CA2452058A1 - Bispecific antibodies that bind to vegf receptors - Google Patents
Bispecific antibodies that bind to vegf receptors Download PDFInfo
- Publication number
- CA2452058A1 CA2452058A1 CA002452058A CA2452058A CA2452058A1 CA 2452058 A1 CA2452058 A1 CA 2452058A1 CA 002452058 A CA002452058 A CA 002452058A CA 2452058 A CA2452058 A CA 2452058A CA 2452058 A1 CA2452058 A1 CA 2452058A1
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- CA
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- Prior art keywords
- seq
- ser
- antibody
- gly
- thr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07K2317/626—Diabody or triabody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
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- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US30129901P | 2001-06-26 | 2001-06-26 | |
| US60/301,299 | 2001-06-26 | ||
| PCT/US2002/020332 WO2003002144A1 (en) | 2001-06-26 | 2002-06-26 | Bispecific antibodies that bind to vegf receptors |
Publications (1)
| Publication Number | Publication Date |
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| CA2452058A1 true CA2452058A1 (en) | 2003-01-09 |
Family
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| CA002452058A Abandoned CA2452058A1 (en) | 2001-06-26 | 2002-06-26 | Bispecific antibodies that bind to vegf receptors |
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| JP (1) | JP2005518336A (enExample) |
| CA (1) | CA2452058A1 (enExample) |
| WO (1) | WO2003002144A1 (enExample) |
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| DK1487856T3 (da) | 2002-03-04 | 2010-10-18 | Imclone Llc | KDR-specifikke humane antistoffer og deres anvendelse |
| GB0305702D0 (en) * | 2003-03-12 | 2003-04-16 | Univ Birmingham | Bispecific antibodies |
| DK1682583T3 (da) | 2003-11-13 | 2012-05-07 | Hanmi Holdings Co Ltd | Proteinkompleksdannelse under anvendelse af immunoglobulinfragment samt fremgangsmåde til fremstilling deraf |
| WO2005077065A2 (en) * | 2004-02-09 | 2005-08-25 | The Regents Of The University Of California | Selective high-affinity polydentate ligands and methods of making such |
| WO2005087812A1 (en) * | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Multivalent antibody materials and methods for vegf/pdgf family of growth factors |
| JP2008523083A (ja) * | 2004-12-08 | 2008-07-03 | イムノメディクス, インコーポレイテッド | 炎症性疾患および免疫調節不全疾患、感染性疾患、病的血管新生およびがんの免疫療法および検出のための方法および組成物 |
| EP1726650A1 (en) * | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
| GB0512225D0 (en) * | 2005-06-16 | 2005-07-27 | Univ Sheffield | Immunoglobulin molecules |
| EP2032162A2 (en) * | 2006-05-22 | 2009-03-11 | Board of Regents, The University of Texas System | Herv-k antigens, antibodies, and methods |
| US20090297530A1 (en) * | 2006-05-22 | 2009-12-03 | Feng Wang-Johanning | Herv-k antigens, antibodies, and methods |
| US8119130B2 (en) * | 2007-07-25 | 2012-02-21 | Medimmune Limited | Targeted binding agents directed to KDR and uses thereof—035 |
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| US5840301A (en) * | 1994-02-10 | 1998-11-24 | Imclone Systems Incorporated | Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors |
| WO2000021560A1 (en) * | 1998-10-09 | 2000-04-20 | Ludwig Institute For Cancer Research | Flt4 (VEGFR-3) AS A TARGET FOR TUMOR IMAGING AND ANTI-TUMOR THERAPY |
| PT1140175E (pt) * | 1998-12-21 | 2006-06-30 | Ludwig Inst Cancer Res | Anticorpos para o vegf-d truncado e suas utilizacoes |
| AU3475100A (en) * | 1999-01-29 | 2000-08-18 | Imclone Systems Incorporated | Antibodies specific to kdr and uses thereof |
| US20020103345A1 (en) * | 2000-05-24 | 2002-08-01 | Zhenping Zhu | Bispecific immunoglobulin-like antigen binding proteins and method of production |
-
2002
- 2002-06-26 EP EP02744670A patent/EP1411983A4/en not_active Withdrawn
- 2002-06-26 JP JP2003508383A patent/JP2005518336A/ja active Pending
- 2002-06-26 WO PCT/US2002/020332 patent/WO2003002144A1/en not_active Ceased
- 2002-06-26 US US10/482,630 patent/US20040242851A1/en not_active Abandoned
- 2002-06-26 CA CA002452058A patent/CA2452058A1/en not_active Abandoned
- 2002-12-24 US US10/520,026 patent/US20090028859A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1411983A1 (en) | 2004-04-28 |
| US20090028859A1 (en) | 2009-01-29 |
| WO2003002144A1 (en) | 2003-01-09 |
| JP2005518336A (ja) | 2005-06-23 |
| EP1411983A4 (en) | 2006-06-21 |
| US20040242851A1 (en) | 2004-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |