CA2341271A1 - Novel isoxazolinone antibacterial agents - Google Patents
Novel isoxazolinone antibacterial agents Download PDFInfo
- Publication number
- CA2341271A1 CA2341271A1 CA002341271A CA2341271A CA2341271A1 CA 2341271 A1 CA2341271 A1 CA 2341271A1 CA 002341271 A CA002341271 A CA 002341271A CA 2341271 A CA2341271 A CA 2341271A CA 2341271 A1 CA2341271 A1 CA 2341271A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- optionally substituted
- phenyl
- alkoxy
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9757498P | 1998-08-24 | 1998-08-24 | |
| US60/097,574 | 1998-08-24 | ||
| PCT/US1999/019265 WO2000010566A1 (en) | 1998-08-24 | 1999-08-23 | Novel isoxazolinone antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2341271A1 true CA2341271A1 (en) | 2000-03-02 |
Family
ID=22264103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002341271A Abandoned CA2341271A1 (en) | 1998-08-24 | 1999-08-23 | Novel isoxazolinone antibacterial agents |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1107756A4 (zh) |
| JP (1) | JP2002523369A (zh) |
| KR (1) | KR20010072945A (zh) |
| CN (1) | CN1314813A (zh) |
| AR (1) | AR020250A1 (zh) |
| AU (1) | AU748750B2 (zh) |
| BR (1) | BR9913225A (zh) |
| CA (1) | CA2341271A1 (zh) |
| CO (1) | CO5160266A1 (zh) |
| CZ (1) | CZ2001669A3 (zh) |
| HU (1) | HUP0103433A3 (zh) |
| ID (1) | ID27690A (zh) |
| IL (1) | IL141542A0 (zh) |
| NO (1) | NO20010916L (zh) |
| NZ (1) | NZ509867A (zh) |
| PE (1) | PE20001063A1 (zh) |
| PL (1) | PL346267A1 (zh) |
| TR (1) | TR200100672T2 (zh) |
| TW (1) | TW572757B (zh) |
| UY (1) | UY25677A1 (zh) |
| WO (1) | WO2000010566A1 (zh) |
| ZA (1) | ZA200101505B (zh) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465456B2 (en) * | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
| JP2002020366A (ja) * | 2000-07-05 | 2002-01-23 | Sumitomo Seika Chem Co Ltd | アルキルチオフェニル酢酸類の製造方法 |
| PE20030044A1 (es) | 2000-11-17 | 2003-02-09 | Upjohn Co | Isoxazolinonas biciclicas de formula i |
| PE20020689A1 (es) | 2000-11-17 | 2002-08-03 | Upjohn Co | Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno |
| US6861433B2 (en) | 2000-12-15 | 2005-03-01 | Pharmacia & Upjohn Company | Oxazolidinone photoaffinity probes |
| ATE319710T1 (de) | 2000-12-21 | 2006-03-15 | Pharmacia & Upjohn Co Llc | Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen |
| ES2180456B1 (es) * | 2001-07-20 | 2004-05-01 | Laboratorios S.A.L.V.A.T., S.A. | Isoxazoles sustituidos y su utilizacion como antibioticos. |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| EP1443930A1 (en) | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Isoxazoline derivatives useful as antimicrobials |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| AU2003265090A1 (en) | 2002-10-10 | 2004-05-04 | Pharmacia & Upjohn Comapny LLC | Antimicrobial 1-aryl dihydropyridone compounds |
| MXPA05007724A (es) * | 2003-02-07 | 2005-09-30 | Warner Lambert Co | Agentes antibacterianos. |
| JP4805139B2 (ja) | 2003-04-30 | 2011-11-02 | モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー | 炭疽および他の感染を治療するためのオキサゾリジノン‐キノリンハイブリッド抗生物質の使用 |
| CN101429170B (zh) * | 2003-06-03 | 2015-05-13 | 梅林塔医疗有限公司 | 联芳基杂环化合物的制备和用途 |
| US6969726B2 (en) | 2003-06-03 | 2005-11-29 | Rib X Pharmaceuticals Inc | Biaryl heterocyclic compounds and methods of making and using the same |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| US20070197541A1 (en) * | 2003-07-29 | 2007-08-23 | Oyelere Adegboyega K | Biaryl heterocyclic amines,amides, and sulfur-containing compounds and methods of making and using the same |
| DE10340485B4 (de) * | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
| US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| AR046782A1 (es) | 2003-12-17 | 2005-12-21 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos. |
| RU2371443C2 (ru) | 2003-12-18 | 2009-10-27 | Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми | Оксазолидинон-хинолонгибридные антибиотики |
| US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
| WO2006133397A2 (en) | 2005-06-08 | 2006-12-14 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of triazoles |
| AT503354B1 (de) * | 2006-02-22 | 2008-07-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen |
| JP4518066B2 (ja) * | 2006-10-25 | 2010-08-04 | 宇部興産株式会社 | ジアルコキシニトリル誘導体及びその製法 |
| CN110423610B (zh) * | 2019-08-29 | 2023-05-12 | 浙江理工大学 | 一种检测双光子汞离子荧光探针及其制备方法与使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2045049A1 (de) * | 1970-09-11 | 1972-03-23 | Dr Karl Thomae GmbH, 7950 Biberach | Neue Nitrofurandenvate und Ver fahren zu ihrer Herstellung |
| US4000155A (en) * | 1975-12-11 | 1976-12-28 | Eli Lilly And Company | Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones] |
| WO1994013649A1 (en) * | 1992-12-08 | 1994-06-23 | The Upjohn Company | Tropone-substituted phenyloxazolidinone antibacterial agents |
| PT863890E (pt) * | 1995-09-15 | 2003-04-30 | Upjohn Co | Agentes antibacterianos de 5-amidometil-3-arilbutirolactona alfa,beta-saturados e insaturados |
| GB9521508D0 (en) * | 1995-10-20 | 1995-12-20 | Zeneca Ltd | Chemical compounds |
| DK0920421T3 (da) * | 1996-08-21 | 2003-03-10 | Upjohn Co | Isoxazolinderivater anvendelige som antimikrobielle midler |
-
1999
- 1999-08-19 TW TW88114208A patent/TW572757B/zh active
- 1999-08-23 WO PCT/US1999/019265 patent/WO2000010566A1/en not_active Application Discontinuation
- 1999-08-23 CN CN99809894A patent/CN1314813A/zh active Pending
- 1999-08-23 BR BR9913225-7A patent/BR9913225A/pt not_active IP Right Cessation
- 1999-08-23 CA CA002341271A patent/CA2341271A1/en not_active Abandoned
- 1999-08-23 EP EP99945157A patent/EP1107756A4/en not_active Withdrawn
- 1999-08-23 TR TR2001/00672T patent/TR200100672T2/xx unknown
- 1999-08-23 JP JP2000565887A patent/JP2002523369A/ja active Pending
- 1999-08-23 PL PL99346267A patent/PL346267A1/xx not_active Application Discontinuation
- 1999-08-23 AU AU57833/99A patent/AU748750B2/en not_active Ceased
- 1999-08-23 ID IDW20010439A patent/ID27690A/id unknown
- 1999-08-23 CO CO99053191A patent/CO5160266A1/es unknown
- 1999-08-23 NZ NZ509867A patent/NZ509867A/en unknown
- 1999-08-23 CZ CZ2001669A patent/CZ2001669A3/cs unknown
- 1999-08-23 IL IL14154299A patent/IL141542A0/xx unknown
- 1999-08-23 KR KR1020017002377A patent/KR20010072945A/ko not_active Application Discontinuation
- 1999-08-23 HU HU0103433A patent/HUP0103433A3/hu unknown
- 1999-08-24 PE PE1999000853A patent/PE20001063A1/es not_active Application Discontinuation
- 1999-08-24 AR ARP990104229A patent/AR020250A1/es not_active Application Discontinuation
- 1999-08-24 UY UY25677A patent/UY25677A1/es unknown
-
2001
- 2001-02-22 ZA ZA200101505A patent/ZA200101505B/en unknown
- 2001-02-23 NO NO20010916A patent/NO20010916L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW572757B (en) | 2004-01-21 |
| CO5160266A1 (es) | 2002-05-30 |
| AR020250A1 (es) | 2002-05-02 |
| CN1314813A (zh) | 2001-09-26 |
| NO20010916L (no) | 2001-04-10 |
| NZ509867A (en) | 2003-08-29 |
| UY25677A1 (es) | 2001-08-27 |
| BR9913225A (pt) | 2001-05-22 |
| ID27690A (id) | 2001-04-19 |
| KR20010072945A (ko) | 2001-07-31 |
| CZ2001669A3 (cs) | 2001-08-15 |
| PE20001063A1 (es) | 2000-12-24 |
| WO2000010566A1 (en) | 2000-03-02 |
| ZA200101505B (en) | 2002-02-22 |
| JP2002523369A (ja) | 2002-07-30 |
| EP1107756A1 (en) | 2001-06-20 |
| AU748750B2 (en) | 2002-06-13 |
| HUP0103433A3 (en) | 2002-08-28 |
| EP1107756A4 (en) | 2003-02-26 |
| AU5783399A (en) | 2000-03-14 |
| IL141542A0 (en) | 2002-03-10 |
| HUP0103433A2 (hu) | 2002-01-28 |
| NO20010916D0 (no) | 2001-02-23 |
| PL346267A1 (en) | 2002-01-28 |
| TR200100672T2 (tr) | 2001-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |