CA2419115C - Microparticles, and method and apparatus for forming same - Google Patents

Microparticles, and method and apparatus for forming same Download PDF

Info

Publication number
CA2419115C
CA2419115C CA2419115A CA2419115A CA2419115C CA 2419115 C CA2419115 C CA 2419115C CA 2419115 A CA2419115 A CA 2419115A CA 2419115 A CA2419115 A CA 2419115A CA 2419115 C CA2419115 C CA 2419115C
Authority
CA
Canada
Prior art keywords
particles
stream
nozzle
liquid
diameter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2419115A
Other languages
English (en)
French (fr)
Other versions
CA2419115A1 (en
Inventor
Kyekyoon Kim
Daniel W. Pack
Cory J. Berkland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
Original Assignee
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois System filed Critical University of Illinois System
Publication of CA2419115A1 publication Critical patent/CA2419115A1/en
Application granted granted Critical
Publication of CA2419115C publication Critical patent/CA2419115C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/04Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82BNANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00Manufacture or treatment of nanostructures
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CA2419115A 2000-08-15 2001-08-15 Microparticles, and method and apparatus for forming same Expired - Lifetime CA2419115C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22552500P 2000-08-15 2000-08-15
US22562000P 2000-08-15 2000-08-15
US60/225,620 2000-08-15
US60/225,525 2000-08-15
PCT/US2001/025674 WO2002013786A2 (en) 2000-08-15 2001-08-15 Method of forming microparticles

Publications (2)

Publication Number Publication Date
CA2419115A1 CA2419115A1 (en) 2002-02-21
CA2419115C true CA2419115C (en) 2011-03-08

Family

ID=26919678

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2419115A Expired - Lifetime CA2419115C (en) 2000-08-15 2001-08-15 Microparticles, and method and apparatus for forming same

Country Status (9)

Country Link
US (3) US6669961B2 (enExample)
EP (1) EP1355630B1 (enExample)
JP (1) JP2004505761A (enExample)
KR (2) KR100902625B1 (enExample)
AT (1) ATE449596T1 (enExample)
AU (1) AU2001284982A1 (enExample)
CA (1) CA2419115C (enExample)
DE (1) DE60140625D1 (enExample)
WO (1) WO2002013786A2 (enExample)

Families Citing this family (253)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101460240B1 (ko) * 2008-06-13 2014-11-21 삼성전자주식회사 메모리 기반 저장 장치 및 그것의 블록 관리 기법
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20020081732A1 (en) 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
CA2419115C (en) * 2000-08-15 2011-03-08 Board Of Trustees Of The University Of Illinois Microparticles, and method and apparatus for forming same
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US7037528B2 (en) 2000-12-22 2006-05-02 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6518330B2 (en) * 2001-02-13 2003-02-11 Board Of Trustees Of University Of Illinois Multifunctional autonomically healing composite material
US6610223B2 (en) 2001-03-30 2003-08-26 Picoliter Inc. Focused acoustic energy in the generation of solid particles
WO2003000741A1 (fr) * 2001-06-22 2003-01-03 Sekisui Chemical Co., Ltd. Procede de preparation de particules de resine, particules de resine et appareil permettant de preparer lesdites particules
WO2003002243A2 (en) 2001-06-27 2003-01-09 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US20040241094A1 (en) * 2001-09-13 2004-12-02 Hesson Chung Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
CN1558755A (zh) * 2001-09-26 2004-12-29 ���ع��ʹ�˾ 通过分散和除去溶剂或液相制备亚微米大小的纳米颗粒
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US7001920B2 (en) * 2002-06-10 2006-02-21 Wyeth Formate salt of O-desmethyl-venlafaxine
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7623908B2 (en) 2003-01-24 2009-11-24 The Board Of Trustees Of The University Of Illinois Nonlinear interferometric vibrational imaging
US20080199701A1 (en) * 2003-02-25 2008-08-21 Kuehnle Manfred R Encapsulated nanoparticles for the absorption of electromagnetic energy
CA2557348A1 (en) * 2003-02-25 2004-09-10 Xmx Corporation Encapsulated nanoparticles for the absorption of electromagnetic energy
JP2006524738A (ja) * 2003-02-25 2006-11-02 マンフレッド・アール・クーンル 紫外線帯域の電磁エネルギー吸収用のカプセル化されたナノ粒子
US7511079B2 (en) * 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles
JP4305729B2 (ja) * 2003-03-28 2009-07-29 セイコーエプソン株式会社 液体吐出装置及びマイクロカプセルの製造方法
CA2784762A1 (en) 2003-04-10 2004-10-28 President And Fellows Of Harvard College Formation and control of fluidic species
US7285306B1 (en) * 2003-04-18 2007-10-23 United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Process for self-repair of insulation material
CA2526362C (en) 2003-05-20 2012-10-09 James F. Collins Ophthalmic drug delivery system
US8012136B2 (en) 2003-05-20 2011-09-06 Optimyst Systems, Inc. Ophthalmic fluid delivery device and method of operation
US7217410B2 (en) * 2003-06-17 2007-05-15 The Board Of Trustees Of The Universtiy Of Illinois Surface modified protein microparticles
US7198777B2 (en) * 2003-06-17 2007-04-03 The Board Of Trustees Of The University Of Illinois Optical contrast agents for optically modifying incident radiation
US8021593B2 (en) * 2003-07-31 2011-09-20 Sijtechnology, Inc. Method of producing a three-dimensional structure and fine three-dimensional structure
CN1842368B (zh) 2003-08-27 2014-05-28 哈佛大学 流体物种的电子控制
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US20070158450A1 (en) * 2003-09-09 2007-07-12 John Scattergood Systems and methods for producing fine particles
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US20050175836A1 (en) * 2003-11-12 2005-08-11 Xmx Corporation Physical color new concepts for color pigments
US20070141342A1 (en) * 2003-11-12 2007-06-21 Kuehnle Manfred R Physical color new concepts for color pigments
US7309500B2 (en) 2003-12-04 2007-12-18 The Board Of Trustees Of The University Of Illinois Microparticles
US9040090B2 (en) 2003-12-19 2015-05-26 The University Of North Carolina At Chapel Hill Isolated and fixed micro and nano structures and methods thereof
CA2549341C (en) 2003-12-19 2014-06-10 The University Of North Carolina At Chapel Hill Methods for fabricating isolated micro- and nano- structures using soft or imprint lithography
US7610074B2 (en) * 2004-01-08 2009-10-27 The Board Of Trustees Of The University Of Illinois Multi-functional plasmon-resonant contrast agents for optical coherence tomography
WO2005077337A2 (en) * 2004-02-05 2005-08-25 Baxter International Inc. Dispersions prepared by use of self-stabilizing agents
CN100431684C (zh) 2004-02-23 2008-11-12 视觉股份公司 离子交联的多糖微球体的生产方法
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7566747B2 (en) * 2004-05-07 2009-07-28 The Board Of Trustees Of The University Of Illinois Wax particles for protection of activators, and multifunctional autonomically healing composite materials
US7311861B2 (en) * 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
EP3326617A1 (en) 2004-06-12 2018-05-30 Collegium Pharmaceutical, Inc. Abuse-deterrent drug formulations
JP4762517B2 (ja) * 2004-09-09 2011-08-31 株式会社オプトニクス精密 プリンター用トナーの製造方法
US8241651B2 (en) 2004-11-10 2012-08-14 The Regents Of The University Of Michigan Multiphasic biofunctional nano-components and methods for use thereof
US8043480B2 (en) 2004-11-10 2011-10-25 The Regents Of The University Of Michigan Methods for forming biodegradable nanocomponents with controlled shapes and sizes via electrified jetting
JP4690418B2 (ja) * 2004-11-10 2011-06-01 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 多相ナノ粒子
US7947772B2 (en) 2004-11-10 2011-05-24 The Regents Of The University Of Michigan Multiphasic nano-components comprising colorants
US8187708B2 (en) 2004-11-10 2012-05-29 The Regents Of The University Of Michigan Microphasic micro-components and methods for controlling morphology via electrified jetting
US7748343B2 (en) 2004-11-22 2010-07-06 The Board Of Trustees Of The University Of Illinois Electrohydrodynamic spraying system
US20060140843A1 (en) * 2004-12-23 2006-06-29 In-Kyung Sung Macroporous structures for heterogeneous catalyst support
US20060147536A1 (en) * 2004-12-30 2006-07-06 Fiore Robert A Method for removing fluids containing dissolved or suspended carbohydrates, lipids, metals, salts, and/or toxins from biological systems
ES2257968B1 (es) * 2005-01-28 2007-07-01 Universidad De Sevilla Procedimiento y dispositivo para la obtencion de particulas de tamaño micro y nanometrico.
WO2006086654A2 (en) * 2005-02-11 2006-08-17 Battelle Memorial Institute Nanoformulations
US20090104269A1 (en) * 2005-02-11 2009-04-23 Brian Graham Nanoformulations
US7586618B2 (en) * 2005-02-28 2009-09-08 The Board Of Trustees Of The University Of Illinois Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7727555B2 (en) * 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7725169B2 (en) * 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US7612152B2 (en) * 2005-05-06 2009-11-03 The Board Of Trustees Of The University Of Illinois Self-healing polymers
US8043323B2 (en) * 2006-10-18 2011-10-25 Inspiremd Ltd. In vivo filter assembly
CA2843097C (en) 2005-05-24 2015-10-27 Inspire M.D Ltd. Stent apparatuses for treatment via body lumens and methods of use
US8961586B2 (en) 2005-05-24 2015-02-24 Inspiremd Ltd. Bifurcated stent assemblies
MX2007015183A (es) * 2005-06-14 2008-02-19 Baxter Int Formulaciones farmaceuticas para minimizar las interacciones farmaco-farmaco.
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
US9463426B2 (en) * 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
JP4854240B2 (ja) * 2005-09-09 2012-01-18 株式会社オプトニクス精密 加圧振動及び噴射造粒による超微粒子
US20070059370A1 (en) * 2005-09-15 2007-03-15 Industrial Technology Research Institute Method and apparatus for fabricating nanoparticles
US20090099031A1 (en) * 2005-09-27 2009-04-16 Stemmer Willem P Genetic package and uses thereof
CA2622441A1 (en) * 2005-09-27 2007-04-05 Amunix, Inc. Proteinaceous pharmaceuticals and uses thereof
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
US7855279B2 (en) * 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US7709544B2 (en) * 2005-10-25 2010-05-04 Massachusetts Institute Of Technology Microstructure synthesis by flow lithography and polymerization
EP1954245A2 (en) * 2005-11-15 2008-08-13 Baxter International Inc. Compositions of lipoxygenase inhibitors
CN1785153B (zh) * 2005-12-06 2010-04-21 青岛大学 纳米级材料制备装置及纳米抗氧化活性多肽药物的制备方法
CN101370479A (zh) * 2005-12-16 2009-02-18 堪萨斯州立大学 用于递送治疗剂的纳米团簇
US7993749B2 (en) * 2005-12-16 2011-08-09 University Of Kansas Nanoparticles comprising a nanoparticle template and a polymer shell having an amide side chain, and method of making thereof
JP4823675B2 (ja) * 2005-12-16 2011-11-24 花王株式会社 ハイドロゲル粒子の製造方法、並びに、それによって製造されるハイドロゲル粒子及びそれを用いた分散体
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7501179B2 (en) 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
JP5738516B2 (ja) 2005-12-30 2015-06-24 ゼンサン (シャンハイ) サイエンス アンド テクノロジー リミテッド 心機能改善のためのニューレグリンの徐放
WO2007082153A2 (en) 2006-01-05 2007-07-19 The Board Of Trustees Of The University Of Illinois Self-healing coating system
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
WO2007090147A2 (en) 2006-01-31 2007-08-09 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US7569625B2 (en) * 2006-06-02 2009-08-04 The Board Of Trustees Of The University Of Illinois Self-healing elastomer system
US8465775B2 (en) 2006-07-27 2013-06-18 The University Of North Carolina At Chapel Hill Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells
EP2054537A2 (en) * 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
US8057534B2 (en) 2006-09-15 2011-11-15 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
EP2399616A1 (en) * 2006-09-15 2011-12-28 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis with biostable inorganic layers
CA2663303A1 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Endoprosthesis with adjustable surface features
WO2008034013A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
US8808726B2 (en) 2006-09-15 2014-08-19 Boston Scientific Scimed. Inc. Bioerodible endoprostheses and methods of making the same
US8002821B2 (en) 2006-09-18 2011-08-23 Boston Scientific Scimed, Inc. Bioerodible metallic ENDOPROSTHESES
US20080075785A1 (en) * 2006-09-22 2008-03-27 San-Laung Chow Controlled release hydrogel formulation
US20110165236A1 (en) * 2006-09-22 2011-07-07 Biokey, Inc. Controlled release hydrogel formulation
WO2008047369A2 (en) 2006-10-18 2008-04-24 Inspiremd Ltd. Knitted stent jackets
US20100324664A1 (en) * 2006-10-18 2010-12-23 Asher Holzer Bifurcated Stent Assemblies
US20080097577A1 (en) * 2006-10-20 2008-04-24 Boston Scientific Scimed, Inc. Medical device hydrogen surface treatment by electrochemical reduction
JP5640196B2 (ja) * 2006-11-02 2014-12-17 国立大学法人名古屋大学 微小カプセルの製造方法
EP1958622A1 (en) * 2006-11-07 2008-08-20 Royal College of Surgeons in Ireland Method of producing microcapsules
CN101578078B (zh) 2006-11-22 2013-01-02 印斯拜尔Md有限公司 优化的支架套
WO2008080047A2 (en) * 2006-12-23 2008-07-03 Baxter International Inc. Magnetic separation of fine particles from compositions
ES2356274T3 (es) 2006-12-28 2011-04-06 Boston Scientific Limited Endoprótesis biodegradables y procedimientos de fabricación de las mismas.
US20080182019A1 (en) * 2007-01-30 2008-07-31 Robert Retter Hollow Microsphere Particle Generator
US20080182056A1 (en) * 2007-01-30 2008-07-31 Eric Bakker Hollow Microsphere Particles
US8222988B2 (en) * 2007-04-09 2012-07-17 The Board Of Trustees Of The University Of Illinois Porous device for optical and electronic applications and method of fabricating the porous device
US7872563B2 (en) * 2007-04-09 2011-01-18 The Board Of Trustees Of The University Of Illinois Variably porous structures
US8237538B2 (en) * 2007-04-09 2012-08-07 The Board Of Trustees Of The University Of Illinois Porous battery electrode for a rechargeable battery and method of making the electrode
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US20080293814A1 (en) * 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
US20080299391A1 (en) * 2007-05-31 2008-12-04 White Scott R Capsules, methods for making capsules, and self-healing composites including the same
BRPI0815416A2 (pt) 2007-08-15 2014-10-21 Amunix Inc Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
EP2055299A1 (en) * 2007-10-23 2009-05-06 Koninklijke Philips Electronics N.V. Methods for preparing polymer microparticles
CN102215821B (zh) * 2007-10-23 2013-05-08 皇家飞利浦电子股份有限公司 用于制备聚合物微颗粒的方法
EP2222281B1 (en) 2007-12-20 2018-12-05 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
EP2172264A1 (en) * 2008-01-02 2010-04-07 Ziel Biopharma Ltd Process and apparatus for the production of microcapsules
US20090181254A1 (en) * 2008-01-15 2009-07-16 The Board Of Trustees Of The University Of Illinois Multi-capsule system and its use for encapsulating active agents
US8115934B2 (en) 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography
US8983580B2 (en) 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US7751057B2 (en) 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
EP2085080A1 (en) * 2008-01-30 2009-08-05 LEK Pharmaceuticals D.D. Preparation of nanoparticles by using a vibrating nozzle device
JP4656167B2 (ja) * 2008-03-03 2011-03-23 株式会社日立プラントテクノロジー 流体機器装置
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US20090297621A1 (en) * 2008-06-03 2009-12-03 Abbott Cardiovascular Systems Inc. Microparticles For The Treatment Of Disease
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
WO2009158724A2 (en) 2008-06-27 2009-12-30 Tepha, Inc. Improved injectable delivery of microparticles and compositions therefore
WO2010011663A2 (en) * 2008-07-21 2010-01-28 Dixie Consumer Products Llc Paper cup manufacture with microencapsulated adhesive
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
WO2010033452A2 (en) * 2008-09-19 2010-03-25 Delaware State University Foundation, Inc. Mono-and multi-element coded libs assays and methods
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
EA020843B1 (ru) 2009-02-03 2015-02-27 Амуникс Оперейтинг Инк. Удлиненные рекомбинантные полипептиды и содержащие их композиции
EP2408372B1 (en) 2009-03-02 2019-01-09 Seventh Sense Biosystems, Inc. Devices associated with blood sampling
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
EP2403546A2 (en) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Self-buffering medical implants
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US20120045487A1 (en) * 2009-04-29 2012-02-23 The Regents Of The University Of Michigan Multiphasic microfibers for spatially guided cell growth
US20120123355A1 (en) * 2009-07-30 2012-05-17 Cook Medical Technologied Erodible embolization material
US20120263701A1 (en) 2009-08-24 2012-10-18 Volker Schellenberger Coagulation factor vii compositions and methods of making and using same
CA2778678A1 (en) 2009-10-30 2011-05-05 Cns Therapeutics, Inc. Improved neurturin molecules
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
JP2013514977A (ja) * 2009-12-16 2013-05-02 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 複数の物質の送達のための粒子
JP5432767B2 (ja) * 2010-02-25 2014-03-05 日本光電工業株式会社 リモートメンテナンスシステム及び中継ユニット
EA015780B1 (ru) * 2010-03-11 2011-12-30 Общество С Ограниченной Ответственностью "Цэм" (Ооо "Цэм") Фармацевтическая композиция пролонгированного действия для снижения аппетита
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
JP2013531044A (ja) 2010-07-15 2013-08-01 コリンシアン オフサルミック,インコーポレイティド 点眼薬送達
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
CA2805426C (en) 2010-07-15 2020-03-24 Corinthian Ophthalmic, Inc. Drop generating device
CA2805635A1 (en) 2010-07-15 2012-01-19 Corinthian Ophthalmic, Inc. Method and system for performing remote treatment and monitoring
EP2593014B1 (en) 2010-07-16 2015-11-04 Seventh Sense Biosystems, Inc. Low-pressure environment for fluid transfer devices
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
GB201016433D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Apparatus and method for making solid beads
GB201016436D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Method of making solid beads
WO2012054841A2 (en) 2010-10-22 2012-04-26 The Regents Of The University Of Michigan Optical devices with switchable particles
EP2992827B1 (en) 2010-11-09 2017-04-19 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
GB201102148D0 (en) 2011-02-08 2011-03-23 Ucl Business Plc Layered bodies, compositions containing them and processes for producing them
EP2702406B1 (en) 2011-04-29 2017-06-21 Seventh Sense Biosystems, Inc. Plasma or serum production and removal of fluids under reduced pressure
AU2012249692A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Delivering and/or receiving fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP3106092A3 (en) 2011-04-29 2017-03-08 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
CA2859174C (en) 2011-12-12 2019-03-05 Orbis Biosciences, Inc. Sustained release particle formulations
JP5960840B2 (ja) 2011-12-12 2016-08-02 アイノビア,インコーポレイティド エジェクタ機構、エジェクタ装置及びそれらの使用方法
MX369862B (es) 2012-02-15 2019-11-25 Bioverativ Therapeutics Inc Composiciones del factor viii y metodos para hacerlas y usarlas.
NZ628014A (en) 2012-02-15 2016-09-30 Biogen Ma Inc Recombinant factor viii proteins
US9163169B2 (en) 2012-03-13 2015-10-20 Georgia-Pacific Chemicals Llc Adhesive compositions having a reduced cure time and methods for making and using same
IN2014KN02616A (enExample) 2012-04-27 2015-05-08 Georgia Pacific Chemicals Llc
EP2866847B1 (en) 2012-07-02 2018-08-22 Boston Scientific Scimed, Inc. Prosthetic heart valve formation
US20140294944A1 (en) 2013-03-28 2014-10-02 Kimberly-Clark Worldwide, Inc. Microencapsulation of oxygen liberating reactants
SG11201508469YA (en) 2013-05-02 2015-11-27 Glaxosmithkline Ip Dev Ltd Therapeutic peptides
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
JP6572244B2 (ja) 2014-02-25 2019-09-04 オービス バイオサイエンシズ, インク.Orbis Biosciences, Inc. 味覚マスキング薬製剤
WO2015153520A1 (en) 2014-04-02 2015-10-08 Georgia-Pacific Chemicals Llc Methods for making lignocellulose composite products with oxidative binders and encapsulated catalyst
CA2951905A1 (en) 2014-06-12 2015-12-17 Orbis Biosciences, Inc. Extended-release drug delivery compositions
KR102125111B1 (ko) * 2014-06-26 2020-06-19 가부시키가이샤 무라타 세이사쿠쇼 정극, 전지, 전지 팩, 전자 기기, 전동 차량, 축전 장치 및 전력 시스템
US10149826B2 (en) 2015-01-20 2018-12-11 Hyalo Technologies, LLC Method of preparing microspheres
WO2016154509A1 (en) 2015-03-26 2016-09-29 Dover Photonics Llc Preparation of fluid samples for laser induced breakdown spectroscopy and/or imaging analysis
US10299915B2 (en) 2015-04-09 2019-05-28 Boston Scientific Scimed, Inc. Synthetic heart valves composed of zwitterionic polymers
US10426609B2 (en) 2015-04-09 2019-10-01 Boston Scientific Scimed, Inc. Fiber reinforced prosthetic heart valve having undulating fibers
US10314696B2 (en) 2015-04-09 2019-06-11 Boston Scientific Scimed, Inc. Prosthetic heart valves having fiber reinforced leaflets
US10716671B2 (en) 2015-07-02 2020-07-21 Boston Scientific Scimed, Inc. Prosthetic heart valve composed of composite fibers
US10413403B2 (en) 2015-07-14 2019-09-17 Boston Scientific Scimed, Inc. Prosthetic heart valve including self-reinforced composite leaflets
CA2994547A1 (en) 2015-08-03 2017-02-09 Bioverativ Therapeutics Inc. Factor ix fusion proteins and methods of making and using same
US10195023B2 (en) 2015-09-15 2019-02-05 Boston Scientific Scimed, Inc. Prosthetic heart valves including pre-stressed fibers
US11148202B2 (en) 2015-12-16 2021-10-19 6K Inc. Spheroidal dehydrogenated metals and metal alloy particles
US10987735B2 (en) 2015-12-16 2021-04-27 6K Inc. Spheroidal titanium metallic powders with custom microstructures
GB2551944B (en) * 2015-12-18 2021-09-01 Midatech Pharma Wales Ltd Microparticle production process and apparatus
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
EP3448360A4 (en) 2016-04-26 2019-12-18 Orbis Biosciences, Inc. BIODEGRADABLE MICROSPHERIC COMPOSITIONS FOR PARENTERAL ADMINISTRATION
EP3457989B1 (en) 2016-05-19 2021-09-29 Boston Scientific Scimed, Inc. Prosthetic valves, valve leaflets and related methods
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
JP6991165B2 (ja) * 2016-06-23 2022-01-12 シックスケー インコーポレイテッド リチウムイオン電池材料
US20180000744A1 (en) * 2016-06-30 2018-01-04 Georgia Southern Research and Service Foundation, Inc. Nanoencapsulated compositions
US10654040B2 (en) 2016-08-18 2020-05-19 Northeastern University Platform for liquid droplet formation and isolation
US10707531B1 (en) 2016-09-27 2020-07-07 New Dominion Enterprises Inc. All-inorganic solvents for electrolytes
US10967102B2 (en) 2016-09-28 2021-04-06 Boston Scientific Limited Cell encapsulation membranes, devices and methods
US11471419B2 (en) 2016-09-30 2022-10-18 The Board Of Trustees Of The University Of Illinois Capsules with intracapsular microspheres for improved survival and function of encapsulated cells
TWI631985B (zh) * 2016-10-26 2018-08-11 財團法人金屬工業研究發展中心 微粒製造方法
WO2018102743A1 (en) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
US10925998B2 (en) 2017-04-25 2021-02-23 Boston Scientific Scimed, Inc. Method of manufacturing a biocompatible composite material
AU2018279940B2 (en) 2017-06-10 2023-12-14 Eyenovia, Inc. Methods and devices for handling a fluid and delivering the fluid to the eye
US11173461B2 (en) 2018-03-22 2021-11-16 Lawrence Livermore National Security, Llc Fabricating structured particles through rapid hardening and tailored collection methods
SG11202010767SA (en) 2018-05-18 2020-11-27 Bioverativ Therapeutics Inc Methods of treating hemophilia a
WO2019246257A1 (en) 2018-06-19 2019-12-26 Amastan Technologies Inc. Process for producing spheroidized powder from feedstock materials
US11684498B2 (en) 2018-10-19 2023-06-27 Inspire M.D Ltd. Methods of using a self-adjusting stent assembly and kits including same
TR201818352A2 (tr) * 2018-12-02 2020-06-22 Bursa Teknik Ueniversitesi Mi̇kroenkapsülasyon yöntemleri̇nde parti̇kül boyutunu küçülten damlatma düzeneği̇
FR3089391A1 (fr) 2018-12-05 2020-06-12 V. Mane Fils Méthode d’amelioration de l’expérience sensorielle d’un arome
SG11202111576QA (en) 2019-04-30 2021-11-29 6K Inc Mechanically alloyed powder feedstock
CA3134579A1 (en) 2019-04-30 2020-11-05 Gregory Wrobel Lithium lanthanum zirconium oxide (llzo) powder
EP4414470A3 (en) 2019-11-18 2024-10-23 6K Inc. Unique feedstocks for spherical powders and methods of manufacturing
US12245935B2 (en) 2019-11-26 2025-03-11 Boston Scientific Limited Composite web-polymer heart valve
CA3164288A1 (en) 2019-12-11 2021-06-17 Eyenovia, Inc. Systems and devices for delivering fluids to the eye and methods of use
US11590568B2 (en) 2019-12-19 2023-02-28 6K Inc. Process for producing spheroidized powder from feedstock materials
CN116034496A (zh) 2020-06-25 2023-04-28 6K有限公司 微观复合合金结构
NL2025932B1 (en) 2020-06-26 2022-02-21 Iamfluidics Holding B V Micro-fluidic system and method
US11351514B2 (en) 2020-07-02 2022-06-07 Lawrence Livermore National Security, Llc Parallelized multiple nozzle system and method to produce layered droplets and fibers for microencapsulation
KR20230038183A (ko) 2020-07-10 2023-03-17 아데어 파마슈티컬스 인코포레이티드 팽윤성 경구 제약 조성물
WO2022067303A1 (en) 2020-09-24 2022-03-31 6K Inc. Systems, devices, and methods for starting plasma
AU2021371051A1 (en) 2020-10-30 2023-03-30 6K Inc. Systems and methods for synthesis of spheroidized metal powders
NL2027229B1 (en) * 2020-12-24 2022-07-20 Medspray B V Device and method to aerosolize nanoparticle formulations
CA3197544A1 (en) 2021-01-11 2022-07-14 6K Inc. Methods and systems for reclamation of li-ion cathode materials using microwave plasma processing
US12042861B2 (en) 2021-03-31 2024-07-23 6K Inc. Systems and methods for additive manufacturing of metal nitride ceramics
US20240237689A1 (en) 2021-05-20 2024-07-18 V. Mane Fils Flavor Beads and Method of Making and Using Same
WO2022246285A1 (en) * 2021-05-21 2022-11-24 The Trustees Of Columbia University In The City Of New York Bio-microbur therapeutic delivery platform
GB202205123D0 (en) * 2022-04-07 2022-05-25 Univ Oxford Innovation Ltd Encapsulation method and particle
US12261023B2 (en) 2022-05-23 2025-03-25 6K Inc. Microwave plasma apparatus and methods for processing materials using an interior liner
US12040162B2 (en) 2022-06-09 2024-07-16 6K Inc. Plasma apparatus and methods for processing feed material utilizing an upstream swirl module and composite gas flows
WO2024044498A1 (en) 2022-08-25 2024-02-29 6K Inc. Plasma apparatus and methods for processing feed material utilizing a powder ingress preventor (pip)
US12195338B2 (en) 2022-12-15 2025-01-14 6K Inc. Systems, methods, and device for pyrolysis of methane in a microwave plasma for hydrogen and structured carbon powder production
US12435622B2 (en) 2023-08-22 2025-10-07 Saudi Arabian Oil Company Identifying drill cuttings with tracer pills

