CA2486157C - Opioid and opioid-like compounds and uses thereof - Google Patents
Opioid and opioid-like compounds and uses thereof Download PDFInfo
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- CA2486157C CA2486157C CA2486157A CA2486157A CA2486157C CA 2486157 C CA2486157 C CA 2486157C CA 2486157 A CA2486157 A CA 2486157A CA 2486157 A CA2486157 A CA 2486157A CA 2486157 C CA2486157 C CA 2486157C
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- Prior art keywords
- methoxy
- morphinan
- compound
- alkyl
- ring
- Prior art date
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Landscapes
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- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
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| PCT/US2003/015461 WO2003097608A2 (en) | 2002-05-17 | 2003-05-16 | Opioid and opioid-like compounds and uses thereof |
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| TW (1) | TWI275591B (OSRAM) |
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| JP2521914Y2 (ja) | 1988-12-23 | 1997-01-08 | エヌティエヌ株式会社 | 大型転がり軸受 |
| US7923454B2 (en) * | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US20040204862A1 (en) | 2003-04-11 | 2004-10-14 | Wainer Irving W. | Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors |
| AU2005244852B2 (en) * | 2004-05-12 | 2011-09-22 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods related to the treatment of neurodegenerative and inflammatory conditions |
| US7691874B2 (en) | 2004-05-14 | 2010-04-06 | Hyoung-Chun KIM | Neuroprotective properties of dextrorotatory morphinans |
| SA07280459B1 (ar) * | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| DK3825306T3 (da) | 2007-05-01 | 2023-09-11 | Sun Pharmaceutical Ind Inc | Morphinanforbindelser |
| EP2183229B1 (en) | 2007-07-26 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| TW200927115A (en) | 2007-11-16 | 2009-07-01 | Boehringer Ingelheim Int | Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| MX360289B (es) * | 2007-11-23 | 2018-10-29 | Gruenenthal Gmbh | Composiciones de tapentadol. |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| WO2009094169A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2715290A1 (en) | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| ES2421537T3 (es) | 2008-05-01 | 2013-09-03 | Vitae Pharmaceuticals Inc | Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1 |
| WO2009134392A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8592410B2 (en) | 2008-05-01 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1 |
| TW200950780A (en) | 2008-05-13 | 2009-12-16 | Boehringer Ingelheim Int | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| ES2432150T3 (es) | 2008-07-25 | 2013-12-02 | Boehringer Ingelheim International Gmbh | Inhibidores cíclicos de la 11 beta-hidroxiesteroide deshidrogenasa 1 |
| JP5777030B2 (ja) | 2008-07-25 | 2015-09-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| EA023962B1 (ru) * | 2008-09-19 | 2016-07-29 | Консерт Фармасьютикалз Инк. | Дейтерированные морфинановые соединения |
| CA2744946A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| TWI531571B (zh) | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物 |
| CN102869360B (zh) | 2010-05-03 | 2015-03-25 | 东生华制药股份有限公司 | 治疗高血压的医药组合物及方法 |
| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| EA201300522A1 (ru) | 2010-11-02 | 2013-11-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические комбинации для лечения метаболических нарушений |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| CA2822453C (en) * | 2010-12-23 | 2019-04-02 | Phoenix Pharmalabs, Inc. | Novel morphinans useful as analgesics |
| EP2744783A1 (en) | 2011-08-17 | 2014-06-25 | Boehringer Ingelheim International GmbH | Indenopyridine derivatives |
| CN102731399B (zh) * | 2012-07-06 | 2013-11-06 | 启东东岳药业有限公司 | 高纯度3-甲氧基-9α,13α,14α吗啡喃盐酸盐的制备方法 |
| CN103254131A (zh) * | 2013-04-23 | 2013-08-21 | 苏州谷力生物科技有限公司 | 一种右美沙芬原料药的精制工艺 |
| GB201308440D0 (en) * | 2013-05-10 | 2013-06-19 | Dalgleish Angus | Therapeutic |
| JP6248711B2 (ja) | 2014-03-06 | 2017-12-20 | 株式会社デンソー | 回転電機の固定子 |
| US9757372B2 (en) * | 2015-03-25 | 2017-09-12 | Taiwanj Pharmaceuticals Co., Ltd. | Toll-like receptor 4 antagonists and use in autoimmune liver diseases |
| KR20180129909A (ko) | 2016-04-22 | 2018-12-05 | 타이완제이 파마슈티컬스 컴퍼니 리미티드 | (비)알콜성 지방간염 또는 비알콜성 지방간 질환의 치료에 사용하기 위한 날메펜, 날트렉손 또는 이의 유도체 |
| US20210130316A1 (en) * | 2017-01-05 | 2021-05-06 | Taiwanj Pharmaceuticals Co., Ltd | Morphinan derivatives and compositions comprising the same for treating autoimmune, inflammation or infection related disorders |
| CN107157998A (zh) * | 2017-05-26 | 2017-09-15 | 张灏 | 右美沙芬的新用途 |
| US20220110315A1 (en) * | 2019-02-19 | 2022-04-14 | Robert Barsotti | Solutions and methods for organ preservation |
| CN119977886B (zh) * | 2025-02-13 | 2025-08-22 | 安徽益普克医药科技发展有限公司 | 一种葡萄糖酸喷他佐辛苯甲酸酯及其制备方法与用途 |
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| US3275638A (en) | 1966-09-27 | Chjcoo- | ||
| NL127995C (OSRAM) | 1963-12-20 | Geigy Ag J R | ||
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| BE788478A (fr) | 1971-09-08 | 1973-03-06 | Bristol Myers Co | Procede de preparation de composes analgesiques |
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| TW264473B (OSRAM) * | 1993-01-06 | 1995-12-01 | Hoffmann La Roche | |
| EP0632041A1 (en) | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| NZ268969A (en) * | 1993-07-23 | 1997-06-24 | Toray Industries | Morphinan derivatives and pharmaceutical compositions |
| CZ281174B6 (cs) | 1993-08-13 | 1996-07-17 | Galena, A.S. | Způsob přípravy 3,14ß-dihydroxy-17-normorfinanu |
| JPH11512699A (ja) * | 1995-09-19 | 1999-11-02 | ビー マーゴリン、ソロモン | 腫瘍壊死因子アルファの阻止 |
| DE19602970A1 (de) | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue 7,8- Dihydromorphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
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-
2003
- 2003-05-16 JP JP2004505341A patent/JP5438250B2/ja not_active Expired - Fee Related
- 2003-05-16 EP EP03728964.2A patent/EP1506174B1/en not_active Expired - Lifetime
- 2003-05-16 CN CN201310094981.6A patent/CN103405431B/zh not_active Expired - Lifetime
- 2003-05-16 AU AU2003234621A patent/AU2003234621A1/en not_active Abandoned
- 2003-05-16 CA CA2486157A patent/CA2486157C/en not_active Expired - Fee Related
- 2003-05-16 WO PCT/US2003/015461 patent/WO2003097608A2/en not_active Ceased
- 2003-05-16 EP EP15186541.7A patent/EP2987788A1/en not_active Withdrawn
- 2003-05-16 MX MXPA04011327A patent/MXPA04011327A/es not_active Application Discontinuation
- 2003-05-16 CN CN038112396A patent/CN1653050B/zh not_active Expired - Lifetime
- 2003-11-17 TW TWOPIOIDANA patent/TWI275591B/zh not_active IP Right Cessation
-
2010
- 2010-08-24 AU AU2010212517A patent/AU2010212517A1/en not_active Abandoned
-
2013
- 2013-11-01 JP JP2013228118A patent/JP6165592B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-24 JP JP2015089558A patent/JP6193298B2/ja not_active Expired - Lifetime
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2016
- 2016-07-18 HK HK16108452.6A patent/HK1220452A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103405431A (zh) | 2013-11-27 |
| JP2015155449A (ja) | 2015-08-27 |
| JP5438250B2 (ja) | 2014-03-12 |
| WO2003097608A3 (en) | 2004-03-18 |
| AU2003234621A1 (en) | 2003-12-02 |
| JP2005530798A (ja) | 2005-10-13 |
| EP2987788A1 (en) | 2016-02-24 |
| JP6193298B2 (ja) | 2017-09-06 |
| CA2486157A1 (en) | 2003-11-27 |
| CN1653050B (zh) | 2013-04-24 |
| HK1192711A1 (zh) | 2014-08-29 |
| AU2010212517A1 (en) | 2010-09-16 |
| EP1506174B1 (en) | 2015-09-30 |
| CN103405431B (zh) | 2016-04-13 |
| TWI275591B (en) | 2007-03-11 |
| WO2003097608A2 (en) | 2003-11-27 |
| HK1220452A1 (en) | 2017-06-09 |
| JP6165592B2 (ja) | 2017-07-19 |
| EP1506174A2 (en) | 2005-02-16 |
| TW200427690A (en) | 2004-12-16 |
| CN1653050A (zh) | 2005-08-10 |
| MXPA04011327A (es) | 2005-08-15 |
| JP2014043452A (ja) | 2014-03-13 |
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