CA2372400C - Expression and export of interferon-alpha proteins as fc fusion proteins - Google Patents
Expression and export of interferon-alpha proteins as fc fusion proteins Download PDFInfo
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- CA2372400C CA2372400C CA2372400A CA2372400A CA2372400C CA 2372400 C CA2372400 C CA 2372400C CA 2372400 A CA2372400 A CA 2372400A CA 2372400 A CA2372400 A CA 2372400A CA 2372400 C CA2372400 C CA 2372400C
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- leu
- alpha
- ser
- glu
- gln
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13489599P | 1999-05-19 | 1999-05-19 | |
| US60/134,895 | 1999-05-19 | ||
| PCT/US2000/013827 WO2000069913A1 (en) | 1999-05-19 | 2000-05-19 | EXPRESSION AND EXPORT OF INTERFERON-ALPHA PROTEINS AS Fc FUSION PROTEINS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2372400A1 CA2372400A1 (en) | 2000-11-23 |
| CA2372400C true CA2372400C (en) | 2010-04-27 |
Family
ID=22465500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2372400A Expired - Lifetime CA2372400C (en) | 1999-05-19 | 2000-05-19 | Expression and export of interferon-alpha proteins as fc fusion proteins |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20020081664A1 (enExample) |
| EP (1) | EP1187852B1 (enExample) |
| JP (1) | JP2003530070A (enExample) |
| KR (1) | KR20020018197A (enExample) |
| CN (1) | CN1361793A (enExample) |
| AT (1) | ATE369384T1 (enExample) |
| AU (1) | AU777963B2 (enExample) |
| BR (1) | BR0010725A (enExample) |
| CA (1) | CA2372400C (enExample) |
| CZ (1) | CZ20014123A3 (enExample) |
| DE (1) | DE60035871T2 (enExample) |
| DK (1) | DK1187852T3 (enExample) |
| ES (1) | ES2291205T3 (enExample) |
| HK (1) | HK1046694A1 (enExample) |
| HU (1) | HUP0201474A3 (enExample) |
| MX (1) | MXPA01011845A (enExample) |
| NO (1) | NO20015587L (enExample) |
| PL (1) | PL352332A1 (enExample) |
| PT (1) | PT1187852E (enExample) |
| RU (1) | RU2262510C9 (enExample) |
| WO (1) | WO2000069913A1 (enExample) |
| ZA (1) | ZA200109227B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| HK1038882A1 (zh) * | 1998-04-15 | 2002-04-04 | 利思进药品公司 | 通过共同给予血管生成抑制剂增强抗体-细胞因子融合蛋白介导的免疫应答 |
| ATE369384T1 (de) * | 1999-05-19 | 2007-08-15 | Emd Lexigen Res Ct Corp | Expression und export von interferon-alpha proteinen als fc fusionsproteine |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| AU778611B2 (en) | 1999-08-09 | 2004-12-16 | Merck Patent Gmbh | Multiple cytokine-antibody complexes |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| CA2391080A1 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Erythropoietin forms with improved properties |
| ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| CA2405550A1 (en) | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| ATE368475T1 (de) | 2000-06-29 | 2007-08-15 | Emd Lexigen Res Ct Corp | Steigerung von durch antikörper-zytokin- fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| BR0207854A (pt) * | 2001-03-07 | 2004-08-24 | Merck Patent Gmbh | Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido |
| WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| US20030065148A1 (en) * | 2001-05-02 | 2003-04-03 | Villarete Lorelie H. | Method for expression of human interferon alpha 1 in Pichia pastoris |
| DK1383785T3 (da) | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Rekombinant tumorspecifikt antistof og anvendelse deraf |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| WO2004046365A2 (en) * | 2002-11-18 | 2004-06-03 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| US7314613B2 (en) | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| DK1572748T3 (da) * | 2002-12-17 | 2010-08-23 | Merck Patent Gmbh | Humaniseret antistof (H14.18) af muse-14.18-antistof der binder til GD2 og dets fusionsprotein med IL-2 |
| CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| MXPA05008704A (es) * | 2003-02-18 | 2005-10-05 | Merck Patent Gmbh | Proteinas de fusion de muteinas de interferon alfa con propiedades mejoradas. |
| US20050176108A1 (en) * | 2003-03-13 | 2005-08-11 | Young-Min Kim | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
| US20040180054A1 (en) * | 2003-03-13 | 2004-09-16 | Hanmi Pharm. Co., Ltd. | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