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US617469A (en) * 1899-01-10 Isaac moore
US2766064A (en) * 1955-08-22 1956-10-09 Howard V Schweitzer Paint gun
US3579245A (en) * 1967-12-07 1971-05-18 Teletype Corp Method of transferring liquid
IE45426B1 (en) * 1976-07-15 1982-08-25 Ici Ltd Atomisation of liquids
DE2725849C3 (de) * 1977-06-08 1980-11-13 Hobeg Hochtemperaturreaktor-Brennelement Gmbh, 6450 Hanau Vorrichtung zur Herstellung von kugelförmigen Teilchen
US4313403A (en) * 1979-09-07 1982-02-02 Bie Jr Norman Internal combustion engine
CA1166413A (en) * 1980-10-30 1984-05-01 Edward E. Timm Process and apparatus for preparing uniform size polymer beads
US4748043A (en) * 1986-08-29 1988-05-31 Minnesota Mining And Manufacturing Company Electrospray coating process
EP0265924B2 (en) * 1986-10-29 1998-04-22 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Uniform polymer particles
US4861627A (en) * 1987-05-01 1989-08-29 Massachusetts Institute Of Technology Preparation of multiwall polymeric microcapsules
US5985354A (en) * 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
CH675370A5 (en) 1988-06-03 1990-09-28 Ciba Geigy Ag Filled pill mfr. - by concentric nozzles receiving ingredients from oscillating diaphragms
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US5226948A (en) * 1990-08-30 1993-07-13 University Of Southern California Method and apparatus for droplet stream manufacturing
US5260002A (en) * 1991-12-23 1993-11-09 Vanderbilt University Method and apparatus for producing uniform polymeric spheres
EP0552013B1 (en) * 1992-01-13 1999-04-07 Hercules Incorporated Thermally bondable fiber for high strength non-woven fabrics
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5711968A (en) 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5344676A (en) 1992-10-23 1994-09-06 The Board Of Trustees Of The University Of Illinois Method and apparatus for producing nanodrops and nanoparticles and thin film deposits therefrom
EP1013270A3 (en) 1992-12-02 2001-03-28 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
DE4242645C2 (de) * 1992-12-17 1997-12-18 Deutsche Forsch Luft Raumfahrt Verfahren und Einrichtung zur Herstellung von Metallkügelchen annähernd gleichen Durchmessers
EP2275089A1 (en) 1993-11-19 2011-01-19 Alkermes Controlled Therapeutics, Inc. Preparation of biodegradable microparticles containing a biologically active agent
US5650173A (en) 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
ES2236700T3 (es) 1993-11-19 2005-07-16 Janssen Pharmaceutica N.V. 1,2-benzazoles microencapsulados.
GB9324250D0 (en) * 1993-11-25 1994-01-12 Minnesota Mining & Mfg Inhaler
GB9406255D0 (en) * 1994-03-29 1994-05-18 Electrosols Ltd Dispensing device
US5922253A (en) 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
WO1997007788A2 (en) 1995-08-31 1997-03-06 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
AU709384B2 (en) * 1996-03-01 1999-08-26 University Of Kansas, The Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US6196525B1 (en) 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
US6187214B1 (en) 1996-05-13 2001-02-13 Universidad De Seville Method and device for production of components for microfabrication
US6197835B1 (en) * 1996-05-13 2001-03-06 Universidad De Sevilla Device and method for creating spherical particles of uniform size
US6189803B1 (en) 1996-05-13 2001-02-20 University Of Seville Fuel injection nozzle and method of use
ES2140998B1 (es) 1996-05-13 2000-10-16 Univ Sevilla Procedimiento de atomizacion de liquidos.
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US6254854B1 (en) * 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US5874111A (en) * 1997-01-07 1999-02-23 Maitra; Amarnath Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles
US5948483A (en) 1997-03-25 1999-09-07 The Board Of Trustees Of The University Of Illinois Method and apparatus for producing thin film and nanoparticle deposits
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US5954907A (en) * 1997-10-07 1999-09-21 Avery Dennison Corporation Process using electrostatic spraying for coating substrates with release coating compositions, pressure sensitive adhesives, and combinations thereof
CA2327716A1 (en) 1998-03-07 1999-09-10 Inotech Ag Method and device for capsulating microbial, plant and animal cells or biological and chemical substances
US6224794B1 (en) 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
GB2345010B (en) * 1998-12-17 2002-12-31 Electrosols Ltd A delivery device
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
BR0009993A (pt) * 1999-04-23 2002-01-08 Battelle Memorial Institute Pulverizador de aerossol eletrohidrodinâmico direcionalmente controlado, dispositivo para liberar gotìculas de aerossol eletricamente neutras, aparelho para liberar gotìculas de aerossol terapêuticas, processo para liberar gotìculas de aerossol, e, dispositivo para liberar aerossol
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
CA2419115C (en) * 2000-08-15 2011-03-08 Board Of Trustees Of The University Of Illinois Microparticles, and method and apparatus for forming same
EP1404516A2 (en) * 2000-12-13 2004-04-07 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
US7309500B2 (en) * 2003-12-04 2007-12-18 The Board Of Trustees Of The University Of Illinois Microparticles
US7748343B2 (en) * 2004-11-22 2010-07-06 The Board Of Trustees Of The University Of Illinois Electrohydrodynamic spraying system

Also Published As

Publication number Publication date
KR20030067660A (ko) 2003-08-14
US7368130B2 (en) 2008-05-06
KR20080050540A (ko) 2008-06-05
US20020054912A1 (en) 2002-05-09
US20080175915A1 (en) 2008-07-24
EP1355630B1 (en) 2009-11-25
CA2419115A1 (en) 2002-02-21
WO2002013786A2 (en) 2002-02-21
JP2004505761A (ja) 2004-02-26
DE60140625D1 (de) 2010-01-07
US20040022939A1 (en) 2004-02-05
EP1355630A2 (en) 2003-10-29
KR100867392B1 (ko) 2008-11-06
AU2001284982A1 (en) 2002-02-25
ATE449596T1 (de) 2009-12-15
KR100902625B1 (ko) 2009-06-15
WO2002013786A3 (en) 2003-08-28
US6669961B2 (en) 2003-12-30

Similar Documents

Publication Publication Date Title
CA2419115C (en) Microparticles, and method and apparatus for forming same
US8409621B2 (en) Microparticles
Berkland et al. Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions
Chong et al. Advances in fabricating double-emulsion droplets and their biomedical applications
Tran et al. Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy?
Bahrami et al. Production of micro-and nano-composite particles by supercritical carbon dioxide
Freitas et al. Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology
CN101410174B (zh) 一种用于生产基于乳化的微观粒子的方法
SE512663C2 (sv) Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
TWI643680B (zh) 微粒噴頭
Padalkar et al. Microparticles: an approach for betterment of drug delivery system
WO2005061095A9 (ja) 微小球体の製造方法およびその製造装置
Liu et al. Tailoring particle microstructures via supercritical CO2 processes for particular drug delivery
JP2004035446A (ja) 微小球体の製造方法およびその製造装置
JP2004262810A (ja) 薬物含有複合粒子の製造方法および経肺製剤
CN107573523B (zh) 一种偏心结构聚合物微球及其制备方法
Athar Alli Dry-Coating of Powder Particles is Current Trend in Pharmaceutical Field.
Kumar et al. Microparticles for cancer therapy
TWI660789B (zh) 微粒成形裝置及其微粒成形方法
Berkland Control of micro-and nano-sphere size distributions: Implications in drug delivery
Song et al. Application of nanofluids to microsphere generation using MEMS technology
Sacchetin et al. Advances in the use of supercritical fluids for the production of poly (α-hydroxyester) particles incorporating bioactive agents
Yadav et al. 47 Microparticulate Drug Delivery Systems
Cui et al. Towards monodisperse microbubble populations via microfluidic chip flow-focusing
Xia Uniform double wall microspheres/microcapsules for protein delivery

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20210816

MKEX Expiry

Effective date: 20210816