CA2341484C - Solid phytase compositions - Google Patents
Solid phytase compositions Download PDFInfo
- Publication number
- CA2341484C CA2341484C CA002341484A CA2341484A CA2341484C CA 2341484 C CA2341484 C CA 2341484C CA 002341484 A CA002341484 A CA 002341484A CA 2341484 A CA2341484 A CA 2341484A CA 2341484 C CA2341484 C CA 2341484C
- Authority
- CA
- Canada
- Prior art keywords
- units
- composition
- phytase
- csl
- phytase activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010011619 6-Phytase Proteins 0.000 title claims abstract description 100
- 229940085127 phytase Drugs 0.000 title claims abstract description 91
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 239000007787 solid Substances 0.000 title claims abstract description 15
- 229920002472 Starch Polymers 0.000 claims abstract description 36
- 108090000790 Enzymes Proteins 0.000 claims abstract description 35
- 102000004190 Enzymes Human genes 0.000 claims abstract description 35
- 229940088598 enzyme Drugs 0.000 claims abstract description 35
- 238000000034 method Methods 0.000 claims abstract description 25
- 150000002016 disaccharides Chemical class 0.000 claims abstract description 13
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims abstract description 12
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 12
- 235000005822 corn Nutrition 0.000 claims abstract description 12
- 235000019698 starch Nutrition 0.000 claims abstract description 11
- 239000008107 starch Substances 0.000 claims abstract description 10
- 239000008187 granular material Substances 0.000 claims description 54
- 230000000694 effects Effects 0.000 claims description 42
- 229940100445 wheat starch Drugs 0.000 claims description 24
- 239000008247 solid mixture Substances 0.000 claims description 14
- 238000003556 assay Methods 0.000 claims description 11
- 238000005507 spraying Methods 0.000 claims description 7
- 239000000945 filler Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000012876 carrier material Substances 0.000 claims description 3
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 241000209149 Zea Species 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract description 53
- 239000004310 lactic acid Substances 0.000 abstract description 26
- 235000014655 lactic acid Nutrition 0.000 abstract description 26
- 240000008042 Zea mays Species 0.000 abstract description 10
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract description 8
- 239000008101 lactose Substances 0.000 abstract description 8
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract description 6
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract description 6
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract description 6
- 239000000523 sample Substances 0.000 description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 31
- 229960000448 lactic acid Drugs 0.000 description 25
- 239000000243 solution Substances 0.000 description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 15
- 235000002949 phytic acid Nutrition 0.000 description 14
- 238000003860 storage Methods 0.000 description 14
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 13
- 238000005469 granulation Methods 0.000 description 12
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- 239000002245 particle Substances 0.000 description 11
- 229940068041 phytic acid Drugs 0.000 description 11
- 239000000467 phytic acid Substances 0.000 description 11
- 239000008351 acetate buffer Substances 0.000 description 10
- 239000000306 component Substances 0.000 description 10
- 230000014509 gene expression Effects 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 235000008504 concentrate Nutrition 0.000 description 9
- 239000012141 concentrate Substances 0.000 description 9
- 230000000875 corresponding effect Effects 0.000 description 8
- 229920001213 Polysorbate 20 Polymers 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 229960001375 lactose Drugs 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 7
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 7
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 229920000136 polysorbate Polymers 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 235000017281 sodium acetate Nutrition 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- PMZURENOXWZQFD-UHFFFAOYSA-L sodium sulphate Substances [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 229940074410 trehalose Drugs 0.000 description 5
- 239000005995 Aluminium silicate Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- 244000024675 Eruca sativa Species 0.000 description 4
- 235000014755 Eruca sativa Nutrition 0.000 description 4
- 235000019482 Palm oil Nutrition 0.000 description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 4
- 238000005054 agglomeration Methods 0.000 description 4
- 230000002776 aggregation Effects 0.000 description 4
- 235000012211 aluminium silicate Nutrition 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000010367 cloning Methods 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
- 150000003893 lactate salts Chemical class 0.000 description 4
- 239000002540 palm oil Substances 0.000 description 4
- BDKLKNJTMLIAFE-UHFFFAOYSA-N 2-(3-fluorophenyl)-1,3-oxazole-4-carbaldehyde Chemical compound FC1=CC=CC(C=2OC=C(C=O)N=2)=C1 BDKLKNJTMLIAFE-UHFFFAOYSA-N 0.000 description 3
- 241000235349 Ascomycota Species 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 3
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- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical compound [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 3
- 229910017604 nitric acid Inorganic materials 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 229940087562 sodium acetate trihydrate Drugs 0.000 description 3
- 229940083982 sodium phytate Drugs 0.000 description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000012089 stop solution Substances 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- -1 superabsorbents Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000003760 tallow Substances 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 241001465318 Aspergillus terreus Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
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- UNTBPXHCXVWYOI-UHFFFAOYSA-O azanium;oxido(dioxo)vanadium Chemical compound [NH4+].[O-][V](=O)=O UNTBPXHCXVWYOI-UHFFFAOYSA-O 0.000 description 2
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- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 239000012520 frozen sample Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000010440 gypsum Substances 0.000 description 1
- 229910052602 gypsum Inorganic materials 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229910052816 inorganic phosphate Inorganic materials 0.000 description 1
- 102000006029 inositol monophosphatase Human genes 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000010935 polish filtration Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 229940076788 pyruvate Drugs 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000011091 sodium acetates Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- LSGOVYNHVSXFFJ-UHFFFAOYSA-N vanadate(3-) Chemical compound [O-][V]([O-])([O-])=O LSGOVYNHVSXFFJ-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- RZLVQBNCHSJZPX-UHFFFAOYSA-L zinc sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Zn+2].[O-]S([O-])(=O)=O RZLVQBNCHSJZPX-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/98—Preparation of granular or free-flowing enzyme compositions
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199801251 | 1998-10-02 | ||
| DKPA199801251 | 1998-10-02 | ||
| PCT/DK1999/000516 WO2000020569A1 (en) | 1998-10-02 | 1999-10-01 | Solid phytase compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2341484A1 CA2341484A1 (en) | 2000-04-13 |
| CA2341484C true CA2341484C (en) | 2009-08-04 |
Family
ID=8102729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002341484A Expired - Lifetime CA2341484C (en) | 1998-10-02 | 1999-10-01 | Solid phytase compositions |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1117771B1 (enExample) |
| JP (1) | JP4455764B2 (enExample) |
| CN (1) | CN1197963C (enExample) |
| AT (1) | ATE238415T1 (enExample) |
| AU (1) | AU761363B2 (enExample) |
| BR (1) | BR9914217A (enExample) |
| CA (1) | CA2341484C (enExample) |
| DE (1) | DE69907240T2 (enExample) |
| DK (1) | DK1117771T3 (enExample) |
| WO (1) | WO2000020569A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003066847A2 (en) | 2002-02-08 | 2003-08-14 | Novozymes A/S | Phytase variants |
| US6451572B1 (en) | 1998-06-25 | 2002-09-17 | Cornell Research Foundation, Inc. | Overexpression of phytase genes in yeast systems |
| MXPA01009809A (es) | 1999-03-31 | 2002-07-30 | Cornell Res Foundation Inc | Fosfatasas con actividad de fitasa mejorada. |
| US6841370B1 (en) | 1999-11-18 | 2005-01-11 | Cornell Research Foundation, Inc. | Site-directed mutagenesis of Escherichia coli phytase |
| WO2003037102A2 (en) | 2001-10-31 | 2003-05-08 | Phytex, Llc | Phytase-containing animal food and method |
| US6815486B2 (en) | 2002-04-12 | 2004-11-09 | Dow Corning Corporation | Thermally conductive phase change materials and methods for their preparation and use |
| CA2925807C (en) | 2002-09-13 | 2020-09-15 | Cornell Research Foundation, Inc. | Using mutations to improve aspergillus phytases |
| AR047658A1 (es) | 2004-02-03 | 2006-02-01 | Cargill Inc | Concentrado de proteinas y corriente acuosa con carbohidratos hidrosolubles |
| CN101056540A (zh) | 2004-09-27 | 2007-10-17 | 诺维信公司 | 酶颗粒 |
| EP1809747B1 (en) | 2004-10-04 | 2016-12-14 | Novozymes A/S | Polypeptides having phytase activity and polynucleotides encoding same |
| AR050895A1 (es) | 2004-10-04 | 2006-11-29 | Novozymes As | Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican |
| ES2443019T1 (es) * | 2005-10-12 | 2014-02-17 | Danisco Us Inc. | Gránulos estables y duraderos con agentes activos |
| US7919297B2 (en) | 2006-02-21 | 2011-04-05 | Cornell Research Foundation, Inc. | Mutants of Aspergillus niger PhyA phytase and Aspergillus fumigatus phytase |
| WO2007104725A1 (de) * | 2006-03-10 | 2007-09-20 | Basf Se | Feste enymformulierungen und verfahren zu deren herstellung |
| DK2365064T3 (en) | 2006-04-04 | 2015-03-30 | Novozymes As | Phytasevarianter |
| US8540984B2 (en) | 2006-08-03 | 2013-09-24 | Cornell Research Foundation, Inc. | Phytases with improved thermal stability |
| EP2051590B1 (en) | 2006-08-07 | 2016-04-20 | Novozymes A/S | Enzyme granules for animal feed |
| US20080031998A1 (en) | 2006-08-07 | 2008-02-07 | Novozymes A/S | Enzyme Granules for Animal Feed |
| DK2129781T3 (da) | 2007-03-26 | 2014-03-31 | Novozymes As | Hafnia-phytase |
| MX2011003132A (es) | 2008-09-26 | 2011-04-21 | Novozymes As | Variantes de fitasa de hafnia. |
| WO2011014458A1 (en) | 2009-07-28 | 2011-02-03 | Novozymes, Inc. | Polypeptides having phytase activity and polynucleotides encoding same |
| CN102917600B (zh) | 2010-03-26 | 2015-07-08 | 诺维信公司 | 热稳定性肌醇六磷酸酶变体 |
| CN103874657A (zh) | 2011-08-16 | 2014-06-18 | 索尔维公司 | 制造含LiPO2F2和LiPF6的混合物 |
| CN102511665B (zh) * | 2011-12-29 | 2013-06-05 | 青岛玛斯特生物技术有限公司 | 一种植酸酶包衣微丸及其制备方法 |
| DK3699271T3 (da) * | 2012-02-07 | 2024-12-09 | Danisco Us Inc | Granulat- og pelletsammensætninger, der omfatter phytase og phytinsyre, og fremgangsmåde til fremstilling deraf |
| GB201308828D0 (en) | 2013-03-12 | 2013-07-03 | Verenium Corp | Phytase |
| GB201308843D0 (en) | 2013-03-14 | 2013-07-03 | Verenium Corp | Phytase formulation |
| CN105408492A (zh) | 2013-07-25 | 2016-03-16 | 巴斯夫酶有限责任公司 | 肌醇六磷酸酶 |
| AU2017269498A1 (en) | 2016-05-24 | 2018-11-08 | Novozymes A/S | Polypeptides having alpha-galactosidase activity and polynucleotides encoding same |
| CN109312321A (zh) | 2016-05-24 | 2019-02-05 | 诺维信公司 | 包含具有半乳聚糖酶活性的多肽和具有β-半乳糖苷酶活性的多肽的组合物 |
| AU2017270269A1 (en) | 2016-05-24 | 2018-11-15 | Novozymes A/S | Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity |
| ES3014057T3 (en) | 2016-05-24 | 2025-04-16 | Novozymes As | Gastric stable polypeptides having alpha-galactosidase activity and polynucleotides encoding same |
| RU2752204C2 (ru) | 2016-07-08 | 2021-07-23 | Новозимс А/С | Варианты ксиланазы и кодирующие их полинуклеотиды |
| MX2019000139A (es) | 2016-07-08 | 2019-06-10 | Novozymes As | Polipeptidos que tienen actividad xilanasa y polinucleotidos que los codifican. |
| AU2017380488B2 (en) | 2016-12-21 | 2023-09-14 | Novozymes A/S | Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof |
| EP3642339B1 (en) | 2017-06-22 | 2025-09-10 | Novozymes A/S | Xylanase variants and polynucleotides encoding same |
| US20200196633A1 (en) | 2017-09-01 | 2020-06-25 | Novozymes A/S | Animal Feed Additives Comprising Polypeptide Having Protease Activity and Uses Thereof |
| CN111050566A (zh) | 2017-09-01 | 2020-04-21 | 诺维信公司 | 包含具有蛋白酶活性的多肽的动物饲料添加剂及其用途 |
| US20210076704A1 (en) | 2017-12-20 | 2021-03-18 | Dsm Ip Assets B.V. | Animal feed compositions and uses thereof |
| US20200337337A1 (en) | 2017-12-20 | 2020-10-29 | Dsm Ip Assets B.V. | Animal feed compositions comprising muramidase and uses thereof |
| BR112020012438A2 (pt) | 2018-01-11 | 2020-11-24 | Novozymes A/S | composição, ração animal ou aditivo de ração animal, e, método de melhoria da liberação de xilana a partir de alimento para animais. |
| BR112020021365A2 (pt) | 2018-04-25 | 2021-01-19 | Novozymes A/S | Ração animal, método para melhoria do fator de eficiência de produção europeu, ganho de peso corporal e/ou razão de conversão de ração de um animal monogástrico, uso de pelo menos um probiótico em combinação com um polipeptídeo tendo atividade de muramidase em uma composição de ração, e, composição de ração ou uma composição de pré-mistura, ou um aditivo de ração para animais. |
| BR112021004826A2 (pt) | 2018-09-17 | 2021-06-08 | Dsm Ip Assets B.V. | composições de ração animal e usos das mesmas |
| AU2019341519A1 (en) | 2018-09-17 | 2021-03-18 | Dsm Ip Assets B.V. | Animal feed compositions and uses thereof |
| BR112021004817A2 (pt) | 2018-09-17 | 2021-06-08 | Dsm Ip Assets B.V. | composições de ração animal e usos das mesmas |
| WO2020058225A1 (en) | 2018-09-17 | 2020-03-26 | Dsm Ip Assets B.V. | Animal feed compositions and uses thereof |
| WO2020115179A1 (en) | 2018-12-05 | 2020-06-11 | Novozymes A/S | Use of an enzyme granule |
| WO2021078839A1 (en) | 2019-10-22 | 2021-04-29 | Novozymes A/S | Animal feed composition |
| CN115605094A (zh) | 2020-05-15 | 2023-01-13 | 帝斯曼知识产权资产管理有限公司（Nl） | 用于改善动物饲料的营养价值的方法 |
| EP4152946A1 (en) | 2020-05-18 | 2023-03-29 | DSM IP Assets B.V. | Animal feed compositions |
| EP4152945A1 (en) | 2020-05-18 | 2023-03-29 | DSM IP Assets B.V. | Animal feed compositions |
| JP2023537982A (ja) | 2020-08-13 | 2023-09-06 | ノボザイムス アクティーゼルスカブ | フィターゼ変異体及びそれをコードするポリヌクレオチド |
| EP4225048A2 (en) | 2020-10-07 | 2023-08-16 | Novozymes A/S | Enzymatic feed preservation |
| WO2022079238A1 (en) | 2020-10-15 | 2022-04-21 | Dsm Ip Assets B.V. | Methods of modulating gastrointestinal metabolites |
| CN114958803B (zh) * | 2022-05-18 | 2024-06-04 | 阳原县仁恒精细粘土有限责任公司 | 植酸酶发酵生产方法 |
| WO2026132160A1 (en) | 2024-12-19 | 2026-06-25 | Novozymes A/S | Stabilization of enzymes in animal feed |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69632669T2 (de) * | 1995-07-28 | 2004-10-07 | Basf Ag | Salz-stabilisierte Enzymzubereitung |
| WO1997039116A1 (en) * | 1996-04-12 | 1997-10-23 | Novo Nordisk A/S | Enzyme-containing granules and process for the production thereof |
-
1999
- 1999-10-01 EP EP99945962A patent/EP1117771B1/en not_active Expired - Lifetime
- 1999-10-01 CN CNB998114618A patent/CN1197963C/zh not_active Expired - Lifetime
- 1999-10-01 AU AU58505/99A patent/AU761363B2/en not_active Expired
- 1999-10-01 DK DK99945962T patent/DK1117771T3/da active
- 1999-10-01 BR BR9914217-1A patent/BR9914217A/pt not_active Application Discontinuation
- 1999-10-01 WO PCT/DK1999/000516 patent/WO2000020569A1/en not_active Ceased
- 1999-10-01 CA CA002341484A patent/CA2341484C/en not_active Expired - Lifetime
- 1999-10-01 DE DE69907240T patent/DE69907240T2/de not_active Expired - Lifetime
- 1999-10-01 AT AT99945962T patent/ATE238415T1/de not_active IP Right Cessation
- 1999-10-01 JP JP2000574666A patent/JP4455764B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1197963C (zh) | 2005-04-20 |
| DK1117771T3 (da) | 2003-06-16 |
| WO2000020569A1 (en) | 2000-04-13 |
| EP1117771A1 (en) | 2001-07-25 |
| CA2341484A1 (en) | 2000-04-13 |
| AU5850599A (en) | 2000-04-26 |
| DE69907240T2 (de) | 2003-11-27 |
| JP4455764B2 (ja) | 2010-04-21 |
| JP2002526106A (ja) | 2002-08-20 |
| DE69907240D1 (de) | 2003-05-28 |
| CN1320161A (zh) | 2001-10-31 |
| ATE238415T1 (de) | 2003-05-15 |
| BR9914217A (pt) | 2001-07-03 |
| EP1117771B1 (en) | 2003-04-23 |
| AU761363B2 (en) | 2003-06-05 |
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