| DE602004031390D1 (de) * | 2003-05-06 | 2011-03-24 | Syntonix Pharmaceuticals Inc | Gerinnungsfaktor VII-Fc chimäre Proteine zur Behandlung von hämostatischen Krankheiten |
| CA2522690A1 (en) * | 2003-05-06 | 2004-11-25 | Syntonix Pharmaceuticals, Inc. | Inhibition of drug binding to serum albumin |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US7348004B2 (en) * | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| US8383132B2 (en) * | 2003-10-16 | 2013-02-26 | The Regents Of The University Of California | Immunostimulatory recombinant intracellular pathogen immunogenic compositions and methods of use |
| CA2545603A1 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto |
| BRPI0406606A (pt) | 2003-11-13 | 2005-12-06 | Hanmi Pharm Ind Co Ltd | Composição farmacêutica compreendendo uma região fc de imunoglobulina como um veìculo |
| US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
| ES2305886T3 (es) | 2003-12-30 | 2008-11-01 | Merck Patent Gmbh | Proteinas de fusion de il-7 con porciones de anticuerpo, su preparacion y su empleo. |
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| US20170121692A1 (en) * | 2005-04-06 | 2017-05-04 | Ibc Pharmaceuticals, Inc. | Methods for Generating Stably Linked Complexes Composed of Homodimers, Homotetramers or Dimers of Dimers and Uses |
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| PT1966238E (pt) * | 2005-12-30 | 2012-07-31 | Merck Patent Gmbh | Uso de hsp70 como um regulador de atividade enzimática |
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| KR101470472B1 (ko) | 2006-09-14 | 2014-12-09 | 메드제닉스 메디칼 이스라엘 리미티드 | 장기 지속형 약물 제형 |
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- 2000-05-19 EP EP00932622A patent/EP1187852B1/en not_active Expired - Lifetime
- 2000-05-19 BR BR0010725-5A patent/BR0010725A/pt not_active IP Right Cessation
- 2000-05-19 HU HU0201474A patent/HUP0201474A3/hu unknown
- 2000-05-19 WO PCT/US2000/013827 patent/WO2000069913A1/en not_active Ceased
- 2000-05-19 HK HK02108255.1A patent/HK1046694A1/zh unknown
- 2000-05-19 JP JP2000618329A patent/JP2003530070A/ja active Pending
- 2000-05-19 DE DE60035871T patent/DE60035871T2/de not_active Expired - Lifetime
- 2000-05-19 CZ CZ20014123A patent/CZ20014123A3/cs unknown
- 2000-05-19 PL PL00352332A patent/PL352332A1/xx unknown
- 2000-05-19 KR KR1020017014691A patent/KR20020018197A/ko not_active Ceased
- 2000-05-19 RU RU2001130984/13A patent/RU2262510C9/ru not_active IP Right Cessation
- 2000-05-19 AU AU50318/00A patent/AU777963B2/en not_active Expired
- 2000-05-19 PT PT00932622T patent/PT1187852E/pt unknown
- 2000-05-19 CA CA2372400A patent/CA2372400C/en not_active Expired - Lifetime
- 2000-05-19 DK DK00932622T patent/DK1187852T3/da active
- 2000-05-19 CN CN00810671A patent/CN1361793A/zh active Pending
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2001
- 2001-10-11 US US09/977,034 patent/US20020081664A1/en not_active Abandoned
- 2001-11-08 ZA ZA200109227A patent/ZA200109227B/en unknown
- 2001-11-15 NO NO20015587A patent/NO20015587L/no not_active Application Discontinuation
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2004
- 2004-09-29 US US10/953,259 patent/US20050042729A1/en not_active Abandoned
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| CA2372400A1 (en) | 2000-11-23 |
| CN1361793A (zh) | 2002-07-31 |
| MXPA01011845A (es) | 2002-06-21 |
| DE60035871D1 (de) | 2007-09-20 |
| HUP0201474A2 (en) | 2002-08-28 |
| DK1187852T3 (da) | 2007-11-26 |
| BR0010725A (pt) | 2002-02-19 |
| NO20015587L (no) | 2002-01-16 |
| RU2262510C9 (ru) | 2006-04-20 |
| NO20015587D0 (no) | 2001-11-15 |
| ZA200109227B (en) | 2003-02-03 |
| JP2003530070A (ja) | 2003-10-14 |
| HUP0201474A3 (en) | 2002-11-28 |
| CZ20014123A3 (cs) | 2002-06-12 |
| DE60035871T2 (de) | 2008-06-05 |
| WO2000069913A1 (en) | 2000-11-23 |
| US20020081664A1 (en) | 2002-06-27 |
| US20050042729A1 (en) | 2005-02-24 |
| EP1187852B1 (en) | 2007-08-08 |
| PL352332A1 (en) | 2003-08-11 |
| RU2262510C2 (ru) | 2005-10-20 |
| EP1187852A1 (en) | 2002-03-20 |
| PT1187852E (pt) | 2007-11-14 |
| AU5031800A (en) | 2000-12-05 |
| ATE369384T1 (de) | 2007-08-15 |
| AU777963B2 (en) | 2004-11-04 |
| KR20020018197A (ko) | 2002-03-07 |
| ES2291205T3 (es) | 2008-03-01 |
| HK1046694A1 (zh) | 2003-01-24 |
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