CA2341271A1 - Nouveaux agents antibacteriens a base d'isoxazolinone - Google Patents

Nouveaux agents antibacteriens a base d'isoxazolinone Download PDF

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Publication number
CA2341271A1
CA2341271A1 CA002341271A CA2341271A CA2341271A1 CA 2341271 A1 CA2341271 A1 CA 2341271A1 CA 002341271 A CA002341271 A CA 002341271A CA 2341271 A CA2341271 A CA 2341271A CA 2341271 A1 CA2341271 A1 CA 2341271A1
Authority
CA
Canada
Prior art keywords
alkyl
optionally substituted
phenyl
alkoxy
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002341271A
Other languages
English (en)
Inventor
Lawrence B. Snyder
Zhizhen Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2341271A1 publication Critical patent/CA2341271A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des dérivés d'isoxazolinone qui exercent une activité antibactérienne et qui conviennent au traitement de maladies bactériennes. D'une manière plus spécifique, l'invention concerne de nouveaux isoxazolinones représentés par la formule générale (I), dans laquelle A et R¿1? sont décrits dans le descriptif.
CA002341271A 1998-08-24 1999-08-23 Nouveaux agents antibacteriens a base d'isoxazolinone Abandoned CA2341271A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9757498P 1998-08-24 1998-08-24
US60/097,574 1998-08-24
PCT/US1999/019265 WO2000010566A1 (fr) 1998-08-24 1999-08-23 Nouveaux agents antibacteriens a base d'isoxazolinone

Publications (1)

Publication Number Publication Date
CA2341271A1 true CA2341271A1 (fr) 2000-03-02

Family

ID=22264103

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002341271A Abandoned CA2341271A1 (fr) 1998-08-24 1999-08-23 Nouveaux agents antibacteriens a base d'isoxazolinone

Country Status (22)

