040038 Amyloid beta precursor like protein 2 Human genes 0.000 description 1
- 108010079054 Amyloid beta-Protein Precursor Proteins 0.000 description 1
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 1
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 description 1
- 102100034594 Angiopoietin-1 Human genes 0.000 description 1
- 102000008873 Angiotensin II receptor Human genes 0.000 description 1
- 108050000824 Angiotensin II receptor Proteins 0.000 description 1
- 108090001067 Angiotensinogen Proteins 0.000 description 1
- 102000004881 Angiotensinogen Human genes 0.000 description 1
- 102100033393 Anillin Human genes 0.000 description 1
- 102100034615 Ankyrin repeat domain-containing protein 10 Human genes 0.000 description 1
- 108010049777 Ankyrins Proteins 0.000 description 1
- 102000008102 Ankyrins Human genes 0.000 description 1
- 108090000672 Annexin A5 Proteins 0.000 description 1
- 102000004121 Annexin A5 Human genes 0.000 description 1
- 102100034278 Annexin A6 Human genes 0.000 description 1
- 108020004491 Antisense DNA Proteins 0.000 description 1
- 102100030949 Apelin receptor Human genes 0.000 description 1
- 102100022954 Apolipoprotein D Human genes 0.000 description 1
- 102000004888 Aquaporin 1 Human genes 0.000 description 1
- 108090001004 Aquaporin 1 Proteins 0.000 description 1
- 102000012002 Aquaporin 4 Human genes 0.000 description 1
- 108010036280 Aquaporin 4 Proteins 0.000 description 1
- 101100404726 Arabidopsis thaliana NHX7 gene Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 208000002109 Argyria Diseases 0.000 description 1
- 102100029361 Aromatase Human genes 0.000 description 1
- 108010078554 Aromatase Proteins 0.000 description 1
- 102100023943 Arylsulfatase L Human genes 0.000 description 1
- 206010003594 Ataxia telangiectasia Diseases 0.000 description 1
- 102000007368 Ataxin-7 Human genes 0.000 description 1
- 108010032953 Ataxin-7 Proteins 0.000 description 1
- 102100039339 Atrial natriuretic peptide receptor 1 Human genes 0.000 description 1
- 101710102163 Atrial natriuretic peptide receptor 1 Proteins 0.000 description 1
- 241000713853 Avian sarcoma virus 17 Species 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 208000004736 B-Cell Leukemia Diseases 0.000 description 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
- 108091007065 BIRCs Proteins 0.000 description 1
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 1
- 102100023045 Band 4.1-like protein 2 Human genes 0.000 description 1
- 108050003326 Band 4.1-like protein 2 Proteins 0.000 description 1
- 102100039848 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 Human genes 0.000 description 1
- 102100027321 Beta-1,4-galactosyltransferase 7 Human genes 0.000 description 1
- 102100029649 Beta-arrestin-1 Human genes 0.000 description 1
- 102100022525 Bone morphogenetic protein 6 Human genes 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 102100028237 Breast cancer anti-estrogen resistance protein 1 Human genes 0.000 description 1
- 108050007340 Breast cancer anti-estrogen resistance protein 1 Proteins 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 102100021743 Bromodomain and PHD finger-containing protein 3 Human genes 0.000 description 1
- 102100029893 Bromodomain-containing protein 9 Human genes 0.000 description 1
- 102100031102 C-C motif chemokine 4 Human genes 0.000 description 1
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 1
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 1
- 102100025250 C-X-C motif chemokine 14 Human genes 0.000 description 1
- 102100026194 C-type lectin domain family 2 member B Human genes 0.000 description 1
- 102000002086 C-type lectin-like Human genes 0.000 description 1
- 108050009406 C-type lectin-like Proteins 0.000 description 1
- 102100037084 C4b-binding protein alpha chain Human genes 0.000 description 1
- 108091008927 CC chemokine receptors Proteins 0.000 description 1
- 108010026988 CCAAT-Binding Factor Proteins 0.000 description 1
- 102100034798 CCAAT/enhancer-binding protein beta Human genes 0.000 description 1
- 102100037676 CCAAT/enhancer-binding protein zeta Human genes 0.000 description 1
- 102000005674 CCR Receptors Human genes 0.000 description 1
- 102100032982 CCR4-NOT transcription complex subunit 9 Human genes 0.000 description 1
- 108010009992 CD163 antigen Proteins 0.000 description 1
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 1
- 102100035793 CD83 antigen Human genes 0.000 description 1
- 108700020472 CDC20 Proteins 0.000 description 1
- 101150047144 CDC28 gene Proteins 0.000 description 1
- 102100028228 COUP transcription factor 1 Human genes 0.000 description 1
- 102100027674 CTD small phosphatase-like protein Human genes 0.000 description 1
- 101150099461 CTL2 gene Proteins 0.000 description 1
- 102100033210 CUGBP Elav-like family member 2 Human genes 0.000 description 1
- 102100024155 Cadherin-11 Human genes 0.000 description 1
- 102100036360 Cadherin-3 Human genes 0.000 description 1
- 102100029761 Cadherin-5 Human genes 0.000 description 1
- 101100456610 Caenorhabditis elegans mdt-6 gene Proteins 0.000 description 1
- 102100027557 Calcipressin-1 Human genes 0.000 description 1
- 101710149003 Calcium-binding protein P Proteins 0.000 description 1
- 102100035632 Calcyphosin Human genes 0.000 description 1
- 101710085913 Calcyphosin Proteins 0.000 description 1
- 102100024436 Caldesmon Human genes 0.000 description 1
- 102100033620 Calponin-1 Human genes 0.000 description 1
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 1
- 101100293794 Canis lupus familiaris NME1 gene Proteins 0.000 description 1
- 101710132601 Capsid protein Proteins 0.000 description 1
- 102100033040 Carbonic anhydrase 12 Human genes 0.000 description 1
- 102100024633 Carbonic anhydrase 2 Human genes 0.000 description 1
- 101710167917 Carbonic anhydrase 2 Proteins 0.000 description 1
- 102100036375 Carbonic anhydrase-related protein Human genes 0.000 description 1
- 108090000489 Carboxy-Lyases Proteins 0.000 description 1
- 102100035023 Carboxypeptidase B2 Human genes 0.000 description 1
- 102100035654 Cathepsin S Human genes 0.000 description 1
- 108090000032 Caveolin 2 Proteins 0.000 description 1
- 102000003692 Caveolin 2 Human genes 0.000 description 1
- 102100035888 Caveolin-1 Human genes 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 101150023302 Cdc20 gene Proteins 0.000 description 1
- 102000011068 Cdc42 Human genes 0.000 description 1
- 108050001278 Cdc42 Proteins 0.000 description 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- 102100038503 Cellular retinoic acid-binding protein 1 Human genes 0.000 description 1
- 108050008847 Cellular retinoic acid-binding protein 1 Proteins 0.000 description 1
- 102100038504 Cellular retinoic acid-binding protein 2 Human genes 0.000 description 1
- 102100031219 Centrosomal protein of 55 kDa Human genes 0.000 description 1
- 102000009410 Chemokine receptor Human genes 0.000 description 1
- 108050000299 Chemokine receptor Proteins 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- 102000019034 Chemokines Human genes 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 102100038731 Chitinase-3-like protein 2 Human genes 0.000 description 1
- 102000009016 Cholera Toxin Human genes 0.000 description 1
- 108010049048 Cholera Toxin Proteins 0.000 description 1
- 102100037327 Chondrolectin Human genes 0.000 description 1
- 101710084930 Chondrolectin Proteins 0.000 description 1
- 102100030289 Chronophin Human genes 0.000 description 1
- 108010071536 Citrate (Si)-synthase Proteins 0.000 description 1
- 102000006732 Citrate synthase Human genes 0.000 description 1
- 102100025567 Citron Rho-interacting kinase Human genes 0.000 description 1
- 102100040836 Claudin-1 Human genes 0.000 description 1
- 108090000600 Claudin-1 Proteins 0.000 description 1
- 102100038445 Claudin-2 Human genes 0.000 description 1
- 108090000580 Claudin-2 Proteins 0.000 description 1
- 102100038446 Claudin-5 Human genes 0.000 description 1
- 108090000582 Claudin-5 Proteins 0.000 description 1
- 102100029057 Coagulation factor XIII A chain Human genes 0.000 description 1
- 101000573945 Coccidioides posadasii (strain C735) Neutral protease 2 homolog MEP2 Proteins 0.000 description 1
- 101000573882 Coccidioides posadasii (strain C735) Neutral protease 2 homolog MEP3 Proteins 0.000 description 1
- 101001013520 Coccidioides posadasii (strain C735) Neutral protease 2 homolog MEP7 Proteins 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 108700010070 Codon Usage Proteins 0.000 description 1
- 102100031045 Coiled-coil domain-containing protein 14 Human genes 0.000 description 1
- 102100034963 Coiled-coil domain-containing protein 167 Human genes 0.000 description 1
- 102100026766 Coiled-coil domain-containing protein 74B Human genes 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102100031611 Collagen alpha-1(III) chain Human genes 0.000 description 1
- 102100022145 Collagen alpha-1(IV) chain Human genes 0.000 description 1
- 102100031519 Collagen alpha-1(VI) chain Human genes 0.000 description 1
- 101710106877 Collagen alpha-1(XIV) chain Proteins 0.000 description 1
- 102100022640 Collagen alpha-1(XV) chain Human genes 0.000 description 1
- 102100040995 Collagen alpha-1(XXI) chain Human genes 0.000 description 1
- 102100036213 Collagen alpha-2(I) chain Human genes 0.000 description 1
- 102100024206 Collectin-10 Human genes 0.000 description 1
- 102100024330 Collectin-12 Human genes 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 102000014447 Complement C1q Human genes 0.000 description 1
- 108010078043 Complement C1q Proteins 0.000 description 1
- 108090000955 Complement C2 Proteins 0.000 description 1
- 102000004381 Complement C2 Human genes 0.000 description 1
- 108010028780 Complement C3 Proteins 0.000 description 1
- 102000016918 Complement C3 Human genes 0.000 description 1
- 108010028773 Complement C5 Proteins 0.000 description 1
- 102100031506 Complement C5 Human genes 0.000 description 1
- 108090000059 Complement factor D Proteins 0.000 description 1
- 102000003706 Complement factor D Human genes 0.000 description 1
- 208000008448 Congenital adrenal hyperplasia Diseases 0.000 description 1
- 102000010970 Connexin Human genes 0.000 description 1
- 108050001175 Connexin Proteins 0.000 description 1
- 108010069241 Connexin 43 Proteins 0.000 description 1
- 102000001045 Connexin 43 Human genes 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 108091004554 Copper Transport Proteins Proteins 0.000 description 1
- 102000037773 Copper transporters Human genes 0.000 description 1
- 108091006566 Copper transporters Proteins 0.000 description 1
- 108010072732 Core Binding Factors Proteins 0.000 description 1
- 102000006990 Core Binding Factors Human genes 0.000 description 1
- 102100031673 Corneodesmosin Human genes 0.000 description 1
- 101710139375 Corneodesmosin Proteins 0.000 description 1
- 101710156796 Cornifin Proteins 0.000 description 1
- 102100032202 Cornulin Human genes 0.000 description 1
- 101000796894 Coturnix japonica Alcohol dehydrogenase 1 Proteins 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- 241001559589 Cullen Species 0.000 description 1
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 description 1
- 102100036239 Cyclin-dependent kinase 2 Human genes 0.000 description 1
- 102100035353 Cyclin-dependent kinase 2-associated protein 1 Human genes 0.000 description 1
- 102100033269 Cyclin-dependent kinase inhibitor 1C Human genes 0.000 description 1
- 102100034770 Cyclin-dependent kinase inhibitor 3 Human genes 0.000 description 1
- 102100031237 Cystatin-A Human genes 0.000 description 1
- 102000005927 Cysteine Proteases Human genes 0.000 description 1
- 108010005843 Cysteine Proteases Proteins 0.000 description 1
- 102100035342 Cysteine dioxygenase type 1 Human genes 0.000 description 1
- 102000005889 Cysteine-Rich Protein 61 Human genes 0.000 description 1
- 108010019961 Cysteine-Rich Protein 61 Proteins 0.000 description 1
- 102100031565 Cytidine and dCMP deaminase domain-containing protein 1 Human genes 0.000 description 1
- 108010074918 Cytochrome P-450 CYP1A1 Proteins 0.000 description 1
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 description 1
- 102100031476 Cytochrome P450 1A1 Human genes 0.000 description 1
- 102100027417 Cytochrome P450 1B1 Human genes 0.000 description 1
- 102100026515 Cytochrome P450 2S1 Human genes 0.000 description 1
- 102100039208 Cytochrome P450 3A5 Human genes 0.000 description 1
- 102100025287 Cytochrome b Human genes 0.000 description 1
- 101710171534 Cytochrome b-c1 complex subunit 1, mitochondrial Proteins 0.000 description 1
- 101800000778 Cytochrome b-c1 complex subunit 9 Proteins 0.000 description 1
- 102400000011 Cytochrome b-c1 complex subunit 9 Human genes 0.000 description 1
- 102100031655 Cytochrome b5 Human genes 0.000 description 1
- 102100031649 Cytochrome c oxidase subunit 6B1 Human genes 0.000 description 1
- 102100028202 Cytochrome c oxidase subunit 6C Human genes 0.000 description 1
- 108010075028 Cytochromes b Proteins 0.000 description 1
- 108010007167 Cytochromes b5 Proteins 0.000 description 1
- 102100035149 Cytosolic endo-beta-N-acetylglucosaminidase Human genes 0.000 description 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 1
- 102100025269 DENN domain-containing protein 2B Human genes 0.000 description 1
- 101710141585 DENN domain-containing protein 2B Proteins 0.000 description 1
- 102100029816 DEP domain-containing mTOR-interacting protein Human genes 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 102100036674 DNA damage-binding protein 1 Human genes 0.000 description 1
- 102100033720 DNA replication licensing factor MCM6 Human genes 0.000 description 1
- 102100033587 DNA topoisomerase 2-alpha Human genes 0.000 description 1
- OAUWKHSGCCPXOD-UHFFFAOYSA-N DOC1 Natural products C1=CC(O)=C2C(CC(=O)NCCCCCNCCCNCCCNCCCN)=CNC2=C1 OAUWKHSGCCPXOD-UHFFFAOYSA-N 0.000 description 1
- 102100028735 Dachshund homolog 1 Human genes 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 102000005721 Death-Associated Protein Kinases Human genes 0.000 description 1
- 108010031042 Death-Associated Protein Kinases Proteins 0.000 description 1
- 102100024354 Dedicator of cytokinesis protein 6 Human genes 0.000 description 1
- 102100037458 Dephospho-CoA kinase Human genes 0.000 description 1
- 102100040606 Dermatan-sulfate epimerase Human genes 0.000 description 1
- 101710127030 Dermatan-sulfate epimerase Proteins 0.000 description 1
- 102100036411 Dermatopontin Human genes 0.000 description 1
- 101710088341 Dermatopontin Proteins 0.000 description 1
- 102100038199 Desmoplakin Human genes 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 108010092943 Dicarboxylic Acid Transporters Proteins 0.000 description 1
- 102000016862 Dicarboxylic Acid Transporters Human genes 0.000 description 1
- 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
- 102100032682 Dimethylaniline monooxygenase [N-oxide-forming] 2 Human genes 0.000 description 1
- 108010028143 Dioxygenases Proteins 0.000 description 1
- 102000016680 Dioxygenases Human genes 0.000 description 1
- 102100028572 Disabled homolog 2 Human genes 0.000 description 1
- 102100036723 Discoidin domain-containing receptor 2 Human genes 0.000 description 1
- 101710127786 Discoidin domain-containing receptor 2 Proteins 0.000 description 1
- 101800000620 Disintegrin-like Proteins 0.000 description 1
- 102100037830 Docking protein 2 Human genes 0.000 description 1
- 102100034583 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 Human genes 0.000 description 1
- 101000827763 Drosophila melanogaster Fibroblast growth factor receptor homolog 1 Proteins 0.000 description 1
- 101100262461 Drosophila melanogaster vih gene Proteins 0.000 description 1
- 102100036109 Dual specificity protein kinase TTK Human genes 0.000 description 1
- 102100037569 Dual specificity protein phosphatase 10 Human genes 0.000 description 1
- 102100028987 Dual specificity protein phosphatase 2 Human genes 0.000 description 1
- 108010000518 Dual-Specificity Phosphatases Proteins 0.000 description 1
- 102000002266 Dual-Specificity Phosphatases Human genes 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 102100026245 E3 ubiquitin-protein ligase RNF43 Human genes 0.000 description 1
- 102100032058 EARP and GARP complex-interacting protein 1 Human genes 0.000 description 1
- 102100040976 EF-hand and coiled-coil domain-containing protein 1 Human genes 0.000 description 1
- 102100031414 EF-hand domain-containing protein D1 Human genes 0.000 description 1
- 102100020865 EKC/KEOPS complex subunit LAGE3 Human genes 0.000 description 1
- 102100025137 Early activation antigen CD69 Human genes 0.000 description 1
- 102100021717 Early growth response protein 3 Human genes 0.000 description 1
- 101710083262 Ectin Proteins 0.000 description 1
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 description 1
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 description 1
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 description 1
- 102100023795 Elafin Human genes 0.000 description 1
- 102100037241 Endoglin Human genes 0.000 description 1
- 102100028773 Endonuclease 8-like 3 Human genes 0.000 description 1
- 108010041308 Endothelial Growth Factors Proteins 0.000 description 1
- 102100031785 Endothelial transcription factor GATA-2 Human genes 0.000 description 1
- 102100021579 Enhancer of filamentation 1 Human genes 0.000 description 1
- 108010062466 Enzyme Precursors Proteins 0.000 description 1
- 102000010911 Enzyme Precursors Human genes 0.000 description 1
- 101800003838 Epidermal growth factor Proteins 0.000 description 1
- 102100024848 Epidermal retinol dehydrogenase 2 Human genes 0.000 description 1
- 101710138625 Epidermal retinol dehydrogenase 2 Proteins 0.000 description 1
- 102100033183 Epithelial membrane protein 1 Human genes 0.000 description 1
- 102100033176 Epithelial membrane protein 2 Human genes 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 102100036823 Erlin-2 Human genes 0.000 description 1
- 101000621102 Escherichia phage Mu Portal protein Proteins 0.000 description 1
- 101000764572 Escherichia phage lambda Tape measure protein Proteins 0.000 description 1
- 108700039887 Essential Genes Proteins 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000490229 Eucephalus Species 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 102100023637 FYVE, RhoGEF and PH domain-containing protein 6 Human genes 0.000 description 1
- 108010074860 Factor Xa Proteins 0.000 description 1
- 102100030431 Fatty acid-binding protein, adipocyte Human genes 0.000 description 1
- 102100035049 Feline leukemia virus subgroup C receptor-related protein 2 Human genes 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 102100040683 Fermitin family homolog 1 Human genes 0.000 description 1
- 102100040684 Fermitin family homolog 2 Human genes 0.000 description 1
- 102100031510 Fibrillin-2 Human genes 0.000 description 1
- 102100035290 Fibroblast growth factor 13 Human genes 0.000 description 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
- 102100038647 Fibroleukin Human genes 0.000 description 1
- 102000017177 Fibromodulin Human genes 0.000 description 1
- 108010013996 Fibromodulin Proteins 0.000 description 1
- 101001067614 Flaveria pringlei Serine hydroxymethyltransferase 2, mitochondrial Proteins 0.000 description 1
- 108010091824 Focal Adhesion Kinase 1 Proteins 0.000 description 1
- 102100037813 Focal adhesion kinase 1 Human genes 0.000 description 1
- 102100020848 Forkhead box protein F2 Human genes 0.000 description 1
- 102100022633 Fructose-2,6-bisphosphatase Human genes 0.000 description 1
- 102100027269 Fructose-bisphosphate aldolase C Human genes 0.000 description 1
- 102000034286 G proteins Human genes 0.000 description 1
- 108010008959 G-Protein-Coupled Receptor Kinases Proteins 0.000 description 1
- 102000006575 G-Protein-Coupled Receptor Kinases Human genes 0.000 description 1
- 102100032524 G-protein coupled receptor family C group 5 member C Human genes 0.000 description 1
- 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 description 1
- 102100024515 GDP-L-fucose synthase Human genes 0.000 description 1
- 101150104463 GOS2 gene Proteins 0.000 description 1
- 102100032950 GPI mannosyltransferase 1 Human genes 0.000 description 1
- 101710100495 GPI mannosyltransferase 1 Proteins 0.000 description 1
- 102100037740 GRB2-associated-binding protein 1 Human genes 0.000 description 1
- 102100033512 GTP:AMP phosphotransferase AK3, mitochondrial Human genes 0.000 description 1
- 102100024412 GTPase IMAP family member 4 Human genes 0.000 description 1
- 102100024421 GTPase IMAP family member 6 Human genes 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102100030525 Gap junction alpha-4 protein Human genes 0.000 description 1
- 102100037260 Gap junction beta-1 protein Human genes 0.000 description 1
- 102100037156 Gap junction beta-2 protein Human genes 0.000 description 1
- 102100039417 Gap junction beta-5 protein Human genes 0.000 description 1
- 208000015872 Gaucher disease Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000058062 Glucose Transporter Type 3 Human genes 0.000 description 1
- 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 1
- 108010055629 Glucosyltransferases Proteins 0.000 description 1
- 102000000340 Glucosyltransferases Human genes 0.000 description 1
- 102000009127 Glutaminase Human genes 0.000 description 1
- 108010073324 Glutaminase Proteins 0.000 description 1
- 102100025945 Glutaredoxin-1 Human genes 0.000 description 1
- 102100028603 Glutaryl-CoA dehydrogenase, mitochondrial Human genes 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 102100023523 Glutathione S-transferase Mu 4 Human genes 0.000 description 1
- 102100033044 Glutathione peroxidase 2 Human genes 0.000 description 1
- 102100033053 Glutathione peroxidase 3 Human genes 0.000 description 1
- 102100022556 Glycerol-3-phosphate dehydrogenase 1-like protein Human genes 0.000 description 1
- 102100021192 Glycerophosphocholine phosphodiesterase GPCPD1 Human genes 0.000 description 1
- 101710180399 Glycine-rich protein Proteins 0.000 description 1
- 102100025303 Glycogenin-2 Human genes 0.000 description 1
- 101710152102 Glycogenin-2 Proteins 0.000 description 1
- 102100023849 Glycophorin-C Human genes 0.000 description 1
- 102100034227 Grainyhead-like protein 2 homolog Human genes 0.000 description 1
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 1
- 108091027874 Group I catalytic intron Proteins 0.000 description 1
- 108091029499 Group II intron Proteins 0.000 description 1
- 102100031153 Growth arrest and DNA damage-inducible protein GADD45 beta Human genes 0.000 description 1
- 102100031487 Growth arrest-specific protein 6 Human genes 0.000 description 1
- 102100033067 Growth factor receptor-bound protein 2 Human genes 0.000 description 1
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 description 1
- 102100034154 Guanine nucleotide-binding protein G(i) subunit alpha-2 Human genes 0.000 description 1
- 102100032610 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Human genes 0.000 description 1
- 102100028963 Guanylate cyclase soluble subunit beta-2 Human genes 0.000 description 1
- 102100028541 Guanylate-binding protein 2 Human genes 0.000 description 1
- 102100034473 H(+)/Cl(-) exchange transporter 6 Human genes 0.000 description 1
- 102100030488 HEAT repeat-containing protein 6 Human genes 0.000 description 1
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 description 1
- 102100033079 HLA class II histocompatibility antigen, DM alpha chain Human genes 0.000 description 1
- 102100031258 HLA class II histocompatibility antigen, DM beta chain Human genes 0.000 description 1
- 102100036241 HLA class II histocompatibility antigen, DQ beta 1 chain Human genes 0.000 description 1
- 102100040505 HLA class II histocompatibility antigen, DR alpha chain Human genes 0.000 description 1
- 108010088729 HLA-A*02:01 antigen Proteins 0.000 description 1
- 108010065026 HLA-DQB1 antigen Proteins 0.000 description 1
- 108010067802 HLA-DR alpha-Chains Proteins 0.000 description 1
- 102100032489 Heat shock 70 kDa protein 13 Human genes 0.000 description 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 1
- 102100028006 Heme oxygenase 1 Human genes 0.000 description 1
- 102100027685 Hemoglobin subunit alpha Human genes 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 102100030500 Heparin cofactor 2 Human genes 0.000 description 1
- 108010020382 Hepatocyte Nuclear Factor 1-alpha Proteins 0.000 description 1
- 108010061414 Hepatocyte Nuclear Factor 1-beta Proteins 0.000 description 1
- 108010068250 Herpes Simplex Virus Protein Vmw65 Proteins 0.000 description 1
- 102100028818 Heterogeneous nuclear ribonucleoprotein L Human genes 0.000 description 1
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 description 1
- 102100022130 High mobility group protein B3 Human genes 0.000 description 1
- 102100028999 High mobility group protein HMGI-C Human genes 0.000 description 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 1
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 1
- 102100039265 Histone H2A type 1-C Human genes 0.000 description 1
- 102100030689 Histone H2B type 1-D Human genes 0.000 description 1
- 102100038147 Histone chaperone ASF1B Human genes 0.000 description 1
- 101710135007 Histone-like protein p6 Proteins 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 108700005087 Homeobox Genes Proteins 0.000 description 1
- 102100022373 Homeobox protein DLX-5 Human genes 0.000 description 1
- 102100034862 Homeobox protein Hox-B2 Human genes 0.000 description 1
- 102100025061 Homeobox protein Hox-B7 Human genes 0.000 description 1
- 102100027893 Homeobox protein Nkx-2.1 Human genes 0.000 description 1
- 102000009331 Homeodomain Proteins Human genes 0.000 description 1
- 108010048671 Homeodomain Proteins Proteins 0.000 description 1
- 101000845090 Homo sapiens 11-beta-hydroxysteroid dehydrogenase type 2 Proteins 0.000 description 1
- 101001126430 Homo sapiens 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Proteins 0.000 description 1
- 101001031333 Homo sapiens 17-beta-hydroxysteroid dehydrogenase type 6 Proteins 0.000 description 1
- 101000934666 Homo sapiens 2-oxoglutarate and iron-dependent oxygenase JMJD4 Proteins 0.000 description 1
- 101000590272 Homo sapiens 26S proteasome non-ATPase regulatory subunit 2 Proteins 0.000 description 1
- 101000835276 Homo sapiens 3-ketoacyl-CoA thiolase, mitochondrial Proteins 0.000 description 1
- 101000640855 Homo sapiens 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Proteins 0.000 description 1
- 101001107433 Homo sapiens 39S ribosomal protein L23, mitochondrial Proteins 0.000 description 1
- 101001097814 Homo sapiens 40S ribosomal protein S21 Proteins 0.000 description 1
- 101000704060 Homo sapiens 40S ribosomal protein S29 Proteins 0.000 description 1
- 101000694288 Homo sapiens 40S ribosomal protein SA Proteins 0.000 description 1
- 101000753696 Homo sapiens 60S ribosomal protein L27a Proteins 0.000 description 1
- 101000716179 Homo sapiens 60S ribosomal protein L39 Proteins 0.000 description 1
- 101000779382 Homo sapiens A-kinase anchor protein 12 Proteins 0.000 description 1
- 101000833180 Homo sapiens AF4/FMR2 family member 1 Proteins 0.000 description 1
- 101000732341 Homo sapiens AP-2 complex subunit beta Proteins 0.000 description 1
- 101000806914 Homo sapiens AP-2 complex subunit sigma Proteins 0.000 description 1
- 101000936262 Homo sapiens ATP synthase subunit alpha, mitochondrial Proteins 0.000 description 1
- 101000730838 Homo sapiens ATP-dependent 6-phosphofructokinase, muscle type Proteins 0.000 description 1
- 101000923360 Homo sapiens ATPase family AAA domain-containing protein 3A Proteins 0.000 description 1
- 101000959247 Homo sapiens Actin, alpha cardiac muscle 1 Proteins 0.000 description 1
- 101000929319 Homo sapiens Actin, aortic smooth muscle Proteins 0.000 description 1
- 101000678433 Homo sapiens Actin, gamma-enteric smooth muscle Proteins 0.000 description 1
- 101000783819 Homo sapiens Actin-binding LIM protein 3 Proteins 0.000 description 1
- 101000783751 Homo sapiens Adenosine receptor A2a Proteins 0.000 description 1
- 101000716952 Homo sapiens Adenosylhomocysteinase Proteins 0.000 description 1
- 101000928189 Homo sapiens Adhesion G protein-coupled receptor L2 Proteins 0.000 description 1
- 101000928511 Homo sapiens Akirin-1 Proteins 0.000 description 1
- 101000780463 Homo sapiens Alcohol dehydrogenase 1C Proteins 0.000 description 1
- 101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 description 1
- 101000779871 Homo sapiens Alpha-amylase 1A Proteins 0.000 description 1
- 101000922043 Homo sapiens Alpha-catulin Proteins 0.000 description 1
- 101000891982 Homo sapiens Alpha-crystallin B chain Proteins 0.000 description 1
- 101000890401 Homo sapiens Amyloid beta precursor like protein 2 Proteins 0.000 description 1
- 101000779315 Homo sapiens Anaphase-promoting complex subunit 10 Proteins 0.000 description 1
- 101000924552 Homo sapiens Angiopoietin-1 Proteins 0.000 description 1
- 101000732632 Homo sapiens Anillin Proteins 0.000 description 1
- 101000924478 Homo sapiens Ankyrin repeat domain-containing protein 10 Proteins 0.000 description 1
- 101000780137 Homo sapiens Annexin A6 Proteins 0.000 description 1
- 101000975827 Homo sapiens Arylsulfatase L Proteins 0.000 description 1
- 101000887635 Homo sapiens Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 Proteins 0.000 description 1
- 101000899390 Homo sapiens Bone morphogenetic protein 6 Proteins 0.000 description 1
- 101000896771 Homo sapiens Bromodomain and PHD finger-containing protein 3 Proteins 0.000 description 1
- 101000794032 Homo sapiens Bromodomain-containing protein 9 Proteins 0.000 description 1
- 101000777471 Homo sapiens C-C motif chemokine 4 Proteins 0.000 description 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 1
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 description 1
- 101000858068 Homo sapiens C-X-C motif chemokine 14 Proteins 0.000 description 1
- 101000912618 Homo sapiens C-type lectin domain family 2 member B Proteins 0.000 description 1
- 101000740685 Homo sapiens C4b-binding protein alpha chain Proteins 0.000 description 1
- 101000945963 Homo sapiens CCAAT/enhancer-binding protein beta Proteins 0.000 description 1
- 101100438661 Homo sapiens CCDC167 gene Proteins 0.000 description 1
- 101000942590 Homo sapiens CCR4-NOT transcription complex subunit 9 Proteins 0.000 description 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 description 1
- 101000860854 Homo sapiens COUP transcription factor 1 Proteins 0.000 description 1
- 101000725950 Homo sapiens CTD small phosphatase-like protein Proteins 0.000 description 1
- 101000944442 Homo sapiens CUGBP Elav-like family member 2 Proteins 0.000 description 1
- 101000762236 Homo sapiens Cadherin-11 Proteins 0.000 description 1
- 101000762243 Homo sapiens Cadherin-13 Proteins 0.000 description 1
- 101000714553 Homo sapiens Cadherin-3 Proteins 0.000 description 1
- 101000794587 Homo sapiens Cadherin-5 Proteins 0.000 description 1
- 101000580357 Homo sapiens Calcipressin-1 Proteins 0.000 description 1
- 101000910297 Homo sapiens Caldesmon Proteins 0.000 description 1
- 101000945318 Homo sapiens Calponin-1 Proteins 0.000 description 1
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 1
- 101000882994 Homo sapiens Carbohydrate sulfotransferase 5 Proteins 0.000 description 1
- 101000946518 Homo sapiens Carboxypeptidase B2 Proteins 0.000 description 1
- 101000715467 Homo sapiens Caveolin-1 Proteins 0.000 description 1
- 101000884317 Homo sapiens Cell division cycle protein 20 homolog Proteins 0.000 description 1
- 101001099851 Homo sapiens Cellular retinoic acid-binding protein 2 Proteins 0.000 description 1
- 101000776447 Homo sapiens Centrosomal protein of 55 kDa Proteins 0.000 description 1
- 101000883325 Homo sapiens Chitinase-3-like protein 2 Proteins 0.000 description 1
- 101000741348 Homo sapiens Chromatin assembly factor 1 subunit A Proteins 0.000 description 1
- 101000582974 Homo sapiens Chronophin Proteins 0.000 description 1
- 101000856200 Homo sapiens Citron Rho-interacting kinase Proteins 0.000 description 1
- 101000918352 Homo sapiens Coagulation factor XIII A chain Proteins 0.000 description 1
- 101000777340 Homo sapiens Coiled-coil domain-containing protein 14 Proteins 0.000 description 1
- 101000910812 Homo sapiens Coiled-coil domain-containing protein 74B Proteins 0.000 description 1
- 101000993285 Homo sapiens Collagen alpha-1(III) chain Proteins 0.000 description 1
- 101000901150 Homo sapiens Collagen alpha-1(IV) chain Proteins 0.000 description 1
- 101000941581 Homo sapiens Collagen alpha-1(VI) chain Proteins 0.000 description 1
- 101000909626 Homo sapiens Collagen alpha-1(XIV) chain Proteins 0.000 description 1
- 101000899935 Homo sapiens Collagen alpha-1(XV) chain Proteins 0.000 description 1
- 101000748976 Homo sapiens Collagen alpha-1(XXI) chain Proteins 0.000 description 1
- 101000875067 Homo sapiens Collagen alpha-2(I) chain Proteins 0.000 description 1
- 101000710876 Homo sapiens Collagen alpha-2(IV) chain Proteins 0.000 description 1
- 101000941585 Homo sapiens Collagen alpha-2(VI) chain Proteins 0.000 description 1
- 101000909632 Homo sapiens Collectin-10 Proteins 0.000 description 1
- 101000909528 Homo sapiens Collectin-12 Proteins 0.000 description 1
- 101000702152 Homo sapiens Cornifin-B Proteins 0.000 description 1
- 101000920981 Homo sapiens Cornulin Proteins 0.000 description 1
- 101000905723 Homo sapiens Cyclic AMP-dependent transcription factor ATF-7 Proteins 0.000 description 1
- 101000737813 Homo sapiens Cyclin-dependent kinase 2-associated protein 1 Proteins 0.000 description 1
- 101000944365 Homo sapiens Cyclin-dependent kinase inhibitor 1C Proteins 0.000 description 1
- 101000945639 Homo sapiens Cyclin-dependent kinase inhibitor 3 Proteins 0.000 description 1
- 101000921786 Homo sapiens Cystatin-A Proteins 0.000 description 1
- 101000737778 Homo sapiens Cysteine dioxygenase type 1 Proteins 0.000 description 1
- 101000777693 Homo sapiens Cytidine and dCMP deaminase domain-containing protein 1 Proteins 0.000 description 1
- 101000725164 Homo sapiens Cytochrome P450 1B1 Proteins 0.000 description 1
- 101000855328 Homo sapiens Cytochrome P450 2S1 Proteins 0.000 description 1
- 101000607486 Homo sapiens Cytochrome b-c1 complex subunit 1, mitochondrial Proteins 0.000 description 1
- 101000922367 Homo sapiens Cytochrome c oxidase subunit 6B1 Proteins 0.000 description 1
- 101000861049 Homo sapiens Cytochrome c oxidase subunit 6C Proteins 0.000 description 1
- 101000877468 Homo sapiens Cytosolic endo-beta-N-acetylglucosaminidase Proteins 0.000 description 1
- 101000865183 Homo sapiens DEP domain-containing mTOR-interacting protein Proteins 0.000 description 1
- 101001018484 Homo sapiens DNA replication licensing factor MCM6 Proteins 0.000 description 1
- 101000915055 Homo sapiens Dachshund homolog 1 Proteins 0.000 description 1
- 101001052950 Homo sapiens Dedicator of cytokinesis protein 6 Proteins 0.000 description 1
- 101001053503 Homo sapiens Dihydropyrimidinase-related protein 2 Proteins 0.000 description 1
- 101000915391 Homo sapiens Disabled homolog 2 Proteins 0.000 description 1
- 101000832767 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 8 Proteins 0.000 description 1
- 101000805166 Homo sapiens Docking protein 2 Proteins 0.000 description 1
- 101000848781 Homo sapiens Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1 Proteins 0.000 description 1
- 101000927648 Homo sapiens Dolichyldiphosphatase 1 Proteins 0.000 description 1
- 101000881127 Homo sapiens Dual specificity protein phosphatase 10 Proteins 0.000 description 1
- 101000838335 Homo sapiens Dual specificity protein phosphatase 2 Proteins 0.000 description 1
- 101000692702 Homo sapiens E3 ubiquitin-protein ligase RNF43 Proteins 0.000 description 1
- 101000921326 Homo sapiens EARP and GARP complex-interacting protein 1 Proteins 0.000 description 1
- 101000815518 Homo sapiens EF-hand and coiled-coil domain-containing protein 1 Proteins 0.000 description 1
- 101000866909 Homo sapiens EF-hand domain-containing protein D1 Proteins 0.000 description 1
- 101001137983 Homo sapiens EKC/KEOPS complex subunit LAGE3 Proteins 0.000 description 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 description 1
- 101000896450 Homo sapiens Early growth response protein 3 Proteins 0.000 description 1
- 101001048718 Homo sapiens Elafin Proteins 0.000 description 1
- 101001123819 Homo sapiens Endonuclease 8-like 3 Proteins 0.000 description 1
- 101001066265 Homo sapiens Endothelial transcription factor GATA-2 Proteins 0.000 description 1
- 101000898310 Homo sapiens Enhancer of filamentation 1 Proteins 0.000 description 1
- 101000851002 Homo sapiens Epithelial membrane protein 2 Proteins 0.000 description 1
- 101000851719 Homo sapiens Erlin-2 Proteins 0.000 description 1
- 101100012856 Homo sapiens FGD6 gene Proteins 0.000 description 1
- 101001062864 Homo sapiens Fatty acid-binding protein, adipocyte Proteins 0.000 description 1
- 101001022717 Homo sapiens Feline leukemia virus subgroup C receptor-related protein 2 Proteins 0.000 description 1
- 101000892670 Homo sapiens Fermitin family homolog 1 Proteins 0.000 description 1
- 101000846890 Homo sapiens Fibrillin-2 Proteins 0.000 description 1
- 101001031613 Homo sapiens Fibroleukin Proteins 0.000 description 1
- 101000931482 Homo sapiens Forkhead box protein F2 Proteins 0.000 description 1
- 101000836545 Homo sapiens Fructose-bisphosphate aldolase C Proteins 0.000 description 1
- 101001014685 Homo sapiens G-protein coupled receptor family C group 5 member C Proteins 0.000 description 1
- 101000868643 Homo sapiens G2/mitotic-specific cyclin-B1 Proteins 0.000 description 1
- 101001052793 Homo sapiens GDP-L-fucose synthase Proteins 0.000 description 1
- 101001024897 Homo sapiens GRB2-associated-binding protein 1 Proteins 0.000 description 1
- 101000833375 Homo sapiens GTPase IMAP family member 4 Proteins 0.000 description 1
- 101000833389 Homo sapiens GTPase IMAP family member 6 Proteins 0.000 description 1
- 101000726582 Homo sapiens Gap junction alpha-4 protein Proteins 0.000 description 1
- 101000954104 Homo sapiens Gap junction beta-1 protein Proteins 0.000 description 1
- 101000954092 Homo sapiens Gap junction beta-2 protein Proteins 0.000 description 1
- 101000889145 Homo sapiens Gap junction beta-5 protein Proteins 0.000 description 1
- 101000856983 Homo sapiens Glutaredoxin-1 Proteins 0.000 description 1
- 101000906399 Homo sapiens Glutathione S-transferase Mu 4 Proteins 0.000 description 1
- 101000871129 Homo sapiens Glutathione peroxidase 2 Proteins 0.000 description 1
- 101000871067 Homo sapiens Glutathione peroxidase 3 Proteins 0.000 description 1
- 101000900194 Homo sapiens Glycerol-3-phosphate dehydrogenase 1-like protein Proteins 0.000 description 1
- 101001040698 Homo sapiens Glycerophosphocholine phosphodiesterase GPCPD1 Proteins 0.000 description 1
- 101000905336 Homo sapiens Glycophorin-C Proteins 0.000 description 1
- 101001069929 Homo sapiens Grainyhead-like protein 2 homolog Proteins 0.000 description 1
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 1
- 101001066164 Homo sapiens Growth arrest and DNA damage-inducible protein GADD45 beta Proteins 0.000 description 1
- 101000923005 Homo sapiens Growth arrest-specific protein 6 Proteins 0.000 description 1
- 101000871017 Homo sapiens Growth factor receptor-bound protein 2 Proteins 0.000 description 1
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 description 1
- 101001070508 Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-2 Proteins 0.000 description 1
- 101001014590 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Proteins 0.000 description 1
- 101001014594 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Proteins 0.000 description 1
- 101001059095 Homo sapiens Guanylate cyclase soluble subunit beta-2 Proteins 0.000 description 1
- 101001058858 Homo sapiens Guanylate-binding protein 2 Proteins 0.000 description 1
- 101000710240 Homo sapiens H(+)/Cl(-) exchange transporter 6 Proteins 0.000 description 1
- 101000990566 Homo sapiens HEAT repeat-containing protein 6 Proteins 0.000 description 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 1
- 101001016638 Homo sapiens Heat shock 70 kDa protein 13 Proteins 0.000 description 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 1
- 101001079623 Homo sapiens Heme oxygenase 1 Proteins 0.000 description 1
- 101001009007 Homo sapiens Hemoglobin subunit alpha Proteins 0.000 description 1
- 101001082432 Homo sapiens Heparin cofactor 2 Proteins 0.000 description 1
- 101001045751 Homo sapiens Hepatocyte nuclear factor 1-alpha Proteins 0.000 description 1
- 101001045758 Homo sapiens Hepatocyte nuclear factor 1-beta Proteins 0.000 description 1
- 101000839078 Homo sapiens Heterogeneous nuclear ribonucleoprotein L Proteins 0.000 description 1
- 101000824104 Homo sapiens High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 description 1
- 101001045794 Homo sapiens High mobility group protein B3 Proteins 0.000 description 1
- 101000986379 Homo sapiens High mobility group protein HMGI-C Proteins 0.000 description 1
- 101001036109 Homo sapiens Histone H2A type 1-C Proteins 0.000 description 1
- 101001084684 Homo sapiens Histone H2B type 1-D Proteins 0.000 description 1
- 101000884473 Homo sapiens Histone chaperone ASF1B Proteins 0.000 description 1
- 101000901627 Homo sapiens Homeobox protein DLX-5 Proteins 0.000 description 1
- 101001019752 Homo sapiens Homeobox protein Hox-B2 Proteins 0.000 description 1
- 101001077539 Homo sapiens Homeobox protein Hox-B7 Proteins 0.000 description 1
- 101001035951 Homo sapiens Hyaluronan-binding protein 2 Proteins 0.000 description 1
- 101000962526 Homo sapiens Hyaluronidase-2 Proteins 0.000 description 1
- 101001035752 Homo sapiens Hydroxycarboxylic acid receptor 3 Proteins 0.000 description 1
- 101001082574 Homo sapiens Hypoxia-inducible factor 1-alpha inhibitor Proteins 0.000 description 1
- 101000840257 Homo sapiens Immunoglobulin kappa constant Proteins 0.000 description 1
- 101000998629 Homo sapiens Importin subunit beta-1 Proteins 0.000 description 1
- 101000852852 Homo sapiens Innate immunity activator protein Proteins 0.000 description 1
- 101000993973 Homo sapiens Inositol-pentakisphosphate 2-kinase Proteins 0.000 description 1
- 101001044940 Homo sapiens Insulin-like growth factor-binding protein 2 Proteins 0.000 description 1
- 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 description 1
- 101000840572 Homo sapiens Insulin-like growth factor-binding protein 4 Proteins 0.000 description 1
- 101000840582 Homo sapiens Insulin-like growth factor-binding protein 6 Proteins 0.000 description 1
- 101001050468 Homo sapiens Integral membrane protein 2B Proteins 0.000 description 1
- 101001035232 Homo sapiens Integrin alpha-9 Proteins 0.000 description 1
- 101001015006 Homo sapiens Integrin beta-4 Proteins 0.000 description 1
- 101001015064 Homo sapiens Integrin beta-6 Proteins 0.000 description 1
- 101001015037 Homo sapiens Integrin beta-7 Proteins 0.000 description 1
- 101001054334 Homo sapiens Interferon beta Proteins 0.000 description 1
- 101000598002 Homo sapiens Interferon regulatory factor 1 Proteins 0.000 description 1
- 101001076422 Homo sapiens Interleukin-1 receptor type 2 Proteins 0.000 description 1
- 101000599056 Homo sapiens Interleukin-6 receptor subunit beta Proteins 0.000 description 1
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 description 1
- 101001053438 Homo sapiens Iroquois-class homeodomain protein IRX-2 Proteins 0.000 description 1
- 101001008989 Homo sapiens KICSTOR subunit 2 Proteins 0.000 description 1
- 101000971351 Homo sapiens KRR1 small subunit processome component homolog Proteins 0.000 description 1
- 101001047041 Homo sapiens Kelch repeat and BTB domain-containing protein 7 Proteins 0.000 description 1
- 101000998011 Homo sapiens Keratin, type I cytoskeletal 19 Proteins 0.000 description 1
- 101001007027 Homo sapiens Keratin, type II cuticular Hb1 Proteins 0.000 description 1
- 101001056452 Homo sapiens Keratin, type II cytoskeletal 6A Proteins 0.000 description 1
- 101001050567 Homo sapiens Kinesin-like protein KIF2C Proteins 0.000 description 1
- 101001139112 Homo sapiens Krueppel-like factor 9 Proteins 0.000 description 1
- 101001047511 Homo sapiens LLGL scribble cell polarity complex component 2 Proteins 0.000 description 1
- 101000972488 Homo sapiens Laminin subunit alpha-4 Proteins 0.000 description 1
- 101001008558 Homo sapiens Laminin subunit beta-2 Proteins 0.000 description 1
- 101000946306 Homo sapiens Laminin subunit gamma-1 Proteins 0.000 description 1
- 101001054649 Homo sapiens Latent-transforming growth factor beta-binding protein 2 Proteins 0.000 description 1
- 101001054646 Homo sapiens Latent-transforming growth factor beta-binding protein 3 Proteins 0.000 description 1
- 101000980823 Homo sapiens Leukocyte surface antigen CD53 Proteins 0.000 description 1
- 101001036258 Homo sapiens Little elongation complex subunit 2 Proteins 0.000 description 1
- 101000941071 Homo sapiens Lysosomal cobalamin transport escort protein LMBD1 Proteins 0.000 description 1
- 101000763322 Homo sapiens M1-specific T cell receptor beta chain Proteins 0.000 description 1
- 101001005708 Homo sapiens MARVEL domain-containing protein 1 Proteins 0.000 description 1
- 101100456893 Homo sapiens METTL9 gene Proteins 0.000 description 1
- 101001056015 Homo sapiens Mannan-binding lectin serine protease 2 Proteins 0.000 description 1
- 101000980026 Homo sapiens Maternal embryonic leucine zipper kinase Proteins 0.000 description 1
- 101000990912 Homo sapiens Matrilysin Proteins 0.000 description 1
- 101001011896 Homo sapiens Matrix metalloproteinase-19 Proteins 0.000 description 1
- 101000636206 Homo sapiens Matrix remodeling-associated protein 8 Proteins 0.000 description 1
- 101000636209 Homo sapiens Matrix-remodeling-associated protein 5 Proteins 0.000 description 1
- 101001055354 Homo sapiens Mediator of RNA polymerase II transcription subunit 6 Proteins 0.000 description 1
- 101001005720 Homo sapiens Melanoma-associated antigen 4 Proteins 0.000 description 1
- 101001005722 Homo sapiens Melanoma-associated antigen 6 Proteins 0.000 description 1
- 101000956335 Homo sapiens Membrane-spanning 4-domains subfamily A member 14 Proteins 0.000 description 1
- 101000956307 Homo sapiens Membrane-spanning 4-domains subfamily A member 8 Proteins 0.000 description 1
- 101000822604 Homo sapiens Methanethiol oxidase Proteins 0.000 description 1
- 101000979001 Homo sapiens Methionine aminopeptidase 2 Proteins 0.000 description 1
- 101000947699 Homo sapiens Microfibril-associated glycoprotein 4 Proteins 0.000 description 1
- 101000969087 Homo sapiens Microtubule-associated protein 2 Proteins 0.000 description 1
- 101000615613 Homo sapiens Mineralocorticoid receptor Proteins 0.000 description 1
- 101001038443 Homo sapiens Mitochondrial glutamate carrier 1 Proteins 0.000 description 1
- 101000882884 Homo sapiens Mitochondrial tRNA methylthiotransferase CDK5RAP1 Proteins 0.000 description 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 1
- 101001133081 Homo sapiens Mucin-2 Proteins 0.000 description 1
- 101000593405 Homo sapiens Myb-related protein B Proteins 0.000 description 1
- 101001022780 Homo sapiens Myosin light chain kinase, smooth muscle Proteins 0.000 description 1
- 101000958771 Homo sapiens N-acylethanolamine-hydrolyzing acid amidase Proteins 0.000 description 1
- 101000958778 Homo sapiens N-alpha-acetyltransferase 60 Proteins 0.000 description 1
- 101000906927 Homo sapiens N-chimaerin Proteins 0.000 description 1
- 101000601616 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Proteins 0.000 description 1
- 101001128634 Homo sapiens NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Proteins 0.000 description 1
- 101000928259 Homo sapiens NADPH:adrenodoxin oxidoreductase, mitochondrial Proteins 0.000 description 1
- 101100294188 Homo sapiens NIN gene Proteins 0.000 description 1
- 101001125322 Homo sapiens Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Proteins 0.000 description 1
- 101001111320 Homo sapiens Nestin Proteins 0.000 description 1
- 101000995204 Homo sapiens Neurabin-1 Proteins 0.000 description 1
- 101000775053 Homo sapiens Neuroblast differentiation-associated protein AHNAK Proteins 0.000 description 1
- 101001014610 Homo sapiens Neuroendocrine secretory protein 55 Proteins 0.000 description 1
- 101000582002 Homo sapiens Neuron navigator 2 Proteins 0.000 description 1
- 101001069237 Homo sapiens Neuronal membrane glycoprotein M6-b Proteins 0.000 description 1
- 101001108246 Homo sapiens Neuronal pentraxin-2 Proteins 0.000 description 1
- 101000596892 Homo sapiens Neurotrimin Proteins 0.000 description 1
- 101000603202 Homo sapiens Nicotinamide N-methyltransferase Proteins 0.000 description 1
- 101000996058 Homo sapiens Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Proteins 0.000 description 1
- 101001023768 Homo sapiens Nuclear factor related to kappa-B-binding protein Proteins 0.000 description 1
- 101000604027 Homo sapiens Nuclear protein localization protein 4 homolog Proteins 0.000 description 1
- 101001109700 Homo sapiens Nuclear receptor subfamily 4 group A member 1 Proteins 0.000 description 1
- 101001109698 Homo sapiens Nuclear receptor subfamily 4 group A member 2 Proteins 0.000 description 1
- 101000991410 Homo sapiens Nucleolar and spindle-associated protein 1 Proteins 0.000 description 1
- 101001038567 Homo sapiens Nucleolar protein 4-like Proteins 0.000 description 1
- 101001109602 Homo sapiens Nucleolar protein 8 Proteins 0.000 description 1
- 101001109719 Homo sapiens Nucleophosmin Proteins 0.000 description 1
- 101000598495 Homo sapiens Nucleoporin Nup37 Proteins 0.000 description 1
- 101000979623 Homo sapiens Nucleoside diphosphate kinase B Proteins 0.000 description 1
- 101000910674 Homo sapiens PAT complex subunit CCDC47 Proteins 0.000 description 1
- 101000585555 Homo sapiens PCNA-associated factor Proteins 0.000 description 1
- 101000693011 Homo sapiens Pancreatic alpha-amylase Proteins 0.000 description 1
- 101001135199 Homo sapiens Partitioning defective 3 homolog Proteins 0.000 description 1
- 101001096050 Homo sapiens Perilipin-2 Proteins 0.000 description 1
- 101001131990 Homo sapiens Peroxidasin homolog Proteins 0.000 description 1
- 101000987493 Homo sapiens Phosphatidylethanolamine-binding protein 1 Proteins 0.000 description 1
- 101000604565 Homo sapiens Phosphatidylinositol glycan anchor biosynthesis class U protein Proteins 0.000 description 1
- 101000801684 Homo sapiens Phospholipid-transporting ATPase ABCA1 Proteins 0.000 description 1
- 101000801640 Homo sapiens Phospholipid-transporting ATPase ABCA3 Proteins 0.000 description 1
- 101000596119 Homo sapiens Plastin-3 Proteins 0.000 description 1
- 101001097889 Homo sapiens Platelet-activating factor acetylhydrolase Proteins 0.000 description 1
- 101000597240 Homo sapiens Pleckstrin homology-like domain family B member 1 Proteins 0.000 description 1
- 101000595198 Homo sapiens Podocalyxin Proteins 0.000 description 1
- 101001049829 Homo sapiens Potassium channel subfamily K member 5 Proteins 0.000 description 1
- 101000610110 Homo sapiens Pre-B-cell leukemia transcription factor 2 Proteins 0.000 description 1
- 101000933173 Homo sapiens Pro-cathepsin H Proteins 0.000 description 1
- 101000901928 Homo sapiens Probable ATP-dependent RNA helicase DHX35 Proteins 0.000 description 1
- 101000983583 Homo sapiens Procathepsin L Proteins 0.000 description 1
- 101000611663 Homo sapiens Prolargin Proteins 0.000 description 1
- 101001135402 Homo sapiens Prostaglandin-H2 D-isomerase Proteins 0.000 description 1
- 101000797903 Homo sapiens Protein ALEX Proteins 0.000 description 1
- 101000728245 Homo sapiens Protein Aster-C Proteins 0.000 description 1
- 101000823451 Homo sapiens Protein FAM174C Proteins 0.000 description 1
- 101000877832 Homo sapiens Protein FAM184A Proteins 0.000 description 1
- 101000911541 Homo sapiens Protein FAM214A Proteins 0.000 description 1
- 101001021281 Homo sapiens Protein HEXIM1 Proteins 0.000 description 1
- 101000979599 Homo sapiens Protein NKG7 Proteins 0.000 description 1
- 101000653788 Homo sapiens Protein S100-A11 Proteins 0.000 description 1
- 101000780643 Homo sapiens Protein argonaute-2 Proteins 0.000 description 1
- 101000931680 Homo sapiens Protein furry homolog Proteins 0.000 description 1
- 101000971400 Homo sapiens Protein kinase C eta type Proteins 0.000 description 1
- 101001122742 Homo sapiens Protein phosphatase 1 regulatory inhibitor subunit 16B Proteins 0.000 description 1
- 101001122995 Homo sapiens Protein phosphatase 1 regulatory subunit 3C Proteins 0.000 description 1
- 101000666171 Homo sapiens Protein-glutamine gamma-glutamyltransferase 2 Proteins 0.000 description 1
- 101001098557 Homo sapiens Proteinase-activated receptor 3 Proteins 0.000 description 1
- 101001125901 Homo sapiens Pterin-4-alpha-carbinolamine dehydratase Proteins 0.000 description 1
- 101001086862 Homo sapiens Pulmonary surfactant-associated protein B Proteins 0.000 description 1
- 101000632467 Homo sapiens Pulmonary surfactant-associated protein D Proteins 0.000 description 1
- 101000822032 Homo sapiens Putative sodium-coupled neutral amino acid transporter 7 Proteins 0.000 description 1
- 101000626165 Homo sapiens Putative tenascin-XA Proteins 0.000 description 1
- 101100140242 Homo sapiens RDH11 gene Proteins 0.000 description 1
- 101000727821 Homo sapiens RING1 and YY1-binding protein Proteins 0.000 description 1
- 101000579758 Homo sapiens Raftlin Proteins 0.000 description 1
- 101001100204 Homo sapiens Ras-related protein Rab-40A-like Proteins 0.000 description 1
- 101000591205 Homo sapiens Receptor-type tyrosine-protein phosphatase mu Proteins 0.000 description 1
- 101000849744 Homo sapiens Regulation of nuclear pre-mRNA domain-containing protein 1B Proteins 0.000 description 1
- 101000665882 Homo sapiens Retinol-binding protein 4 Proteins 0.000 description 1
- 101000856696 Homo sapiens Rho GDP-dissociation inhibitor 2 Proteins 0.000 description 1
- 101000703435 Homo sapiens Rho GTPase-activating protein 44 Proteins 0.000 description 1
- 101000709027 Homo sapiens Rho-related BTB domain-containing protein 1 Proteins 0.000 description 1
- 101001111742 Homo sapiens Rhombotin-2 Proteins 0.000 description 1
- 101001103771 Homo sapiens Ribonuclease H2 subunit A Proteins 0.000 description 1
- 101000707215 Homo sapiens SH2 domain-containing protein 2A Proteins 0.000 description 1
- 101000588007 Homo sapiens SPARC-like protein 1 Proteins 0.000 description 1
- 101000706557 Homo sapiens SUN domain-containing protein 1 Proteins 0.000 description 1
- 101000936917 Homo sapiens Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Proteins 0.000 description 1
- 101000632270 Homo sapiens Semaphorin-3B Proteins 0.000 description 1
- 101001067604 Homo sapiens Serine hydroxymethyltransferase, mitochondrial Proteins 0.000 description 1
- 101001041393 Homo sapiens Serine protease HTRA1 Proteins 0.000 description 1
- 101000868090 Homo sapiens Serine-rich coiled-coil domain-containing protein 2 Proteins 0.000 description 1
- 101000674040 Homo sapiens Serine-tRNA ligase, mitochondrial Proteins 0.000 description 1
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 1
- 101000987310 Homo sapiens Serine/threonine-protein kinase PAK 2 Proteins 0.000 description 1
- 101000785890 Homo sapiens Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Proteins 0.000 description 1
- 101001068019 Homo sapiens Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Proteins 0.000 description 1
- 101000836394 Homo sapiens Sestrin-1 Proteins 0.000 description 1
- 101000651890 Homo sapiens Slit homolog 2 protein Proteins 0.000 description 1
- 101000713169 Homo sapiens Solute carrier family 52, riboflavin transporter, member 2 Proteins 0.000 description 1
- 101000836226 Homo sapiens Solute carrier organic anion transporter family member 2B1 Proteins 0.000 description 1
- 101000693265 Homo sapiens Sphingosine 1-phosphate receptor 1 Proteins 0.000 description 1
- 101000642262 Homo sapiens Spondin-1 Proteins 0.000 description 1
- 101000651299 Homo sapiens Sprouty-related, EVH1 domain-containing protein 2 Proteins 0.000 description 1
- 101000875401 Homo sapiens Sterol 26-hydroxylase, mitochondrial Proteins 0.000 description 1
- 101000820460 Homo sapiens Stomatin Proteins 0.000 description 1
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 description 1
- 101000685001 Homo sapiens Stromal cell-derived factor 2-like protein 1 Proteins 0.000 description 1
- 101000708766 Homo sapiens Structural maintenance of chromosomes protein 3 Proteins 0.000 description 1
- 101000630748 Homo sapiens Surfeit locus protein 6 Proteins 0.000 description 1
- 101000648549 Homo sapiens Sushi domain-containing protein 4 Proteins 0.000 description 1
- 101000820700 Homo sapiens Switch-associated protein 70 Proteins 0.000 description 1
- 101000658110 Homo sapiens Synaptotagmin-like protein 2 Proteins 0.000 description 1
- 101000740523 Homo sapiens Syntenin-1 Proteins 0.000 description 1
- 101000763321 Homo sapiens T cell receptor beta chain MC.7.G5 Proteins 0.000 description 1
- 101000648624 Homo sapiens TATA element modulatory factor Proteins 0.000 description 1
- 101000596277 Homo sapiens TSC22 domain family protein 3 Proteins 0.000 description 1
- 101000798942 Homo sapiens Target of Myb protein 1 Proteins 0.000 description 1
- 101000665590 Homo sapiens Tax1-binding protein 1 Proteins 0.000 description 1
- 101000626153 Homo sapiens Tensin-3 Proteins 0.000 description 1
- 101000800047 Homo sapiens Testican-2 Proteins 0.000 description 1
- 101000772239 Homo sapiens Testis-specific serine/threonine-protein kinase 2 Proteins 0.000 description 1
- 101000759892 Homo sapiens Tetraspanin-13 Proteins 0.000 description 1
- 101000613001 Homo sapiens Tetraspanin-6 Proteins 0.000 description 1
- 101000612838 Homo sapiens Tetraspanin-7 Proteins 0.000 description 1
- 101000659879 Homo sapiens Thrombospondin-1 Proteins 0.000 description 1
- 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 description 1
- 101000679485 Homo sapiens Trafficking protein particle complex subunit 6A Proteins 0.000 description 1
- 101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 description 1
- 101001067250 Homo sapiens Transcription cofactor HES-6 Proteins 0.000 description 1
- 101000800583 Homo sapiens Transcription factor 20 Proteins 0.000 description 1
- 101000800546 Homo sapiens Transcription factor 21 Proteins 0.000 description 1
- 101000976959 Homo sapiens Transcription factor 4 Proteins 0.000 description 1
- 101000596771 Homo sapiens Transcription factor 7-like 2 Proteins 0.000 description 1
- 101000732336 Homo sapiens Transcription factor AP-2 gamma Proteins 0.000 description 1
- 101000642514 Homo sapiens Transcription factor SOX-4 Proteins 0.000 description 1
- 101000940144 Homo sapiens Transcriptional repressor protein YY1 Proteins 0.000 description 1
- 101000652736 Homo sapiens Transgelin Proteins 0.000 description 1
- 101000629921 Homo sapiens Translocon-associated protein subunit delta Proteins 0.000 description 1
- 101000834926 Homo sapiens Transmembrane protein 106B Proteins 0.000 description 1
- 101000645447 Homo sapiens Transmembrane protein 168 Proteins 0.000 description 1
- 101000763433 Homo sapiens Transmembrane protein 204 Proteins 0.000 description 1
- 101000831834 Homo sapiens Transmembrane protein 231 Proteins 0.000 description 1
- 101000801314 Homo sapiens Transmembrane protein 47 Proteins 0.000 description 1
- 101000680652 Homo sapiens Tripartite motif-containing protein 14 Proteins 0.000 description 1
- 101000597770 Homo sapiens Tropomodulin-1 Proteins 0.000 description 1
- 101000851334 Homo sapiens Troponin I, cardiac muscle Proteins 0.000 description 1
- 101000851357 Homo sapiens Troponin T, slow skeletal muscle Proteins 0.000 description 1
- 101000795074 Homo sapiens Tryptase alpha/beta-1 Proteins 0.000 description 1
- 101000838301 Homo sapiens Tubulin gamma-1 chain Proteins 0.000 description 1
- 101001087418 Homo sapiens Tyrosine-protein phosphatase non-receptor type 12 Proteins 0.000 description 1
- 101000760764 Homo sapiens Tyrosyl-DNA phosphodiesterase 1 Proteins 0.000 description 1
- 101000894586 Homo sapiens UPF0687 protein C20orf27 Proteins 0.000 description 1
- 101000760229 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 13 Proteins 0.000 description 1
- 101000662026 Homo sapiens Ubiquitin-like modifier-activating enzyme 7 Proteins 0.000 description 1
- 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 description 1
- 101000932776 Homo sapiens Uncharacterized protein C1orf115 Proteins 0.000 description 1
- 101000742596 Homo sapiens Vascular endothelial growth factor C Proteins 0.000 description 1
- 101000860430 Homo sapiens Versican core protein Proteins 0.000 description 1
- 101000631914 Homo sapiens Vesicle-trafficking protein SEC22c Proteins 0.000 description 1
- 101000666063 Homo sapiens WD repeat-containing protein 74 Proteins 0.000 description 1
- 101000708573 Homo sapiens Y+L amino acid transporter 2 Proteins 0.000 description 1
- 101000781866 Homo sapiens Zinc finger CCCH domain-containing protein 7A Proteins 0.000 description 1
- 101000784545 Homo sapiens Zinc finger and SCAN domain-containing protein 18 Proteins 0.000 description 1
- 101000915742 Homo sapiens Zinc finger protein ZPR1 Proteins 0.000 description 1
- 101000976442 Homo sapiens Zona pellucida sperm-binding protein 3 Proteins 0.000 description 1
- 101001052394 Homo sapiens [F-actin]-monooxygenase MICAL1 Proteins 0.000 description 1
- 101000734339 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Proteins 0.000 description 1
- 101000795753 Homo sapiens mRNA decay activator protein ZFP36 Proteins 0.000 description 1
- 101000838340 Homo sapiens tRNA-dihydrouridine(20) synthase [NAD(P)+]-like Proteins 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
- 102100039238 Hyaluronan-binding protein 2 Human genes 0.000 description 1
- 102100039285 Hyaluronidase-2 Human genes 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 102100039356 Hydroxycarboxylic acid receptor 3 Human genes 0.000 description 1
- 108010052919 Hydroxyethylthiazole kinase Proteins 0.000 description 1
- 108010027436 Hydroxymethylpyrimidine kinase Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 102100030481 Hypoxia-inducible factor 1-alpha inhibitor Human genes 0.000 description 1
- 108010007666 IMP cyclohydrolase Proteins 0.000 description 1
- 108010073807 IgG Receptors Proteins 0.000 description 1
- 102000009490 IgG Receptors Human genes 0.000 description 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 102100029572 Immunoglobulin kappa constant Human genes 0.000 description 1
- 102100033258 Importin subunit beta-1 Human genes 0.000 description 1
- 102100036724 Innate immunity activator protein Human genes 0.000 description 1
- 102100020796 Inosine 5'-monophosphate cyclohydrolase Human genes 0.000 description 1
- 102100031525 Inositol-pentakisphosphate 2-kinase Human genes 0.000 description 1
- 102100022710 Insulin-like growth factor-binding protein 2 Human genes 0.000 description 1
- 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 description 1
- 102100029224 Insulin-like growth factor-binding protein 4 Human genes 0.000 description 1
- 102100029180 Insulin-like growth factor-binding protein 6 Human genes 0.000 description 1
- 102100023350 Integral membrane protein 2B Human genes 0.000 description 1
- 102100039903 Integrin alpha-9 Human genes 0.000 description 1
- 102100033000 Integrin beta-4 Human genes 0.000 description 1
- 102100033011 Integrin beta-6 Human genes 0.000 description 1
- 102100033016 Integrin beta-7 Human genes 0.000 description 1
- 108010064600 Intercellular Adhesion Molecule-3 Proteins 0.000 description 1
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 description 1
- 102100026720 Interferon beta Human genes 0.000 description 1
- 102100036981 Interferon regulatory factor 1 Human genes 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108700003107 Interleukin-1 Receptor-Like 1 Proteins 0.000 description 1
- 102100026017 Interleukin-1 receptor type 2 Human genes 0.000 description 1
- 102100036706 Interleukin-1 receptor-like 1 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 101710152369 Interleukin-6 receptor subunit beta Proteins 0.000 description 1
- 108010002586 Interleukin-7 Proteins 0.000 description 1
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 description 1
- 102100024434 Iroquois-class homeodomain protein IRX-2 Human genes 0.000 description 1
- 108010044467 Isoenzymes Proteins 0.000 description 1
- 102000004195 Isomerases Human genes 0.000 description 1
- 108090000769 Isomerases Proteins 0.000 description 1
- 102000017714 KCNJ8 Human genes 0.000 description 1
- 101710024993 KIAA1109 Proteins 0.000 description 1
- 102100027622 KICSTOR subunit 2 Human genes 0.000 description 1
- 102100021559 KRR1 small subunit processome component homolog Human genes 0.000 description 1
- 108010062228 Karyopherins Proteins 0.000 description 1
- 102000011781 Karyopherins Human genes 0.000 description 1
- 102100022835 Kelch repeat and BTB domain-containing protein 7 Human genes 0.000 description 1
- 102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 description 1
- 102100023129 Keratin, type I cytoskeletal 9 Human genes 0.000 description 1
- 102100028340 Keratin, type II cuticular Hb1 Human genes 0.000 description 1
- 102100025656 Keratin, type II cytoskeletal 6A Human genes 0.000 description 1
- 101710134369 Kinesin-like protein KIF2C Proteins 0.000 description 1
- 102100020684 Krueppel-like factor 9 Human genes 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- GGLZPLKKBSSKCX-YFKPBYRVSA-N L-ethionine Chemical compound CCSCC[C@H](N)C(O)=O GGLZPLKKBSSKCX-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 description 1
- 108010084772 LIM Domain Proteins Proteins 0.000 description 1
- 102000005633 LIM Domain Proteins Human genes 0.000 description 1
- 102100022957 LLGL scribble cell polarity complex component 2 Human genes 0.000 description 1
- 108010085895 Laminin Proteins 0.000 description 1
- 102000007547 Laminin Human genes 0.000 description 1
- 102100022743 Laminin subunit alpha-4 Human genes 0.000 description 1
- 102100027017 Latent-transforming growth factor beta-binding protein 2 Human genes 0.000 description 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
- 102100031036 Leucine-rich repeat-containing G-protein coupled receptor 5 Human genes 0.000 description 1
- 101710174256 Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 description 1
- 102100024221 Leukocyte surface antigen CD53 Human genes 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102100039420 Little elongation complex subunit 2 Human genes 0.000 description 1
- 108010015179 Low Density Lipoprotein Receptor-Related Protein-6 Proteins 0.000 description 1
- 102000001774 Low Density Lipoprotein Receptor-Related Protein-6 Human genes 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 102100031335 Lysosomal cobalamin transport escort protein LMBD1 Human genes 0.000 description 1
- 102100026964 M1-specific T cell receptor beta chain Human genes 0.000 description 1
- 102000042257 MAPRE family Human genes 0.000 description 1
- 108091077621 MAPRE family Proteins 0.000 description 1
- 102100025069 MARVEL domain-containing protein 1 Human genes 0.000 description 1
- 108010018650 MEF2 Transcription Factors Proteins 0.000 description 1
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 description 1
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 description 1
- 102000006722 Mannosyltransferases Human genes 0.000 description 1
- 108010087568 Mannosyltransferases Proteins 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 208000001826 Marfan syndrome Diseases 0.000 description 1
- 102100030612 Mast cell carboxypeptidase A Human genes 0.000 description 1
- 102100024299 Maternal embryonic leucine zipper kinase Human genes 0.000 description 1
- 108090000855 Matrilysin Proteins 0.000 description 1
- 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 description 1
- 102100030218 Matrix metalloproteinase-19 Human genes 0.000 description 1
- 101710085938 Matrix protein Proteins 0.000 description 1
- 102100030777 Matrix remodeling-associated protein 8 Human genes 0.000 description 1
- 102100030776 Matrix-remodeling-associated protein 5 Human genes 0.000 description 1
- 101710159527 Maturation protein A Proteins 0.000 description 1
- 101710091157 Maturation protein A2 Proteins 0.000 description 1
- 102100026174 Mediator of RNA polymerase II transcription subunit 6 Human genes 0.000 description 1
- 102100025077 Melanoma-associated antigen 4 Human genes 0.000 description 1
- 102100025075 Melanoma-associated antigen 6 Human genes 0.000 description 1
- 241000282345 Meles Species 0.000 description 1
- 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 description 1
- 101710127721 Membrane protein Proteins 0.000 description 1
- 102100038465 Membrane-spanning 4-domains subfamily A member 14 Human genes 0.000 description 1
- 102100038557 Membrane-spanning 4-domains subfamily A member 8 Human genes 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 102100022465 Methanethiol oxidase Human genes 0.000 description 1
- 102100023174 Methionine aminopeptidase 2 Human genes 0.000 description 1
- 108060004795 Methyltransferase Proteins 0.000 description 1
- 102000016397 Methyltransferase Human genes 0.000 description 1
- 102100036103 Microfibril-associated glycoprotein 4 Human genes 0.000 description 1
- 102100021316 Mineralocorticoid receptor Human genes 0.000 description 1
- 102100040273 Mitochondrial glutamate carrier 1 Human genes 0.000 description 1
- 102100038450 Mitochondrial tRNA methylthiotransferase CDK5RAP1 Human genes 0.000 description 1
- 108010006519 Molecular Chaperones Proteins 0.000 description 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
- 101710090981 Monooxygenase 3 Proteins 0.000 description 1
- 101710167839 Morphogenetic protein Proteins 0.000 description 1
- 102100034263 Mucin-2 Human genes 0.000 description 1
- 208000001089 Multiple system atrophy Diseases 0.000 description 1
- 101001052792 Mus musculus GDP-L-fucose synthase Proteins 0.000 description 1
- 101100042271 Mus musculus Sema3b gene Proteins 0.000 description 1
- 101000658113 Mus musculus Synaptotagmin-like protein 4 Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 102100034670 Myb-related protein B Human genes 0.000 description 1
- 108010083674 Myelin Proteins Proteins 0.000 description 1
- 102000006386 Myelin Proteins Human genes 0.000 description 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
- 102100039229 Myocyte-specific enhancer factor 2C Human genes 0.000 description 1
- 101710089434 Myosin heavy chain, non-muscle Proteins 0.000 description 1
- 102100035044 Myosin light chain kinase, smooth muscle Human genes 0.000 description 1
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- 102100038360 N-acylethanolamine-hydrolyzing acid amidase Human genes 0.000 description 1
- 102100038334 N-alpha-acetyltransferase 60 Human genes 0.000 description 1
- 102100023648 N-chimaerin Human genes 0.000 description 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 101710167853 N-methyltransferase Proteins 0.000 description 1
- 150000001204 N-oxides Chemical class 0.000 description 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 1
- 102100037508 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Human genes 0.000 description 1
- 102100032194 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial Human genes 0.000 description 1
- 102100036777 NADPH:adrenodoxin oxidoreductase, mitochondrial Human genes 0.000 description 1
- 101150065592 NME2 gene Proteins 0.000 description 1
- 102100029448 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Human genes 0.000 description 1
- 102100024014 Nestin Human genes 0.000 description 1
- 102100034438 Neurabin-1 Human genes 0.000 description 1
- 102100031837 Neuroblast differentiation-associated protein AHNAK Human genes 0.000 description 1
- 102100038819 Neuromedin-B Human genes 0.000 description 1
- 102100030465 Neuron navigator 2 Human genes 0.000 description 1
- 102100033800 Neuronal membrane glycoprotein M6-b Human genes 0.000 description 1
- 102100021878 Neuronal pentraxin-2 Human genes 0.000 description 1
- 101100344969 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) med-6 gene Proteins 0.000 description 1
- 102000005665 Neurotransmitter Transport Proteins Human genes 0.000 description 1
- 108010084810 Neurotransmitter Transport Proteins Proteins 0.000 description 1
- 102100035107 Neurotrimin Human genes 0.000 description 1
- 102100038951 Nicotinamide N-methyltransferase Human genes 0.000 description 1
- 108010064862 Nicotinamide phosphoribosyltransferase Proteins 0.000 description 1
- 102100033223 Nicotinamide phosphoribosyltransferase Human genes 0.000 description 1
- 102100034450 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Human genes 0.000 description 1
- 102100023121 Ninein Human genes 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 102100035397 Nuclear factor related to kappa-B-binding protein Human genes 0.000 description 1
- 102100038438 Nuclear protein localization protein 4 homolog Human genes 0.000 description 1
- 102100022679 Nuclear receptor subfamily 4 group A member 1 Human genes 0.000 description 1
- 102100022676 Nuclear receptor subfamily 4 group A member 2 Human genes 0.000 description 1
- 102100030991 Nucleolar and spindle-associated protein 1 Human genes 0.000 description 1
- 102100040313 Nucleolar protein 4-like Human genes 0.000 description 1
- 102100022740 Nucleolar protein 8 Human genes 0.000 description 1
- 102100022678 Nucleophosmin Human genes 0.000 description 1
- 108010025568 Nucleophosmin Proteins 0.000 description 1
- 102100037837 Nucleoporin Nup37 Human genes 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 108010020361 Oncogene Protein gp140(v-fms) Proteins 0.000 description 1
- 108090000630 Oncostatin M Proteins 0.000 description 1
- 102000004140 Oncostatin M Human genes 0.000 description 1
- 108010089503 Organic Anion Transporters Proteins 0.000 description 1
- 102000007990 Organic Anion Transporters Human genes 0.000 description 1
- 102000016978 Orphan receptors Human genes 0.000 description 1
- 108070000031 Orphan receptors Proteins 0.000 description 1
- 101800002327 Osteoinductive factor Proteins 0.000 description 1
- 108010077077 Osteonectin Proteins 0.000 description 1
- 102000009890 Osteonectin Human genes 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 102000004020 Oxygenases Human genes 0.000 description 1
- 108090000417 Oxygenases Proteins 0.000 description 1
- 102100034925 P-selectin glycoprotein ligand 1 Human genes 0.000 description 1
- 101710137390 P-selectin glycoprotein ligand 1 Proteins 0.000 description 1
- 102000002131 PAS domains Human genes 0.000 description 1
- 108050009469 PAS domains Proteins 0.000 description 1
- 102100024093 PAT complex subunit CCDC47 Human genes 0.000 description 1
- 102100029879 PCNA-associated factor Human genes 0.000 description 1
- 102000000470 PDZ domains Human genes 0.000 description 1
- 108050008994 PDZ domains Proteins 0.000 description 1
- 101150089545 PYCR3 gene Proteins 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000032136 Palmoplantar Epidermolytic Keratoderma Diseases 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 102100026367 Pancreatic alpha-amylase Human genes 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- 102100033496 Partitioning defective 3 homolog Human genes 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010034277 Pemphigoid Diseases 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108010067902 Peptide Library Proteins 0.000 description 1
- 102100034601 Peroxidasin homolog Human genes 0.000 description 1
- 102100028489 Phosphatidylethanolamine-binding protein 1 Human genes 0.000 description 1
- 108010022678 Phosphofructokinase-2 Proteins 0.000 description 1
- 102100033623 Phospholipid-transporting ATPase ABCA3 Human genes 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 102100035182 Plastin-2 Human genes 0.000 description 1
- 102100035220 Plastin-3 Human genes 0.000 description 1
- 108010003541 Platelet Activating Factor Proteins 0.000 description 1
- 102100037518 Platelet-activating factor acetylhydrolase Human genes 0.000 description 1
- 101000686491 Platymeris rhadamanthus Venom redulysin 1 Proteins 0.000 description 1
- 102100035150 Pleckstrin homology-like domain family B member 1 Human genes 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 102100036031 Podocalyxin Human genes 0.000 description 1
- 102100023202 Potassium channel subfamily K member 5 Human genes 0.000 description 1
- 102100040168 Pre-B-cell leukemia transcription factor 2 Human genes 0.000 description 1
- 102100025974 Pro-cathepsin H Human genes 0.000 description 1
- 102100033237 Pro-epidermal growth factor Human genes 0.000 description 1
- 102100022424 Probable ATP-dependent RNA helicase DHX35 Human genes 0.000 description 1
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
- 102100026534 Procathepsin L Human genes 0.000 description 1
- 102100040659 Prolargin Human genes 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 108010065942 Prostaglandin-F synthase Proteins 0.000 description 1
- 102100033279 Prostaglandin-H2 D-isomerase Human genes 0.000 description 1
- 102100029804 Protein Aster-C Human genes 0.000 description 1
- 101800004937 Protein C Proteins 0.000 description 1
- 102100022628 Protein FAM174C Human genes 0.000 description 1
- 102100035471 Protein FAM184A Human genes 0.000 description 1
- 102100026957 Protein FAM214A Human genes 0.000 description 1
- 102100023370 Protein NKG7 Human genes 0.000 description 1
- 229940096437 Protein S Drugs 0.000 description 1
- 101710110945 Protein S100-A11 Proteins 0.000 description 1
- 102100034207 Protein argonaute-2 Human genes 0.000 description 1
- 102100020918 Protein furry homolog Human genes 0.000 description 1
- 101710093047 Protein grainyhead Proteins 0.000 description 1
- 102100021556 Protein kinase C eta type Human genes 0.000 description 1
- 102100028740 Protein phosphatase 1 regulatory inhibitor subunit 16B Human genes 0.000 description 1
- 102100028506 Protein phosphatase 1 regulatory subunit 3C Human genes 0.000 description 1
- 102100026221 Protein-L-histidine N-pros-methyltransferase Human genes 0.000 description 1
- 102100038095 Protein-glutamine gamma-glutamyltransferase 2 Human genes 0.000 description 1
- 108700020978 Proto-Oncogene Proteins 0.000 description 1
- 102000052575 Proto-Oncogene Human genes 0.000 description 1
- 101710184733 Pterin-4-alpha-carbinolamine dehydratase Proteins 0.000 description 1
- 102100032617 Pulmonary surfactant-associated protein B Human genes 0.000 description 1
- 102100027845 Pulmonary surfactant-associated protein D Human genes 0.000 description 1
- 102100021471 Putative sodium-coupled neutral amino acid transporter 7 Human genes 0.000 description 1
- 102100024653 Putative tenascin-XA Human genes 0.000 description 1
- 102100029760 RING1 and YY1-binding protein Human genes 0.000 description 1
- 108020005067 RNA Splice Sites Proteins 0.000 description 1
- 102000015097 RNA Splicing Factors Human genes 0.000 description 1
- 108010039259 RNA Splicing Factors Proteins 0.000 description 1
- 230000004570 RNA-binding Effects 0.000 description 1
- 102100038416 Ras-related protein Rab-40A-like Human genes 0.000 description 1
- 102000001218 Rec A Recombinases Human genes 0.000 description 1
- 108010055016 Rec A Recombinases Proteins 0.000 description 1
- 108010045108 Receptor for Advanced Glycation End Products Proteins 0.000 description 1
- 102100034090 Receptor-type tyrosine-protein phosphatase mu Human genes 0.000 description 1
- 102100033796 Regulation of nuclear pre-mRNA domain-containing protein 1B Human genes 0.000 description 1
- 102100021269 Regulator of G-protein signaling 1 Human genes 0.000 description 1
- 101710140408 Regulator of G-protein signaling 1 Proteins 0.000 description 1
- 206010038357 Renal amyloidosis Diseases 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 102100022828 Retinoblastoma-like protein 2 Human genes 0.000 description 1
- 108050002651 Retinoblastoma-like protein 2 Proteins 0.000 description 1
- 102100023916 Retinol dehydrogenase 11 Human genes 0.000 description 1
- 102100038246 Retinol-binding protein 4 Human genes 0.000 description 1
- 102100025622 Rho GDP-dissociation inhibitor 2 Human genes 0.000 description 1
- 102100030754 Rho GTPase-activating protein 44 Human genes 0.000 description 1
- 102100032659 Rho-related BTB domain-containing protein 1 Human genes 0.000 description 1
- 102100023876 Rhombotin-2 Human genes 0.000 description 1
- 102100039493 Ribonuclease H2 subunit A Human genes 0.000 description 1
- 102000004167 Ribonuclease P Human genes 0.000 description 1
- 108090000621 Ribonuclease P Proteins 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- XKGDWZQXVZSXAO-ADYSOMBNSA-N Ricinoleic Acid methyl ester Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC(=O)OC XKGDWZQXVZSXAO-ADYSOMBNSA-N 0.000 description 1
- 102100031779 SH2 domain-containing protein 2A Human genes 0.000 description 1
- 108091006622 SLC12A4 Proteins 0.000 description 1
- 108091006296 SLC2A1 Proteins 0.000 description 1
- 108091006298 SLC2A3 Proteins 0.000 description 1
- 108091006567 SLC31A2 Proteins 0.000 description 1
- 108091006647 SLC9A1 Proteins 0.000 description 1
- 108700022176 SOS1 Proteins 0.000 description 1
- 102100031581 SPARC-like protein 1 Human genes 0.000 description 1
- 102100031130 SUN domain-containing protein 1 Human genes 0.000 description 1
- 101000592082 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 60S ribosomal protein L28 Proteins 0.000 description 1
- 101100197320 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) RPL35A gene Proteins 0.000 description 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 101800001700 Saposin-D Proteins 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 102100027733 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Human genes 0.000 description 1
- 102100025831 Scavenger receptor cysteine-rich type 1 protein M130 Human genes 0.000 description 1
- 101100010298 Schizosaccharomyces pombe (strain 972 / ATCC 24843) pol2 gene Proteins 0.000 description 1
- 102100037235 Sciellin Human genes 0.000 description 1
- 101710090926 Sciellin Proteins 0.000 description 1
- 102100023843 Selenoprotein P Human genes 0.000 description 1
- 108010042443 Selenoprotein P Proteins 0.000 description 1
- 102100027979 Semaphorin-3B Human genes 0.000 description 1
- 108091081021 Sense strand Proteins 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 102100034606 Serine hydroxymethyltransferase, mitochondrial Human genes 0.000 description 1
- 102100021119 Serine protease HTRA1 Human genes 0.000 description 1
- 102100032895 Serine-rich coiled-coil domain-containing protein 2 Human genes 0.000 description 1
- 102100040597 Serine-tRNA ligase, mitochondrial Human genes 0.000 description 1
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 1
- 102100027939 Serine/threonine-protein kinase PAK 2 Human genes 0.000 description 1
- 102100029938 Serine/threonine-protein kinase SMG1 Human genes 0.000 description 1
- 101710085356 Serine/threonine-protein kinase SMG1 Proteins 0.000 description 1
- 102100026283 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform Human genes 0.000 description 1
- 102100034470 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Human genes 0.000 description 1
- 102000019208 Serotonin Plasma Membrane Transport Proteins Human genes 0.000 description 1
- 108010012996 Serotonin Plasma Membrane Transport Proteins Proteins 0.000 description 1
- 102100022056 Serum response factor Human genes 0.000 description 1
- 102100027288 Sestrin-1 Human genes 0.000 description 1
- 102100037576 Sestrin-2 Human genes 0.000 description 1
- 101710142587 Short-chain dehydrogenase/reductase Proteins 0.000 description 1
- 102100029719 Single-stranded DNA-binding protein, mitochondrial Human genes 0.000 description 1
- 102100027340 Slit homolog 2 protein Human genes 0.000 description 1
- 102000054750 Sm-like protein Lsm7 Human genes 0.000 description 1
- 108700035667 Sm-like protein Lsm7 Proteins 0.000 description 1
- 108020004688 Small Nuclear RNA Proteins 0.000 description 1
- 102000039471 Small Nuclear RNA Human genes 0.000 description 1
- 102100036758 Small nuclear ribonucleoprotein F Human genes 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102100034244 Solute carrier family 12 member 4 Human genes 0.000 description 1
- 102100023536 Solute carrier family 2, facilitated glucose transporter member 1 Human genes 0.000 description 1
- 102100036862 Solute carrier family 52, riboflavin transporter, member 2 Human genes 0.000 description 1
- 102100032929 Son of sevenless homolog 1 Human genes 0.000 description 1
- 101150100839 Sos1 gene Proteins 0.000 description 1
- 102100021909 Sperm-associated antigen 6 Human genes 0.000 description 1
- 101710098565 Sperm-associated antigen 6 Proteins 0.000 description 1
- 102100025750 Sphingosine 1-phosphate receptor 1 Human genes 0.000 description 1
- 241000251131 Sphyrna Species 0.000 description 1
- 102100039575 Splicing factor ESS-2 homolog Human genes 0.000 description 1
- 102100036428 Spondin-1 Human genes 0.000 description 1
- 102100027650 Sprouty-related, EVH1 domain-containing protein 2 Human genes 0.000 description 1
- 102100024519 Src-like-adapter Human genes 0.000 description 1
- 101150098540 Srpx gene Proteins 0.000 description 1
- 102100030510 Stanniocalcin-2 Human genes 0.000 description 1
- 101710142154 Stanniocalcin-2 Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 102100038035 Starch-binding domain-containing protein 1 Human genes 0.000 description 1
- 101710150214 Starch-binding domain-containing protein 1 Proteins 0.000 description 1
- 101000720079 Stichodactyla helianthus DELTA-stichotoxin-She4a Proteins 0.000 description 1
- 102100021685 Stomatin Human genes 0.000 description 1
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 description 1
- 102100023183 Stromal cell-derived factor 2-like protein 1 Human genes 0.000 description 1
- 241000258128 Strongylocentrotus purpuratus Species 0.000 description 1
- 102100032723 Structural maintenance of chromosomes protein 3 Human genes 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 description 1
- 101710097011 Suppressor of tumorigenicity 14 protein Proteins 0.000 description 1
- 101800001271 Surface protein Proteins 0.000 description 1
- 102100026318 Surfeit locus protein 6 Human genes 0.000 description 1
- 108010002687 Survivin Proteins 0.000 description 1
- 102100028860 Sushi domain-containing protein 4 Human genes 0.000 description 1
- 108700005085 Switch Genes Proteins 0.000 description 1
- 102100021701 Switch-associated protein 70 Human genes 0.000 description 1
- 102100035581 Synaptojanin-2-binding protein Human genes 0.000 description 1
- 101710155018 Synaptojanin-2-binding protein Proteins 0.000 description 1
- 102100035604 Synaptopodin Human genes 0.000 description 1
- 101710119889 Synaptopodin Proteins 0.000 description 1
- 102100035007 Synaptotagmin-like protein 2 Human genes 0.000 description 1
- 102100035002 Synaptotagmin-like protein 4 Human genes 0.000 description 1
- 102100035721 Syndecan-1 Human genes 0.000 description 1
- 108090000058 Syndecan-1 Proteins 0.000 description 1
- 102000050707 Syntaxin-11 Human genes 0.000 description 1
- 102100024174 Syntaxin-7 Human genes 0.000 description 1
- 102100025293 Syntaxin-binding protein 1 Human genes 0.000 description 1
- 101710096016 Syntaxin-binding protein 1 Proteins 0.000 description 1
- 108010083130 Syntenins Proteins 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 102100028866 TATA element modulatory factor Human genes 0.000 description 1
- 108090000925 TNF receptor-associated factor 2 Proteins 0.000 description 1
- 102100034779 TRAF family member-associated NF-kappa-B activator Human genes 0.000 description 1
- 102100035260 TSC22 domain family protein 3 Human genes 0.000 description 1
- 241001441722 Takifugu rubripes Species 0.000 description 1
- 101100016403 Takifugu rubripes hars1 gene Proteins 0.000 description 1
- 102100034024 Target of Myb protein 1 Human genes 0.000 description 1
- 102100038193 Tax1-binding protein 1 Human genes 0.000 description 1
- 102100024547 Tensin-1 Human genes 0.000 description 1
- 102100024548 Tensin-3 Human genes 0.000 description 1
- 108010088950 Tensins Proteins 0.000 description 1
- 244000247617 Teramnus labialis var. labialis Species 0.000 description 1
- 102100033371 Testican-2 Human genes 0.000 description 1
- 102100029355 Testis-specific serine/threonine-protein kinase 2 Human genes 0.000 description 1
- 102100024996 Tetraspanin-13 Human genes 0.000 description 1
- 102100040869 Tetraspanin-6 Human genes 0.000 description 1
- 102100040952 Tetraspanin-7 Human genes 0.000 description 1
- 102000005488 Thioesterase Human genes 0.000 description 1
- 102000002932 Thiolase Human genes 0.000 description 1
- 108060008225 Thiolase Proteins 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 102100036034 Thrombospondin-1 Human genes 0.000 description 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
- 102100027624 Thymidine kinase 2, mitochondrial Human genes 0.000 description 1
- 108010057966 Thyroid Nuclear Factor 1 Proteins 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 101710120037 Toxin CcdB Proteins 0.000 description 1
- 102100022607 Trafficking protein particle complex subunit 6A Human genes 0.000 description 1
- 102100021386 Trans-acting T-cell-specific transcription factor GATA-3 Human genes 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 102100034424 Transcription cofactor HES-6 Human genes 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102100033142 Transcription factor 20 Human genes 0.000 description 1
- 102100033121 Transcription factor 21 Human genes 0.000 description 1
- 102100023489 Transcription factor 4 Human genes 0.000 description 1
- 102000004893 Transcription factor AP-2 Human genes 0.000 description 1
- 108090001039 Transcription factor AP-2 Proteins 0.000 description 1
- 102100033345 Transcription factor AP-2 gamma Human genes 0.000 description 1
- 102100036693 Transcription factor SOX-4 Human genes 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 description 1
- 102000004060 Transforming Growth Factor-beta Type II Receptor Human genes 0.000 description 1
- 102100025946 Transforming growth factor beta activator LRRC32 Human genes 0.000 description 1
- 101710169732 Transforming growth factor beta activator LRRC32 Proteins 0.000 description 1
- 102100031013 Transgelin Human genes 0.000 description 1
- 102100026226 Translocon-associated protein subunit delta Human genes 0.000 description 1
- 102100026232 Transmembrane protein 106B Human genes 0.000 description 1
- 102100025712 Transmembrane protein 168 Human genes 0.000 description 1
- 102100027027 Transmembrane protein 204 Human genes 0.000 description 1
- 102100024183 Transmembrane protein 231 Human genes 0.000 description 1
- 102100033526 Transmembrane protein 47 Human genes 0.000 description 1
- 102100025378 Transmembrane protein KIAA1109 Human genes 0.000 description 1
- 108010078184 Trefoil Factor-3 Proteins 0.000 description 1
- 102100039145 Trefoil factor 3 Human genes 0.000 description 1
- 101710085765 Tricarboxylate transport protein Proteins 0.000 description 1
- 102100022350 Tripartite motif-containing protein 14 Human genes 0.000 description 1
- 102100035291 Tropomodulin-1 Human genes 0.000 description 1
- 102100036859 Troponin I, cardiac muscle Human genes 0.000 description 1
- 102100036860 Troponin T, slow skeletal muscle Human genes 0.000 description 1
- 101100512517 Trypanosoma brucei brucei MCA4 gene Proteins 0.000 description 1
- 102100029639 Tryptase alpha/beta-1 Human genes 0.000 description 1
- 102100028979 Tubulin gamma-1 chain Human genes 0.000 description 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
- 101710140697 Tumor protein 63 Proteins 0.000 description 1
- 108010046308 Type II DNA Topoisomerases Proteins 0.000 description 1
- 102100033020 Tyrosine-protein phosphatase non-receptor type 12 Human genes 0.000 description 1
- 102100024579 Tyrosyl-DNA phosphodiesterase 1 Human genes 0.000 description 1
- 102100028262 U6 snRNA-associated Sm-like protein LSm4 Human genes 0.000 description 1
- 101150027514 UBE2C gene Proteins 0.000 description 1
- 102100029152 UDP-glucuronosyltransferase 1A1 Human genes 0.000 description 1
- 101710205316 UDP-glucuronosyltransferase 1A1 Proteins 0.000 description 1
- 102100021441 UPF0687 protein C20orf27 Human genes 0.000 description 1
- 102000044159 Ubiquitin Human genes 0.000 description 1
- 108090000848 Ubiquitin Proteins 0.000 description 1
- 102100024720 Ubiquitin carboxyl-terminal hydrolase 13 Human genes 0.000 description 1
- 102100037256 Ubiquitin-conjugating enzyme E2 C Human genes 0.000 description 1
- 102100037938 Ubiquitin-like modifier-activating enzyme 7 Human genes 0.000 description 1
- 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 description 1
- 102100025480 Uncharacterized protein C1orf115 Human genes 0.000 description 1
- 108091023045 Untranslated Region Proteins 0.000 description 1
- 102100038232 Vascular endothelial growth factor C Human genes 0.000 description 1
- 102100028437 Versican core protein Human genes 0.000 description 1
- 102100028759 Vesicle-trafficking protein SEC22c Human genes 0.000 description 1
- 241000711975 Vesicular stomatitis virus Species 0.000 description 1
- 101100068489 Vicia faba AGPC gene Proteins 0.000 description 1
- 102100038091 WD repeat-containing protein 74 Human genes 0.000 description 1
- 208000013058 Weber syndrome Diseases 0.000 description 1
- 206010047924 Wheezing Diseases 0.000 description 1
- 101710087237 Whey acidic protein Proteins 0.000 description 1
- 108010062653 Wiskott-Aldrich Syndrome Protein Family Proteins 0.000 description 1
- 102100037104 Wiskott-Aldrich syndrome protein family member 3 Human genes 0.000 description 1
- 108010063641 Xylosylprotein 4-beta-galactosyltransferase Proteins 0.000 description 1
- 210000002593 Y chromosome Anatomy 0.000 description 1
- 102100032803 Y+L amino acid transporter 2 Human genes 0.000 description 1
- 101100221226 Zea mays COAC2 gene Proteins 0.000 description 1
- 102100036644 Zinc finger CCCH domain-containing protein 7A Human genes 0.000 description 1
- 102100020915 Zinc finger and SCAN domain-containing protein 18 Human genes 0.000 description 1
- 101710185494 Zinc finger protein Proteins 0.000 description 1
- 102100023597 Zinc finger protein 816 Human genes 0.000 description 1
- 102100028959 Zinc finger protein ZPR1 Human genes 0.000 description 1
- 102100023634 Zona pellucida sperm-binding protein 3 Human genes 0.000 description 1
- 102100024306 [F-actin]-monooxygenase MICAL1 Human genes 0.000 description 1
- 102100034825 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Human genes 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 108010023082 activin A Proteins 0.000 description 1
- 208000021841 acute erythroid leukemia Diseases 0.000 description 1
- 102000035181 adaptor proteins Human genes 0.000 description 1
- 108091005764 adaptor proteins Proteins 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 201000008395 adenosquamous carcinoma Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 150000001323 aldoses Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 125000005600 alkyl phosphonate group Chemical group 0.000 description 1
- 108010075843 alpha-2-HS-Glycoprotein Proteins 0.000 description 1
- 102000012005 alpha-2-HS-Glycoprotein Human genes 0.000 description 1
- HUMHYXGDUOGHTG-HEZXSMHISA-N alpha-D-GalpNAc-(1->3)-[alpha-L-Fucp-(1->2)]-D-Galp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](O)[C@@H](CO)OC1O HUMHYXGDUOGHTG-HEZXSMHISA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003816 antisense DNA Substances 0.000 description 1
- 230000005975 antitumor immune response Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 238000005899 aromatization reaction Methods 0.000 description 1
- 238000002820 assay format Methods 0.000 description 1
- 210000003050 axon Anatomy 0.000 description 1
- 229960002756 azacitidine Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 150000001556 benzimidazoles Chemical class 0.000 description 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 description 1
- 108010032969 beta-Arrestin 1 Proteins 0.000 description 1
- RNBGYGVWRKECFJ-ARQDHWQXSA-N beta-D-fructofuranose 1,6-bisphosphate Chemical compound O[C@H]1[C@H](O)[C@@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O RNBGYGVWRKECFJ-ARQDHWQXSA-N 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 108010047153 bovine corneal protein 54 Proteins 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 201000007293 brain stem infarction Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- ABXWTRBPSFPYRM-UHFFFAOYSA-N butan-2-yl 2-[2-[2-(1-butan-2-yloxy-1-oxopropan-2-yl)oxycarbonyloxyethoxy]ethoxycarbonyloxy]propanoate Chemical compound CCC(C)OC(=O)C(C)OC(=O)OCCOCCOC(=O)OC(C)C(=O)OC(C)CC ABXWTRBPSFPYRM-UHFFFAOYSA-N 0.000 description 1
- 238000010805 cDNA synthesis kit Methods 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 108010068032 caltractin Proteins 0.000 description 1
- 108010087312 carbonic anhydrase XII Proteins 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 101150055766 cat gene Proteins 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 239000002458 cell surface marker Substances 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 208000001088 cerebrotendinous xanthomatosis Diseases 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000009104 chemotherapy regimen Methods 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- LHHGDZSESBACKH-UHFFFAOYSA-N chlordecone Chemical compound ClC12C3(Cl)C(Cl)(Cl)C4(Cl)C2(Cl)C2(Cl)C4(Cl)C3(Cl)C1(Cl)C2=O LHHGDZSESBACKH-UHFFFAOYSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000013611 chromosomal DNA Substances 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000003081 coactivator Effects 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000006552 constitutive activation Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 101150075015 cox-17 gene Proteins 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical compound NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 230000021953 cytokinesis Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 108010049285 dephospho-CoA kinase Proteins 0.000 description 1
- 230000002074 deregulated effect Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
- 239000005546 dideoxynucleotide Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 108010057167 dimethylaniline monooxygenase (N-oxide forming) Proteins 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 229960003668 docetaxel Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000002121 endocytic effect Effects 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 230000009762 endothelial cell differentiation Effects 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 229940116977 epidermal growth factor Drugs 0.000 description 1
- 208000007150 epidermolysis bullosa simplex Diseases 0.000 description 1
- 201000006011 epidermolytic palmoplantar keratoderma Diseases 0.000 description 1
- 210000000918 epididymis Anatomy 0.000 description 1
- 201000010063 epididymitis Diseases 0.000 description 1
- 108010008594 epithelial membrane protein-1 Proteins 0.000 description 1
- 108010002591 epsilon receptor Proteins 0.000 description 1
- 230000000925 erythroid effect Effects 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- VCFOGNPFMKWERT-UHFFFAOYSA-N ethyl 2-(benzenesulfonamido)acetate Chemical compound CCOC(=O)CNS(=O)(=O)C1=CC=CC=C1 VCFOGNPFMKWERT-UHFFFAOYSA-N 0.000 description 1
- HCRBXQFHJMCTLF-UHFFFAOYSA-N ethyl 2-methylbutyrate Chemical compound CCOC(=O)C(C)CC HCRBXQFHJMCTLF-UHFFFAOYSA-N 0.000 description 1
- 201000007891 familial visceral amyloidosis Diseases 0.000 description 1
- 230000006126 farnesylation Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 150000008195 galaktosides Chemical class 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 229940044627 gamma-interferon Drugs 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000001641 gel filtration chromatography Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 102000034356 gene-regulatory proteins Human genes 0.000 description 1
- 108091006104 gene-regulatory proteins Proteins 0.000 description 1
- 230000004077 genetic alteration Effects 0.000 description 1
- 231100000118 genetic alteration Toxicity 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 108091072255 glycosyltransferase 1 family Proteins 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 229940029575 guanosine Drugs 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 229960002411 imatinib Drugs 0.000 description 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 108010065909 injurin Proteins 0.000 description 1
- 102000028416 insulin-like growth factor binding Human genes 0.000 description 1
- 108091022911 insulin-like growth factor binding Proteins 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 108010028930 invariant chain Proteins 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 230000037427 ion transport Effects 0.000 description 1
- 229940084651 iressa Drugs 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- 101150066555 lacZ gene Proteins 0.000 description 1
- 108700010824 lambda-like proteins Proteins 0.000 description 1
- 108010009114 laminin beta2 Proteins 0.000 description 1
- 208000003849 large cell carcinoma Diseases 0.000 description 1
- 238000000370 laser capture micro-dissection Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 208000036546 leukodystrophy Diseases 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 101710098598 mRNA decay activator protein ZFP36 Proteins 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 230000023881 membrane protein ectodomain proteolysis Effects 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000012775 microarray technology Methods 0.000 description 1
- 238000012737 microarray-based gene expression Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000003632 microfilament Anatomy 0.000 description 1
- 210000001589 microsome Anatomy 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 238000002715 modification method Methods 0.000 description 1
- 102000035118 modified proteins Human genes 0.000 description 1
- 108091005573 modified proteins Proteins 0.000 description 1
- 239000007932 molded tablet Substances 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 201000005935 monilethrix Diseases 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 239000012120 mounting media Substances 0.000 description 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 1
- 238000012243 multiplex automated genomic engineering Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- NJHLGKJQFKUSEA-UHFFFAOYSA-N n-[2-(4-hydroxyphenyl)ethyl]-n-methylnitrous amide Chemical compound O=NN(C)CCC1=CC=C(O)C=C1 NJHLGKJQFKUSEA-UHFFFAOYSA-N 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000017095 negative regulation of cell growth Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002687 nonaqueous vehicle Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- 102000026415 nucleotide binding proteins Human genes 0.000 description 1
- 108091014756 nucleotide binding proteins Proteins 0.000 description 1
- 208000031237 olivopontocerebellar atrophy Diseases 0.000 description 1
- 238000010397 one-hybrid screening Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 230000000858 peroxisomal effect Effects 0.000 description 1
- 238000011338 personalized therapy Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical compound NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 108010049148 plastin Proteins 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 108010040003 polyglutamine Proteins 0.000 description 1
- 229920000155 polyglutamine Polymers 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- CVNWOVUZADASQH-UHFFFAOYSA-N propyl 2-thiocyanatoacetate Chemical compound CCCOC(=O)CSC#N CVNWOVUZADASQH-UHFFFAOYSA-N 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- 230000004853 protein function Effects 0.000 description 1
- 102000029739 protein tyrosine kinase binding proteins Human genes 0.000 description 1
- 108091009293 protein tyrosine kinase binding proteins Proteins 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- VMXUWOKSQNHOCA-UKTHLTGXSA-N ranitidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UKTHLTGXSA-N 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 108010035291 retinol dehydrogenase Proteins 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 108020004418 ribosomal RNA Proteins 0.000 description 1
- 108010008790 ribosomal phosphoprotein P1 Proteins 0.000 description 1
- 108010025387 ribosomal protein L39 Proteins 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 238000003118 sandwich ELISA Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 108010006908 signal sequence receptor Proteins 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 108010039827 snRNP Core Proteins Proteins 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- GFWRVVCDTLRWPK-KPKJPENVSA-N sofalcone Chemical compound C1=CC(OCC=C(C)C)=CC=C1\C=C\C(=O)C1=CC=C(OCC=C(C)C)C=C1OCC(O)=O GFWRVVCDTLRWPK-KPKJPENVSA-N 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000003408 sphingolipids Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000007447 staining method Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000001574 stearyl tartrate Substances 0.000 description 1
- 230000004960 subcellular localization Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 108010006247 sulfoxide reductase Proteins 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 108091029536 tRNA precursor Proteins 0.000 description 1
- 102100028986 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like Human genes 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 108020002982 thioesterase Proteins 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 102000029947 transforming growth factor beta binding proteins Human genes 0.000 description 1
- 108091014793 transforming growth factor beta binding proteins Proteins 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 102000027257 transmembrane receptors Human genes 0.000 description 1
- 108091008578 transmembrane receptors Proteins 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 229960000575 trastuzumab Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- RTMBXAOPKJNOGZ-UHFFFAOYSA-N tris(2-methylphenyl) borate Chemical compound CC1=CC=CC=C1OB(OC=1C(=CC=CC=1)C)OC1=CC=CC=C1C RTMBXAOPKJNOGZ-UHFFFAOYSA-N 0.000 description 1
- 102000012344 tuftelin Human genes 0.000 description 1
- 108010022248 tuftelin Proteins 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- 238000003160 two-hybrid assay Methods 0.000 description 1
- 238000007039 two-step reaction Methods 0.000 description 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 description 1
- UOHFCPXBKJPCAD-UHFFFAOYSA-N tyrphostin 1 Chemical compound COC1=CC=C(C=C(C#N)C#N)C=C1 UOHFCPXBKJPCAD-UHFFFAOYSA-N 0.000 description 1
- 108010000982 uK-ATP-1 potassium channel Proteins 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 208000010576 undifferentiated carcinoma Diseases 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- WQAJKOXBERTWBK-UHFFFAOYSA-N verdine Natural products CC1CNC2C(C1)OC3(CCC4C5CCC6(O)CC(O)CC(O)C6(C)C5C(=O)C4=C3C)C2C WQAJKOXBERTWBK-UHFFFAOYSA-N 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Public Health (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41467302P | 2002-09-30 | 2002-09-30 | |
| US60/414,673 | 2002-09-30 | ||
| US45137403P | 2003-02-28 | 2003-02-28 | |
| US60/451,374 | 2003-02-28 | ||
| US46610003P | 2003-04-28 | 2003-04-28 | |
| US60/466,100 | 2003-04-28 | ||
| PCT/JP2003/012072 WO2004031413A2 (en) | 2002-09-30 | 2003-09-22 | Method for diagnosing non-small cell lung cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2500151A1 true CA2500151A1 (en) | 2004-04-15 |
Family
ID=32074369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002500151A Abandoned CA2500151A1 (en) | 2002-09-30 | 2003-09-22 | Ttk protein kinase gene for diagnosing and treating non-small cell lung cancers |
Country Status (8)
| Country | Link |
|---|---|
| EP (30) | EP2270214A3 (enExample) |
| JP (4) | JP4425141B2 (enExample) |
| KR (2) | KR20110020953A (enExample) |
| AT (1) | ATE541053T1 (enExample) |
| AU (1) | AU2003272088A1 (enExample) |
| CA (1) | CA2500151A1 (enExample) |
| TW (1) | TW200413725A (enExample) |
| WO (1) | WO2004031413A2 (enExample) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5300469A (en) * | 1992-12-08 | 1994-04-05 | Engelhard Corporation | Composition for passivating vanadium in catalytic cracking and preparation thereof |
| US8048629B2 (en) * | 1996-03-15 | 2011-11-01 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum |
| JP2006512924A (ja) * | 2002-08-15 | 2006-04-20 | ジェンザイム・コーポレーション | 脳内皮細胞発現パターン |
| WO2005090991A1 (en) * | 2004-03-24 | 2005-09-29 | Oncotherapy Science, Inc. | Adam8 as tumor marker and therapeutic target for non-small cell lung cancer |
| JP4742023B2 (ja) * | 2003-01-03 | 2011-08-10 | ゲンシア コーポレーション | 脱毛に関与する遺伝子の、siRNA転写後遺伝子サイレンシング |
| US20050112622A1 (en) * | 2003-08-11 | 2005-05-26 | Ring Brian Z. | Reagents and methods for use in cancer diagnosis, classification and therapy |
| US20050186577A1 (en) | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
| TW200533376A (en) * | 2004-03-24 | 2005-10-16 | Oncotherapy Science Inc | Compositions and methods for treating lung cancer |
| EP1787122B1 (en) * | 2004-08-10 | 2010-10-06 | Oncotherapy Science, Inc. | NON-SMALL CELL LUNG CANCER-RELATED GENE, ANLN, AND ITS INTERACTIONS WITH RhoA |
| DE602005025231D1 (de) * | 2004-08-10 | 2011-01-20 | Oncotherapy Science Inc | Gene und polypeptide in verbindung mit brustkrebserkrankungen |
| JP4908402B2 (ja) * | 2004-09-24 | 2012-04-04 | オンコセラピー・サイエンス株式会社 | URLC8のtRNA−ジヒドロウリジンシンターゼ活性によって非小細胞肺癌を診断する方法 |
| DE602005018250D1 (de) | 2004-10-19 | 2010-01-21 | Onco Therapy Science Inc | Pkp3-onkogen als prognostischer indikator für lungenadenokarzinom |
| WO2006056080A1 (en) * | 2004-11-29 | 2006-06-01 | Diagnocure Inc. | Gpx2 a specific and sensitive target for lung cancer diagnosis, prognosis and/or theranosis |
| WO2007053161A2 (en) * | 2004-12-15 | 2007-05-10 | Beth Israel Deaconess Medical Center | Nucleic acids and polypeptides useful for diagnosing and treating complications of pregnancy |
| EP2295601A1 (en) | 2005-02-10 | 2011-03-16 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| US7847060B2 (en) | 2005-02-25 | 2010-12-07 | Oncotherapy Science, Inc. | Peptide vaccines for lung cancers expressing TTK, URLC10 or KOC1 polypeptides |
| EP1854473A1 (en) * | 2005-03-03 | 2007-11-14 | Takeda Pharmaceutical Company Limited | Preventive/therapeutic agent for cancer |
| WO2006105642A1 (en) * | 2005-04-05 | 2006-10-12 | British Columbia Cancer Agency | Biomarkers for the detection of lung cancer and uses thereof |
| EP1888639A1 (en) * | 2005-05-12 | 2008-02-20 | Oncotherapy Science, Inc. | Methods for damaging cells using effector function of anti-dsc2 antibody |
| US8053183B2 (en) | 2005-07-27 | 2011-11-08 | Oncotherapy Science, Inc. | Method of diagnosing esophageal cancer |
| DE102005052384B4 (de) * | 2005-10-31 | 2009-09-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Erkennung, Markierung und Behandlung von epithelialen Lungentumorzellen sowie Mittel zur Durchführung des Verfahrens |
| KR100759288B1 (ko) * | 2005-11-14 | 2007-09-17 | 가톨릭대학교 산학협력단 | 비교유전자보합법을 이용한 폐암 및 폐암의 하부유형 진단방법 |
| WO2007091328A1 (ja) | 2006-02-10 | 2007-08-16 | Oncotherapy Science, Inc. | 肺癌の治療方法 |
| EP2018440A1 (en) * | 2006-04-20 | 2009-01-28 | Oncotherapy Science, Inc. | NMU-GHSR1b/NTSR1 ONCOGENIC SIGNALING PATHWAY AS A THERAPEUTIC TARGET FOR LUNG CANCER |
| EP2049905B1 (en) * | 2006-08-01 | 2010-05-19 | Roche Diagnostics GmbH | Use of nnmt as a marker for lung cancer |
| EP2059610A1 (en) * | 2006-08-18 | 2009-05-20 | Oncotherapy Science, Inc. | Imp-1 oncogene as a therapeutic target and prognostic indicator for lung cancer |
| US7851144B2 (en) | 2006-08-18 | 2010-12-14 | The University Of Washington | Compositions and methods for detecting cancer |
| WO2008020653A1 (en) * | 2006-08-18 | 2008-02-21 | Oncotherapy Science, Inc. | Use of holliday junction-recognizing protein related to cancer |
| EP2423332A1 (en) | 2006-08-25 | 2012-02-29 | Oncotherapy Science, Inc. | Prognostic markers and therapeutic targets for lung cancer |
| WO2008026946A2 (en) * | 2006-08-30 | 2008-03-06 | Genesis Research And Development Corporation Limited | Compositions and methods for the treatment and prevention of neoplastic disorders |
| ES2545457T3 (es) | 2006-10-17 | 2015-09-11 | Oncotherapy Science, Inc. | Vacunas de péptidos para cánceres que expresan los polipéptidos DEPDC1 |
| EP2468887A1 (en) | 2006-12-13 | 2012-06-27 | Oncotherapy Science, Inc. | TTK as tumor marker and therapeutic target for lung cancer |
| KR100846354B1 (ko) * | 2007-03-21 | 2008-07-15 | (주) 프로탄바이오 | 혈청 당단백질부터 분리한 폐암 진단용 마커 |
| US20100184047A1 (en) * | 2007-03-30 | 2010-07-22 | Oncotherapy Science, Inc. | Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex |
| WO2008151110A2 (en) * | 2007-06-01 | 2008-12-11 | The University Of North Carolina At Chapel Hill | Molecular diagnosis and typing of lung cancer variants |
| WO2009016691A1 (en) * | 2007-07-30 | 2009-02-05 | Oncotherapy Science, Inc. | Cancer associated gene ly6k |
| MX2010002001A (es) * | 2007-08-20 | 2010-03-11 | Oncotherapy Science Inc | Peptido cdca1 y agente farmaceutico que comprende elmismo. |
| CN108117584B (zh) | 2007-08-20 | 2021-08-24 | 肿瘤疗法科学股份有限公司 | Foxm1肽和包含foxm1肽的药剂 |
| CA2696591C (en) | 2007-08-20 | 2016-10-11 | Oncotherapy Science, Inc. | Cdh3 peptide and medicinal agent comprising the same |
| US8541183B2 (en) | 2007-09-11 | 2013-09-24 | Cancer Prevention And Cure, Ltd. | Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof |
| CA2705509A1 (en) | 2007-11-14 | 2009-05-22 | Forerunner Pharma Research Co., Ltd. | Diagnosis and treatment of cancer using anti-gpr49 antibody |
| TWI526219B (zh) | 2008-06-19 | 2016-03-21 | 腫瘤療法 科學股份有限公司 | Cdca1抗原決定位胜肽及含此胜肽的疫苗 |
| RU2011103199A (ru) | 2008-06-30 | 2012-08-10 | Онкотерапи Сайенс, Инк. (Jp) | Антитела против cdh3, меченные радиоизотопной меткой, и их применение |
| TWI466680B (zh) | 2008-08-01 | 2015-01-01 | Oncotherapy Science Inc | Melk抗原決定位胜肽及含此胜肽的疫苗 |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| TWI580431B (zh) | 2008-08-19 | 2017-05-01 | 腫瘤療法 科學股份有限公司 | Hig2與urlc10抗原決定位胜肽以及含此胜肽之疫苗 |
| EP2334790A1 (en) * | 2008-08-27 | 2011-06-22 | Oncotherapy Science, Inc. | Pancreatic cancer related gene ttll4 |
| JP2012501166A (ja) * | 2008-08-27 | 2012-01-19 | オンコセラピー・サイエンス株式会社 | 乳癌関連遺伝子rqcd1 |
| US20110160288A1 (en) * | 2008-08-28 | 2011-06-30 | Oncotherapy Science, Inc. | Oip5 as a target gene for cancer therapy and diagnosis |
| KR101064561B1 (ko) * | 2008-09-24 | 2011-09-14 | 고려대학교 산학협력단 | 폐선암 수술 후 초기 재발 예측용 바이오마커 |
| JP2012511305A (ja) * | 2008-12-12 | 2012-05-24 | オンコセラピー・サイエンス株式会社 | 癌の治療および診断の標的遺伝子としてのネクチン−4 |
| TWI469791B (zh) | 2009-02-18 | 2015-01-21 | Oncotherapy Science Inc | Foxm1胜肽以及含此胜肽之疫苗 |
| EP3444359A1 (en) | 2009-03-12 | 2019-02-20 | Cancer Prevention And Cure, Ltd. | Methods of identification of non-small cell lung cancer |
| TW201102081A (en) | 2009-05-11 | 2011-01-16 | Oncotherapy Science Inc | TTK peptides and vaccines including the same |
| KR101757798B1 (ko) | 2009-09-03 | 2017-07-14 | 도레이 카부시키가이샤 | 면역 유도제 |
| JP5728718B2 (ja) | 2009-12-28 | 2015-06-03 | オンコセラピー・サイエンス株式会社 | 抗cdh3抗体およびその使用 |
| TWI485245B (zh) | 2010-01-25 | 2015-05-21 | Oncotherapy Science Inc | 經修飾之melk胜肽及含此胜肽之疫苗 |
| AU2011225577B2 (en) | 2010-03-11 | 2017-01-19 | Oncotherapy Science, Inc. | HJURP peptides and vaccines including the same |
| WO2011129427A1 (ja) * | 2010-04-16 | 2011-10-20 | 第一三共株式会社 | 癌の診断剤および治療剤 |
| BR112013002182B8 (pt) | 2010-07-30 | 2023-02-28 | Oncotherapy Science Inc | Compostos derivados de quinolina, composição farmacêutica, inibidor de melk, agente modulador de expressão de melk, agente antitumor, agente terapêutico e/ou preventivo para uma doença que envolve a superexpressão de melk contendo os mesmos e uso dos referidos compostos |
| WO2012028899A1 (en) * | 2010-09-02 | 2012-03-08 | Inserm ( Institut National De La Sante Et De La Recherche Medicale) | Methods for the treatment and the diagnosis of cancer |
| AU2012249288C1 (en) | 2011-04-29 | 2017-12-21 | Lung Cancer Proteomics Llc | Methods of identification and diagnosis of lung diseases using classification systems and kits thereof |
| WO2012153492A1 (en) * | 2011-05-06 | 2012-11-15 | Oncotherapy Science, Inc. | Nptx2 as tumor marker and therapeutic target for cancer |
| WO2012157239A1 (en) * | 2011-05-16 | 2012-11-22 | Oncotherapy Science, Inc. | Chodl as tumor marker and therapeutic target for cancer |
| CA2842887C (en) | 2011-08-12 | 2021-01-19 | Oncotherapy Science, Inc. | Mphosph1 peptides and vaccines including the same |
| US9926604B2 (en) | 2011-10-14 | 2018-03-27 | The Regents Of The University Of California | Multiplex PCR-based testing of cutaneous squamous cell carcinoma and pseudoepitheliomatous hyperplasia and methods for distinguishing the same |
| MX366983B (es) | 2012-01-19 | 2019-08-01 | Oncotherapy Science Inc | Derivados de 1,5-naftiridina e inhibidores de cinasa de cremallallera de leucina embrionica materna que los contienen. |
| KR101308924B1 (ko) * | 2012-02-21 | 2013-09-23 | 차의과학대학교 산학협력단 | 신규한 miRNA hc-smR-S2-5 및 이의 용도 |
| WO2013133405A1 (ja) | 2012-03-09 | 2013-09-12 | オンコセラピー・サイエンス株式会社 | ペプチドを含む医薬組成物 |
| JO3623B1 (ar) | 2012-05-18 | 2020-08-27 | Amgen Inc | البروتينات المرتبطة بمولد المستضاد st2 |
| JP6255593B2 (ja) | 2012-07-10 | 2018-01-10 | オンコセラピー・サイエンス株式会社 | Th1細胞のCDCA1エピトープペプチドおよびこれを含有するワクチン |
| EP2872531A4 (en) | 2012-07-10 | 2016-04-06 | Oncotherapy Science Inc | LY6K EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING SAME |
| GB201213229D0 (en) * | 2012-07-25 | 2012-09-05 | Isis Innovation | Assay |
| TWI658049B (zh) | 2013-03-12 | 2019-05-01 | 腫瘤療法 科學股份有限公司 | Kntc2胜肽及含此胜肽之疫苗 |
| KR101447901B1 (ko) | 2013-04-16 | 2014-10-16 | 한양대학교 산학협력단 | 지방세포 표적 비바이러스성 유전자 전달체 |
| TWI627182B (zh) | 2013-05-24 | 2018-06-21 | 腫瘤療法 科學股份有限公司 | 對於th1細胞之imp-3抗原決定位胜肽及含此之疫苗 |
| EP3149209B1 (en) | 2014-05-30 | 2021-02-17 | Genecentric Therapeutics, Inc. | Methods for typing of lung cancer |
| IL250235B (en) | 2014-08-04 | 2022-07-01 | Oncotherapy Science Inc | Urlc10-derived peptide and vaccine containing same |
| CN111925413B (zh) | 2014-08-04 | 2025-04-18 | 肿瘤疗法科学股份有限公司 | Koc1衍生的肽和包含它们的疫苗 |
| JPWO2016121715A1 (ja) * | 2015-01-26 | 2017-11-02 | 国立大学法人名古屋大学 | 肺がん患者の予後を評価するための情報を提供する方法、肺がん患者の予後予測方法、内部標準、抗体、肺がん患者の予後予測装置、予後予測装置のプログラム及び記録媒体 |
| CN107849613A (zh) * | 2015-04-14 | 2018-03-27 | 基因中心治疗公司 | 用于肺癌分型的方法 |
| CA2997674A1 (en) * | 2015-09-09 | 2017-03-16 | Theoria Science Inc. | Exosome secretion inhibitor |
| AU2016334778B2 (en) | 2015-10-08 | 2020-12-17 | Oncotherapy Science, Inc. | MPHOSPH1-derived peptide, and vaccine including same |
| EP3360886B1 (en) | 2015-10-08 | 2023-01-25 | Oncotherapy Science, Inc. | Foxm1-derived peptide, and vaccine including same |
| WO2021016946A1 (zh) | 2019-07-31 | 2021-02-04 | 京东方科技集团股份有限公司 | 显示基板及其制备方法、显示面板、显示装置 |
| US10934595B2 (en) | 2016-05-17 | 2021-03-02 | Genecentric Therapeutics, Inc. | Methods for subtyping of lung adenocarcinoma |
| CA3024744A1 (en) | 2016-05-17 | 2017-11-23 | Genecentric Therapeutics, Inc. | Methods for subtyping of lung squamous cell carcinoma |
| IL264826B2 (en) | 2016-08-31 | 2024-06-01 | Oncotherapy Science Inc | Monoclonal antibody against melk and utilization thereof |
| TWI762516B (zh) | 2016-10-06 | 2022-05-01 | 日商腫瘤療法 科學股份有限公司 | 針對fzd10之單株抗體及其用途 |
| NL2020004B1 (en) | 2016-12-09 | 2018-07-02 | Ary Flohil Jacob | Treatment of diffuse intrinsic pontine glioma |
| MY192920A (en) * | 2017-03-15 | 2022-09-15 | Cancer Res Malaysia | Immunogenic peptide composition |
| WO2018187496A2 (en) | 2017-04-04 | 2018-10-11 | Lung Cancer Proteomics, Llc | Plasma based protein profiling for early stage lung cancer prognosis |
| TW202023581A (zh) | 2018-08-02 | 2020-07-01 | 日商腫瘤療法 科學股份有限公司 | 來自cdca1的胜肽及含有此的疫苗 |
| KR102540416B1 (ko) * | 2021-04-09 | 2023-06-12 | 주식회사 애티스랩 | 암 진단용 조성물, 키트, 및 이를 이용한 암 진단 방법 |
| KR102732170B1 (ko) | 2021-05-20 | 2024-11-19 | 한국식품연구원 | 구강미생물 정보를 이용한 폐암의 조기진단 및 위험성 예측 방법 또는 이를 위한 조성물 |
| CN113925877B (zh) * | 2021-10-28 | 2022-06-07 | 青岛西凯生物技术有限公司 | 基因增强型免疫细胞在肺癌中的应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0239102A3 (en) | 1986-03-28 | 1989-07-12 | Tsuji, Kimiyoshi | Process for the formation of human-human hybridoma |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
| GB9114005D0 (en) | 1991-06-28 | 1991-08-14 | Automotive Prod Plc | A clutch control system |
| WO1993002227A1 (en) | 1991-07-15 | 1993-02-04 | Eco-Tec Limited | Process and apparatus for treating fluoride containing acid solutions |
| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1994002602A1 (en) | 1992-07-24 | 1994-02-03 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5403494A (en) | 1993-07-15 | 1995-04-04 | The Lawrence Paper Company | Method of recovery of single color printing ink wastes |
| JP4312259B2 (ja) | 1995-04-27 | 2009-08-12 | アムジェン フレモント インク. | 免疫したゼノマウス(XenoMouse)に由来するヒト抗体 |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| JP2002519000A (ja) * | 1998-01-28 | 2002-07-02 | カイロン コーポレイション | ヒト遺伝子および遺伝子発現産物ii |
| AU4187499A (en) * | 1998-05-14 | 1999-11-29 | Chiron Corporation | Human genes and gene expression products v |
| US20020103360A1 (en) | 1998-09-01 | 2002-08-01 | Yang Pan | Novel protein related to melanoma-inhibiting protein and uses thereof |
| EP1130094A3 (en) * | 1999-07-08 | 2001-11-21 | Helix Research Institute | Primers for synthesizing full length cDNA clones and their use |
| IL147902A0 (en) * | 1999-08-12 | 2002-08-14 | Agensys Inc | C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof |
| CA2399776A1 (en) * | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| AU2001287269A1 (en) * | 2000-03-28 | 2001-10-08 | Chiron Corporation | Human genes and expression products |
| AU2001251084A1 (en) * | 2000-03-29 | 2001-10-08 | Diadexus, Inc. | Polynucleotides and polypeptides as well as methods for diagnosing and treating lung cancer |
| US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| EP1358349A2 (en) * | 2000-06-05 | 2003-11-05 | Avalon Pharmaceuticals | Cancer gene determination and therapeutic screening using signature gene sets |
| US6974667B2 (en) * | 2000-06-14 | 2005-12-13 | Gene Logic, Inc. | Gene expression profiles in liver cancer |
| EP1343886A2 (en) * | 2000-07-11 | 2003-09-17 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| WO2002059271A2 (en) * | 2001-01-25 | 2002-08-01 | Gene Logic, Inc. | Gene expression profiles in breast tissue |
| CN101732717A (zh) * | 2001-02-21 | 2010-06-16 | 诺华疫苗和诊断公司 | 用于诊断和作为癌症治疗靶标的ttk |
| US20030087250A1 (en) * | 2001-03-14 | 2003-05-08 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer |
| AU2002309583A1 (en) * | 2001-04-18 | 2002-11-05 | Protein Desing Labs, Inc. | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
| TW200533376A (en) * | 2004-03-24 | 2005-10-16 | Oncotherapy Science Inc | Compositions and methods for treating lung cancer |
| US7847060B2 (en) * | 2005-02-25 | 2010-12-07 | Oncotherapy Science, Inc. | Peptide vaccines for lung cancers expressing TTK, URLC10 or KOC1 polypeptides |
| EP2423332A1 (en) * | 2006-08-25 | 2012-02-29 | Oncotherapy Science, Inc. | Prognostic markers and therapeutic targets for lung cancer |
| JP2010536366A (ja) * | 2007-08-24 | 2010-12-02 | オンコセラピー・サイエンス株式会社 | 肺癌の治療及び診断の標的遺伝子のためのebi3、dlx5、nptx1、及びcdkn3 |
-
2003
- 2003-09-15 TW TW092125317A patent/TW200413725A/zh unknown
- 2003-09-22 EP EP10010322A patent/EP2270214A3/en not_active Withdrawn
- 2003-09-22 EP EP10010308A patent/EP2264187A1/en not_active Withdrawn
- 2003-09-22 EP EP06022167A patent/EP1743947B1/en not_active Expired - Lifetime
- 2003-09-22 EP EP10010315A patent/EP2270501A3/en not_active Withdrawn
- 2003-09-22 EP EP10010319A patent/EP2270211A3/en not_active Withdrawn
- 2003-09-22 EP EP10010320A patent/EP2270212A3/en not_active Withdrawn
- 2003-09-22 EP EP10010324A patent/EP2270216A3/en not_active Withdrawn
- 2003-09-22 JP JP2004541231A patent/JP4425141B2/ja not_active Expired - Fee Related
- 2003-09-22 EP EP10010312A patent/EP2270498A3/en not_active Withdrawn
- 2003-09-22 EP EP10010332A patent/EP2270224A3/en not_active Withdrawn
- 2003-09-22 EP EP10010316A patent/EP2270502A3/en not_active Withdrawn
- 2003-09-22 AT AT06022167T patent/ATE541053T1/de active
- 2003-09-22 EP EP10010321A patent/EP2270213A3/en not_active Withdrawn
- 2003-09-22 WO PCT/JP2003/012072 patent/WO2004031413A2/en not_active Ceased
- 2003-09-22 EP EP10010326A patent/EP2270218A2/en not_active Withdrawn
- 2003-09-22 EP EP10010331A patent/EP2270223A2/en not_active Withdrawn
- 2003-09-22 EP EP10010333A patent/EP2270225A3/en not_active Withdrawn
- 2003-09-22 EP EP10010311A patent/EP2278028A1/en not_active Withdrawn
- 2003-09-22 EP EP10010307A patent/EP2264186A1/en not_active Withdrawn
- 2003-09-22 EP EP10010318A patent/EP2270210A3/en not_active Withdrawn
- 2003-09-22 EP EP10010314A patent/EP2270500A1/en not_active Withdrawn
- 2003-09-22 EP EP10010310A patent/EP2264457A1/en not_active Withdrawn
- 2003-09-22 EP EP10010317A patent/EP2270503A3/en not_active Withdrawn
- 2003-09-22 AU AU2003272088A patent/AU2003272088A1/en not_active Abandoned
- 2003-09-22 EP EP10010325A patent/EP2270217A3/en not_active Withdrawn
- 2003-09-22 EP EP03753941A patent/EP1551998A2/en not_active Withdrawn
- 2003-09-22 EP EP10010306A patent/EP2264185A1/en not_active Withdrawn
- 2003-09-22 EP EP10010328A patent/EP2270220A3/en not_active Withdrawn
- 2003-09-22 CA CA002500151A patent/CA2500151A1/en not_active Abandoned
- 2003-09-22 KR KR1020117003536A patent/KR20110020953A/ko not_active Abandoned
- 2003-09-22 EP EP10010327A patent/EP2270219A3/en not_active Withdrawn
- 2003-09-22 EP EP10010323A patent/EP2270215A3/en not_active Withdrawn
- 2003-09-22 KR KR1020057005561A patent/KR101075158B1/ko not_active Expired - Fee Related
- 2003-09-22 EP EP10010330A patent/EP2270222A2/en not_active Withdrawn
- 2003-09-22 EP EP10010309A patent/EP2264190A1/en not_active Withdrawn
- 2003-09-22 EP EP10010313A patent/EP2270499A1/en not_active Withdrawn
- 2003-09-22 EP EP10010329A patent/EP2270221A3/en not_active Withdrawn
-
2009
- 2009-06-09 JP JP2009138122A patent/JP4921522B2/ja not_active Expired - Fee Related
- 2009-10-05 JP JP2009231138A patent/JP2010042016A/ja active Pending
-
2012
- 2012-01-11 JP JP2012003039A patent/JP2012125247A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1743947B1 (en) | Methods and compositions for the treatment of non-small cell lung cancer | |
| US20060024692A1 (en) | Method for diagnosing non-small cell lung cancers | |
| CN1854313B (zh) | 非小细胞肺癌的诊断方法 | |
| JP2008505601A (ja) | 前立腺癌に関連した遺伝子及びポリペプチド |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130924 |