CA2487211C - Pyrazolo(1,5a) pyrimidine compounds as antiviral agents - Google Patents

Pyrazolo(1,5a) pyrimidine compounds as antiviral agents Download PDF

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Publication number
CA2487211C
CA2487211C CA2487211A CA2487211A CA2487211C CA 2487211 C CA2487211 C CA 2487211C CA 2487211 A CA2487211 A CA 2487211A CA 2487211 A CA2487211 A CA 2487211A CA 2487211 C CA2487211 C CA 2487211C
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CA
Canada
Prior art keywords
mmol
pyrazolo
cyclohexyl
phenyl
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2487211A
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English (en)
French (fr)
Other versions
CA2487211A1 (en
Inventor
Gerald W. Shipps, Jr.
Kristin E. Rosner
Janeta Popovici-Muller
Yongqi Deng
Tong Wang
Patrick J. Curran
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Neogenesis Pharmaceuticals Inc
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Neogenesis Pharmaceuticals Inc
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Publication date
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Publication of CA2487211A1 publication Critical patent/CA2487211A1/en
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Publication of CA2487211C publication Critical patent/CA2487211C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA2487211A 2002-06-04 2003-06-02 Pyrazolo(1,5a) pyrimidine compounds as antiviral agents Expired - Fee Related CA2487211C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38583702P 2002-06-04 2002-06-04
US60/385,837 2002-06-04
PCT/US2003/017368 WO2003101993A1 (en) 2002-06-04 2003-06-02 Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents

Publications (2)

Publication Number Publication Date
CA2487211A1 CA2487211A1 (en) 2003-12-11
CA2487211C true CA2487211C (en) 2010-09-14

Family

ID=29712216

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2487211A Expired - Fee Related CA2487211C (en) 2002-06-04 2003-06-02 Pyrazolo(1,5a) pyrimidine compounds as antiviral agents

Country Status (11)

Country Link
US (1) US7196111B2 (https=)
EP (1) EP1511751B1 (https=)
JP (1) JP4602076B2 (https=)
CN (1) CN1671710A (https=)
AT (1) ATE389656T1 (https=)
AU (1) AU2003240488A1 (https=)
CA (1) CA2487211C (https=)
DE (1) DE60319820T2 (https=)
ES (1) ES2304511T3 (https=)
MX (1) MXPA04012245A (https=)
WO (1) WO2003101993A1 (https=)

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US20040038993A1 (en) 2004-02-26
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EP1511751A1 (en) 2005-03-09
WO2003101993A1 (en) 2003-12-11
JP2005533040A (ja) 2005-11-04
JP4602076B2 (ja) 2010-12-22
CN1671710A (zh) 2005-09-21
US7196111B2 (en) 2007-03-27
ATE389656T1 (de) 2008-04-15
EP1511751B1 (en) 2008-03-19
MXPA04012245A (es) 2005-09-30
AU2003240488A1 (en) 2003-12-19
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