Country Link
EP (1) EP1107756A4 (fr)
JP (1) JP2002523369A (fr)
KR (1) KR20010072945A (fr)
CN (1) CN1314813A (fr)
AR (1) AR020250A1 (fr)
AU (1) AU748750B2 (fr)
BR (1) BR9913225A (fr)
CA (1) CA2341271A1 (fr)
CO (1) CO5160266A1 (fr)
CZ (1) CZ2001669A3 (fr)
HU (1) HUP0103433A3 (fr)
ID (1) ID27690A (fr)
IL (1) IL141542A0 (fr)
NO (1) NO20010916L (fr)
NZ (1) NZ509867A (fr)
PE (1) PE20001063A1 (fr)
PL (1) PL346267A1 (fr)
TR (1) TR200100672T2 (fr)
TW (1) TW572757B (fr)
UY (1) UY25677A1 (fr)
WO (1) WO2000010566A1 (fr)
ZA (1) ZA200101505B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465456B2 (en) * 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
JP2002020366A (ja) * 2000-07-05 2002-01-23 Sumitomo Seika Chem Co Ltd アルキルチオフェニル酢酸類の製造方法
PE20030044A1 (es) 2000-11-17 2003-02-09 Upjohn Co Isoxazolinonas biciclicas de formula i
PE20020689A1 (es) 2000-11-17 2002-08-03 Upjohn Co Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno
US6861433B2 (en) 2000-12-15 2005-03-01 Pharmacia & Upjohn Company Oxazolidinone photoaffinity probes
CA2424402A1 (fr) 2000-12-21 2002-08-01 Pharmacia & Upjohn Company Derives antimicrobiens de la quinolone et leur utilisation pour le traitement d'infections bacteriennes
ES2180456B1 (es) * 2001-07-20 2004-05-01 Laboratorios S.A.L.V.A.T., S.A. Isoxazoles sustituidos y su utilizacion como antibioticos.
WO2003031443A1 (fr) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Antibiotiques a action duale renfermant une oxazolidinone et une quinolone ou une fraction de naphthyridinone
JP2005512975A (ja) 2001-10-25 2005-05-12 アストラゼネカ アクチボラグ 抗菌薬として有用なイソキサゾリン誘導体
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
MXPA05003774A (es) * 2002-10-10 2005-06-08 Pharmacia & Upjohn Co Llc Compuestos de 1-aril-dihidropiridona con actividad antimicrobiana.
WO2004069832A2 (fr) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Agents antibacteriens
RU2351335C2 (ru) 2003-04-30 2009-04-10 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Применение оксазолидинон-хинолиновых гибридных антибиотиков для лечения сибирской язвы и других инфекций
AR045690A1 (es) 2003-06-03 2005-11-09 Rib X Pharmaceuticals Inc Compuestos biaril heterociclicos y metodos para preparar y utilizar los mismos
WO2005070904A2 (fr) * 2003-06-03 2005-08-04 Rib-X Pharmaceutical, Inc. Composes de sulfamide, procedes de preparation et d'utilisation de ces derniers
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
WO2005012270A2 (fr) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Composes contenant des biarylamines heterocycliques, des amides et du soufre, et procedes de production et d'utilisation de ces composes
DE10340485B4 (de) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
JP2007514782A (ja) 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
ES2310299T5 (es) 2003-12-18 2014-02-10 Morphochem Aktiengesellschaft für kombinatorische Chemie Antibióticos híbridos a base de oxazolidinona-quinolona
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
WO2005082900A2 (fr) * 2004-01-28 2005-09-09 Pharmacia & Upjohn Company Llc Amidoxines d'oxazolidinone utilisees en tant qu'agents antibacteriens
WO2006133397A2 (fr) 2005-06-08 2006-12-14 Rib-X Pharmaceuticals, Inc. Procede permettant de realiser la synthese de triazoles
AT503354B1 (de) * 2006-02-22 2008-07-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen
JP4518066B2 (ja) * 2006-10-25 2010-08-04 宇部興産株式会社 ジアルコキシニトリル誘導体及びその製法
CN110423610B (zh) * 2019-08-29 2023-05-12 浙江理工大学 一种检测双光子汞离子荧光探针及其制备方法与使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2045049A1 (de) * 1970-09-11 1972-03-23 Dr Karl Thomae GmbH, 7950 Biberach Neue Nitrofurandenvate und Ver fahren zu ihrer Herstellung
US4000155A (en) * 1975-12-11 1976-12-28 Eli Lilly And Company Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones]
ATE161833T1 (de) * 1992-12-08 1998-01-15 Upjohn Co Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel
US5708169A (en) * 1995-09-15 1998-01-13 Pharmacia & Upjohn Company 5-amidomethyl α,β-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents
GB9521508D0 (en) * 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
PT920421E (pt) * 1996-08-21 2003-03-31 Upjohn Co Derivados de isoxazolina uteis como agentes antimicrobianos

Also Published As

Publication number Publication date
CO5160266A1 (es) 2002-05-30
AU748750B2 (en) 2002-06-13
CZ2001669A3 (cs) 2001-08-15
KR20010072945A (ko) 2001-07-31
EP1107756A4 (fr) 2003-02-26
AU5783399A (en) 2000-03-14
NO20010916D0 (no) 2001-02-23
NZ509867A (en) 2003-08-29
BR9913225A (pt) 2001-05-22
JP2002523369A (ja) 2002-07-30
HUP0103433A2 (hu) 2002-01-28
WO2000010566A1 (fr) 2000-03-02
ZA200101505B (en) 2002-02-22
PL346267A1 (en) 2002-01-28
UY25677A1 (es) 2001-08-27
CN1314813A (zh) 2001-09-26
EP1107756A1 (fr) 2001-06-20
AR020250A1 (es) 2002-05-02
HUP0103433A3 (en) 2002-08-28
TR200100672T2 (tr) 2001-07-23
IL141542A0 (en) 2002-03-10
ID27690A (id) 2001-04-19
TW572757B (en) 2004-01-21
NO20010916L (no) 2001-04-10
PE20001063A1 (es) 2000-12-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued